Giovanni Passalacqua

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint ARIA update: I--Systematic review of complementary and alternative medicine for rhinitis and asthma
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Italy
    J Allergy Clin Immunol 117:1054-62. 2006
  2. ncbi request reprint New insights in sublingual immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa Italy
    Curr Allergy Asthma Rep 6:407-12. 2006
  3. ncbi request reprint Sublingual immunotherapy: update 2006
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Curr Opin Allergy Clin Immunol 6:449-54. 2006
  4. ncbi request reprint Novel therapeutic interventions for allergic rhinitis
    Giovanni Passalacqua
    University of Genoa, Padiglione Maragliano, Allergy and Respiratory Diseases, Department of Internal Medicine, Largo Rossana Benzi 10, Genoa, Italy
    Expert Opin Investig Drugs 15:1615-25. 2006
  5. ncbi request reprint Complementary and alternative medicine for the treatment and diagnosis of asthma and allergic diseases
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Monaldi Arch Chest Dis 63:47-54. 2005
  6. doi request reprint The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy
    G Passalacqua
    Allergy and Respiratory Diseases, IRCCS San Martino Hospital University of Genoa IST, Genoa, Italy
    Allergy 68:1029-33. 2013
  7. pmc "United airways disease" and phenotypic peculiarities of respiratory allergy in immigrants
    Carlo Lombardi
    From the Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    World Allergy Organ J 2:13-6. 2009
  8. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  9. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
  10. doi request reprint Grading local side effects of sublingual immunotherapy for respiratory allergy: speaking the same language
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    J Allergy Clin Immunol 132:93-8. 2013

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint ARIA update: I--Systematic review of complementary and alternative medicine for rhinitis and asthma
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Italy
    J Allergy Clin Immunol 117:1054-62. 2006
    ..There are also unresolved safety concerns. Therapeutic efficacy of complementary-alternative treatments for rhinitis and asthma is not supported by currently available evidence...
  2. ncbi request reprint New insights in sublingual immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa Italy
    Curr Allergy Asthma Rep 6:407-12. 2006
    ..Additionally, the mechanisms of action are beginning to be systematically studied. Some points need further investigation, such as the effect in asthma, the mechanisms of action, and the optimal dose to be administered...
  3. ncbi request reprint Sublingual immunotherapy: update 2006
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Curr Opin Allergy Clin Immunol 6:449-54. 2006
    ..In the past 2 years, new data concerning clinical, immunological and practical aspects of sublingual immunotherapy have been published, and many critical points have been addressed...
  4. ncbi request reprint Novel therapeutic interventions for allergic rhinitis
    Giovanni Passalacqua
    University of Genoa, Padiglione Maragliano, Allergy and Respiratory Diseases, Department of Internal Medicine, Largo Rossana Benzi 10, Genoa, Italy
    Expert Opin Investig Drugs 15:1615-25. 2006
    ..Finally, one of the major goals is to modify the T(H)2-biased immune response by improving the characteristics and modes of action of allergen immunotherapy...
  5. ncbi request reprint Complementary and alternative medicine for the treatment and diagnosis of asthma and allergic diseases
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Monaldi Arch Chest Dis 63:47-54. 2005
    ..Therefore these tests must not be used, since they can lead to delayed or incorrect diagnosis and therapy...
  6. doi request reprint The additional values of microarray allergen assay in the management of polysensitized patients with respiratory allergy
    G Passalacqua
    Allergy and Respiratory Diseases, IRCCS San Martino Hospital University of Genoa IST, Genoa, Italy
    Allergy 68:1029-33. 2013
    ..This may pose diagnostic challenges in polysensitized patients. Microarray techniques detect specific IgE against multiple molecules, but their value in term of additional information and economic saving has not been yet defined...
  7. pmc "United airways disease" and phenotypic peculiarities of respiratory allergy in immigrants
    Carlo Lombardi
    From the Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    World Allergy Organ J 2:13-6. 2009
    ..The immigration model strongly suggests that environmental factors overcome the genetic background, and that the clinical phenotype of respiratory allergy in migrants has some peculiarities...
  8. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  9. pmc EAACI: A European Declaration on Immunotherapy. Designing the future of allergen specific immunotherapy
    Moises A Calderon
    Section of Allergy and Clinical Immunology, Imperial College, National Heart and Lung Institute, Dovehouse Street, London, SW3 6LY, UK
    Clin Transl Allergy 2:20. 2012
    ....
  10. doi request reprint Grading local side effects of sublingual immunotherapy for respiratory allergy: speaking the same language
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    J Allergy Clin Immunol 132:93-8. 2013
    ..The proposed grading system for SLIT-induced local reactions is expected to improve and harmonize surveillance and reporting of the safety of SLIT. ..
  11. doi request reprint Sublingual immunotherapy for allergic rhinitis and conjunctivitis
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, IRCCS San Martino IST University of Genoa, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Immunotherapy 5:257-64. 2013
    ..Only six anaphylaxes and no fatalities have been so far reported. Due to the good risk:benefit ratio, SLIT is currently being investigated in diseases other than respiratory allergy, such as food allergy and atopic dermatitis...
  12. doi request reprint Adherence to pharmacological treatment and specific immunotherapy in allergic rhinitis
    G Passalacqua
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    Clin Exp Allergy 43:22-8. 2013
    ..In this article, the literature concerning the adherence to pharmacological treatments and immunotherapy in allergic rhinitis was searched and reviewed...
  13. doi request reprint Emerging drugs for perennial allergic rhinitis
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, IRCCS S Martino IST University of Genoa, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Expert Opin Emerg Drugs 17:543-53. 2012
    ..According to its duration, AR can be either intermittent or persistent. In the persistent form, the inflammatory component usually predominates...
  14. pmc Diagnostic tools in Rhinology EAACI position paper
    Glenis Scadding
    Royal National Throat, Nose and Ear Institute, London, UK
    Clin Transl Allergy 1:2. 2011
    ..A panel of European experts in the field of Rhinology has contributed to this consensus document on Diagnostic Tools in Rhinology...
  15. doi request reprint Oral immunotherapy for cow's milk allergy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Italy
    Curr Opin Allergy Clin Immunol 12:271-7. 2012
    ..As no pharmacological treatment is available, specific desensitization has been considered an attractive strategy...
  16. pmc Lack of neo-sensitization to Pen a 1 in patients treated with mite sublingual immunotherapy
    Renato E Rossi
    Allergy Unit, National Health Service, Rete di Allergologia Regione Piemonte, Cuneo 1, Italy
    Clin Mol Allergy 8:4. 2010
    ..Some studies reported the possible induction of food allergy, caused by neo-sensitization to cross-reacting allergens, during immunotherapy with aeroallergens, while other studies ruled out such possibility...
  17. ncbi request reprint Allergic rhinitis and its impact on asthma update: allergen immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Allergy Clin Immunol 119:881-91. 2007
    ..Novel approaches for immunotherapy are currently under evaluation, including the use of adjuvants, peptides, and DNA-conjugated and recombinant allergens...
  18. ncbi request reprint Non-injection routes for allergen immunotherapy: focus on sublingual immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Inflamm Allergy Drug Targets 5:43-51. 2006
    ..Several points still need to be elucidated, including: mechanisms of action, optimal dosages, and indications in pediatric patients...
  19. ncbi request reprint Euro coins and contact dermatitis
    C Lombardi
    Allergy and Respiratory Diseases, Department of Internal Medicine, Pad Maragliano, Largo R Benzi 10, 16132 Genoa, Italy
    Allergy 59:669-70. 2004
  20. doi request reprint Specific immunotherapy in asthma: efficacy and safety
    G Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    Clin Exp Allergy 41:1247-55. 2011
    ..In such case, a measurable clinical benefit on asthma symptoms can be expected. On the other hand, SIT cannot be presently recommended as single therapy when asthma is the unique manifestation of respiratory allergy...
  21. doi request reprint Sublingual immunotherapy for allergic respiratory diseases: efficacy and safety
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Padiglione Maragliano, Largo Rosanna Benzio 10, 16132 Genoa, Italy
    Immunol Allergy Clin North Am 31:265-77, ix. 2011
    ..The sublingual route (SLIT) seemed to be a good candidate for the clinical practice because of its satisfactory safety profile and is now considered an acceptable alternative to SCIT in adults and children...
  22. ncbi request reprint Efficacy and safety of sublingual immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Ann Allergy Asthma Immunol 93:3-12; quiz 12-3, 103. 2004
    ....
  23. ncbi request reprint A review of the evidence from comparative studies of levocetirizine and desloratadine for the symptoms of allergic rhinitis
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Clin Ther 27:979-92. 2005
    ..Levocetirizine and desloratadine are newer antihistamines indicated for the treatment of allergic rhinitis and chronic idiopathic urticaria...
  24. doi request reprint Allergic and non-allergic rhinitis in swimmers: clinical and cytological aspects
    Matteo Gelardi
    Department of Otolaryngology II, University of Bari, Bari, Italy
    Br J Sports Med 46:54-8. 2012
    ..The aim of this study was to detail the clinical and cytological characteristics of rhinitis in swimmers, and to assess the possible role of chlorine-induced symptoms...
  25. ncbi request reprint Latex-jujube cross-reactivity: case report and immunological study
    C Lombardi
    Allergy and Respiratory Diseases, Department of Internal Medicine Padiglione Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Allergy 60:971-2. 2005
  26. doi request reprint Sublingual immunotherapy for allergic rhinitis: an update
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Curr Opin Otolaryngol Head Neck Surg 19:43-7. 2011
    ..We will review herein a brief history of SLIT, its indications and the safety aspects and will discuss the main unmet needs and the points to be developed in the field...
  27. doi request reprint Specific immunotherapy: beyond the clinical scores
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Italy
    Ann Allergy Asthma Immunol 107:401-6. 2011
    ..The literature is reviewed to evaluate the available experimental data on this...
  28. ncbi request reprint An update on the asthma-rhinitis link
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University, Italy
    Curr Opin Allergy Clin Immunol 4:177-83. 2004
    ..For the present article we collected and reviewed the more relevant experimental results concerning the asthma-rhinitis link in allergic diseases, published since January 2002...
  29. ncbi request reprint Sublingual immunotherapy: an update
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Curr Opin Allergy Clin Immunol 4:31-6. 2004
    ..Recently published studies have provided answers to some of these points...
  30. doi request reprint Investigational drugs for allergic rhinitis
    Giovanni Passalacqua
    University of Genoa, Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, 16132 Genoa, Italy
    Expert Opin Investig Drugs 19:93-103. 2010
    ..Thus, an intense research activity is presently ongoing with the aim of improving the characteristics and modes of action of this treatment...
  31. pmc Allergy and the lung
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internatl Medicine, San Martino Hospital, Padigliano Maragliano, Italy
    Clin Exp Immunol 153:12-6. 2008
    ..The recent introduction of biological treatments (monoclonal antibodies) has allowed elucidation of some of the pathogenic features of allergic asthma...
  32. ncbi request reprint Rhinitis, rhinosinusitis and quality of life in children
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Pediatr Allergy Immunol 18:40-5. 2007
    ..It has become clear that the QoL questionnaires measure the aspects of the disease that partially differ from the routinely evaluated parameters and that QoL should integrate, not replace, the objective measurements...
  33. ncbi request reprint Comparison of the effects in the nose and skin of a single dose of desloratadine and levocetirizine over 24 hours
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 135:143-7. 2004
    ..We compared the effects of a single dose of the two drugs in the nose and skin over 24 h...
  34. ncbi request reprint Pharmacokinetics of radiolabelled Par j 1 administered intranasally to allergic and healthy subjects
    G Passalacqua
    Allergy and Respiratory Diseases, University of Genoa, Genoa, Italy
    Clin Exp Allergy 35:880-3. 2005
    ..Local nasal immunotherapy is accepted as an alternative to the injection route for allergic rhinitis. Despite this, little is known about the kinetics of the allergen after nasal delivery in allergic subjects...
  35. ncbi request reprint Quantitative assessment of the compliance with once-daily sublingual immunotherapy in children (EASY project: evaluation of a novel SLIT formulation during a year)
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    Pediatr Allergy Immunol 18:58-62. 2007
    ..4%) for side effects probably related to therapy. These data obtained in a quite large sample of children and in real-life confirm that the compliance with SLITOne is good, despite the therapy managed at home...
  36. ncbi request reprint Allergic rhinitis in women
    Giovanni Passalacqua
    University of Genoa, Allergy and Respiratory Diseases, Department of Internal Medicine, PadiglioneMaragliano, L go R Benzi 10, 16132, Genoa, Italy
    Womens Health (Lond Engl) 3:603-11. 2007
    ..This review will examine the aforementioned aspects, with particular regard to the pharmacotherapy of rhinitis in pregnancy...
  37. ncbi request reprint Sublingual immunotherapy
    Giovanni Passalacqua
    Department of Internal Medicine, University of Genoa, Italy
    Rev Alerg Mex 50:220-5. 2003
    ..This paper reviews the up-to-date aspects about clinical efficacy, safety and pharmacokinetics of sublingual immunotherapy...
  38. ncbi request reprint Advances in allergen-specific immunotherapy
    Giovanni Passalacqua
    DIMI, University of Genoa, Italy
    Curr Drug Targets 10:1255-62. 2009
    ..The last frontier seems to be the manipulation of genoma with replicons and allergen-encoding plasmids...
  39. ncbi request reprint Levocetirizine in persistent allergic rhinitis: continuous or on-demand use? A pilot study
    Giorgio Walter Canonica
    University of Genoa, Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa, Italy
    Curr Med Res Opin 24:2829-39. 2008
    ..According to the ARIA initiative, it is classified as intermittent and persistent, the latter being the most troublesome...
  40. doi request reprint The possible influence of the environment on respiratory allergy: a survey on immigrants to Italy
    Carlo Lombardi
    Allergy Unit, Department of Internal Medicine, Sant Orsola Hospital, Brescia, Italy
    Ann Allergy Asthma Immunol 106:407-11. 2011
    ..Respiratory allergy is influenced and determined by genetic and environmental factors. Migration is a good model to indirectly evaluate the possible influence of environment...
  41. ncbi request reprint Pharmacokinetics of Der p 2 allergen and derived monomeric allergoid in allergic volunteers
    Marcello Bagnasco
    Medical and Radiometabolic Therapy, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 138:197-202. 2005
    ..We aimed at assessing the biodistribution of iodine-123-radiolabelled Der p 2 in allergic volunteers...
  42. ncbi request reprint Sublingual and oral immunotherapy
    Giorgio Walter Canonica
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Padiglione Maragliano, L go R Benzi 10, Genoa 16132, Italy
    Immunol Allergy Clin North Am 24:685-704, vii. 2004
    ..The indications for SLIT are similar to those for the subcutaneous route. A long-lasting effect has been demonstrated for the sublingual route, but data are needed to determine the optimal dose and the preventive effect in asthma...
  43. doi request reprint Specific immunotherapy for respiratory allergy: state of the art according to current meta-analyses
    Enrico Compalati
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Ann Allergy Asthma Immunol 102:22-8. 2009
    ..To evaluate the efficacy of allergen specific immunotherapy in the treatment of allergic asthma and rhinitis as derived by the available meta-analyses...
  44. ncbi request reprint Randomized open comparison of the safety of SLIT in a no-updosing and traditional updosing schedule in patients with Parietaria allergy
    Laura Guerra
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Allergol Immunopathol (Madr) 34:82-3. 2006
    ..Due to optimal safety of sublingual immunotherapy (SLIT), it was suggested that a slow up-dosing phase maybe not necessary, and therefore the treatment will be more patient-friendly, avoiding dosing mistakes...
  45. ncbi request reprint Clinical and therapeutic aspects of allergic asthma in adolescents
    Carlo Lombardi
    Allergy and Respiratory Unit, Department of Internal Medicine, S Orsola Hospital, Brescia, Italy
    Pediatr Allergy Immunol 14:453-7. 2003
    ..From a clinical and functional point of view, asthma in adolescents did not differ from other age ranges. Nevertheless, the management (diagnosis and therapy) emerged to be unsatisfactory from many points of view...
  46. doi request reprint The clinical characteristics of respiratory allergy in immigrants in northern Italy
    Carlo Lombardi
    Allergy Unit, Department of Internal Medicine, Sant Orsola Hospital, Brescia, Italy
    Int Arch Allergy Immunol 147:231-4. 2008
    ..Migration is a good epidemiological model to indirectly assess the influence of the environment. We assessed the clinical characteristics of respiratory allergy in immigrants in Brescia, Italy...
  47. ncbi request reprint Metaanalysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age
    Martin Penagos
    Division of Allergy and Respiratory Diseases, Department of Internal, edicine, University of Genoa, Genoa, Italy
    Chest 133:599-609. 2008
    ..We evaluated the efficacy of SLIT in the treatment of allergic asthma in children by a metaanalysis of randomized, double-blind, and placebo-controlled (DBPC) clinical trials...
  48. ncbi request reprint Role of contact sensitization in chronic urticaria
    Laura Guerra
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    J Am Acad Dermatol 56:88-90. 2007
    ..In all patients, avoidance measures led to a complete remission within 1 month. We suggest that testing for contact sensitization can be helpful in the management of chronic urticaria...
  49. ncbi request reprint Safety of allergen-specific sublingual immunotherapy and nasal immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University, Genoa, Italy
    Chem Immunol Allergy 82:109-18. 2003
    ..Its safety is also supported by pharmacokinetics and immunological data. Experimental data on the safety of sublingual and nasal immunotherapy will be reviewed...
  50. ncbi request reprint Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a meta-analysis of randomized, placebo-controlled, double-blind trials
    Martin Penagos
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Ann Allergy Asthma Immunol 97:141-8. 2006
    ..To evaluate the efficacy of sublingual immunotherapy (SLIT) in the treatment of allergic rhinitis in children...
  51. ncbi request reprint Oral and sublingual immunotherapy in paediatric patients
    Giovanni Passalacqua
    Department of Internal Medicine, University of Genoa, Italy
    Curr Opin Allergy Clin Immunol 3:139-45. 2003
    ..This article will review the available literature on oral and sublingual immunotherapy, discussing the possible use of sublingual immunotherapy in paediatric patients...
  52. doi request reprint Evidences of efficacy of allergen immunotherapy in atopic dermatitis: an updated review
    Enrico Compalati
    Allergy and Respiratory Diseases Clinic, Department of Internal Medicine, University of Genoa, Genova, Italy
    Curr Opin Allergy Clin Immunol 12:427-33. 2012
    ..To update and assess the quality of the evidence concerning the efficacy of allergen immunotherapy for atopic eczema. Desensitization for eczema as a clinical manifestation of food allergy was not a target of this review...
  53. ncbi request reprint The safety of allergen specific sublingual immunotherapy
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Curr Drug Saf 2:117-23. 2007
    ..Finally, it seems that the occurrence of some adverse events, at variance with injection route, does not depend strictly on the dose of allergen administered...
  54. ncbi request reprint Effects of fexofenadine and other antihistamines on components of the allergic response: adhesion molecules
    Giorgio Ciprandi
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Allergy Clin Immunol 112:S78-82. 2003
    ....
  55. ncbi request reprint Nasal eosinophils display the best correlation with symptoms, pulmonary function and inflammation in allergic rhinitis
    Giorgio Ciprandi
    Head Neck Department, S Martino Hospital, Genoa, Italy
    Int Arch Allergy Immunol 136:266-72. 2005
    ..We assessed nasal symptoms and flow, cytology, cytokines, pulmonary function and methacholine positivity in a large number of patients with pure pollinosis...
  56. pmc Allergy and the nose
    G Ciprandi
    Semeiotica e Metodologia Medica I, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Exp Immunol 153:22-6. 2008
    ..Therefore, the management of AR patients should be rigorously careful and multi-disciplinary...
  57. doi request reprint 100 years of immunotherapy: the Monaco charter. under the high patronage of His Serene Highness Prince Albert II of Monaco
    G Walter Canonica
    Allergy and Respiratory Disease Clinic, University of Genoa, IRCCS AOU San Martino IST, Genoa, Italy
    Int Arch Allergy Immunol 160:346-9. 2013
    ....
  58. doi request reprint The IgE repertoire in children and adolescents resolved at component level: a cross-sectional study
    Giovanni Melioli
    UOC Laboratorio Centrale di Analisi, Istituto Giannina Gaslini, Genoa, Italy
    Pediatr Allergy Immunol 23:433-40. 2012
    ..However, little information is available on the evolution of the IgE repertoire directed to single allergenic components. In this cross-sectional, observational study, the evolution of the IgE repertoire was analysed at component level...
  59. pmc Effects of different up-dosing regimens for hymenoptera venom immunotherapy on serum CTLA-4 and IL-10
    Anna Maria Riccio
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 7:e37980. 2012
    ..It has been shown that the circulating form of CTLA-4 is elevated in patients with hymenoptera allergy and can be down regulated by immunotherapy...
  60. doi request reprint The functional connection between oral allergy syndrome and united airways disease assessed by oral challenge
    Carlo Lombardi
    Allergy Unit, Department of Internal Medicine, Sant Orsola Hospital, Brescia, Italy
    Ann Allergy Asthma Immunol 108:30-3. 2012
    ..The airways and the upper digestive tract have a common embryonic origin. In sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis, or oral allergy syndrome [OAS])...
  61. ncbi request reprint Allergen biodistribution in humans
    Marcello Bagnasco
    Allergy and Clinical Immunology Unit, Department of Internal Medicine, Genoa University, Genoa, Italy
    Chem Immunol Allergy 82:33-43. 2003
    ..These data are potentially useful to improve immunotherapy treatment protocols by noninjectable routes...
  62. doi request reprint Impact of bariatric surgery on pulmonary function and nitric oxide in asthmatic and non-asthmatic obese patients
    Carlo Lombardi
    Allergy Unit, Department of Internal Medicine, Sant Orsola Poliambulanza Hospital, Brescia, Italy
    J Asthma 48:553-7. 2011
    ..Asthma is an important co-morbidity of obesity. This study evaluated the impact of bariatric surgery on respiratory function in obese patients and compared the outcomes in asthmatic and non-asthmatic subjects...
  63. doi request reprint Emerging sublingual immunotherapy drugs
    Enrico Compalati
    University of Genoa, Allergy and Respiratory Diseases Clinic, Department of Internal Medicine, Italy
    Expert Opin Pharmacother 11:2963-72. 2010
    ..Sublingual immunotherapy (SLIT) has gained increasing interest for its efficacy comparable to traditional subcutaneous immunotherapy and its good safety profile...
  64. ncbi request reprint Noninjection routes for immunotherapy
    Giorgio Walter Canonica
    Division of Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    J Allergy Clin Immunol 111:437-48; quiz 449. 2003
    ..Although the long-lasting efficacy has been recently documented for the sublingual route, several points still need to be elucidated, including mechanisms of action, optimal dosage, cost-effectiveness, and adherence...
  65. ncbi request reprint Levocetirizine in persistent allergic rhinitis and asthma: effects on symptoms, quality of life and inflammatory parameters
    M Pasquali
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    Clin Exp Allergy 36:1161-7. 2006
    ..In the active group, only two patients used rescue medications compared with 13 patients in the placebo group. Conclusions LCZ is clinically effective and capable of improving the rhinitis-asthma-related QoL...
  66. doi request reprint Clinical and cytologic characteristics of allergic rhinitis in elderly patients
    Maria Teresa Ventura
    Department of Internal Medicine, Immunology and Infectious Diseases, University of Bari, Bari, Italy
    Ann Allergy Asthma Immunol 108:141-4. 2012
    ..Thus, special attention to allergic diseases in elderly people has begun to emerge, but little is known about the effect and features of allergic rhinitis in elderly people...
  67. ncbi request reprint Targeted therapy for allergic asthma: predicting and evaluating response to omalizumab
    Francesco Tarantini
    Pulmunologist, PhD Student, DIMI University of Genoa, Allergy and Respiratory Diseases, Padiglione Maragliano, Largo R Benzi, 16132 Genova, Italy
    Expert Rev Clin Immunol 3:463-7. 2007
    ..The results established that it is difficult to predict which patients will gain most benefit from treatment, according to pretreatment baseline characteristics...
  68. ncbi request reprint Emerging anti-inflammatory agents for allergic rhinitis
    Giorgio Ciprandi
    Dipartimento Patologie Testa Collo, Azienda Ospedaliera Universitaria San Martino, Allergologia U O ORL, Largo R Benzi 10, 16132 Genoa, Italy
    Expert Opin Emerg Drugs 10:689-705. 2005
    ..Finally, one of the major goals is to modify the TH2-biased immune response by improving the characteristics and modes of action of allergen immunotherapy...
  69. ncbi request reprint Single-dose oral tolerance test with alternative compounds for the management of adverse reactions to drugs
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, DIMI, Department of Internal Medicine, Genoa University, Italy
    Int Arch Allergy Immunol 129:242-7. 2002
    ..Adverse reactions to drugs are common in the clinical practice. Many outpatients are frequently referred to allergists in order to determine which drugs they can safely take in the future...
  70. doi request reprint Sublingual immunotherapy: other indications
    Giovanni Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Padiglione Maragliano, Largo R Benzi 10, Genoa 16132, Italy
    Immunol Allergy Clin North Am 31:279-87, ix. 2011
    ..In hymenoptera allergy, the only trial available is a proof-of-concept study in large local reactions that needs to be confirmed in well-controlled studies...
  71. ncbi request reprint Underdiagnosis and undertreatment of asthma: a 9-year study of Italian conscripts
    G Ciprandi
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Italy
    Int Arch Allergy Immunol 125:211-5. 2001
    ..During the last 20 years, the epidemiology of asthma has been investigated in various populations, thus providing interesting data including the accuracy of diagnosis and the adequacy of treatment...
  72. ncbi request reprint Intranasal mometasone furoate reduces late-phase inflammation after allergen challenge
    G Ciprandi
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Ann Allergy Asthma Immunol 86:433-8. 2001
    ..Topical corticosteroids have been accepted as a highly effective anti-inflammatory therapy for allergic rhinitis...
  73. doi request reprint The safety of sublingual immunotherapy with one or more allergens in adults
    C Lombardi
    Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Allergy 63:375-6. 2008
  74. ncbi request reprint Long-term cetirizine treatment reduces allergic symptoms and drug prescriptions in children with mite allergy
    G Ciprandi
    Allergy and Immunology Clinic, Genoa, Italy
    Ann Allergy Asthma Immunol 87:222-6. 2001
    ..This suggests that long-term continuous treatment be included in the global strategy of allergy treatment...
  75. doi request reprint Component-resolved diagnosis in pediatric allergic rhinoconjunctivitis and asthma
    Giovanni Melioli
    Department of Experimental Medicine, Istituto Giannina Gaslini, Genova, Italy
    Curr Opin Allergy Clin Immunol 13:446-51. 2013
    ..The aim of this review is to update readers on the growing impact of a molecular approach (CRD) to the diagnosis and treatment of children with respiratory allergies..
  76. doi request reprint Efficacy of mometasone furoate nasal spray in the treatment of allergic rhinitis. Meta-analysis of randomized, double-blind, placebo-controlled, clinical trials
    M Penagos
    Allergy and Respiratory Diseases Clinic, Department of Internal Medicine, Universita degli Studi di Genova, Genoa, Italy
    Allergy 63:1280-91. 2008
    ....
  77. ncbi request reprint Role of leukotriene receptor antagonists in the management of mild-to-moderate asthma
    M Milanese
    Department of Internal Medicine, University of Genoa, Italy
    Monaldi Arch Chest Dis 56:508-13. 2001
    ..For this reason, even if ICS are superior to LTRAs in controlling asthma outcomes and in improving pulmonary function, in children and elderly patients LTRAs can be considered an alternative to low-dose ICS...
  78. ncbi request reprint Asthma treatment: 'magic bullets which seek their own targets'
    F Tarantini
    Allergy and Respiratory Diseases, DIMI University of Genoa, Genova, Italy
    Allergy 62:605-10. 2007
    ..In fact, it proved to reduce exacerbations and symptom scores, and to improve quality of life, with a very good safety profile...
  79. pmc Sublingual Immunotherapy: Clinical Indications in the WAO-SLIT Position Paper
    Giovanni Passalacqua
    From Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    World Allergy Organ J 3:216-9. 2010
    ..Atopic dermatitis, latex allergy, and hymenoptera hypersensitivity are promising fields of use of SLIT, but they are still considered only experimental uses...
  80. ncbi request reprint The asthma-rhinitis association: between the clinical hypothesis and the scientific theory
    Giovanni Passalacqua
    Allergy and Respiratory Diseases Department of Internal Medicine, University of Genoa, Padiglione Maragliano, Largo R Benzi, 10, 16132 Genoa, Italy
    Curr Allergy Asthma Rep 3:191-3. 2003
  81. doi request reprint The efficacy of sublingual immunotherapy for house dust mites respiratory allergy: results of a GA2LEN meta-analysis
    E Compalati
    Allergy and Respiratory Disease Clinic, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Allergy 64:1570-9. 2009
    ..These findings suggest that more data are needed, derived from large-population-based high quality studies, and corroborated by objective outcomes, mainly for AA...
  82. ncbi request reprint Effects on symptoms and quality of life of hypertonic saline nasal spray added to antihistamine in persistent allergic rhinitis--a randomized controlled study
    A Rogkakou
    Allergy and Respiratory Diseases, DIMI, University of Genoa
    Eur Ann Allergy Clin Immunol 37:353-6. 2005
  83. pmc Is sublingual immunotherapy the final answer? Implications for the allergist
    Giorgio Walter Canonica
    From the Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy This work has been partially supported by the Associazione Ricerca Malattie Immunologiche e Allergiche
    World Allergy Organ J 1:70-2. 2008
    ..Nonetheless, as happens with injection immunotherapy, it is mandatory that the prescription of SLIT is made by a trained specialist, and that a detailed diagnosis is made before prescribing it...
  84. ncbi request reprint Economic evaluation of sublingual immunotherapy: an analysis of literature
    G Ciprandi
    Dipartimento di malattie immuno allergologiche, Semeiotica Medica I, Ospedale Universitario S Martino, Genoa, Italy
    Eur Ann Allergy Clin Immunol 39:21-6. 2007
    ..The data obtained, although the number of studies is still limited, provide preliminary evidence supporting a SLIT effect on sparing costs for respiratory allergy...
  85. ncbi request reprint Localized eosinophilic ileitis with mastocytosis successfully treated with oral budesonide
    C Lombardi
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa, Italy
    Allergy 62:1343-5. 2007
  86. ncbi request reprint Sublingual immunotherapy in the treatment of adult allergic rhinitis patients
    G W Canonica
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Padiglione Maragliano, Genoa, Italy
    Allergy 61:20-3. 2006
    ..Key priorities for further investigation are the mechanisms of action, the efficacy in asthma, the cost/effectiveness and the identification of those patients who will achieve the maximum benefit with SLIT...
  87. ncbi request reprint Aerobiologic diagnosis of brassicaceae-induced asthma
    A Fiorina
    Allergy and Respiratory Diseases, Department of Internal Medicine, Pad Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Allergy 58:829-30. 2003
  88. ncbi request reprint Randomized double-blind controlled study with sublingual carbamylated allergoid immunotherapy in mild rhinitis due to mites
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Genoa, Italy
    Allergy 61:849-54. 2006
    ..The clinical efficacy of sublingual immunotherapy (SLIT) in mite allergy and in mild disease is still a matter of debate, thus we performed a long-term clinical trial...
  89. ncbi request reprint Continuing medical education. The point of view of asthmatic patients at the beginning of a mandatory CME system
    F Braido
    Allergy and Respiratory Diseases, DIMI, Genoa University, Genoa, Italy
    J Investig Allergol Clin Immunol 14:274-7. 2004
    ..The patient's opinion is a critical feedback signal for the outcomes of CME. We attempted, through a structured questionnaire, to evaluate the patient's opinion on CME a few months after its introduction...
  90. ncbi request reprint Looking for immunotolerance: a case of allergy to baker's yeast (Saccharomyces cerevisiae)
    G B Pajno
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Italy
    Eur Ann Allergy Clin Immunol 37:271-2. 2005
    ..We speculate that the continuous exposure to saccharomyces in foods may have lead to an immunotolerance with a progressive reduction of symptoms, whereas why the allergens is active only in ready-baked foods remains unexplained...
  91. ncbi request reprint The nose-lung interaction in allergic rhinitis and asthma: united airways disease
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University, Italy
    Curr Opin Allergy Clin Immunol 1:7-13. 2001
    ..In this article, therefore, we collected and reviewed the most relevant experimental results available to support the hypothesis for united airways disease and the studies conducted on the possible mechanisms of nose-lung interaction...
  92. pmc Impact of rhinitis on airway inflammation: biological and therapeutic implications
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Respir Res 2:320-3. 2001
    ..We discuss some of the recent observations on the nose-lung interaction and some of the novel therapeutic approaches used to treat rhinitis and asthma that arise from this...
  93. ncbi request reprint Oral and sublingual immunotherapy: general aspects and critical considerations
    G Passalacqua
    Department of Allergy and Respiratory Diseases, Genoa University, Italy
    Wien Med Wochenschr 149:433-7. 1999
    ..Furthermore, SLIT reduces time and money expenses usually required by SIT since it is self-administered...
  94. ncbi request reprint Rhinasthma: a new specific QoL questionnaire for patients with rhinitis and asthma
    I Baiardini
    Allergy and Respiratory Diseases, DIMI, Genoa University, Genoa, Italy
    Allergy 58:289-94. 2003
    ..The aim of our study was to develop and validate a specific quality of life (QoL) questionnaire for adult patients with rhinoconjunctivitis, asthma or both...
  95. ncbi request reprint Severe respiratory allergy induced by indirect exposure to rabbit dander: a case report
    G Liccardi
    Allergy and Respiratory Diseases, Department of Internal Medicine, Pad Maragliano, L go R Benzi 10 16132, Genoa, Italy
    Allergy 59:1237-8. 2004
  96. ncbi request reprint Specific immunotherapy among Italian specialists
    C Lombardi
    Department of Internal Medicine Padiglione Maragliano, Genoa, Italy
    Allergy 61:898-9. 2006
  97. ncbi request reprint Pattern of use and diagnostic value of complementary/alternative tests for adverse reactions to food
    G Senna
    Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, L go R Benzi 10, 16132 Genoa, Italy
    Allergy 60:1216-7. 2005
  98. ncbi request reprint Recommendations for standardization of clinical trials with Allergen Specific Immunotherapy for respiratory allergy. A statement of a World Allergy Organization (WAO) taskforce
    G W Canonica
    Allergy and Respiratory Diseases, DIMI, University of Genoa, Genoa, Italy
    Allergy 62:317-24. 2007
    ..This document summarizes the recommendations for study design, patients' selection, appropriate outcomes and statistical treatment to be used in planning and performing clinical trials with specific immunotherapy...
  99. ncbi request reprint Correlation among FEV, nitric oxide and asthma control test in newly diagnosed asthma
    G Senna
    Allergy and Respiratory Diseases, Department of Internal Medicine, Padiglione Maragliano, L go R Benzi 10 16132, Genoa, Italy
    Allergy 62:207-8. 2007
  100. ncbi request reprint Allergen-specific sublingual immunotherapy for respiratory allergy
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University, Genoa, Italy
    BioDrugs 15:509-19. 2001
    ..It is intended to be used in association with proper pharmacological treatment, at the earliest stages of the disease, for optimal management of respiratory allergy...
  101. ncbi request reprint Treating the allergic patient: think globally, treat globally
    G Passalacqua
    Allergy and Respiratory Diseases, Department of Internal Medicine, University of Genoa, Italy
    Allergy 57:876-83. 2002