G Parati

..abstract:..

..Instructions to users on how to properly perform HBPM are provided as an appendix...

..This review will address whether antihypertensive treatment should target alterations in BPV, in addition to reducing absolute BP levels, in order to achieve the highest CV and renal protection in hypertensive and renal patients...

..This relationship is stronger with measures of BP variability focusing on short-term changes, such as ARV and weighted 24-hour SD...

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..They are at the same time aimed at reminding respiration experts to consider the occurrence of hypertension in patients with respiratory problems at night...

..TRIAL REGISTRATION: ClinicalTrials.gov: NCT00873899...

..This study is aimed at briefly summarizing a few important issues in this context, and at emphasizing the work done by Tom Pickering in this field, as a tribute to his unique contributions to medical science and patient care...

..Regular slow breathing is known to improve autonomic cardiac regulation and reduce chemoreflex sensitivity in heart failure. We explored the acceptability and usefulness of a device for paced slow breathing at the home setting...

..The present document, which provides concise and updated guidelines on the use of HBPM for practising physicians, was therefore prepared by including the comments and feedback of general practitioners...

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..Increasing the dose or adding a second antihypertensive agent are 2 possible therapeutic choices when blood pressure (BP) is poorly controlled with monotherapy...

..The aim of this meta-analysis was to compare the 24-h antihypertensive efficacy of different treatments using the smoothness index...

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..Further studies are still needed to confirm that, in humans, interventions that can reduce BPV can also reduce the rate of cardiovascular events...

..This review offers an update on the most recent data published on the above issues...

..The final section deals with the problems related to the implementation of these recommendations in clinical practice...

..Teletransmission facilities may offer a more efficient approach to long-term home blood pressure monitoring...

..The development of fixed-dose angiotensin receptor blocker-calcium channel blocker therapy offers additional benefits in terms of adherence to treatment...

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..Long-lasting drugs or drug combinations are preferable to ensure a homogeneous and smooth 24-h blood pressure profile...

..The role of HBP teletransmission in the context of integrated patients' management programmes is also addressed, with indications for further progress in this field...

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..High-dose valsartan is safe and effective in uncomplicated mild-to-moderate hypertension independently of the initial response to a moderate dose. High-dose ARB monotherapy may thus be a viable option in hypertension management...

..The importance of effective BP control in type 2 diabetic patients to prevent CV outcomes and other diabetes-related complications is underlined, with emphasis on early, tight, and continuous BP control to optimize patients' protection...

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..In particular, these methods offer the possibility of investigating the dynamic modulation of baroreflex sensitivity occurring either on a minute-to-minute basis or over 24 hours...

..Finally methodological aspects related to the use of noninvasive ambulatory blood pressure monitoring in the assessment of blood pressure variability are discussed...

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..These results demonstrate that celiprolol is an effective once daily treatment for hypertension...

..Data from clinical practice are rather scant. Thus, we examined the prevalence and correlates of ARD in a large sample of hypertensive patients referred by general practitioners for a routine echocardiographic examination...

..For systolic BP, the greater error can be minimized by using correction factors...

..Office measurement, however, gives no information about blood pressure outside the office. This paper describes a HOT substudy in which patients underwent both office measurement and 24 h ambulatory blood pressure monitoring...

..It is now possible to perform 24 h dynamic spectral analysis of blood pressure and heart rate on continuous blood pressure recordings obtained noninvasively by a finger pressure device...

..This is particularly the case when these analyses are performed on 24 h continuous BP and HR recordings in ambulant subjects...

..5 threshold also after baroreceptor denervation...

..Their role as additional surrogate endpoints in essential hypertension needs to be addressed in future studies...

..In conclusion, in our cohort of obese children and adolescents, daytime and night-time hypertension were associated with activation of the sympathoadrenal system and worst metabolic conditions, respectively...

..The AM-5600 allows accurate description of SBP and DBP profiles and thus may be suitable to describe the abrupt BP changes accompanying a number of clinical events...

..These findings identify additional cardiovascular risk factors for patients cured of Cushing's disease...

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..This review will briefly survey the methods most widely used to assess baroreflex function in humans, in the laboratory and in daily life...

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..Since 24-h blood pressure control is now widely accepted as an important goal of antihypertensive therapy, ABPM has a potentially useful role in monitoring treatment in clinical trials in elderly patients...

..This is the case for daytime versus nighttime BP, the day/night BP difference, the morning BP rise, and overall BP variability...

..The aim of the present study was to determine whether IMT independently relates to additional information obtained through ambulatory BP, in particular to SBP or PP variability...

..Because of the complementary mechanism of action and the evidence of cardiovascular protective effects they include the combination of a calcium antagonist and an angiotensin receptor antagonist among the priorital ones to employ...

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..Information on the features of long-term modifications of clinic and 24-h ambulatory blood pressure (ABP) by treatment is limited. The present study aimed to address this issue...

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..Future directions for research and treatment of hypertension will need to consider the circadian cycle of blood pressure, the effect of treatment on blood pressure variability, and the magnitude of blood pressure changes in daily life...

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..To investigate the possibility that statins reduce blood pressure as well as cholesterol concentrations through clinic and 24 hour ambulatory blood pressure monitoring...

..Future directions for research and treatment of hypertension will need to consider the circadian cycle of blood pressure, the effect of treatment on blood pressure variability, and the magnitude of blood pressure changes in daily life...

..This paper is intended to provide an overview of important recent progress in this field, and to highlight future perspectives...

..The combined and significant changes in other variables probably contribute to the suppression of hepcidin in this setting...

..Available evidence therefore suggests that celiprolol is an effective and safe antihypertensive drug, the favorable ancillary properties of which are likely to make its administration feasible in a broad range of patients...

..Finally, the applicability of the procedure to biological data was verified by analysing five experimental HR tracings recorded in normal subjects during laboratory and daily life conditions...

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..The combination of sympathetic predominance, vagal withdrawal, and blunted baroreflex sensitivity might represent a treatable mechanistic link between psychosocial factors and future incidence of hypertension...

..This article will summarize, based on available epidemiologic and clinical studies, the key variables influencing heart rate and heart rate variability in view of the known association between heart rate and cardiovascular disease...

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..This cardiac parameter is closely related to LV mass and its severity is highly prevalent in women...

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..We analyzed the inodilator properties of levosimendan in patients with chronic heart failure and severe functional mitral regurgitation...

..Moreover, posture and physical activity have important effects on local scaling exponents, and on the range of beat scales n where alpha(n) can be approximated by a constant alpha2 coefficient...

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..The actual clinical relevance of this new parameter has to be assessed by longitudinal outcome studies...

..At high altitude, ventilation increases owing to hypoxia. We hypothesize that ventilation increase reduces body CO2 stores affecting ventilation kinetics during exercise...

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..83+0.07, 0.91+0.05, 1.06+0.06). Results suggest that heart-rate self-similarity depends on vascular sympathetic control, because it is altered by spinal-cord lesions, even when cardiac neural control is intact...

..e. the NYHA class, ventricular pump function and aerobic performance is sometimes difficult to estabilish...

..CONCLUSION: In the placebo group, but not the active treatment group, increased night-time systolic blood pressure variability on admission to the Syst-Eur trial was an independent risk factor for stroke during the trial...

..Using 24-h ambulatory blood pressure monitoring, we studied the repeatability of the morning blood pressure in older (> or =60 years) patients with isolated systolic hypertension...

..To assess, by smoothness index (SI), distribution of the antihypertensive effect of extended-release (ER) felodipine over 24 hours in elderly patients with hypertension...

..To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial...

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