D Parolaro

Summary

Affiliation: University of Insubria
Country: Italy

Publications

  1. ncbi request reprint Endocannabinoids and drug dependence
    Daniela Parolaro
    DBSF, and Center of Neurosciences, Univ of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Curr Drug Targets CNS Neurol Disord 4:643-55. 2005
  2. ncbi request reprint The endocannabinoid system and schizophrenia: integration of evidence
    Erica Zamberletti
    Department of Theoretical and Applied Sciences, Biomedical Division, and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Curr Pharm Des 18:4980-90. 2012
  3. pmc Is cannabinoid transmission involved in rewarding properties of drugs of abuse?
    Daniela Parolaro
    DBSF, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Br J Pharmacol 136:1083-4. 2002
  4. ncbi request reprint Cannabinoids as potential new therapy for the treatment of gliomas
    Daniela Parolaro
    Department of Structural and Functional Biology, Pharmacology Section, Center of Neuroscience, University of Insubria, Via A da Giussano 10, Busto Arsizio VA, Italy
    Expert Rev Neurother 8:37-49. 2008
  5. ncbi request reprint Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain
    Daniela Vigano
    DBSF, Pharmacology Unit, University of Insubria, Busto Arsizio VA, Italy
    Neuropsychopharmacology 28:1160-7. 2003
  6. ncbi request reprint The role of the endogenous cannabinoid system in drug addiction
    D Parolaro
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    Drug News Perspect 21:149-57. 2008
  7. doi request reprint The endocannabinoid system and psychiatric disorders
    Daniela Parolaro
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Exp Neurol 224:3-14. 2010
  8. ncbi request reprint Cellular mechanisms underlying the interaction between cannabinoid and opioid system
    D Parolaro
    Department of Structural and Functional Biology and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy
    Curr Drug Targets 11:393-405. 2010
  9. ncbi request reprint Endocannabinoids in the immune system and cancer
    Daniela Parolaro
    Department of Structural and Functional Biology, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:319-32. 2002
  10. doi request reprint The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Neurotox Res 15:291-302. 2009

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Endocannabinoids and drug dependence
    Daniela Parolaro
    DBSF, and Center of Neurosciences, Univ of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Curr Drug Targets CNS Neurol Disord 4:643-55. 2005
    ..This review will discuss the latest advances on the mechanisms of cannabinoid dependence and the possible role of the endocannabinoid system in the treatment of addiction, not only to marijuana but also to the other common illicit drugs...
  2. ncbi request reprint The endocannabinoid system and schizophrenia: integration of evidence
    Erica Zamberletti
    Department of Theoretical and Applied Sciences, Biomedical Division, and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Curr Pharm Des 18:4980-90. 2012
    ..In fact literature from animal models support adolescence as a highly vulnerable age for the consequences of cannabis exposure on different domains (such as cognition and social behaviour) that are altered in psychotic disorders...
  3. pmc Is cannabinoid transmission involved in rewarding properties of drugs of abuse?
    Daniela Parolaro
    DBSF, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Br J Pharmacol 136:1083-4. 2002
  4. ncbi request reprint Cannabinoids as potential new therapy for the treatment of gliomas
    Daniela Parolaro
    Department of Structural and Functional Biology, Pharmacology Section, Center of Neuroscience, University of Insubria, Via A da Giussano 10, Busto Arsizio VA, Italy
    Expert Rev Neurother 8:37-49. 2008
    ....
  5. ncbi request reprint Chronic morphine modulates the contents of the endocannabinoid, 2-arachidonoyl glycerol, in rat brain
    Daniela Vigano
    DBSF, Pharmacology Unit, University of Insubria, Busto Arsizio VA, Italy
    Neuropsychopharmacology 28:1160-7. 2003
    ....
  6. ncbi request reprint The role of the endogenous cannabinoid system in drug addiction
    D Parolaro
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    Drug News Perspect 21:149-57. 2008
    ....
  7. doi request reprint The endocannabinoid system and psychiatric disorders
    Daniela Parolaro
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Exp Neurol 224:3-14. 2010
    ..Besides all these limitations, SR141716A and cannabidiol show the most constant antipsychotic properties in dopamine- and glutamate-based models of schizophrenia, with profiles similar to an atypical antipsychotic drug...
  8. ncbi request reprint Cellular mechanisms underlying the interaction between cannabinoid and opioid system
    D Parolaro
    Department of Structural and Functional Biology and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy
    Curr Drug Targets 11:393-405. 2010
    ..Further insights about the cannabinoid/opioid interaction could pave the way for new and promising therapeutic approaches...
  9. ncbi request reprint Endocannabinoids in the immune system and cancer
    Daniela Parolaro
    Department of Structural and Functional Biology, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio Varese, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:319-32. 2002
    ..The experimental evidence reviewed in this article argues in favor of the therapeutic potential of these compounds in immune disorders and cancer...
  10. doi request reprint The depressive phenotype induced in adult female rats by adolescent exposure to THC is associated with cognitive impairment and altered neuroplasticity in the prefrontal cortex
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Neurotox Res 15:291-302. 2009
    ..This picture demonstrates the presence of cognitive impairment in THC-induced depressive phenotype...
  11. ncbi request reprint Molecular mechanisms involved in the asymmetric interaction between cannabinoid and opioid systems
    Daniela Vigano
    DBSF, Pharmacology Section and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052, Busto Arsizio, VA, Italy
    Psychopharmacology (Berl) 182:527-36. 2005
    ..This might open up new therapeutic opportunities for relief of chronic pain through cannabinoid-opioid coadministration...
  12. ncbi request reprint Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Cereb Cortex 18:1292-301. 2008
    ....
  13. doi request reprint Chronic URB597 treatment at adulthood reverted most depressive-like symptoms induced by adolescent exposure to THC in female rats
    N Realini
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Neuropharmacology 60:235-43. 2011
    ..These results support a role for the endocannabinoid system in the neurobiology of depression and suggest the use of URB597 as a new therapeutic tool with antidepressant properties...
  14. ncbi request reprint CB1 receptor stimulation in specific brain areas differently modulate anxiety-related behaviour
    T Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Neuropharmacology 54:151-60. 2008
    ..The molecular underpinnings of these effects involve a direct stimulation of CB1 receptors ending in pCREB modulation and/or a possible alteration in the fine tuning of local neuromodulator release...
  15. pmc Chronic blockade of CB(1) receptors reverses startle gating deficits and associated neurochemical alterations in rats reared in isolation
    E Zamberletti
    Department of Theoretical and Applied Sciences, Biomedical Division and Center of Neuroscience, University of Insubria, Busto Arsizio VA, Italy
    Br J Pharmacol 167:1652-64. 2012
    ....
  16. ncbi request reprint Changes in endocannabinoid levels in a rat model of behavioural sensitization to morphine
    Daniela Vigano
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Eur J Neurosci 20:1849-57. 2004
    ....
  17. ncbi request reprint The psychoactive ingredient of marijuana induces behavioural sensitization
    T Rubino
    Department of Structural and Functional Biology, University of Insubria, Via Dunant 3, 21100 Varese, Italy
    Eur J Neurosci 14:884-6. 2001
    ....
  18. ncbi request reprint Modulation of extracellular signal-regulated kinases cascade by chronic delta 9-tetrahydrocannabinol treatment
    Tiziana Rubino
    DBSF, Pharmacology Unit and Center of Neuroscience, University of Insubria, 21052 Busto Arsizio VA, Italy
    Mol Cell Neurosci 25:355-62. 2004
    ..In fact, Ras-GRF1 ko mice did not develop tolerance to THC analgesic and hypolocomotor effect. Our data suggest that ERK cascade could play a pivotal role in the induction of synaptic plasticity due to cannabinoid chronic exposure...
  19. ncbi request reprint Cellular mechanisms of Delta 9-tetrahydrocannabinol behavioural sensitization
    T Rubino
    DBSF, Pharmacology Unit, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA Italy
    Eur J Neurosci 17:325-30. 2003
    ..The intracellular picture in sensitized rats suggests that besides the cAMP cascade, other signalling pathways may participate in the development of cannabinoid sensitization...
  20. doi request reprint Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats
    E Zamberletti
    Department of Structural and Functional Biology and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
    Neuroscience 204:245-57. 2012
    ..Alterations in NMDA, D1 and D2 receptors might be involved in the behavioral responses induced by maternal deprivation and in their modulation by THC...
  21. doi request reprint Neurobiological alterations at adult age triggered by adolescent exposure to cannabinoids
    N Realini
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, VA, Italy
    Pharmacol Res 60:132-8. 2009
    ..There is an urgent need of multidisciplinary approaches combining behaviour with neurochemical and genetic studies to build a scientific based opinion on the long-lasting consequences of cannabis use in adolescence...
  22. doi request reprint Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood
    Tiziana Rubino
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio, VA, Italy
    Hippocampus 19:763-72. 2009
    ....
  23. ncbi request reprint Changes in the expression of G protein-coupled receptor kinases and beta-arrestins in mouse brain during cannabinoid tolerance: a role for RAS-ERK cascade
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio VA, Italy
    Mol Neurobiol 33:199-213. 2006
    ....
  24. ncbi request reprint Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Busto Arsizio, Italy
    J Neurochem 93:984-91. 2005
    ..These findings suggest that at least in the caudate putamen and cerebellum, the Ras/ERK pathway is essential for triggering the alteration in CB1 receptor function responsible for tolerance to THC-induced hypomotility...
  25. ncbi request reprint Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats
    Tiziana Rubino
    DBSF, Pharmacology Section and Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio, Varese, Italy
    Neuropsychopharmacology 32:2036-45. 2007
    ....
  26. pmc Cannabidiol inhibits angiogenesis by multiple mechanisms
    M Solinas
    Department of Biomedical, Computer and Communication Sciences, University of Insubria, Busto Arsizio VA, Italy
    Br J Pharmacol 167:1218-31. 2012
    ..As its anti-angiogenic properties have not been thoroughly investigated to date, and given its very favourable pharmacological and toxicological profile, here, we evaluated the ability of CBD to modulate tumour angiogenesis...
  27. ncbi request reprint Cannabinoids, immune system and cytokine network
    P Massi
    DBSF Pharmacology Unit and Centre of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Curr Pharm Des 12:3135-46. 2006
    ....
  28. ncbi request reprint Molecular and cellular basis of cannabinoid and opioid interactions
    Daniela Vigano
    DBSF, Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Pharmacol Biochem Behav 81:360-8. 2005
    ..Further studies are needed since a better knowledge of the opioid-cannabinoid interaction may lead to exciting therapeutic possibilities...
  29. doi request reprint Chronic delta 9-tetrahydrocannabinol during adolescence provokes sex-dependent changes in the emotional profile in adult rats: behavioral and biochemical correlates
    Tiziana Rubino
    DBSF, Pharmacology Section, and Neuroscience Center, University of Insubria, Varese, Italy
    Neuropsychopharmacology 33:2760-71. 2008
    ....
  30. doi request reprint Involvement of the endocannabinoid system in phencyclidine-induced cognitive deficits modelling schizophrenia
    Daniela Vigano
    DBSF and Neuroscience Center, University of Insubria, Busto Arsizio VA, Italy
    Int J Neuropsychopharmacol 12:599-614. 2009
    ....
  31. ncbi request reprint Expression and function of the endocannabinoid system in glial cells
    Paola Massi
    Department of Structural and Functional Biology, Center of Neuroscience, University of Insubria, Via A da Giussano 10, 21052 Busto Arsizio VA, Italy
    Curr Pharm Des 14:2289-98. 2008
    ..The present paper will review the evidence supporting the regulatory role of (endo)cannabinoids in glia function, holding in consideration their therapeutic potential as neuroprotective and/or anticancer agents...
  32. doi request reprint Long lasting consequences of cannabis exposure in adolescence
    T Rubino
    DBSF and Neuroscience Center, University of Insubria, Via A da Giussano 10, Busto Arsizio VA, Italy
    Mol Cell Endocrinol 286:S108-13. 2008
    ..Therefore, the potential problems arising in relation to marijuana consumption in adolescence suggest that this developmental phase is a vulnerable period for persistent adverse effects of cannabinoids...
  33. pmc Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
    Angelo Vaccani
    Department of Structural and Functional Biology, Pharmacology Section, Center of Neurosciences, University of Insubria, Via A da Giussano 10, Busto Arsizio VA 21052, Italy
    Br J Pharmacol 144:1032-6. 2005
    ..These results reinforce the evidence of antitumoral properties of CBD, demonstrating its ability to limit tumor invasion, although the mechanism of its pharmacological effects remains to be clarified...
  34. ncbi request reprint Comparative analysis of molecular strategies attenuating positional effects in lentiviral vectors carrying multiple genes
    Daniela Osti
    Department of Structural and Functional Biology, University of Insubria, Busto Arsizio 21052, Italy
    J Virol Methods 136:93-101. 2006
    ..These results indicate that chromatin insulator sequences can be useful molecular tools to overcome positional effects in the context of lentiviral vectors...
  35. pmc Antiinflammatory action of endocannabinoid palmitoylethanolamide and the synthetic cannabinoid nabilone in a model of acute inflammation in the rat
    Silvia Conti
    Department of Biotechnology and Bioscience, Faculty of Sciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Br J Pharmacol 135:181-7. 2002
    ..6. Our findings show the antiinflammatory effect of nabilone and confirm that of palmitoylethanolamide indicating that these actions are mediated by an uncharacterized CB(2)-like cannabinoid receptor...
  36. ncbi request reprint ERK-dependent modulation of cerebellar synaptic plasticity after chronic Delta9-tetrahydrocannabinol exposure
    Raffaella Tonini
    Department of Cellular and Developmental Biology, University La Sapienza, 00185 Rome, Italy
    J Neurosci 26:5810-8. 2006
    ..This contributes to generation of forms of pathological synaptic plasticity that might play a role in cannabinoid dependence...
  37. ncbi request reprint Chronic exposure to morphine, cocaine or ethanol in rats produced different effects in brain cannabinoid CB(1) receptor binding and mRNA levels
    Sara Gonzalez
    Departamento de Bioquijmica y Biologija Molecular, Facultad de Medicina, Universidad Complutense, 2804, Madrid, Spain
    Drug Alcohol Depend 66:77-84. 2002
    ..Alcohol did not produce any effects on CB(1) receptor binding and mRNA levels, whereas cocaine only affected transcript levels in selected regions and morphine produced divergent and region-dependent effects...
  38. ncbi request reprint Cannabimimetic activity, binding, and degradation of stearoylethanolamide within the mouse central nervous system
    Mauro Maccarrone
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Rome, Italy
    Mol Cell Neurosci 21:126-40. 2002
    ..Moreover, SEA potentiates the decrease of cAMP induced by AEA in mouse cortical slices, suggesting that SEA might also be an "entourage" compound...
  39. ncbi request reprint A molecular basis of analgesic tolerance to cannabinoids
    Anke Tappe-Theodor
    Pharmacology Institute, University of Heidelberg, 69120 Heidelberg, Germany
    J Neurosci 27:4165-77. 2007
    ..These results suggest that GASP1 is a key regulator of the fate of CB1 after agonist exposure in the nervous system and critically determines analgesic tolerance to cannabinoids...
  40. pmc Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
    Nitin Agarwal
    Institute for Pharmacology, University of Heidelberg, Im Neuenheimer Feld, Heidelberg, 69120 Germany
    Nat Neurosci 10:870-9. 2007
    ....
  41. ncbi request reprint Intrauterine position has long-term influence on brain mu-opioid receptor density and behaviour in mice
    Sara Morley-Fletcher
    Section of Behavioural Pathophysiology, Labor F O S, Istituto Superiore di Sanita, Viale Regina Elena, 299 00161 Rome, Italy
    Psychoneuroendocrinology 28:386-400. 2003
    ....
  42. ncbi request reprint Involvement of kappa-opioid and endocannabinoid system on Salvinorin A-induced reward
    Daniela Braida
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
    Biol Psychiatry 63:286-92. 2008
    ..The abuse of selective k-agonists is a novel phenomenon, the mechanism of which is not fully understood...
  43. ncbi request reprint Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines
    Paola Massi
    Department of Pharmacology, University of Milan, Milan, Italy
    J Pharmacol Exp Ther 308:838-45. 2004
    ..In conclusion, the nonpsychoactive CBD was able to produce a significant antitumor activity both in vitro and in vivo, thus suggesting a possible application of CBD as an antineoplastic agent...
  44. ncbi request reprint Cannabinoids and opioids share cAMP pathway in rat splenocytes
    Paola Massi
    Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Via Vanvitelli 32, 20129 Milan, Italy
    J Neuroimmunol 145:46-54. 2003
    ..Thus, these results strengthen the hypothesis of cAMP as part of the common intracellular pathway shared by opiates and cannabinoids at immune cell level...
  45. ncbi request reprint Bidirectional regulation of mu-opioid and CB1-cannabinoid receptor in rats self-administering heroin or WIN 55,212-2
    Liana Fattore
    Institute of Neuroscience, National Research Council CNR, Section of Cagliari, Italy
    Eur J Neurosci 25:2191-200. 2007
    ....
  46. ncbi request reprint Chronic treatment with the endocannabinoid anandamide increases cytochrome P450 metabolizing system in the rat
    Barbara Costa
    Dipartimento di Biotecnologie e Bioscienze, Facolta di Scienze, Universita Milano Bicocca, Milan 20126, Italy
    Eur J Pharmacol 449:61-9. 2002
    ..The present findings demonstrate that anandamide administration increased the metabolic activity of the cytochrome P450 system in rat liver and brain...