Research Topics
| Francesco PattiSummaryAffiliation: University of Catania Country: Italy Publications
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Detail Information
Publications
Treatment of cognitive impairment in patients with multiple sclerosisFrancesco Patti
University Hospital Catania, Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, Neuroscience Section, GF Ingrassia Department, Via Santa Sofia 78, 95123 Catania, Italy
Expert Opin Investig Drugs 21:1679-99. 2012..However, the methods used to diagnose cognitive impairment, and to assess the effect of treatment on function over time and need to be refined...- Longitudinal changes in social functioning in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) study (II)Francesco Patti
Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital, and Department of Neurology, University of Catania, Catania, Italy
Qual Life Res 21:1111-21. 2012..To report longitudinal changes in and explore the influence of cognition on social functioning in mildly disabled patients with relapsing-remitting multiple sclerosis (RRMS)... 
Changes in magnetic resonance imaging disease measures over 3 years in mildly disabled patients with relapsing-remitting multiple sclerosis receiving interferon β-1a in the COGnitive Impairment in MUltiple Sclerosis (COGIMUS) studyStefano Bastianello
National Neurological Institute, C Mondino Foundation, Pavia, Italy
BMC Neurol 11:125. 2011..In clinical trials, MRI has been found to detect treatment effects with greater sensitivity than clinical measures; however, clinical and MRI outcomes tend to correlate poorly...- Cognitive impairment and its relation with disease measures in mildly disabled patients with relapsing-remitting multiple sclerosis: baseline results from the Cognitive Impairment in Multiple Sclerosis (COGIMUS) studyF Patti
Department of Neurosciences, University of Catania, Catania, Italy
Mult Scler 15:779-88. 2009..Cognitive impairment is a common symptom of multiple sclerosis (MS), but the association between cognitive impairment and magnetic resonance imaging (MRI) disease measures in patients with relapsing-remitting (RR) MS is unclear... - Subcutaneous Interferon Beta-1a Has a Positive Effect on Cognitive Performance in Mildly Disabled Patients with Relapsing-Remitting Multiple Sclerosis: 2-Year Results from the COGIMUS StudyFrancesco Patti
Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Via Santa Sofia 78, 95123 Catania, Italy
Ther Adv Neurol Disord 2:67-77. 2009..94-22.64). These interim results show that IFN beta-1a sc tiw may have beneficial effects on cognitive function as early as 2 years after treatment initiation, but the final 3-year data of the study are required to confirm these results... 
A double blind, placebo-controlled, phase II, add-on study of cyclophosphamide (CTX) for 24 months in patients affected by multiple sclerosis on a background therapy with interferon-beta study denomination: CYCLINF Patti
Dipartimento Scienze Neurologiche, Centro Sclerosi Multipla, Universita di Catania, Catania, Italy
J Neurol Sci 223:69-71. 2004..Vital signs and eventual adverse events will be collected monthly. The study will last 36 months, 12 for the enrollment phase and 24 for the treatment phase. The study will start on April 2004...- Effects of interferon beta-1a and -1b over time: 6-year results of an observational head-to-head studyF Patti
Centro Sclerosi Multipla, Universita di Catania, Catania, Italy
Acta Neurol Scand 113:241-7. 2006..To evaluate and compare the long-term efficacy and safety of two different beta-interferon preparations (IFN-beta-1a vs IFN-beta-1b)... - Quality of life, depression and fatigue in mildly disabled patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon beta-1a: 3-year results from the COGIMUS (COGnitive Impairment in MUltiple Sclerosis) studyF Patti
Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital, Catania, Italy
Mult Scler 17:991-1001. 2011..The precise relationships among quality of life, depression, fatigue and cognitive impairment in multiple sclerosis (MS) are complex and poorly understood... - Predictors of quality of life among patients with multiple sclerosis: an Italian cross-sectional studyFrancesco Patti
Policlinico Universitario, Clinica Neurologica, Catania, Italy
J Neurol Sci 252:121-9. 2007..The Italian FAMS questionnaire is a valid measure to assess the QoL concerns of patients with MS. FAMS is also easy to administer and is well accepted by patients... - Treatment options of cognitive impairment in multiple sclerosisFrancesco Patti
Department of Neuroscience, Centre of Multiple Sclerosis, Catania, Italy
Neurol Sci 31:S265-9. 2010..Treatment strategies for cognitive impairment in MS are still in their infancy. This article will summarize several pharmacological attempts to enhance cognitive performances in people with MS... - Caregiver quality of life in multiple sclerosis: a multicentre Italian studyF Patti
Department of Neurology, University of Catania, Via Santa Sofia 78, 95123 Catania, Italy
Mult Scler 13:412-9. 2007..Therefore, caregiver QoL was significantly influenced by patient characteristics, and supportive strategies for MS caregivers are warranted... - Effects of education level and employment status on HRQoL in early relapsing-remitting multiple sclerosisF Patti
Department of Neurological Sciences, Multiple Sclerosis Centre, University of Catania, Italy
Mult Scler 13:783-91. 2007..5; stable disease on enrollment; and no previous treatment with interferons, glatiramer acetate, or immunosuppressive drugs. Quality of life (QoL) was evaluated by the Multiple Sclerosis Quality of Life-54 questionnaire (MSQoL-54)... - Effects of immunomodulatory treatment with subcutaneous interferon beta-1a on cognitive decline in mildly disabled patients with relapsing-remitting multiple sclerosisF Patti
Multiple Sclerosis Centre Sicilia Region, First Neurology Clinic, University Hospital Catania, Catania, Italy
Mult Scler 16:68-77. 2010..These findings suggest that sc IFNbeta-1a may have dose-dependent cognitive benefits in mildly disabled patients with RRMS, and may support early initiation of high-dose IFNbeta-1a treatment... - Cognitive impairment in multiple sclerosisF Patti
Department of Neurology, University of Catania, Catania, Italy
Mult Scler 15:2-8. 2009..Detailed studies of cognitive impairment in MS are rare and guidelines for the assessment of cognitive function in MS are lacking... - Health-related quality of life and depression in an Italian sample of multiple sclerosis patientsFrancesco Patti
Dipartimento Neuroscienze, Sezione Sclerosi Multipla e Malattie Demielinizzanti, Azienda Policlinico Via Santa Sofia 78, 95123 Catania, Italy
J Neurol Sci 211:55-62. 2003..Depression strongly influenced the HRQoL of MS patients. EDSS and time since diagnosis also affected the HRQoL of MS patients. Our results are comparable with other European studies... - Increasing frequency of multiple sclerosis in Catania, Sicily: a 30-year surveyAlessandra Nicoletti
Department of Neurosciences, University of Catania, Catania, Italy
Mult Scler 17:273-80. 2011..The objective of this study was to determine the prevalence and incidence of multiple sclerosis (MS) and its temporal profiles from 1975 to 2005 in the city of Catania... - Stabilization of rapidly worsening multiple sclerosis for 36 months in patients treated with interferon beta plus cyclophosphamide followed by interferon betaFrancesco Patti
Department of Neurological Sciences, Via Santa Sofia 78, 95123, Catania, Italy
J Neurol 251:1502-6. 2004..These encouraging findings and the absence of significant recorded side effects affirm that the association of CTX plus interferon-beta is amenable, safe and can be recommended in rapidly worsening MS patients... - The combination of cyclophosphamide plus interferon beta as rescue therapy could be used to treat relapsing-remitting multiple sclerosis patients-- twenty-four months follow-upEster Reggio
Centre of Multiple Sclerosis and Degenerative Disease of the Nervous System, University of Catania, Via Conti 6, Italy
J Neurol 252:1255-61. 2005.... - A possible spatial and temporal cluster of multiple sclerosis in the town of Linguaglossa, SicilyAlessandra Nicoletti
Dept of Neuroscience, University of Catania, Catania, Italy
J Neurol 252:921-5. 2005.... - Epidural analgesia and cesarean delivery in multiple sclerosis post-partum relapses: the Italian cohort studyLuisa Pastò
Department of Neurology, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
BMC Neurol 12:165. 2012..abstract:.. - Epilepsy and multiple sclerosis in Sicily: a population-based studyAlessandra Nicoletti
Department of Neuroscience, University of Catania, Catania, Italy
Epilepsia 44:1445-8. 2003..To evaluate the association between epilepsy and multiple sclerosis (MS), we analyzed the incidence of epilepsy in a population-based incidence cohort of MS in Catania, Sicily... - Multiple sclerosis and CCSVI: a population-based case control studyFrancesco Patti
Department DANA GF Ingrassia, Section of Neurosciences, University of Catania, Catania, Italy
PLoS ONE 7:e41227. 2012..Chronic cerebrospinal venous insufficiency (CCSVI) has been associated to multiple sclerosis (MS)... - Effects of a short outpatient rehabilitation treatment on disability of multiple sclerosis patients--a randomised controlled trialFrancesco Patti
Institute of Neurological Sciences, University of Catania, Via Santa Sofia 78, 95125 Catania, Italy
J Neurol 250:861-6. 2003..This study demonstrates that a short outpatient rehabilitation treatment improves disability of MS patients, without changing their impairment and confirms the effectiveness of rehabilitation in people with MS... - Psychometric properties of the Italian version of the Guy's Neurological Disability ScaleAngelo Pappalardo
Department of Neurological Sciences, University of Catania, Italy
Funct Neurol 25:223-33. 2010..77; p<0.001), in the RRMS patients (r=0.65, p<0.01), and in those with SPMS (r=0.48, p<0.05). In conclusion, the Italian version of the GNDS emerges as a valid assessment instrument with adequate basic psychometric properties... - Brain atrophy and lesion load in a large population of patients with multiple sclerosisG Tedeschi
Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, 80138 Naples, Italy
Neurology 65:280-5. 2005..To measure white matter (WM) and gray matter (GM) atrophy and lesion load in a large population of patients with multiple sclerosis (MS) using a fully automated, operator-independent, multiparametric segmentation method... - Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trialG Comi
Institute of Experimental Neurology, Department of Neurology, University Vita Salute, Scientific Institute San Raffaele, Milan, Italy
Lancet 374:1503-11. 2009..We assessed the efficacy of early treatment with glatiramer acetate in delaying onset of clinically definite multiple sclerosis... - The Rao's Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian populationM P Amato
Department of Neurology, University of Florence, Viale Morgagni, 85 50134 Florence, Italy
Mult Scler 12:787-93. 2006..Increasing age was associated with worse performance on the ST in version A, and on the SRT-LTS, SRT-CLTR and WLG in version B. Our data can improve the applicability of the BRB for both clinical and research purposes... - Headache and multiple sclerosis: a population-based case-control study in Catania, SicilyA Nicoletti
Department of Neurosciences, University of Catania, Catania, Italy
Cephalalgia 28:1163-9. 2008..18 (95% confidence interval 1.27, 3.93). Frequency of headaches in our MS population is higher than in the general population, supporting the hypothesis of a possible association between these two conditions... - The impact of outpatient rehabilitation on quality of life in multiple sclerosisFrancesco Patti
Department of Neurological Sciences, Centro Sclerosi Multipla, Policlinico Universitario di Catania, Via Santa Sofia 78, 95123 Catania, Italy
J Neurol 249:1027-33. 2002..001). The results of this study confirm the effectiveness of a short comprehensive outpatient model of rehabilitative treatment in people with MS and in particular in their QoL... - Prevalence and incidence of multiple sclerosis in Catania, SicilyA Nicoletti
Institute of Neurological Science, University of Catania, Italy
Neurology 56:62-6. 2001..An epidemiologic survey was conducted to determine the prevalence and incidence of MS in the city of Catania, Sicily, Italy. Prevalence rate was calculated as point prevalence at January 1,1995, and incidence during 1974 to 1995... - Brain atrophy evolution and lesion load accrual in multiple sclerosis: a 2-year follow-up studyG Tedeschi
Department of Neurological Sciences, Second University of Naples, Naples, Italy
Mult Scler 15:204-11. 2009..To investigate in a large cohort of patients with multiple sclerosis (MS), lesion load and atrophy evolution, and the relationship between clinical and magnetic resonance imaging (MRI) correlates of disease progression... - Treatment of multiple sclerosis with interferon beta in clinical practice: 2-year follow-up data from the South Italy Mobile MRI ProjectS Bonavita
Department of Neurological Sciences, Second University of Naples, Piazza Miraglia 2, I-80138 Naples, Italy
Neurol Sci 27:S365-8. 2006..Despite some limitations in the trial design, the results from this follow-up study provide helpful clinical and MRI data on the efficacy of interferon beta regimens in MS patients treated in the clinical setting... - Cognitive and psychosocial features in childhood and juvenile MS: two-year follow-upM P Amato
Department of Neurology, University of Florence, Viale Morgagni 85, Florence, Italy
Neurology 75:1134-40. 2010..To assess the evolution of cognitive and psychosocial functioning in a cohort of childhood and juvenile multiple sclerosis (MS) cases after a mean period of 2 years had elapsed since baseline evaluation... - Pregnancy and fetal outcomes after Glatiramer Acetate exposure in patients with multiple sclerosis: a prospective observational multicentric studyMarta Giannini
Department of Neurology, University of Florence, Florence, Italy
BMC Neurol 12:124. 2012.... - Outcome of psychiatric symptoms presenting at onset of multiple sclerosis: a retrospective studySalvatore Lo Fermo
Department of Neurosciences, University of Catania, Catania, Italy
Mult Scler 16:742-8. 2010..3), 14 subjects (87%) had a supplementary diagnosis of psychiatric illness. Psychiatric symptoms at onset of multiple sclerosis may be indicators of possible maintenance of psychiatric morbidity in a sizeable proportion of patients... - Pregnancy and fetal outcomes after interferon-β exposure in multiple sclerosisM P Amato
Department of Neurology, University of Florence, Florence, Italy
Neurology 75:1794-802. 2010..To assess pregnancy and fetal outcomes after in utero exposure to interferon-β (IFNβ) in all pregnancies occurring in women with multiple sclerosis (MS) during the study period, with a specific focus on the risk of spontaneous abortion... - Correlation between fatigue and brain atrophy and lesion load in multiple sclerosis patients independent of disabilityGioacchino Tedeschi
Department of Neurological Sciences, Second University of Naples, Naples, Italy
J Neurol Sci 263:15-9. 2007..Fatigue is a major problem in multiple sclerosis (MS), and its association with MRI features is debated... - [Neurogenic dysphagia: physiology, physiopathology and rehabilitative treatment]F Patti
Dipartimento di Scienze Neurologiche, Universita di Catania, Policlinico Via Santa Sofia 78, 95123 Catania
Clin Ter 153:403-19. 2002..Rehabilitation is aimed to make patient able for a safe oral feeding. We can use classic specific physiotherapy, compensatory movements of head and neck, electrostimulation, and the chemical myotomia by botulinum toxin injection... - Psychosocial issue in children and adolescents with multiple sclerosisB Goretti
Department of Neurology, University of Florence, Florence, Italy
Neurol Sci 31:467-70. 2010..Our study confirms the critical role of psychosocial difficulties in children and adolescents with MS and provides a few cues to clinical management... - Combination of cyclophosphamide and interferon-beta halts progression in patients with rapidly transitional multiple sclerosisF Patti
Department of Neurological Sciences, University of Catania, Via S Sofia 78, 95123 Catania, Italy
J Neurol Neurosurg Psychiatry 71:404-7. 2001..The possibility is considered of carrying out further studies to test the efficacy of the association between the two drugs for patients who are not responsive to IFN-beta or other active disease modifying therapies... - Possible increasing risk of multiple sclerosis in Catania, SicilyA Nicoletti
Department of Neurosciences, University of Catania, Catania, Italy
Neurology 65:1259-63. 2005..To update prevalence and incidence rates of multiple sclerosis (MS) in Catania, Italy during 1990 to 1999 and evaluate their temporal profiles to assess a possible increase in the MS risk in our study population... - Cognitive and psychosocial features of childhood and juvenile MSM P Amato
Department of Neurology, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
Neurology 70:1891-7. 2008..To assess the impact of multiple sclerosis (MS) on cognitive and psychosocial functioning in childhood and juvenile cases... - Sporadic motor neuron disease in a familial novel SOD1 mutation: incomplete penetrance or chance association?Francesca L Conforti
Department of Neurosciences, University of Catania, Catania, Italy
Amyotroph Lateral Scler 12:220-2. 2011..The G61R mutation segregated in three unaffected relatives including the 80-year-old mother and two of the proband's siblings. Potential mechanisms include an autosomal dominant condition with reduced penetrance or a chance association... - Impact of sociodemographic characteristics on cognitive performance in an elderly Sicilian populationGiuseppe Salemi
Department of Neurology, University of Palermo, Italy
Neuroepidemiology 21:44-9. 2002..CONCLUSION: Our findings suggest that age, sex, education and employment status are the sociodemographic characteristics associated with cognitive impairment in the elderly as measured by the SPMSQ... - Drug rash with eosinophilia and systemic signs syndrome in a patient with multiple sclerosisAngelo Caruso
Department of Internal Medicine, University of Catania, Catania, Italy
Clin Ther 31:580-4. 2009..We describe a case of DRESS syndrome in a patient with multiple sclerosis (MS), characterized by a very high eosinophilia and cholestatic hepatitis... - The brief neuropsychological battery for children: a screening tool for cognitive impairment in childhood and juvenile multiple sclerosisE Portaccio
Department of Neurology, University of Florence, Florence, Italy
Mult Scler 15:620-6. 2009.... - Validation of the DYMUS questionnaire for the assessment of dysphagia in multiple sclerosisRoberto Bergamaschi
Multiple Sclerosis Centre, IRCCS C Mondino Institute of Neurology, Pavia, Italy
Funct Neurol 24:159-62. 2009.... - Is in utero early-exposure to interferon beta a risk factor for pregnancy outcomes in multiple sclerosis?F Patti
Dept of Neurosciences, University of Catania, Via Santa Sofia 78, 95123, Catania, Italy
J Neurol 255:1250-3. 2008..Aim of this study is to evaluate risks of the administration of INFbeta related not only to the foetus, but also to children development up to 12-months developmental milestones... - The prevalence of pain in multiple sclerosis: a multicenter cross-sectional studyC Solaro
Department of Neurology, P A Micone Hospital, Genova, Italy
Neurology 63:919-21. 2004..This study underlines the relevance of pain in the clinical history of MS... - [Management of neuropathic bladder in multiple sclerosis]A Pappalardo
Centro Sclerosi Multipla, Azienda Policlinico, Universita di Catania, Italia
Clin Ter 155:183-6. 2004..Therapy can usually eliminate or reduce the symptoms of neuropathic bladder. In the following pages is discussed the complex management of urinary symptoms in MS patients... - An exploration of anger phenomenology in multiple sclerosisU Nocentini
Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
Eur J Neurol 16:1312-7. 2009..Multiple sclerosis (MS) patients are often emotionally disturbed. We investigated anger in these patients in relation to demographic, clinical, and mood characteristics... - An MRI study of Chlamydia pneumoniae infection in Italian multiple sclerosis patientsL M E Grimaldi
Department of Neurosciences, AUSL 2 Caltanissetta, Via G Cusmano 3, 93100 Caltanissetta, Italy
Mult Scler 9:467-71. 2003..5 +/- 5 versus 4.4 +/- 4 years; P = 0.016) at the time of clinical evaluation. These findings, although indirectly, suggest that CP infection of the central nervous system (CNS) might affect disease course in a subgroup of MS patients... - The antiinflammatory cytokine interleukin-13 is not detectable in the circulation of multiple sclerosis patients and is not inducible by interferon-beta1b treatment, that neither modifies its ex vivo secretion from peripheral blood mononuclear cellsF Nicoletti
Institute of Neurology, University of Catania, Italy
Autoimmunity 32:265-70. 2000.... - The DYMUS questionnaire for the assessment of dysphagia in multiple sclerosisR Bergamaschi
Multiple Sclerosis Centre, Neurological Institute C Mondino, Pavia, Italy
J Neurol Sci 269:49-53. 2008..It can be used for preliminary selection of patients to submit to more specific instrumental analyses, and to direct toward programs for prevention of aspiration... - Clinical efficacy issues in the treatment of multiple sclerosis: update of natalizumabFrancesco Patti
Multiple Sclerosis Center, University of Catania, Catania, Italy Physical Medicine and Rehabilitation Unit, Hospital of Acireale, Catania, Italy
Clinicoecon Outcomes Res 1:45-51. 2009..From the analyses of the six cases, it seems that the overall risk is around 1/1,000 and could increase with the number of NA infusions... - Lights and shadows of cyclophosphamide in the treatment of multiple sclerosisFrancesco Patti
Department of Neuroscience, University of Catania, Catania, Italy
Autoimmune Dis 2011:961702. 2011.... - Botulinum toxin treatment of painful tonic spasms in multiple sclerosisD A Restivo
Department of Neurology, Garibaldi Hospital, Catania, Italy
Neurology 61:719-20. 2003 - Improvement of diabetic autonomic gustatory sweating by botulinum toxin type AD A Restivo
Department of Physiological Sciences, University of Catania, Italy
Neurology 59:1971-3. 2002..This therapeutic approach, which could be used to reduce the severity of diabetic gustatory sweating, appears to be long lasting, adverse effect free, and minimally invasive... - Osteoporotic vertebral compression fracture pain (back pain): our experience with balloon kyphoplastyA Guglielmino
Anesthesia and Intensive Care Unit, University Polyclinic, Catania, Italy
Minerva Anestesiol 73:77-100. 2007.... - Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis ratR Di Marco
Department of Microbiological and Gynaecological Sciences, University of Catania, Catania, Italy
Mult Scler 7:101-4. 2001..These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis... - Frequency of celiac disease is not increased among multiple sclerosis patientsA Nicoletti
Dipartimento di Neuroscienze, Universita di Catania, Via Santa Sofia no 78, Catania, Italy
Mult Scler 14:698-700. 2008..Our data did not show an increased frequency of celiac disease among patients with MS... - [Spasticity in multiple sclerosis]A Pappalardo
Centro Sclerosi Multipla, Universita di Catania, Italia
Clin Ter 155:135-8. 2004..In this article, the therapeutical management of MS spasticity, in all its components (pharmacological, rehabilitative, surgical) is reviewed...