L Parnetti

Summary

Affiliation: University of Perugia
Country: Italy

Publications

  1. ncbi request reprint Diagnosing prodromal Alzheimer's disease: role of CSF biochemical markers
    Lucilla Parnetti
    Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Silvestrini, S Andrea delle Fratte, 06156 Perugia, Italy
    Mech Ageing Dev 127:129-32. 2006
  2. doi request reprint Cerebrospinal fluid biomarkers in Parkinson disease
    Lucilla Parnetti
    Clinica Neurologica, Universita di Perugia, Ospedale Santa Maria della Misericordia, 06132 Santa Andrea delle Fratte, Perugia, Italy
    Nat Rev Neurol 9:131-40. 2013
  3. doi request reprint Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment
    Lucilla Parnetti
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    J Alzheimers Dis 29:229-38. 2012
  4. doi request reprint Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
    Lucilla Parnetti
    Clinica Neurologica, Universita di Perugia, Perugia, Italy
    Mov Disord 26:1428-35. 2011
  5. ncbi request reprint Cognitive enhancement therapy for Alzheimer's disease. The way forward
    L Parnetti
    Perugia University, Italy
    Drugs 53:752-68. 1997
  6. doi request reprint CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer's disease
    Davide Chiasserini
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
    J Alzheimers Dis 22:1281-8. 2010
  7. doi request reprint Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease
    L Parnetti
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita degli Studi di Perugia, Perugia, Italy
    Acta Neurol Scand 124:122-9. 2011
  8. doi request reprint Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies
    L Parnetti
    Section of Neurology, University of Perugia, Italy
    Neurobiol Dis 34:484-6. 2009
  9. doi request reprint Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies
    Lucilla Parnetti
    Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia General Hospital, Perugia, Italy
    Biol Psychiatry 64:850-5. 2008
  10. ncbi request reprint Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke
    L Parnetti
    Department of Neuroscience, Stroke Unit, University of Perugia, Via Enrico Dal Pozzo, I 06126 Perugia, Italy
    Neurol Sci 25:13-7. 2004

Collaborators

Detail Information

Publications73

  1. ncbi request reprint Diagnosing prodromal Alzheimer's disease: role of CSF biochemical markers
    Lucilla Parnetti
    Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Ospedale Silvestrini, S Andrea delle Fratte, 06156 Perugia, Italy
    Mech Ageing Dev 127:129-32. 2006
    ..On the contrary, 29 out of 33 stable MCI (88%) showed no or one pathological CSF value. We confirm that pathological levels in >or=2 CSF biomarkers reliably predict MCI conversion to AD and correctly identify the stable form of MCI...
  2. doi request reprint Cerebrospinal fluid biomarkers in Parkinson disease
    Lucilla Parnetti
    Clinica Neurologica, Universita di Perugia, Ospedale Santa Maria della Misericordia, 06132 Santa Andrea delle Fratte, Perugia, Italy
    Nat Rev Neurol 9:131-40. 2013
    ..These studies support the usefulness of a combination of various CSF biomarkers of PD to increase diagnostic accuracy during early phases of the disease, and to differentiate PD from other neurodegenerative disorders...
  3. doi request reprint Performance of aβ1-40, aβ1-42, total tau, and phosphorylated tau as predictors of dementia in a cohort of patients with mild cognitive impairment
    Lucilla Parnetti
    Clinica Neurologica, Universita degli Studi di Perugia, Perugia, Italy
    J Alzheimers Dis 29:229-38. 2012
    ..The best model of logistic regression analysis retained Aβ1-42 and p-tau (sensitivity 75%, 95%CI: 70-80%; specificity 96%, 95%CI: 94-98%). We can conclude that Aβ1-42 and p-tau reliably predict conversion to AD in MCI patients...
  4. doi request reprint Cerebrospinal fluid Tau/α-synuclein ratio in Parkinson's disease and degenerative dementias
    Lucilla Parnetti
    Clinica Neurologica, Universita di Perugia, Perugia, Italy
    Mov Disord 26:1428-35. 2011
    ..In particular, total tau/α-synuclein and phosphorylated tau/α-synuclein ratios can contribute to the discrimination of Parkinson's disease. © 2011 Movement Disorder Society...
  5. ncbi request reprint Cognitive enhancement therapy for Alzheimer's disease. The way forward
    L Parnetti
    Perugia University, Italy
    Drugs 53:752-68. 1997
    ..These lines of pharmacological intervention represent an important premise for future therapeutic strategies capable of counteracting the pathogenesis of Alzheimer's disease...
  6. doi request reprint CSF levels of heart fatty acid binding protein are altered during early phases of Alzheimer's disease
    Davide Chiasserini
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita di Perugia, Perugia, Italy
    J Alzheimers Dis 22:1281-8. 2010
    ..7). A significant correlation between HFABP/Aβ1-42 ratio and MMSE annual decrease rate was also documented (p<0.0001). HFABP /Aβ1-42 ratio might be a useful predictor of conversion in MCI patients...
  7. doi request reprint Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease
    L Parnetti
    Clinica Neurologica, Ospedale S Maria della Misericordia, Universita degli Studi di Perugia, Perugia, Italy
    Acta Neurol Scand 124:122-9. 2011
    ....
  8. doi request reprint Cerebrospinal fluid beta-glucocerebrosidase activity is reduced in Dementia with Lewy Bodies
    L Parnetti
    Section of Neurology, University of Perugia, Italy
    Neurobiol Dis 34:484-6. 2009
    ..Conversely, beta-glucocerebrosidase activity was selectively reduced in DLB, further suggesting that this enzyme might specifically be impaired in synucleinopathies...
  9. doi request reprint Cerebrospinal fluid biomarkers in Parkinson's disease with dementia and dementia with Lewy bodies
    Lucilla Parnetti
    Section of Neurology, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Perugia General Hospital, Perugia, Italy
    Biol Psychiatry 64:850-5. 2008
    ..Thus, analysis of cerebrospinal fluid (CSF) biomarkers (beta-amyloid(1-42) [Abeta42], total tau, and hyperphosphorylated tau [p-tau]) in living subjects might provide significant pathophysiological information on these diseases...
  10. ncbi request reprint Mild hyperhomocysteinemia is a risk-factor in all etiological subtypes of stroke
    L Parnetti
    Department of Neuroscience, Stroke Unit, University of Perugia, Via Enrico Dal Pozzo, I 06126 Perugia, Italy
    Neurol Sci 25:13-7. 2004
    ..0001; OR=1.425; 95% CI, 1.300-1562) and hyperlipidemia (p=0.018; OR=2.243; 95% CI, 1.147-4.385). Hyperhomocyst(e)inemia is an independent risk factor for all stroke subtypes and should be routinely measured and treated in stroke patients...
  11. ncbi request reprint Efficacy of thrombolytic (rt-PA) therapy in old stroke patients: the Perugia Stroke Unit experience
    Lucilla Parnetti
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:397-404. 2006
    ..Age did not influence prognosis in patients treated with rt-PA. The oldest stroke patients should not be excluded from rt-PA treatment on the basis of age per se...
  12. ncbi request reprint Stroke prevention and statin treatment
    Lucilla Parnetti
    Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:335-44. 2006
    ..In patients with prior strokes, statins reduce the incidence of coronary events, but it is not yet proven if drugs of this class actually reduce the incidence of recurrent strokes in terms of secondary prevention...
  13. ncbi request reprint Hyperhomocyst(e)inemia: a risk factor for cerebrovascular disease
    Lucilla Parnetti
    Neuroscience Department, University of Perugia, Italy
    Clin Exp Hypertens 24:501-9. 2002
    ..Further studies are needed, in order to better characterize the association between Hcy concentrations and risk of stroke...
  14. doi request reprint Role of CSF biomarkers in the diagnosis of prodromal Alzheimer's disease
    Lucilla Parnetti
    Center for Memory Disturbances, Laboratory of Clinical Neurochemistry, Section of Neurology, University of Perugia, Perugia, Italy
    Biomark Med 5:479-84. 2011
    ..The final aim is to introduce a panel of AD biomarkers that is able to describe the preclinical phases of AD, as fully as possible paving the way to a routine early diagnosis in view of treatment by means of disease-modifying drugs...
  15. ncbi request reprint Proton magnetic resonance spectroscopy can differentiate Alzheimer's disease from normal aging
    L Parnetti
    Medical School, Perugia University, Italy
    Mech Ageing Dev 97:9-14. 1997
    ..In particular, the gray matter NAA/ml ratio seems to be able to differentiate normal cerebral aging from Alzheimer's disease...
  16. ncbi request reprint Vascular dementia Italian sulodexide study (VA.D.I.S.S.). Clinical and biological results
    L Parnetti
    Section of Gerontology and Geriatrics, Perugia University, Italy
    Thromb Res 87:225-33. 1997
    ..A parallel improvement of G.B.S. Rating Scale for dementia scores was observed in Sdx group. These results seem to indicate that sulodexide treatment can have positive effects in vascular dementia...
  17. ncbi request reprint Diagnosing Alzheimer's disease in very elderly patients. Relevance of some functional and psychobehavioral aspects assessed by the Gottfries-Bråne-Steen Rating Scale for Dementia. Study Group on Brain Aging, Italian Society of Gerontology and Geriatrics
    L Parnetti
    Sezione di Gerontologia e Geriatria, Universita di Perugia, Italy
    Gerontology 43:335-42. 1997
    ....
  18. ncbi request reprint Pathophysiology of vascular dementia and white matter changes
    L Parnetti
    Institute of Nervous and Mental Diseases, University of Perugia, Italy adresse ci dessus
    Rev Neurol (Paris) 155:754-8. 1999
    ..Finally, it should also be considered the role of the summation of various lesion types, since many cases of dementia occurring in stroke patients are multifactorial...
  19. ncbi request reprint Cerebrospinal fluid pyruvate levels in Alzheimer's disease and vascular dementia
    L Parnetti
    Institute of Nervous and Mental Diseases, University of Perugia, Italy
    Neurology 54:735-7. 2000
    ..The similarities of CSF pyruvate patterns observed in AD and possible VaD patients implicate a neurodegenerative component in this VaD subgroup...
  20. ncbi request reprint Therapeutic options in dementia
    L Parnetti
    Institute of Mental and Nervous Diseases, University of Perugia, Italy
    J Neurol 247:163-8. 2000
    ..Among the psychoactive drugs indicated for behavioral disorders, significant improvement in terms of both efficacy and tolerability can be expected from the use of new antipsychotic drugs...
  21. ncbi request reprint Pharmacological treatment of non-cognitive disturbances in dementia disorders
    L Parnetti
    Department of Neuroscience, University of Perugia, Via Enrico Dal Pozzo, 06126, Perugia, Italy
    Mech Ageing Dev 122:2063-9. 2001
    ..Atypical or novel antipsychotic drugs represent the reference drugs for treating BPSD. Among these, risperidone is considered as a drug of choice. Also, selective serotonin reuptake inhibitors (SSRIs) are useful in the treatment of BPSD...
  22. ncbi request reprint Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors
    L Parnetti
    Department of Neuroscience, Perugia University, Perugia, Italy
    Neurol Sci 23:S95-6. 2002
    ..We conclude that AChE inhibitors induce different effects on CSF AChE activity, while other CSF biomarkers are not significantly affected by treatment...
  23. ncbi request reprint Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina
    S Amici
    Department of Neuroscience, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy
    Mech Ageing Dev 122:2057-62. 2001
    ..Both drugs did not change BuChE activity and tended to restore the physiological pattern of AChE isoform. The possible significance of the influence of AChEIs on CSF AChE activity and isoforms is discussed...
  24. ncbi request reprint Atrial fibrillation in patients with first-ever stroke: frequency, antithrombotic treatment before the event and effect on clinical outcome
    M Paciaroni
    Stroke Unit and Division of Cardiovascular Medicine, University of Perugia, Perugia, Italy
    J Thromb Haemost 3:1218-23. 2005
    ....
  25. ncbi request reprint Cerebrospinal fluid biochemical markers in early detection and in differential diagnosis of dementia disorders in routine clinical practice
    L Parnetti
    Memory Clinic, Alzheimer Center, Department of Neuroscience, University of Perugia, Perugia, Italy
    Neurol Sci 24:199-200. 2003
    ..We confirm that these biomarkers have a role in the clinical work-up of patients with cognitive deficits...
  26. ncbi request reprint Early admission to stroke unit influences clinical outcome
    G Silvestrelli
    Neuroscience, University of Perugia, Perugia, Italy
    Eur J Neurol 13:250-5. 2006
    ..8%). Old age, history of TIA, cardioembolic etiology, severity of neurological deficit and hemorrhagic stroke type all led to earlier arrival time. Admission within 3 hours 'per se' improves outcome and reduced disability at three months...
  27. ncbi request reprint Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissection
    V Gallai
    Neuroscience Department, University of Perugia, Perugia, Italy
    Stroke 32:714-8. 2001
    ..Consecutive patients with CAD and age-matched control subjects have been studied by serum levels of homocyst(e)ine and the genotype of 5,10-methylenetetrahydrofolate reductase (MTHFR)...
  28. ncbi request reprint CSF phosphorylated tau is a possible marker for discriminating Alzheimer's disease from dementia with Lewy bodies. Phospho-Tau International Study Group
    L Parnetti
    Neuroscience Department, University of Perugia, Italy
    Neurol Sci 22:77-8. 2001
    ..782 +/- 0.048 (mean +/- SE) for tau and to 0.839 +/- 0.042 for phospho-tau (p = 0.039) for differentiation of AD from DLB. The present results indicate that CSF phospho-tau may be a good marker for differentiation between AD and DLB...
  29. ncbi request reprint Neurovascular territory involved in different etiological subtypes of ischemic stroke in the Perugia Stroke Registry
    M Paciaroni
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Eur J Neurol 10:361-5. 2003
    ..7%), being mostly localized in the deep MCA territory; large artery disease includes more than two-thirds of watershed infarcts; the most prevalent territories involved in cardioembolic stroke are the entire MCA and posterior fossa...
  30. ncbi request reprint Secondary prevention of cardioembolic stroke: oldest and newest promises
    F Corea
    Stroke Unit, Department of Neurology, Università Vita Salute IRCCS, S Raffaele, Milano, Italy
    Clin Exp Hypertens 28:413-20. 2006
    ..In the next decade, the challenge will be to understand competitiveness between old and new drugs with endovascular implants...
  31. ncbi request reprint Multimodal use of computed tomography in early acute stroke, part 2
    R Scaroni
    Servizio di Neuroradiologia, Azienda Ospedaliera di Perugia, Perugia, Italy
    Clin Exp Hypertens 28:427-31. 2006
    ..Currently, the term "multimodal CT" indicates the combined use of these three techniques in order to obtain a complete picture of the extension of ischemic damage in acute stroke patients...
  32. ncbi request reprint First-ever stroke and outcome in patients admitted to Perugia Stroke Unit: predictors for death, dependency, and recurrence of stroke within the first three months
    Monica Acciarresi
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:287-94. 2006
    ..The best predictors for dependency after 3 months were age and stroke severity. The only variable identified as the best predictor for recurrence was the presence of diabetes mellitus...
  33. doi request reprint A novel spinocerebellar ataxia type 15 family with involuntary movements and cognitive decline
    A Castrioto
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Eur J Neurol 18:1263-5. 2011
    ..SCA15 is a recently identified spinocerebellar ataxia with pure cerebellar involvement. Here, we report a novel SCA15 Italian family with atypical clinical features...
  34. ncbi request reprint Educational approach on stroke training in Europe
    F Corea
    Stroke Unit, Neurologia, San Raffaele University Hospital, Milano, Italy
    Clin Exp Hypertens 28:433-7. 2006
    ..In the future, this may be translated into better patient outcome and a reduction in the global burden of this condition...
  35. doi request reprint A magnetization transfer study of mild and advanced Parkinson's disease
    N Tambasco
    Clinica Neurologica, Azienda Ospedaliera Università di Perugia, Italy
    Eur J Neurol 18:471-7. 2011
    ..However, how these tissue changes differ along the course of the illness is still unclear. This study was aimed at investigating how MTR values change from mild PD (PD1) to patients with advanced PD (PD2)...
  36. ncbi request reprint Choline alphoscerate in cognitive decline and in acute cerebrovascular disease: an analysis of published clinical data
    L Parnetti
    Department of Neuroscience, University of Perugia, Via E dal Pozzo, 06126, Perugia, Italy. parnetti.unipg.it
    Mech Ageing Dev 122:2041-55. 2001
    ....
  37. ncbi request reprint A convergent model for cognitive dysfunctions in Parkinson's disease: the critical dopamine-acetylcholine synaptic balance
    Paolo Calabresi
    Clinica Neurologica, Dip Specialità Medico Chirurgiche, Universita di Perugia, Italy
    Lancet Neurol 5:974-83. 2006
    ..We also discuss a convergent versus parallel model to explain cognitive dysfunctions in Parkinson's disease according to dopamine-acetylcholine dependent alterations in synaptic plasticity...
  38. ncbi request reprint Cerebrospinal fluid neuron-specific enolase: a further marker of Alzheimer's disease?
    Barbara Palumbo
    Department of Radiological Sciences, University of Perugia, Italy
    Funct Neurol 23:93-6. 2008
    ..370, p=0<0001). In conclusion, CSF NSE emerged as a specific indicator of AD and showed the same behaviour as the other accepted markers of AD, being correlated with both biomarkers...
  39. ncbi request reprint Dysphagia following Stroke
    Maurizio Paciaroni
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Eur Neurol 51:162-7. 2004
    ..We aimed to study the prognosis of dysphagia (assessed clinically) over the first 3 months after acute stroke and to determine whether specific neurovascular-anatomical sites were associated with swallowing dysfunction...
  40. ncbi request reprint Treatment of Alzheimer's disease: from pharmacology to a better understanding of disease pathophysiology
    Giorgio Silvestrelli
    Section of Neurology, Department of Medical and Surgical Specialisties and Public Health, University of Perugia, Ospedale Silvestrini, 06156 Perugia, Italy
    Mech Ageing Dev 127:148-57. 2006
    ..This paper reviews the main symptomatic strategies available for treating AD and future strategies for improving our therapeutic approach to AD...
  41. ncbi request reprint Risk factors and stroke subtypes: results of five consecutive years of the Perugia Stroke Registry
    Giorgio Silvestrelli
    Stroke Unit, Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:279-86. 2006
    ..3%; cigarette smoking in 21.6%. Different potentially modifiable risk factors profiles were identified for each ischemic subtype of stroke, while in hemorrhagic lobar stroke subtypes, only male gender was an independent risk factor...
  42. ncbi request reprint Semi-quantitative analysis of perfusion of Brodmann areas in the differential diagnosis of cognitive impairment in Alzheimer's disease, fronto-temporal dementia and mild cognitive impairment
    Cristina Tranfaglia
    Nuclear Medicine Section, Department of Surgical, Radiological and Odontostomatological Sciences, University of Perugia, Ospedale Santa Maria della Misericordia, Località S Andrea delle Fratte i 06134, Perugia, Italy
    Hell J Nucl Med 12:110-4. 2009
    ..In MCI patients, no hypoperfusion pattern is identified...
  43. ncbi request reprint Brain CT-scan in acute stroke patients: silent infarcts and relation to outcome
    Francesco Corea
    Stroke Unit, Dip Neuroscienze, Univ Perugia, Perugia, Italy
    Clin Exp Hypertens 24:669-76. 2002
    ..In our study SI were associated with ageing, smoke habit and lacunar stroke. Silent infarcts size influenced the rate of in-hospital mortality...
  44. ncbi request reprint Stroke related to carotid artery dissection in a young patient with Takayasu arteritis, systemic lupus erythematosus and antiphospholipid antibody syndrome
    V Caso
    Stroke Unit, Department of Neuroscience, Unit of Internal Medicine and Oncological Sciences, University of Perugia, Italy
    Cerebrovasc Dis 13:67-9. 2002
    ..We suggest a single disimmune disorder may have led to carotid artery dissection...
  45. ncbi request reprint Characteristics of delayed admission to stroke unit
    Giorgio Silvestrelli
    Department of Neuroscience, University of Perugia, Perugia, Italy
    Clin Exp Hypertens 28:405-11. 2006
    ..To increase the proportion of stroke patients arriving in the SU within 3 hr of symptom onset, it is necessary to improve public and general practitioner awareness of stroke through educational programs...
  46. ncbi request reprint Levetiracetam monotherapy in Alzheimer patients with late-onset seizures: a prospective observational study
    V Belcastro
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Eur J Neurol 14:1176-8. 2007
    ..These results suggest the need for controlled studies to confirm if LEV can be a first-choice drug in AD...
  47. doi request reprint Short-term and long-term plasticity at corticostriatal synapses: implications for learning and memory
    Massimiliano Di Filippo
    Clinica Neurologica, Laboratori di Neurologia Sperimentale, Universita di Perugia, Perugia, Italy
    Behav Brain Res 199:108-18. 2009
    ....
  48. ncbi request reprint Selection of thrombogenetic antiphospholipid antibodies in cerebrovascular disease patients
    Valeria Caso
    Department of Neuroscience, University of Perugia, Via Enrico Dal Pozzo, 06126 Perugia, Italy
    J Neurol 250:593-7. 2003
    ..9 % versus 4.9 % (p = 0.02) and aPLmix/beta(2)GP1 15.6 % versus 4.9 % (p = 0.01). These latter tests seem to be useful in assessing the autoimmune and therefore the thrombogenetic antibodies...
  49. ncbi request reprint The Perugia hospital-based Stroke Registry: report of the 2nd year
    Giorgio Silvestrelli
    Department of Neuroscience, University of Perugia, Italy
    Clin Exp Hypertens 24:485-91. 2002
    ..5%. Overall hospital mortality was 10%. In cerebral hemorrhage mortality was 18% (44/240) vs. 6.3% (32/534) in ischemic stroke (p < 0.05). The distribution of stroke types and mortality was similar to other previous reports...
  50. ncbi request reprint Phospholipid autoantibodies: time for a new immuno-assay?
    Valeria Caso
    Department of Neuroscience, University of Perugia, Italy
    Clin Exp Hypertens 24:511-6. 2002
    ..There are other negatively charged PL, largely represented within the cellular membrane and involved in the coagulation. Different studies have demonstrated a positive correlation among other aPL and stroke...
  51. pmc Differences in extracellular matrix production and basic fibroblast growth factor response in skin fibroblasts from sporadic and familial Alzheimer's disease
    Catia Bellucci
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Mol Med 13:542-50. 2007
    ..These observations in association with the changes in FGF gene expression and in the FGF receptor number, suggest that cellular mechanisms downstream from FGF receptor binding are involved in the two different forms of AD...
  52. ncbi request reprint Cholinergic precursors in the treatment of cognitive impairment of vascular origin: ineffective approaches or need for re-evaluation?
    Lucilla Parnetti
    Clinica Neurologica, Dipartimento di Specialità Medico Chirurgiche e Sanità Pubblica, Universita di Perugia, Perugia, Italy
    J Neurol Sci 257:264-9. 2007
    ..However, they probably would justify reconsideration of the most promising molecules in larger carefully controlled studies...
  53. ncbi request reprint Genetics of ischemic stroke
    Michele Venti
    Stroke Unit, Department of Neuroscience, University of Perugia, Italy
    Clin Exp Hypertens 24:531-4. 2002
    ..The genetic approach could permit, in the future, a better characterization of stroke patients and a more effective individual preventive and therapeutic approach...
  54. ncbi request reprint Neurotransmitter deficits in behavioural and psychological symptoms of Alzheimer's disease
    Alessia Lanari
    Dipartimento di Neuroscienze, Universita di Perugia, Perugia, Italy
    Mech Ageing Dev 127:158-65. 2006
    ..On the site of psychotropic drugs, atypical or novel antipsychotics represent the reference drugs for treating BPSD, whereas classic antipsychotic drugs for their profile and the potential side effects should be avoided...
  55. ncbi request reprint Is ultrasound examination sufficient in the evaluation of patients with internal carotid artery severe stenosis or occlusion?
    Maurizio Paciaroni
    Department of Neuroscience, University of Perugia, Perugia, Italy
    Cerebrovasc Dis 15:173-6. 2003
    ..to evaluate when a symptomatic ICA occlusion shown by ultrasound could actually be a patent artery and therefore benefit from CE...
  56. ncbi request reprint Brain CT scan in acute ischemic stroke: early signs and functional outcome
    Nicola Tambasco
    Dipartimento di Neuroscienze, Universita di Perugia, Perugia, Italy
    Clin Exp Hypertens 24:687-96. 2002
    ..Between hemorrhagic transformation, only the large hematomas seems to be related to early deterioration and death. Brain Computed Tomography (CT) examination can give information about prognosis and therapeutic choice...
  57. doi request reprint Levetiracetam in newly diagnosed late-onset post-stroke seizures: a prospective observational study
    Vincenzo Belcastro
    Clinica Neurologica, Universita degli Studi di Perugia, Ospedale S Maria della Misericordia, Perugia, Italy
    Epilepsy Res 82:223-6. 2008
    ..These observations suggest that LEV exhibits safety and efficacy profiles which make it an optimal candidate as a first-choice drug against post-stroke seizures...
  58. doi request reprint Association between migraine and headache attributed to stroke: a case-control study
    Katiuscia Nardi
    Neurologic Clinic, Department of Medical and Surgical Specialties and Public Health, University of Perugia, Italy
    Headache 48:1468-75. 2008
    ..Several studies were carried out to investigate the occurrence of headache attributed to acute stroke in patients with a lifetime history of migraine...
  59. ncbi request reprint Recanalization of cervical artery dissection: influencing factors and role in neurological outcome
    Valeria Caso
    Department of Neuroscience, University of Perugia, Perugia General Hospital, Italy
    Cerebrovasc Dis 17:93-7. 2004
    ..The recanalization rate of CAD can be up to 85% within 3 months. This study evaluates the variables that might affect recanalization and the role of recanalization as a predictor for neurological outcome...
  60. ncbi request reprint Lysosomal hydrolases in cerebrospinal fluid from subjects with Parkinson's disease
    Chiara Balducci
    Dipartimento di Medicina Interna, Universita degli Studi di Perugia, Perugia, Italy
    Mov Disord 22:1481-4. 2007
    ..This study indicates that in PD several lysosomal hydrolases have decreased activities, further supporting a possible link between pathophysiological mechanisms underlying PD and lysosomal hydrolases...
  61. ncbi request reprint Arterial hypertension and cognitive dysfunction in physiologic and pathologic aging of the brain
    Alessia Lanari
    Section of Neurology, University of Perugia, Perugia, Italy
    Am J Geriatr Cardiol 16:158-64. 2007
    ..Different and probably converging pathophysiologic mechanisms explain the role of arterial hypertension in causing cognitive dysfunction in pathologic aging of the brain, specifically, vascular dementia and Alzheimer's disease...
  62. ncbi request reprint The inflammatory response in cerebral ischemia: focus on cytokines in stroke patients
    Maria Grazia De Simoni
    Department of Neuroscience, Mario Negri Institute for Pharmacological Research, Milano, Italy
    Clin Exp Hypertens 24:535-42. 2002
    ....
  63. ncbi request reprint Arterial hypertension and stroke prevention: an update
    Natan Bornstein
    Department of Neurology, Sourasky Medical Center, Tel Aviv, Israel
    Clin Exp Hypertens 28:317-26. 2006
    ..than ACE-Is? Should ACE-Is and ARBs be considered routinely for either high-risk stroke patients or patients with history of stroke or transient ischemic attack, irrespective of blood pressure? What is the role of lifestyle in BP control?..
  64. ncbi request reprint Analytical performance and clinical utility of the INNOTEST PHOSPHO-TAU181P assay for discrimination between Alzheimer's disease and dementia with Lewy bodies
    Hugo Vanderstichele
    Innogenetics NV, Industriepark Zwijnaarde 7, 9052 Gent, Belgium
    Clin Chem Lab Med 44:1472-80. 2006
    ..Differential diagnosis from dementia with Lewy bodies (DLB) in clinical settings is difficult...
  65. ncbi request reprint Heart-brain relationship: atrial fibrillation and stroke
    Natan Bornstein
    Dep Neurology, University Hospital, Tel Aviv, Israel
    Clin Exp Hypertens 24:493-9. 2002
    ..More efforts should be spent to increase the number of treated subjects, in order to achieve effective prevention on stroke...
  66. ncbi request reprint Influence of dementia on antithrombotic therapy prescribed before stroke in patients with atrial fibrillation
    Catherine Lefebvre
    Department of Neurology, University of Lille, Lille, and Department of Neurology, Ste Anne Hospital, Paris, France
    Cerebrovasc Dis 21:401-7. 2006
    ..The aim of this study was to test the hypothesis that prestroke dementia influenced the nonprescription of OAC before stroke...
  67. ncbi request reprint Secondary prevention of stroke in patients with atrial fibrillation: factors influencing the prescription of oral anticoagulation at discharge
    Dominique Deplanque
    Department of Pharmacology, University of Lille II, Lille, France, and Department of Neurosciences and Mental Health, Hospital Santa Maria, Lisbon, Portugal
    Cerebrovasc Dis 21:372-9. 2006
    ..However, OAC is still underused, even at discharge from neurological centers. The objective of this study was to identify the reasons underlying the prescription of OAC at discharge after an ischemic stroke in patients with NVAF...
  68. ncbi request reprint Effect of treatment with choline alphoscerate on hippocampus microanatomy and glial reaction in spontaneously hypertensive rats
    Daniele Tomassoni
    Sezione di Anatomia Umana, Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Camerino, Italy
    Brain Res 1120:183-90. 2006
    ..The observation that treatment with choline alphoscerate attenuates the extent of glial reaction in the hippocampus of SHR suggests also that the compound may afford neuroprotection in this animal model of vascular brain damage...
  69. ncbi request reprint Multimodal use of computed tomography in early acute stroke, part 1
    Nicola Tambasco
    Dipartimento di Neurologia e Neuroriabilitazione, Villa Pini d Abruzzo, Chieti, Italy
    Clin Exp Hypertens 28:421-6. 2006
    ....
  70. pmc Stroke prevention and atrial fibrillation: reasons leading to an inappropriate management. Main results of the SAFE II study
    Dominique Deplanque
    Department of Pharmacology, University of Lille, France
    Br J Clin Pharmacol 57:798-806. 2004
    ..The aim of the Stroke and Atrial Fibrillation Ensemble (SAFE) II study was to identify the reasons underlying the under-utilization of oral anticoagulation (OAC) in patients with nonvalvular atrial fibrillation (NVAF)...
  71. ncbi request reprint Parkinsonism and cognitive impairment following chronic exposure to potassium cyanide
    Massimiliano Di Filippo
    Mov Disord 23:468-70. 2008