Giuseppe Passarino

Summary

Affiliation: University of Calabria
Country: Italy

Publications

  1. ncbi request reprint Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms
    Giuseppe Passarino
    Dipartimento di Biologia Cellulare, Universita della Calabria, Ponte Pietro Bucci c da Arcavacata, 87030 Rende, Italy
    Eur J Hum Genet 10:521-9. 2002
  2. doi request reprint Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Biogerontology 11:575-88. 2010
  3. pmc A novel similarity-measure for the analysis of genetic data in complex phenotypes
    Vincenzo Lagani
    Department of Electronis, Informatics and Systems, University of Calabria, Via Ponte Pietro Bucci 41C, 87036, Rende, Italy
    BMC Bioinformatics 10:S24. 2009
  4. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
  5. ncbi request reprint Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians
    Giuseppe Passarino
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Hum Mutat 21:554-5. 2003
  6. ncbi request reprint Sex and age specificity of susceptibility genes modulating survival at old age
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, Rende, Italy
    Hum Hered 62:213-20. 2006
  7. ncbi request reprint Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines
    Dina Bellizzi
    Department of Cell Biology, 87030 Rende, University of Calabria, Italy
    Genes Cells 11:883-91. 2006
  8. ncbi request reprint Genetic polymorphism of the major regulatory element HS-40 upstream of the human alpha-globin gene cluster
    Cornelis L Harteveld
    Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 119:848-54. 2002
  9. ncbi request reprint Association of the mitochondrial DNA haplogroup J with longevity is population specific
    Serena Dato
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 12:1080-2. 2004
  10. ncbi request reprint A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Different genetic components in the Norwegian population revealed by the analysis of mtDNA and Y chromosome polymorphisms
    Giuseppe Passarino
    Dipartimento di Biologia Cellulare, Universita della Calabria, Ponte Pietro Bucci c da Arcavacata, 87030 Rende, Italy
    Eur J Hum Genet 10:521-9. 2002
    ..Other minor genetic influences on the Norwegian population from Uralic speakers and Mediterranean populations were also highlighted...
  2. doi request reprint Mitochondrial function, mitochondrial DNA and ageing: a reappraisal
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Biogerontology 11:575-88. 2010
    ..The present paper aims to review the findings of the last few years in order to outline a general framework to understand how mitochondria can affect ageing and how ageing affects mitochondria...
  3. pmc A novel similarity-measure for the analysis of genetic data in complex phenotypes
    Vincenzo Lagani
    Department of Electronis, Informatics and Systems, University of Calabria, Via Ponte Pietro Bucci 41C, 87036, Rende, Italy
    BMC Bioinformatics 10:S24. 2009
    ..e., cases and controls) taking into account that genetic profiles are usually distributed in a population group according to the Hardy Weinberg equilibrium...
  4. pmc The mitochondrial DNA control region shows genetically correlated levels of heteroplasmy in leukocytes of centenarians and their offspring
    Giuseppina Rose
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    BMC Genomics 8:293. 2007
    ....
  5. ncbi request reprint Molecular variation of human HSP90alpha and HSP90beta genes in Caucasians
    Giuseppe Passarino
    Department of Genetics, Stanford University School of Medicine, Stanford, California, USA
    Hum Mutat 21:554-5. 2003
    ..Only three of the observed mutations altered the genic product. Interestingly, one of the variations observed was a missense mutation leading to the impairment of the hsp90alpha protein...
  6. ncbi request reprint Sex and age specificity of susceptibility genes modulating survival at old age
    Giuseppe Passarino
    Department of Cell Biology, University of Calabria, Rende, Italy
    Hum Hered 62:213-20. 2006
    ..We aimed to investigate the influence of the genetic variability of candidate genes on survival at old age in good health...
  7. ncbi request reprint Gene expression of cytokines and cytokine receptors is modulated by the common variability of the mitochondrial DNA in cybrid cell lines
    Dina Bellizzi
    Department of Cell Biology, 87030 Rende, University of Calabria, Italy
    Genes Cells 11:883-91. 2006
    ..These findings provide a first experimental evidence of a relationship between mtDNA common variability and expression pattern of stress responder nuclear genes in human cells...
  8. ncbi request reprint Genetic polymorphism of the major regulatory element HS-40 upstream of the human alpha-globin gene cluster
    Cornelis L Harteveld
    Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Br J Haematol 119:848-54. 2002
    ....
  9. ncbi request reprint Association of the mitochondrial DNA haplogroup J with longevity is population specific
    Serena Dato
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 12:1080-2. 2004
    ..This finding shows that, as for other genetic factors, the association of mtDNA inherited variability with longevity is population specific...
  10. ncbi request reprint A novel sampling design to explore gene-longevity associations: the ECHA study
    Francesco De Rango
    Department of Cell Biology, University of Calabria, Rende, Italy
    Eur J Hum Genet 16:236-42. 2008
    ..This will allow to dimension future sampling campaigns to study-genetic basis of human longevity...
  11. pmc Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes
    Jin Zhang
    Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA
    Proc Natl Acad Sci U S A 100:1116-21. 2003
    ....
  12. ncbi request reprint A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    Dina Bellizzi
    Department of Cell Biology, University of Calabria, 87036 Rende, Italy
    Genomics 85:258-63. 2005
    ..Thus the underexpression of a human sirtuin gene seems to be detrimental for longevity as it occurs in model organisms...
  13. doi request reprint The impact of mitochondrial DNA on human lifespan: a view from studies on centenarians
    Stefano Salvioli
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Biotechnol J 3:740-9. 2008
    ....
  14. doi request reprint Resistance of mtDNA-depleted cells to apoptosis
    Roberta Ferraresi
    Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
    Cytometry A 73:528-37. 2008
    ..The resistance to apoptosis of rho(0) cells could be not only due to an increased scavenger capacity of GSH, but also due to a selection of multidrug resistant cells that hyperexpress P-gp...
  15. ncbi request reprint Human longevity within an evolutionary perspective: the peculiar paradigm of a post-reproductive genetics
    Miriam Capri
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, I 40126 Bologna, Italy
    Exp Gerontol 43:53-60. 2008
    ..6) The concomitant and integrated use of new in silico and high throughput strategies will greatly accelerate the identification of new longevity genes in humans...
  16. ncbi request reprint Heat shock response by EBV-immortalized B-lymphocytes from centenarians and control subjects: a model to study the relevance of stress response in longevity
    Marina Marini
    Institute of Histology and General Embryology, University of Bologna, Via Belmerloro 8, Bologna 40126, Italy
    Exp Gerontol 39:83-90. 2004
    ..We found that cells from AA centenarian females displayed a lower synthesis of HSP70...
  17. ncbi request reprint Handgrip strength among nonagenarians and centenarians in three European regions
    Bernard Jeune
    Aging Research Center, and Epidemiology, Institute of Public Health, University of Southern Denmark, 5000 Odense C, Denmark
    J Gerontol A Biol Sci Med Sci 61:707-12. 2006
    ..Handgrip strength is an important predictor of disability and mortality among old people. The aim was to compare the grip strength among very old people in three regions of Europe...
  18. ncbi request reprint Mitochondrial DNA involvement in human longevity
    Aurelia Santoro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 12, 40126 Bologna, Italy
    Biochim Biophys Acta 1757:1388-99. 2006
    ..To test this hypothesis is one of the main challenge in the genetics of aging and longevity in the next future...
  19. pmc The role of selection in the evolution of human mitochondrial genomes
    Toomas Kivisild
    Department of Human and Clinical Genetics, Leiden University Medical Center, 2333 AL Leiden, The Netherlands
    Genetics 172:373-87. 2006
    ..We introduce a new calibration method of the mutation rate of synonymous transitions to estimate the coalescent times of mtDNA haplogroups...
  20. ncbi request reprint The enigma of the San Lesmes (response to Langdon, 2002)
    Geoffrey K Chambers
    Hum Mutat 19:181-2. 2002