Carmela Parenti

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. doi request reprint Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, Catania 95125, Italy
    Molecules 20:16758-69. 2015
  2. doi request reprint Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain
    Carmela Parenti
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 34:412-8. 2012
  3. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
  4. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
  5. doi request reprint Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Vle A Doria 6, 95125 Catania, Italy
    Peptides 31:696-700. 2010
  6. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
  7. doi request reprint Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain
    Giovanna M Scoto
    Department of Pharmaceutical Sciences, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Life Sci 85:206-10. 2009
  8. doi request reprint A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, University of Catania, Viale A Doria, 6, 95125 Catania, Italy
    Life Sci 82:549-53. 2008
  9. doi request reprint Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
    J Med Chem 53:5881-5. 2010
  10. doi request reprint Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
    Giovanna M Scoto
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Pharmacol Biochem Behav 100:639-44. 2012

Detail Information

Publications19

  1. doi request reprint Involvement of the Heme-Oxygenase Pathway in the Antiallodynic and Antihyperalgesic Activity of Harpagophytum procumbens in Rats
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, Catania 95125, Italy
    Molecules 20:16758-69. 2015
    ..p.) induced a clear antiallodynic response in carrageenan injected rats. These results suggest the involvement of HO-1/CO system in the antiallodynic and antihyperalgesic effect of H. procumbens in carrageenan-induced inflammatory pain. ..
  2. doi request reprint Supraspinal injection of Substance P attenuates allodynia and hyperalgesia in a rat model of inflammatory pain
    Carmela Parenti
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 34:412-8. 2012
    ..These results suggest a significant antinociceptive role for SP and the NK1 receptor in inflammatory pain at the supraspinal level, possibly through the release of endogenous opioids...
  3. doi request reprint Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:957-61. 2012
    ..The aim of this work was to determine whether the antinociceptive effect produced by LP1 was central or peripheral and to assess which opioid receptor subtypes are involved in its effects...
  4. doi request reprint The benzomorphan-based LP1 ligand is a suitable MOR/DOR agonist for chronic pain treatment
    Lorella Pasquinucci
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Life Sci 90:66-70. 2012
    ..The aim of this work was to evaluate and compare the induction of tolerance to antinociceptive effects from treatment with LP1 and morphine...
  5. doi request reprint Selective inhibition of the NOP receptor in the ventrolateral periaqueductal gray attenuates the development and the expression of tolerance to morphine-induced antinociception in rats
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, Vle A Doria 6, 95125 Catania, Italy
    Peptides 31:696-700. 2010
    ..These data suggest that the N/OFQ in the vlPAG may play a key role in opioid-induced antinociceptive tolerance...
  6. doi request reprint The multitarget opioid ligand LP1's effects in persistent pain and in primary cell neuronal cultures
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Neuropharmacology 71:70-82. 2013
    ..Our studies seem to support that multitarget ligand approach should be useful for persistent pain conditions in which mechanical allodynia and thermal hyperalgesia are significant components of the nociceptive response...
  7. doi request reprint Involvement of the Nociceptin/Orphanin FQ-NOP receptor system in the ventrolateral periaqueductal gray following mechanical allodynia in chronic pain
    Giovanna M Scoto
    Department of Pharmaceutical Sciences, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Life Sci 85:206-10. 2009
    ..The aim of the present study was to identify the role of the vlPAG Nociceptin/Orphanin FQ/NOP receptor system in allodynia, a nociceptive behavioral response associated with chronic pain...
  8. doi request reprint A new sigma ligand, (+/-)-PPCC, antagonizes kappa opioid receptor-mediated antinociceptive effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, University of Catania, Viale A Doria, 6, 95125 Catania, Italy
    Life Sci 82:549-53. 2008
    ..This study confirms that (+/-)-PPCC plays the role of sigma agonist in this model and strengthens the hypothesis of the sigma receptor modulatory role on KOP-mediated analgesia...
  9. doi request reprint Synthesis and resolution of cis-(+/-)-methyl (1R,2S/1S,2R)-2-[(4-hydroxy-4-phenylpiperidin-1-yl)methyl]-1-(4-methylphenyl)cyclopropanecarboxylate [(+/-)-PPCC)]: new sigma receptor ligands with neuroprotective effect
    Orazio Prezzavento
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Catania, Italy
    J Med Chem 53:5881-5. 2010
    ..They exhibited in vivo anti-opioid effects on kappa opioid (KOP) receptor-mediated analgesia. Our findings demonstrate that the enantiomers display mainly sigma(1) agonist activity and that they have neuroprotective effects...
  10. doi request reprint Effects of intraplantar nocistatin and (±)-J 113397 injections on nociceptive behavior in a rat model of inflammation
    Giovanna M Scoto
    Department of Drug Sciences Pharmacology and Toxicology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Pharmacol Biochem Behav 100:639-44. 2012
    ..Thus, it is likely that the peripheral N/OFQ/NOP receptor system contributes to the abnormal pain sensitivity in an inflammatory state...
  11. doi request reprint The antagonistic effect of the sigma 1 receptor ligand (+)-MR200 on persistent pain induced by inflammation
    Carmela Parenti
    Pharmacology and Toxicology Section, Department of Drug Sciences, University of Catania, 95125, Catania, Italy
    Inflamm Res 63:231-7. 2014
    ..Here, we investigated the effect of σ1 blockade in an inflammatory pain model...
  12. doi request reprint Evaluation of N-substitution in 6,7-benzomorphan compounds
    Lorella Pasquinucci
    Department of Pharmaceutical Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    Bioorg Med Chem 18:4975-82. 2010
    ..LP1, possessing a mu/delta agonist profile, could represent a lead in further developing benzomorphan-based ligands with potent in vivo analgesic activity and a reduced tendency to induce side effects...
  13. doi request reprint Novel potent and selective σ ligands: evaluation of their agonist and antagonist properties
    Agostino Marrazzo
    Department of Drug Sciences, Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy
    J Med Chem 54:3669-73. 2011
    ..The σ(2) ligand (-)-9 displayed agonist properties in an in vitro isolated organ bath assay and antiproliferative effects on LNCaP and PC3 prostate cancer cell lines...
  14. doi request reprint Effects of a selective sigma 1 antagonist compound on inflammatory pain
    Carmela Parenti
    Department of Drug Sciences, Pharmacology and Toxicology Section, University of Catania, Viale A Doria 6, 95125, Catania, Italy
    Inflammation 37:261-6. 2014
    ..c.) also inhibited paw edemawith a significant inhibition of 61.53 % 3 h aftercarrageenan treatment [corrected]. These results provide a strongbasis for the use of σ1 receptor antagonists in thetreatment of inflammatory pain...
  15. ncbi request reprint Blockade of the nociceptin/orphanin FQ/NOP receptor system in the rat ventrolateral periaqueductal gray potentiates DAMGO analgesia
    Giovanna M Scoto
    Department of Pharmaceutical Sciences Pharmacology Section, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Peptides 28:1441-6. 2007
    ..N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG...
  16. doi request reprint Multitarget opioid ligands in pain relief: New players in an old game
    Rita Turnaturi
    Department of Drug Sciences Medicinal Chemistry Section, University of Catania, Viale A Doria 6, 95125 Catania, Italy Electronic address
    Eur J Med Chem 108:211-28. 2016
    ..Moreover, the potential of these compounds, both as analgesic drugs and pharmacological tools to explore heteromer receptors, has been stressed. ..
  17. pmc HDAC and HAT inhibitors differently affect analgesia mediated by group II metabotropic glutamate receptors
    Magda Zammataro
    Department of Drug Sciences, Section of Pharmacology and Toxicology, University of Catania, 95125 Catania, Italy
    Mol Pain 10:68. 2014
    ..However whether inhibition of HAT activity also regulates mGlu2 expression has not been reported...
  18. pmc Wilms' tumor gene 1 (WT1) silencing inhibits proliferation of malignant peripheral nerve sheath tumor sNF96.2 cell line
    Rosalba Parenti
    Department of Biomedical and Biotechnological Sciences, Physiology Section, University of Catania, 95125 Catania, Italy
    PLoS ONE 9:e114333. 2014
    ..Thus, WT1 is suggested to serve as a potential therapeutic target for MPNSTs. ..
  19. ncbi request reprint In vivo evaluation of (+)-MR200 as a new selective sigma ligand modulating MOP, DOP and KOP supraspinal analgesia
    Agostino Marrazzo
    Department of Pharmaceutical Sciences, University of Catania, Italy
    Life Sci 78:2449-53. 2006
    ..c.v.) analgesia. The mechanism involved in these effects was not clear, but provided additional data on a diverging modulator role of selective sigma-1 antagonists on KOP analgesia...