Research Topics
| L ParnettiSummaryAffiliation: University of Perugia Country: Italy Publications
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Publications
Diagnosing prodromal Alzheimer's disease: role of CSF biochemical markersLucilla Parnetti
Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Silvestrini, S Andrea delle Fratte, 06156 Perugia, Italy
Mech Ageing Dev 127:129-32. 2006..On the contrary, 29 out of 33 stable MCI (88%) showed no or one pathological CSF value. We confirm that pathological levels in >or=2 CSF biomarkers reliably predict MCI conversion to AD and correctly identify the stable form of MCI...
Cerebrospinal fluid biomarkers in Parkinson diseaseLucilla Parnetti
Clinica Neurologica, Universita di Perugia, Ospedale Santa Maria della Misericordia, 06132 Santa Andrea delle Fratte, Perugia, Italy
Nat Rev Neurol 9:131-40. 2013..These studies support the usefulness of a combination of various CSF biomarkers of PD to increase diagnostic accuracy during early phases of the disease, and to differentiate PD from other neurodegenerative disorders...- Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairmentLucilla Parnetti
Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
J Alzheimers Dis 29:229-38. 2012..The best model of logistic regression analysis retained Aβ1-42 and p-tau (sensitivity 75%, 95%CI: 70-80%; specificity 96%, 95%CI: 94-98%). We can conclude that Aβ1-42 and p-tau reliably predict conversion to AD in MCI patients... - Cognitive enhancement therapy for Alzheimer's disease. The way forwardL Parnetti
Perugia University, Italy
Drugs 53:752-68. 1997..These lines of pharmacological intervention represent an important premise for future therapeutic strategies capable of counteracting the pathogenesis of Alzheimer's disease... - CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer's diseaseDavide Chiasserini
Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
J Alzheimers Dis 22:1281-8. 2010..7). A significant correlation between HFABP/Aβ1-42 ratio and MMSE annual decrease rate was also documented (p<0.0001). HFABP /Aβ1-42 ratio might be a useful predictor of conversion in MCI patients... - Hyperhomocyst(e)inemia: a risk factor for cerebrovascular diseaseLucilla Parnetti
Neuroscience Department, University of Perugia, Italy
Clin Exp Hypertens 24:501-9. 2002..Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke... - Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's diseaseL Parnetti
Clinica Neurologica, Ospedale S Maria della Misericordia, Universita degli Studi di Perugia, Perugia, Italy
Acta Neurol Scand 124:122-9. 2011.... - Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy BodiesL Parnetti
Section of Neurology, University of Perugia, Italy
Neurobiol Dis 34:484-6. 2009..Conversely, beta-glucocerebrosidase activity was selectively reduced in DLB, further suggesting that this enzyme might specifically be impaired in synucleinopathies... - Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodiesLucilla Parnetti
Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia General Hospital, Perugia, Italy
Biol Psychiatry 64:850-5. 2008..Thus, analysis of cerebrospinal fluid (CSF) biomarkers (beta-amyloid(1-42) [Abeta42], total tau, and hyperphosphorylated tau [p-tau]) in living subjects might provide significant pathophysiological information on these diseases... - Efficacy of thrombolytic (rt-PA) therapy in old stroke patients: the Perugia Stroke Unit experienceLucilla Parnetti
Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
Clin Exp Hypertens 28:397-404. 2006..Age did not influence prognosis in patients treated with rt-PA. The oldest stroke patients should not be excluded from rt-PA treatment on the basis of age per se... - Stroke prevention and statin treatmentLucilla Parnetti
Department of Neuroscience, University of Perugia, Perugia, Italy
Clin Exp Hypertens 28:335-44. 2006..In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention... - Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of strokeL Parnetti
Department of Neuroscience, Stroke Unit, University of Perugia, Via Enrico Dal Pozzo, I 06126 Perugia, Italy
Neurol Sci 25:13-7. 2004..0001; OR=1.425; 95% CI, 1.300-1562) and hyperlipidemia (p=0.018; OR=2.243; 95% CI, 1.147-4.385). Hyperhomocyst(e)inemia is an independent risk factor for all stroke subtypes and should be routinely measured and treated in stroke patients... - Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementiasLucilla Parnetti
Clinica Neurologica, Universita di Perugia, Perugia, Italy
Mov Disord 26:1428-35. 2011..In particular, total tau/α-synuclein and phosphorylated tau/α-synuclein ratios can contribute to the discrimination of Parkinson's disease. © 2011 Movement Disorder Society... - Role of CSF biomarkers in the diagnosis of prodromal Alzheimer's diseaseLucilla Parnetti
Center for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy
Biomark Med 5:479-84. 2011..The final aim is to introduce a panel of AD biomarkers that is able to describe the preclinical phases of AD, as fully as possible paving the way to a routine early diagnosis in view of treatment by means of disease-modifying drugs... - Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal agingL Parnetti
Medical School, Perugia University, Italy
Mech Ageing Dev 97:9-14. 1997..In particular, the gray matter NAA/ml ratio seems to be able to differentiate normal cerebral aging from Alzheimer's disease... - Vascular dementia Italian sulodexide study (VA.D.I.S.S.). Clinical and biological resultsL Parnetti
Section of Gerontology and Geriatrics, Perugia University, Italy
Thromb Res 87:225-33. 1997..A parallel improvement of G.B.S. Rating Scale for dementia scores was observed in Sdx group. These results seem to indicate that sulodexide treatment can have positive effects in vascular dementia... - Diagnosing Alzheimer's disease in very elderly patients. Relevance of some functional and psychobehavioral aspects assessed by the Gottfries-Bråne-Steen Rating Scale for Dementia. Study Group on Brain Aging, Italian Society of Gerontology and GeriatricsL Parnetti
Sezione di Gerontologia e Geriatria, Universita di Perugia, Italy
Gerontology 43:335-42. 1997.... - Pathophysiology of vascular dementia and white matter changesL Parnetti
Institute of Nervous and Mental Diseases, University of Perugia, Italy adresse ci dessus
Rev Neurol (Paris) 155:754-8. 1999..Finally, it should also be considered the role of the summation of various lesion types, since many cases of dementia occurring in stroke patients are multifactorial... - Cerebrospinal fluid pyruvate levels in Alzheimer's disease and vascular dementiaL Parnetti
Institute of Nervous and Mental Diseases, University of Perugia, Italy
Neurology 54:735-7. 2000..The similarities of CSF pyruvate patterns observed in AD and possible VaD patients implicate a neurodegenerative component in this VaD subgroup... - Therapeutic options in dementiaL Parnetti
Institute of Mental and Nervous Diseases, University of Perugia, Italy
J Neurol 247:163-8. 2000..Among the psychoactive drugs indicated for behavioral disorders, significant improvement in terms of both efficacy and tolerability can be expected from the use of new antipsychotic drugs... - Pharmacological treatment of non-cognitive disturbances in dementia disordersL Parnetti
Department of Neuroscience, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
Mech Ageing Dev 122:2063-9. 2001..Atypical or novel antipsychotic drugs represent the reference drugs for treating BPSD. Among these, risperidone is considered as a drug of choice. Also, selective serotonin reuptake inhibitors (SSRIs) are useful in the treatment of BPSD... - Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitorsL Parnetti
Department of Neuroscience, Perugia University, Perugia, Italy
Neurol Sci 23:S95-6. 2002..We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment... - Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigminaS Amici
Department of Neuroscience, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
Mech Ageing Dev 122:2057-62. 2001..Both drugs did not change BuChE activity and tended to restore the physiological pattern of AChE isoform. The possible significance of the influence of AChEIs on CSF AChE activity and isoforms is discussed... - Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event and effect on clinical outcomeM Paciaroni
Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
J Thromb Haemost 3:1218-23. 2005.... - Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practiceL Parnetti
Memory Clinic, Alzheimer Center, Department of Neuroscience, University of Perugia, Perugia, Italy
Neurol Sci 24:199-200. 2003..We confirm that these biomarkers have a role in the clinical work-up of patients with cognitive deficits... - Early admission to stroke unit influences clinical outcomeG Silvestrelli
Neuroscience, University of Perugia, Perugia, Italy
Eur J Neurol 13:250-5. 2006..8%). Old age, history of TIA, cardioembolic etiology, severity of neurological deficit and hemorrhagic stroke type all led to earlier arrival time. Admission within 3 hours 'per se' improves outcome and reduced disability at three months... - Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissectionV Gallai
Neuroscience Department, University of Perugia, Perugia, Italy
Stroke 32:714-8. 2001..Consecutive patients with CAD and age-matched control subjects have been studied by serum levels of homocyst(e)ine and the genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR)... - CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study GroupL Parnetti
Neuroscience Department, University of Perugia, Italy
Neurol Sci 22:77-8. 2001..782 +/- 0.048 (mean +/- SE) for tau and to 0.839 +/- 0.042 for phospho-tau (p = 0.039) for differentiation of AD from DLB. The present results indicate that CSF phospho-tau may be a good marker for differentiation between AD and DLB... - Neurovascular territory involved in different etiological subtypes of ischemic stroke in the Perugia Stroke RegistryM Paciaroni
Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
Eur J Neurol 10:361-5. 2003..7%), being mostly localized in the deep MCA territory; large artery disease includes more than two-thirds of watershed infarcts; the most prevalent territories involved in cardioembolic stroke are the entire MCA and posterior fossa... - Secondary prevention of cardioembolic stroke: oldest and newest promisesF Corea
Stroke Unit, Department of Neurology, Università Vita Salute IRCCS, S Raffaele, Milano, Italy
Clin Exp Hypertens 28:413-20. 2006..In the next decade, the challenge will be to understand competitiveness between old and new drugs with endovascular implants... - Multimodal use of computed tomography in early acute stroke, part 2R Scaroni
Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia, Perugia, Italy
Clin Exp Hypertens 28:427-31. 2006..Currently, the term "multimodal CT" indicates the combined use of these three techniques in order to obtain a complete picture of the extension of ischemic damage in acute stroke patients... - First-ever stroke and outcome in patients admitted to Perugia Stroke Unit: predictors for death, dependency, and recurrence of stroke within the first three monthsMonica Acciarresi
Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
Clin Exp Hypertens 28:287-94. 2006..The best predictors for dependency after 3 months were age and stroke severity. The only variable identified as the best predictor for recurrence was the presence of diabetes mellitus... - A novel spinocerebellar ataxia type 15 family with involuntary movements and cognitive declineA Castrioto
Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
Eur J Neurol 18:1263-5. 2011..SCA15 is a recently identified spinocerebellar ataxia with pure cerebellar involvement. Here, we report a novel SCA15 Italian family with atypical clinical features... - Educational approach on stroke training in EuropeF Corea
Stroke Unit, Neurologia, San Raffaele University Hospital, Milano, Italy
Clin Exp Hypertens 28:433-7. 2006..In the future, this may be translated into better patient outcome and a reduction in the global burden of this condition... - A magnetization transfer study of mild and advanced Parkinson's diseaseN Tambasco
Clinica Neurologica, Azienda Ospedaliera Università di Perugia, Italy
Eur J Neurol 18:471-7. 2011..However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2)... - Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical dataL Parnetti
Department of Neuroscience, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy. parnetti.unipg.it
Mech Ageing Dev 122:2041-55. 2001.... - A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balancePaolo Calabresi
Clinica Neurologica, Dip Specialità Medico Chirurgiche, Universita di Perugia, Italy
Lancet Neurol 5:974-83. 2006..We also discuss a convergent versus parallel model to explain cognitive dysfunctions in Parkinson's disease according to dopamine-acetylcholine dependent alterations in synaptic plasticity... - Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's disease?Barbara Palumbo
Department of Radiological Sciences, University of Perugia, Italy
Funct Neurol 23:93-6. 2008..370, p=0<0001). In conclusion, CSF NSE emerged as a specific indicator of AD and showed the same behaviour as the other accepted markers of AD, being correlated with both biomarkers... - Risk factors and stroke subtypes: results of five consecutive years of the Perugia Stroke RegistryGiorgio Silvestrelli
Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
Clin Exp Hypertens 28:279-86. 2006..3%; cigarette smoking in 21.6%. Different potentially modifiable risk factors profiles were identified for each ischemic subtype of stroke, while in hemorrhagic lobar stroke subtypes, only male gender was an independent risk factor... - Treatment of Alzheimer's disease: from pharmacology to a better understanding of disease pathophysiologyGiorgio Silvestrelli
Section of Neurology, Department of Medical and Surgical Specialisties and Public Health, University of Perugia, Ospedale Silvestrini, 06156 Perugia, Italy
Mech Ageing Dev 127:148-57. 2006..This paper reviews the main symptomatic strategies available for treating AD and future strategies for improving our therapeutic approach to AD... - Dysphagia following StrokeMaurizio Paciaroni
Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
Eur Neurol 51:162-7. 2004..We aimed to study the prognosis of dysphagia (assessed clinically) over the first 3 months after acute stroke and to determine whether specific neurovascular-anatomical sites were associated with swallowing dysfunction... - Semi-quantitative analysis of perfusion of Brodmann areas in the differential diagnosis of cognitive impairment in Alzheimer's disease, fronto-temporal dementia and mild cognitive impairmentCristina Tranfaglia
Nuclear Medicine Section, Department of Surgical, Radiological and Odontostomatological Sciences, University of Perugia, Ospedale Santa Maria della Misericordia, Località S Andrea delle Fratte i 06134, Perugia, Italy
Hell J Nucl Med 12:110-4. 2009..In MCI patients, no hypoperfusion pattern is identified... - Brain CT-scan in acute stroke patients: silent infarcts and relation to outcomeFrancesco Corea
Stroke Unit, Dip Neuroscienze, Univ Perugia, Perugia, Italy
Clin Exp Hypertens 24:669-76. 2002..In our study SI were associated with ageing, smoke habit and lacunar stroke. Silent infarcts size influenced the rate of in-hospital mortality... - Stroke related to carotid artery dissection in a young patient with Takayasu arteritis, systemic lupus erythematosus and antiphospholipid antibody syndromeV Caso
Stroke Unit, Department of Neuroscience, Unit of Internal Medicine and Oncological Sciences, University of Perugia, Italy
Cerebrovasc Dis 13:67-9. 2002..We suggest a single disimmune disorder may have led to carotid artery dissection... - Characteristics of delayed admission to stroke unitGiorgio Silvestrelli
Department of Neuroscience, University of Perugia, Perugia, Italy
Clin Exp Hypertens 28:405-11. 2006..To increase the proportion of stroke patients arriving in the SU within 3 hr of symptom onset, it is necessary to improve public and general practitioner awareness of stroke through educational programs... - Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational studyV Belcastro
Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
Eur J Neurol 14:1176-8. 2007..These results suggest the need for controlled studies to confirm if LEV can be a first-choice drug in AD... 
Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's diseaseCatia Bellucci
Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
Mol Med 13:542-50. 2007..These observations in association with the changes in FGF gene expression and in the FGF receptor number, suggest that cellular mechanisms downstream from FGF receptor binding are involved in the two different forms of AD...- Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memoryMassimiliano Di Filippo
Clinica Neurologica, Laboratori di Neurologia Sperimentale, Universita di Perugia, Perugia, Italy
Behav Brain Res 199:108-18. 2009.... - Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?Lucilla Parnetti
Clinica Neurologica, Dipartimento di Specialità Medico Chirurgiche e Sanità Pubblica, Universita di Perugia, Perugia, Italy
J Neurol Sci 257:264-9. 2007..However, they probably would justify reconsideration of the most promising molecules in larger carefully controlled studies... - Genetics of ischemic strokeMichele Venti
Stroke Unit, Department of Neuroscience, University of Perugia, Italy
Clin Exp Hypertens 24:531-4. 2002..The genetic approach could permit, in the future, a better characterization of stroke patients and a more effective individual preventive and therapeutic approach... - Phospholipid autoantibodies: time for a new immuno-assay?Valeria Caso
Department of Neuroscience, University of Perugia, Italy
Clin Exp Hypertens 24:511-6. 2002..There are other negatively charged PL, largely represented within the cellular membrane and involved in the coagulation. Different studies have demonstrated a positive correlation among other aPL and stroke... - Selection of thrombogenetic antiphospholipid antibodies in cerebrovascular disease patientsValeria Caso
Department of Neuroscience, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
J Neurol 250:593-7. 2003..9 % versus 4.9 % (p = 0.02) and aPLmix/beta(2)GP1 15.6 % versus 4.9 % (p = 0.01). These latter tests seem to be useful in assessing the autoimmune and therefore the thrombogenetic antibodies... - The Perugia hospital-based Stroke Registry: report of the 2nd yearGiorgio Silvestrelli
Department of Neuroscience, University of Perugia, Italy
Clin Exp Hypertens 24:485-91. 2002..5%. Overall hospital mortality was 10%. In cerebral hemorrhage mortality was 18% (44/240) vs. 6.3% (32/534) in ischemic stroke (p < 0.05). The distribution of stroke types and mortality was similar to other previous reports... - Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's diseaseAlessia Lanari
Dipartimento di Neuroscienze, , Perugia, Italy
Mech Ageing Dev 127:158-65. 2006..On the site of psychotropic drugs, atypical or novel antipsychotics represent the reference drugs for treating BPSD, whereas classic antipsychotic drugs for their profile and the potential side effects should be avoided... - Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational studyVincenzo Belcastro
Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
Epilepsy Res 82:223-6. 2008..These observations suggest that LEV exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke seizures... - Association between migraine and headache attributed to stroke: a case-control studyKatiuscia Nardi
Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
Headache 48:1468-75. 2008..Several studies were carried out to investigate the occurrence of headache attributed to acute stroke in patients with a lifetime history of migraine... - The inflammatory response in cerebral ischemia: focus on cytokines in stroke patientsMaria Grazia De Simoni
Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
Clin Exp Hypertens 24:535-42. 2002.... - Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's diseaseChiara Balducci
Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Perugia, Italy
Mov Disord 22:1481-4. 2007..This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases... - Arterial hypertension and cognitive dysfunction in physiologic and pathologic aging of the brainAlessia Lanari
Section of Neurology, University of Perugia, Perugia, Italy
Am J Geriatr Cardiol 16:158-64. 2007..Different and probably converging pathophysiologic mechanisms explain the role of arterial hypertension in causing cognitive dysfunction in pathologic aging of the brain, specifically, vascular dementia and Alzheimer's disease... - Brain CT scan in acute ischemic stroke: early signs and functional outcomeNicola Tambasco
Dipartimento di Neuroscienze, Universita di Perugia, Perugia, Italy
Clin Exp Hypertens 24:687-96. 2002..Between hemorrhagic transformation, only the large hematomas seems to be related to early deterioration and death. Brain Computed Tomography (CT) examination can give information about prognosis and therapeutic choice... - Recanalization of cervical artery dissection: influencing factors and role in neurological outcomeValeria Caso
Department of Neuroscience, University of Perugia, Perugia General Hospital, Italy
Cerebrovasc Dis 17:93-7. 2004..The recanalization rate of CAD can be up to 85% within 3 months. This study evaluates the variables that might affect recanalization and the role of recanalization as a predictor for neurological outcome... - Is ultrasound examination sufficient in the evaluation of patients with internal carotid artery severe stenosis or occlusion?Maurizio Paciaroni
Department of Neuroscience, University of Perugia, Perugia, Italy
Cerebrovasc Dis 15:173-6. 2003..to evaluate when a symptomatic ICA occlusion shown by ultrasound could actually be a patent artery and therefore benefit from CE... - Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodiesHugo Vanderstichele
Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent, Belgium
Clin Chem Lab Med 44:1472-80. 2006..Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult... - Arterial hypertension and stroke prevention: an updateNatan Bornstein
Department of Neurology, Sourasky Medical Center, Tel Aviv, Israel
Clin Exp Hypertens 28:317-26. 2006..than ACE-Is? Should ACE-Is and ARBs be considered routinely for either high-risk stroke patients or patients with history of stroke or transient ischemic attack, irrespective of blood pressure? What is the role of lifestyle in BP control?.. - Parkinsonism and cognitive impairment following chronic exposure to potassium cyanideMassimiliano Di Filippo
Mov Disord 23:468-70. 2008 - Secondary prevention of stroke in patients with atrial fibrillation: factors influencing the prescription of oral anticoagulation at dischargeDominique Deplanque
Department of Pharmacology, University of Lille II, Lille, France, and Department of Neurosciences and Mental Health, Hospital Santa Maria, Lisbon, Portugal
Cerebrovasc Dis 21:372-9. 2006..However, OAC is still underused, even at discharge from neurological centers. The objective of this study was to identify the reasons underlying the prescription of OAC at discharge after an ischemic stroke in patients with NVAF... - Heart-brain relationship: atrial fibrillation and strokeNatan Bornstein
Dep Neurology, University Hospital, Tel Aviv, Israel
Clin Exp Hypertens 24:493-9. 2002..More efforts should be spent to increase the number of treated subjects, in order to achieve effective prevention on stroke... - Influence of dementia on antithrombotic therapy prescribed before stroke in patients with atrial fibrillationCatherine Lefebvre
Department of Neurology, University of Lille, Lille, and Department of Neurology, Ste Anne Hospital, Paris, France
Cerebrovasc Dis 21:401-7. 2006..15; 95% CI: 1.48-6.69). CONCLUSION: In daily practice, the under-prescription of OAC in patients with NVAF mainly depends on co-morbidity and on characteristics of the physician, not on prestroke dementia... - Multimodal use of computed tomography in early acute stroke, part 1Nicola Tambasco
Dipartimento di Neurologia e Neuroriabilitazione, Villa Pini d Abruzzo, Chieti, Italy
Clin Exp Hypertens 28:421-6. 2006.... - Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive ratsDaniele Tomassoni
Sezione di Anatomia Umana, , , Camerino, Italy
Brain Res 1120:183-90. 2006..The observation that treatment with choline alphoscerate attenuates the extent of glial reaction in the hippocampus of SHR suggests also that the compound may afford neuroprotection in this animal model of vascular brain damage... - Stroke prevention and atrial fibrillation: reasons leading to an inappropriate management. Main results of the SAFE II studyDominique Deplanque
Department of Pharmacology, University of Lille, France
Br J Clin Pharmacol 57:798-806. 2004..The aim of the Stroke and Atrial Fibrillation Ensemble (SAFE) II study was to identify the reasons underlying the under-utilization of oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (NVAF)...