R Pasquali

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Obesity, fat distribution and infertility
    Renato Pasquali
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Maturitas 54:363-71. 2006
  2. ncbi Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:3970-80. 2006
  3. doi Insulin sensitizers in polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, IT 40138 Bologna, Italy
    Front Horm Res 40:83-102. 2013
  4. doi Parallel variations of insulin-like peptide 3 (INSL3) and antimüllerian hormone (AMH) in women with the polycystic ovary syndrome according to menstrual cycle pattern
    Carla Pelusi
    Department of Medical and Surgical Science, Division of Endocrinology, University Alma Mater Studiorum, Sant Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 98:E1575-82. 2013
  5. ncbi Glucose intolerance states in women with the polycystic ovary syndrome
    R Pasquali
    Division of Endocrinology, Department of Medical and Surgical Sciences DIMEC, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, Bologna, Italy
    J Endocrinol Invest 36:648-53. 2013
  6. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
  7. doi Androgen profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in healthy normal-weight ovulatory and anovulatory late adolescent and young women
    Flaminia Fanelli
    Endocrinology Unit, and Department of Medical and Surgical Sciences and Center for Applied Biomedical Sciences, St Orsola Malpighi Hospital, University Alma Mater Studiorum, 40138 Bologna, Italy
    J Clin Endocrinol Metab 98:3058-67. 2013
  8. doi Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on italian high-school students
    Alessandra Gambineri
    Endocrinology Unit, Department of Clinical Medicine, St Orsola Malpighi Hospital, Bologna, Italy
    J Clin Endocrinol Metab 98:1641-50. 2013
  9. pmc The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy
    Ann N Y Acad Sci 1264:20-35. 2012
  10. pmc Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study
    Alessandra Gambineri
    Endocrinology Unit, Department of Clinical Medicine, St Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Diabetes 61:2369-74. 2012

Detail Information

Publications90

  1. ncbi Obesity, fat distribution and infertility
    Renato Pasquali
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Maturitas 54:363-71. 2006
    ..Weight loss can improve hormonal abnormalities and fertility rates in both women and men. Erectile dysfunction, which is very common in obese males, can also be improved by lifestyle intervention strategies favouring weight loss...
  2. ncbi Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:3970-80. 2006
    ..All these studies are, however, characterized by a short to medium period of treatment...
  3. doi Insulin sensitizers in polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, IT 40138 Bologna, Italy
    Front Horm Res 40:83-102. 2013
    ..They may ease the suffering of women with PCOS because insulin resistance and hyperinsulinemia appear to be major contributors to the pathophysiology of the syndrome. ..
  4. doi Parallel variations of insulin-like peptide 3 (INSL3) and antimüllerian hormone (AMH) in women with the polycystic ovary syndrome according to menstrual cycle pattern
    Carla Pelusi
    Department of Medical and Surgical Science, Division of Endocrinology, University Alma Mater Studiorum, Sant Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 98:E1575-82. 2013
    ..Antimüllerian hormone (AMH) and insulin-like factor 3 (INSL3) represent ovarian functional markers of granulosa and theca cells, respectively...
  5. ncbi Glucose intolerance states in women with the polycystic ovary syndrome
    R Pasquali
    Division of Endocrinology, Department of Medical and Surgical Sciences DIMEC, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, Bologna, Italy
    J Endocrinol Invest 36:648-53. 2013
    ..In addition, some insights on potential factors responsible for individual susceptibility are discussed. Targeted intervention studies focused on prevention and treatment of glucose intolerance states in PCOS are warranted. ..
  6. pmc The empowerment of translational research: lessons from laminopathies
    Sara Benedetti
    National Research Council of Italy, Institute of Molecular Genetics, IGM CNR, Unit of Bologna, Via Di Barbiano 1 10, 40136, Bologna, Italy
    Orphanet J Rare Dis 7:37. 2012
    ....
  7. doi Androgen profiling by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in healthy normal-weight ovulatory and anovulatory late adolescent and young women
    Flaminia Fanelli
    Endocrinology Unit, and Department of Medical and Surgical Sciences and Center for Applied Biomedical Sciences, St Orsola Malpighi Hospital, University Alma Mater Studiorum, 40138 Bologna, Italy
    J Clin Endocrinol Metab 98:3058-67. 2013
    ..The accurate determination of circulating androgens is the best indicator of hyperandrogenism. However, reliable reference intervals for adolescent and young women are not available...
  8. doi Prevalence of hyperandrogenic states in late adolescent and young women: epidemiological survey on italian high-school students
    Alessandra Gambineri
    Endocrinology Unit, Department of Clinical Medicine, St Orsola Malpighi Hospital, Bologna, Italy
    J Clin Endocrinol Metab 98:1641-50. 2013
    ..Most of the estimates of the prevalence of hyperandrogenic states refer to the general adult population...
  9. pmc The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy
    Ann N Y Acad Sci 1264:20-35. 2012
    ..This challenge may potentially imply a different pathophysiological perspective and, possibly, a specific treatment...
  10. pmc Polycystic ovary syndrome is a risk factor for type 2 diabetes: results from a long-term prospective study
    Alessandra Gambineri
    Endocrinology Unit, Department of Clinical Medicine, St Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Diabetes 61:2369-74. 2012
    ..This study demonstrates that the risk of type 2 diabetes is markedly elevated in middle-aged women with PCOS and suggests including BMI, glucose, and SHBG-circulating levels in the risk stratification...
  11. ncbi Metabolic alterations and cardiovascular risk factors in the polycystic ovary syndrome
    R Pasquali
    Department of Internal Medicine, University of Bologna, S Orsola Malpighi Hospital, Bologna, Italy
    Minerva Ginecol 57:79-85. 2005
    ..This evidence should be taken into consideration in future strategies focusing on prevention of metabolic and cardiovascular disorders in PCOS, not only on treatment of infertility and signs of androgen excess...
  12. doi Sex-dependent role of glucocorticoids and androgens in the pathophysiology of human obesity
    R Pasquali
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Int J Obes (Lond) 32:1764-79. 2008
    ....
  13. ncbi Metabolic effects of obesity on reproduction
    Renato Pasquali
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Italy
    Reprod Biomed Online 12:542-51. 2006
    ..Obesity-associated hyperleptinaemia may represent an additional factor involved in anovulation, not only through the induction of insulin resistance, but also through a direct impairment of ovarian function...
  14. ncbi The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
    Ann N Y Acad Sci 1083:111-28. 2006
    ....
  15. ncbi Obesity and androgens: facts and perspectives
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, Sant Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Fertil Steril 85:1319-40. 2006
    ..This review discusses androgen status in male and female obesity, according to their specific phenotype, and the main mechanisms responsible...
  16. ncbi Role of changes in dietary habits in polycystic ovary syndrome
    Renato Pasquali
    Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Reprod Biomed Online 8:431-9. 2004
    ..Individualized pharmacological support aimed at favouring weight loss and maintenance and improving insulin resistance may play a complementary role to lifestyle intervention...
  17. doi Steroids and the metabolic syndrome
    Renato Pasquali
    Division of Endocrinology, Department Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40125 Bologna, Italy
    J Steroid Biochem Mol Biol 109:258-65. 2008
  18. ncbi Polycystic ovary syndrome: a multifaceted disease from adolescence to adult age
    Renato Pasquali
    Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Ann N Y Acad Sci 1092:158-74. 2006
    ..Identification of major complaints and features of PCOS during the different ages of an affected woman may help, in fact, to plan individual therapeutic strategies, and, possibly, prevent long-term chronic metabolic diseases...
  19. ncbi The impact of obesity on reproduction in women with polycystic ovary syndrome
    R Pasquali
    Division of Endocrinology, Department of Internal Medicine, University Alma Mater Studiorum and Centre for Advanced Biology Research C R B A, S Orsola Malpighi Hospital, Bologna, Italy
    BJOG 113:1148-59. 2006
    ..This may have great relevance in preventive medicine and offer the opportunity to expand our still limited knowledge of the genetic and environmental background favouring the development of the PCOS...
  20. ncbi Insulin-sensitizing agents in women with polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, University Alma Mater Studiorum of Bologna, Bologna, Italy
    Fertil Steril 86:S28-9. 2006
    ..The improvement of insulin resistance and the decrease in insulin concentration can be achieved in different ways: (1) by lifestyle modifications; (2) by using insulin sensitizing agents; and (3) by using antiandrogens...
  21. ncbi 17-hydroxyprogesterone responses to gonadotropin-releasing hormone disclose distinct phenotypes of functional ovarian hyperandrogenism and polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, Sant Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 92:4208-17. 2007
    ..The exaggerated 17-hydroxyprogesterone response to GnRH agonists, which reflects functional ovarian hyperandrogenism (FOH), is believed to be the prominent abnormality in women with polycystic ovary syndrome (PCOS)...
  22. ncbi Obesity and infertility
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy
    Curr Opin Endocrinol Diabetes Obes 14:482-7. 2007
    ..To summarize major factors affecting fertility in obesity...
  23. ncbi Insulin-sensitizing agents in polycystic ovary syndrome
    Renato Pasquali
    Unité Operativa di Endocrinologia, Dipartimento di Medicina Interna, Università Alma Mater Studiorum, Azienda Policlinico S Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Endocrinol 154:763-75. 2006
    ..Lifestyle interventions should therefore be combined with insulin sensitizers in PCOS when obesity is present...
  24. doi Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, St Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Endocrinol 164:53-60. 2011
    ..Objective This follow-up study aimed to investigate obese women with PCOS treated with a long-term lifestyle program to evaluate responsiveness and predictability...
  25. doi Targeting insulin sensitivity in the treatment of polycystic ovary syndrome
    Renato Pasquali
    University Alma Mater Studiorum, S Orsola Malpighi Hospital, Division of Endocrinology, Department of Clinical Medicine, Bologna, Italy
    Expert Opin Ther Targets 13:1205-26. 2009
    ....
  26. ncbi Effect of long-term treatment with metformin added to hypocaloric diet on body composition, fat distribution, and androgen and insulin levels in abdominally obese women with and without the polycystic ovary syndrome
    R Pasquali
    Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Bologna, Italy
    J Clin Endocrinol Metab 85:2767-74. 2000
    ..Leptin levels decreased only during metformin treatment in both PCOS and control groups. (ABSTRACT TRUNCATED)..
  27. doi Prominent role of low HDL-cholesterol in explaining the high prevalence of the metabolic syndrome in polycystic ovary syndrome
    A Gambineri
    Division of Endocrinology, Dept of Internal Medicine, Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    Nutr Metab Cardiovasc Dis 19:797-804. 2009
    ....
  28. ncbi Secretion of major adrenal androgens following ACTH administration in obese women with different body fat distribution
    V Vicennati
    Department of Internal Medicine and Gastroenterology, S. Orsola Hospital, University of Bologna, Italy
    Horm Metab Res 30:133-6. 1998
    ....
  29. ncbi Anti-androgen treatment increases circulating ghrelin levels in obese women with polycystic ovary syndrome
    A Gambineri
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, Center for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, Bologna, Italy
    J Endocrinol Invest 26:629-34. 2003
    ..We, therefore, conclude that androgens are independent modulators of circulating ghrelin concentrations...
  30. doi Basal insulin-like factor 3 levels predict functional ovarian hyperandrogenism in the polycystic ovary syndrome
    A Gambineri
    Department of Internal Medicine, S Orsola Malpighi Hospital, Bologna, Italy
    J Endocrinol Invest 34:685-91. 2011
    ..The aims of the study were to understand the association between insulin-like factor 3 (INSL3) and functional ovarian hyperandrogenism (FOH) in PCOS and the regulatory role played by LH...
  31. ncbi Type 2 diabetes and the polycystic ovary syndrome
    B Pelusi
    Endocrinology Unit Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Minerva Ginecol 56:41-51. 2004
    ..However, other risk factors such as obesity, a positive family history of type 2 diabetes and hyperandrogenism may contribute to increasing the diabetes risk in PCOS...
  32. ncbi Acyl ghrelin and metabolic hormones in pregnant and lactating sows
    N Govoni
    Department of Veterinary Morphophysiology and Animal Production DIMORFIPA, University of Bologna, Ozzano Emilia, Bologna, Italy
    Reprod Domest Anim 42:39-43. 2007
    ..In conclusion, ghrelin concentrations in sow maternal circulation does not seem to play an important role in maintaining circulating GH levels during lactation; moreover, ghrelin is not associated with leptin, NEFA and IGF-1 levels...
  33. ncbi alpha2-adrenoceptor regulation of the hypothalamic-pituitary-adrenocortical axis in obesity
    R Pasquali
    Endocrinology Section, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Bologna, Italy
    Clin Endocrinol (Oxf) 52:413-21. 2000
    ..Catecholamines are involved in the regulation of the HPA axis, particularly during stress, via alpha-adrenoceptor modulation...
  34. doi The endocannabinoid system and energy metabolism
    L Bellocchio
    Department of Internal Medicine and Gastroenterology, Endocrinology Unit and Center of Applied Biomedical Research, S Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    J Neuroendocrinol 20:850-7. 2008
    ....
  35. ncbi Short-term modification of sex hormones is associated with changes in ghrelin circulating levels in healthy normal-weight men
    A Gambineri
    Endocrinology Unit, Department of Internal Medicine, and Center for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, Bologna, Italy
    J Endocrinol Invest 28:241-6. 2005
    ..These data, therefore, suggest that sex steroids are important regulators of ghrelin in normal-weight healthy men too...
  36. ncbi Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome
    A Gambineri
    Division of Endocrinology, Department of Internal Medicine, and Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy
    J Endocrinol Invest 32:210-8. 2009
    ..This study aimed to examine the association between cortisol metabolism and ACTH-dependent adrenal hyperandrogenism in PCOS, independently of obesity...
  37. ncbi Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors
    Alessandra Gambineri
    U O di Endocrinologia, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico Sant Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Diabetes 53:2353-8. 2004
    ..Our findings indicate that PCOS patients with GI represent a subgroup with specific clinical and hormonal characteristics. Our observations may have an important impact in preventative and therapeutic strategies...
  38. ncbi Testosterone levels in obese male patients with obstructive sleep apnea syndrome: relation to oxygen desaturation, body weight, fat distribution and the metabolic parameters
    A Gambineri
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Endocrinol Invest 26:493-8. 2003
    ..This may contribute in worsening metabolic abnormalities which, in men with OSAS, exceed those expected on the basis of degree of obesity and pattern of fat distribution...
  39. doi Monogenic polycystic ovary syndrome due to a mutation in the lamin A/C gene is sensitive to thiazolidinediones but not to metformin
    A Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Endocrinol 159:347-53. 2008
    ..Despite the very high prevalence of the polycystic ovary syndrome (PCOS), the underlying pathogenetic mechanism has remained obscure...
  40. doi A placebo-controlled, randomized clinical trial using testosterone undecanoate with injectable norethisterone enanthate: effect on anthropometric, metabolic and biochemical parameters
    C Pelusi
    Department of Clinical Medicine, Division of Endocrinology, University Alma Mater Studiorum, S Orsola Malpighi Hospital, Bologna, Italy
    Int J Androl 34:548-55. 2011
    ..In conclusion, NETE and TU for 48 weeks were not accompanied by any metabolic changes and any adverse effects. The weight gain of the highest NETE plus TU dosage was mainly because of gain in muscle mass...
  41. doi Stress-related development of obesity and cortisol in women
    Valentina Vicennati
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum of Bologna, Bologna, Italy
    Obesity (Silver Spring) 17:1678-83. 2009
    ..These findings support the concept that SRO has distinct pathophysiological mechanisms, including hyperactivity of the HPA axis...
  42. ncbi Low ghrelin concentrations in nonalcoholic fatty liver disease are related to insulin resistance
    G Marchesini
    Unit of Metabolic Diseases, Alma Mater Studiorum, University of Bologna, I 40138 Bologna, Italy
    J Clin Endocrinol Metab 88:5674-9. 2003
    ..79; 95% confidence interval, 2.62-12.81; P < 0.0001) and specifically in NAFLD (2.96; 1.12-7.79; P = 0.028). The study suggests that insulin resistance is a major factor controlling ghrelin levels in subjects with and without NAFLD...
  43. ncbi Response of the hypothalamic-pituitary-adrenal axis to small dose arginine-vasopressin and daily urinary free cortisol before and after alprazolam pre-treatment differs in obesity
    V Vicennati
    Departement of Internal Medicine, S Orsola Malpighi Hospital, Italy
    J Endocrinol Invest 27:541-7. 2004
    ....
  44. ncbi Gastric immunolocalization and plasma profiles of acyl-ghrelin in fasted and fasted-refed prepuberal gilts
    N Govoni
    Department of Veterinary Morphophysiology and Animal Production, University of Bologna, Via Tolara di Sopra 50, 40064 Ozzano Emilia BO, Italy
    J Endocrinol 186:505-13. 2005
    ..The absence of detectable changes in ghrelin cells, as seen in immunohistochemistry, could be due to a large intracellular storage of potentially releasable acylghrelin...
  45. ncbi Adrenal and gonadal function in obesity
    R Pasquali
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Endocrinol Invest 25:893-8. 2002
    ....
  46. ncbi Lack of mutations of type 1 11beta-hydroxysteroid dehydrogenase gene in patients with abdominal obesity
    E Caramelli
    Institute of Histology and General Embriology, Bologna, Italy
    Endocr Res 27:47-61. 2001
    ....
  47. doi Cannabinoid type 1 receptor: another arrow in the adipocytes' bow
    L Bellocchio
    Center of Applied Biomedical Research CRBA, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, Bologna, Italy
    J Neuroendocrinol 20:130-8. 2008
    ....
  48. ncbi Activity of the hypothalamic-pituitary-adrenal axis in different obesity phenotypes
    R Pasquali
    Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Italy
    Int J Obes Relat Metab Disord 24:S47-9. 2000
    ....
  49. ncbi Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, 40138 Bologna, Italy
    J Clin Endocrinol Metab 87:5625-9. 2002
    ..In addition, regardless of the presence of PCOS, a marked negative correlation exists between ghrelin and androstenedione levels, suggestive of an interaction between ghrelin and steroid synthesis or action...
  50. ncbi Testosterone replacement therapy restores normal ghrelin in hypogonadal men
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy 40138
    J Clin Endocrinol Metab 88:4139-43. 2003
    ..This may be consistent with the concept that ghrelin may exert a relevant role in the endocrine network connecting the control of the reproductive system with the regulation of energy balance...
  51. ncbi Testosterone in ageing men
    A Gambineri
    Endocrinology Unit, Department of Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy
    Expert Opin Investig Drugs 10:477-92. 2001
    ....
  52. ncbi Obesity and the polycystic ovary syndrome
    A Gambineri
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Int J Obes Relat Metab Disord 26:883-96. 2002
    ..These obviously emphasize the role of obesity in the pathophysiology of PCOS...
  53. ncbi Comment: response of the hypothalamic-pituitary-adrenocortical axis to high-protein/fat and high-carbohydrate meals in women with different obesity phenotypes
    Valentina Vicennati
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University Alma Mater of Bologna, 40138 Bologna, Italy
    J Clin Endocrinol Metab 87:3984-8. 2002
    ..We also suggest that the activation of the HPA axis following the ingestion of large amounts of carbohydrates may have some pathophysiological relevance, specifically in women with the abdominal obesity phenotype...
  54. ncbi Relationship between socio-economic and cultural status, psychological factors and body fat distribution in middle-aged women living in Northern Italy
    D Cota
    Department of Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Italy
    Eat Weight Disord 6:205-13. 2001
    ..029). These results are consistent with the hypothesis that psychological and socio-economic handicaps are associated with a higher prevalence of abdominal fatness in middle-aged women living in Northern Italy..
  55. ncbi Characterization of obese women with reduced sex hormone-binding globulin concentrations
    R Pasquali
    Istituto di Clinica Medica e Gastroenterologia, S. Orsola Hospital, University Alma Mater, Bologna, Italy
    Horm Metab Res 22:303-6. 1990
    ..40; P less than 0.005). Therefore, compared to NSO, LSO women have distinctive clinical and endocrine characteristics, namely more pronounced hyperinsulinemia, higher E1 concentrations and a central type body fat distribution...
  56. ncbi How many sites of action for endocannabinoids to control energy metabolism?
    U Pagotto
    Department of Internal Medicine and Gastroenterology, Endocrinology Unit, Center for Applied Biomedical Research C R B A, S Orsola Malpighi General Hospital, Bologna, Italy
    Int J Obes (Lond) 30:S39-43. 2006
    ..This review describes the roles of endocannabinoids and the cannabinoid type 1 receptor (CB1) in the control of energy balance...
  57. ncbi Endocannabinoids and energy metabolism
    U Pagotto
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology and C R B A, S Orsola Malpighi Hospital, Alma Mater Studiorum University of Bologna, 40138 Bologna, Italy
    J Endocrinol Invest 29:66-76. 2006
    ....
  58. ncbi The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease
    Roberta Giordano
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    Eur J Endocrinol 153:535-43. 2005
    ..The stomach is the major source of circulating ghrelin levels that are negatively associated with body mass, insulin and glucose levels. The role of glucocorticoids in ghrelin secretion and action is still unclear...
  59. ncbi Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Italy
    Clin Endocrinol (Oxf) 60:241-9. 2004
    ....
  60. pmc Body mass index-independent metabolic alterations in narcolepsy with cataplexy
    Francesca Poli
    Sleep Disorders Center, Department of Neurological Sciences, University of Bologna, Bologna, Italy
    Sleep 32:1491-7. 2009
    ..To contribute to the anthropometric and metabolic phenotyping of orexin-A-deficient narcoleptic patients, and to explore a possible risk of their developing a metabolic syndrome...
  61. ncbi Cannabinoid receptor antagonists and the metabolic syndrome: Novel promising therapeutical approaches
    C Cervino
    Endocrinology Unit, Dept of Internal Medicine and Gastroenterology, CRBA, S Orsola Malpighi Hospital, Via Massarenti, 9, 40138 Bologna, Italy
    Mini Rev Med Chem 7:21-30. 2007
    ..This mini-review will provide a concise and updated revision of the state of art on this topic...
  62. ncbi Active and total ghrelin concentrations in the newborn
    Piero Pirazzoli
    Department of Pediatrics, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Bologna, Italy
    J Pediatr Endocrinol Metab 18:379-84. 2005
    ..An acyl modification is indispensable for biological activity. Acylated and desacylated forms of ghrelin are both present in the blood. No data exist about the ratio between active ghrelin and total ghrelin in the first period of life...
  63. ncbi Polycystic ovary syndrome in adolescents: pathophysiology and treatment implications
    Carla Pelusi
    Endocrinology Unit, Department of Internal Medicine, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Treat Endocrinol 2:215-30. 2003
    ..Early recognition of the syndrome and thus, early treatment, may prevent and possibly ameliorate all the symptoms and the potential later development of metabolic and cardiovascular complications...
  64. ncbi Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, S Orsola Malpighi General Hospital, Università Alma Mater Studiorum, Bologna 40138, Italy
    Lancet 365:1363-4. 2005
  65. ncbi [Pharmacological therapy of obesity]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:83S-93S. 2008
    ..9 kg/m2 with major obesity-related comorbidities such as hypertension, diabetes, dyslipidemia, obstructive sleep apnea, and metabolic syndrome...
  66. ncbi Obesity and reproductive disorders in women
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, University of Bologna, Italy
    Hum Reprod Update 9:359-72. 2003
    ..This may be beneficial even during pregnancy, thereby permitting favourable physiological delivery and healthy babies...
  67. ncbi Cortisol and ACTH response to oral dexamethasone in obesity and effects of sex, body fat distribution, and dexamethasone concentrations: a dose-response study
    Renato Pasquali
    Department of Internal Medicine, Endocrinology Unit, University of Bologna, I 40100 Bologna, Italy
    J Clin Endocrinol Metab 87:166-75. 2002
    ..On the other hand, our data suggest that, at least in women, abdominal fat distribution may partially counteract the progressively greater suppressibility of the HPA axis that would be expected according to increasing BMI...
  68. ncbi The endocannabinoid system and the treatment of obesity
    Uberto Pagotto
    Endocrinology Unit and Center for Applied Biomedical Research, Dept of Internal Medicine and Gastroenterology, S Orsola Malpighi General Hospital, Bologna, Italy
    Ann Med 37:270-5. 2005
    ....
  69. ncbi The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    Uberto Pagotto
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy, and Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Germany
    Endocr Rev 27:73-100. 2006
    ..The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases, including obesity...
  70. ncbi Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity
    Valentina Vicennati
    Division of Endocrinology, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Obesity (Silver Spring) 14:235-43. 2006
    ..This study was carried out to investigate the role of sex in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and its relationship with testosterone levels in male and female obesity...
  71. ncbi Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases
    Luigi Bellocchio
    Endocrinology Unit and CRBA, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Curr Opin Pharmacol 6:586-91. 2006
    ....
  72. ncbi [Endocannabinoid system and energy metabolism: physiology and pathophysiology]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:74S-82S. 2008
    ....
  73. ncbi The endocannabinoid system in the regulation of cardiometabolic risk factors
    Luigi Bellocchio
    Endocrinology Unit and Center for Applied Biomedical Research, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Am J Cardiol 100:7P-17P. 2007
    ..In addition, we provide evidence that supports the recently proposed hypothesis that a close association exists between obesity and overactivation of the EC system...
  74. ncbi Efficacy of octreotide-LAR in dieting women with abdominal obesity and polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 90:3854-62. 2005
    ..Somatostatin reduces LH, GH, and insulin, and somatostatin receptors are present at the ovarian level; somatostatin analogs are thus potential candidates for treatment of the polycystic ovary syndrome (PCOS)...
  75. ncbi Circulating obestatin levels and the ghrelin/obestatin ratio in obese women
    Valentina Vicennati
    Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research CRBA, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138, Bologna, Italy
    Eur J Endocrinol 157:295-301. 2007
    ..We measured blood levels of obestatin, total ghrelin, and the ghrelin/obestatin ratio and their relationship with anthropometric and metabolic parameters, adiponectin and insulin resistance, in overweight/obese and normal-weight women...
  76. ncbi Insulin-like factor 3: a new circulating hormone related to luteinizing hormone-dependent ovarian hyperandrogenism in the polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, Bologna, Italy
    J Clin Endocrinol Metab 92:2066-73. 2007
    ....
  77. doi Maternal polycystic ovary syndrome may be associated with adverse pregnancy outcomes
    Paola Altieri
    Division of Endocrinology, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Obstet Gynecol Reprod Biol 149:31-6. 2010
    ..To determine whether maternal polycystic ovary syndrome (PCOS) is associated with adverse pregnancy outcomes in a population of Italian parturients...
  78. doi Organic cation transporter 1 polymorphisms predict the metabolic response to metformin in women with the polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Clinical Medicine, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    J Clin Endocrinol Metab 95:E204-8. 2010
    ..It is noteworthy that four of the seven variants, R61C (C>T), G401S (G>A), G465R (G>A), and 420del, are present in individuals of European descent...
  79. ncbi Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group
    E De Menis
    Department of Internal Medicine, General Hospital, v Monte Grappa 30, 31044 Montebelluna, Italy
    J Endocrinol Invest 34:60-4. 2011
    ..Continuous positive airway pressure is the cornerstone of therapy, but patients' acceptance may be critical. Control of GH/IGF-I secretion is important to improve SAS. Management of SAS requires cooperation between specialists...
  80. ncbi Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:731-8. 2008
    ..However, as for other guidelines previously issued in the field, no data are available on their clinical application...
  81. ncbi Genetic variation in 11beta-hydroxysteroid dehydrogenase type 1 predicts adrenal hyperandrogenism among lean women with polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:2295-302. 2006
    ..11beta-HSD1 deficiency may protect against obesity and its metabolic consequences because of impaired regeneration of cortisol in adipose tissue...
  82. doi CB(1) signaling in forebrain and sympathetic neurons is a key determinant of endocannabinoid actions on energy balance
    Carmelo Quarta
    Endocrinology Unit and Centro di Ricerca Biomedica Applicata, Department of Clinical Medicine, University of Bologna, Bologna 40138, Italy
    Cell Metab 11:273-85. 2010
    ..In conclusion, CB(1) signaling in the forebrain and sympathetic neurons is a key determinant of the ECS control of energy balance...
  83. doi Here, there and everywhere: the endocannabinoid system
    Roberto Vettor
    J Neuroendocrinol 20:iv-vi. 2008
  84. ncbi Glucose tolerance, insulin secretion and insulin sensitivity in polycystic ovary syndrome
    Renato Pasquali
    JOP 3:1-7. 2002
  85. pmc The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    Daniela Cota
    Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 112:423-31. 2003
    ....
  86. ncbi Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry of the National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli Naples, Italy
    J Clin Endocrinol Metab 91:3171-80. 2006
    ..Cannabinoid CB(1) receptor blockade decreases weight and hyperinsulinemia in obese animals and humans in a way greatly independent from food intake...
  87. ncbi Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity
    Elisabetta Bugianesi
    Division of Gastroenterology, University of Turin, Ospedale San Giovanni Battista, Corso Bramante 88, I 10126 Torino, Italy
    J Clin Endocrinol Metab 90:3498-504. 2005
    ..Hypoadiponectinemia in NAFLD is part of a metabolic disturbance characterized by ectopic fat accumulation in the central compartment...
  88. pmc Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
    Laura Tedesco
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Diabetes 57:2028-36. 2008
    ..This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes...
  89. ncbi The biological balance between psychological well-being and distress: a clinician's point of view
    Renato Pasquali
    Psychother Psychosom 75:69-71. 2006
  90. ncbi Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function
    Daniela Cota
    Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 148:1574-81. 2007
    ....