Research Topics
| G ParadiesSummaryAffiliation: University of Bari Country: Italy Publications
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Detail Information
Publications
Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipinGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
Free Radic Biol Med 46:88-94. 2009..These results may prove useful in elucidating the mechanism underlying mitochondrial dysfunction associated with heart aging...- Changes in the mitochondrial permeability transition pore in aging and age-associated diseasesGiuseppe Paradies
Department of Biosciences Biotechnologies and Biopharmaceutical, University of Bari and Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, Italy
Mech Ageing Dev 134:1-9. 2013..This article examines data relevant to this issue. The important role of a principal lipidic counter-partner of the MPTP, cardiolipin, will also be discussed... - Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and diseaseGiuseppe Paradies
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
Cell Calcium 45:643-50. 2009..In this review, we provide an overview of the role of CL peroxidation and Ca(2+) in mitochondrial dysfunction and disease... - Oxidative stress, mitochondrial bioenergetics, and cardiolipin in agingGiuseppe Paradies
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari 70126, Italy
Free Radic Biol Med 48:1286-95. 2010..In this review, we discuss several aspects of mitochondrial bioenergetic alterations in aging and the role played by reactive oxygen species and cardiolipin in these alterations... - Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatoninGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
J Pineal Res 48:340-6. 2010..Our results might have implications in the necrotic and apoptotic myocytes cell death in aged myocardium, particularly in ischemia/reperfusion injury... - Melatonin, cardiolipin and mitochondrial bioenergetics in health and diseaseGiuseppe Paradies
Department of Biochemistry and Molecular Biology, CNR Institute of Biomebranes, Bioenergetics University of Bari, Italy
J Pineal Res 48:297-310. 2010..In this review, we discuss the role of melatonin in preventing mitochondrial dysfunction and disease... 
Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipinGiuseppe Paradies
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
Circ Res 94:53-9. 2004..These findings may provide an explanation for some of the factors responsible for myocardial reperfusion injury...- Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipinGiuseppe Paradies
Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy
Neurochem Int 58:447-57. 2011..In this review, we focus on the role played by oxidative stress and cardiolipin in mitochondrial bioenergetic alterations associated with brain aging... - The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondriaG Paradies
Department of Biochemistry and Molecular Biology, University of Bari, Italy
FEBS Lett 454:207-9. 1999.... - The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particlesG Paradies
Department of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy
FEBS Lett 466:323-6. 2000..These results may prove useful in probing molecular mechanism of ROS-induced peroxidative damage to mitochondria which have been proposed to contribute to aging, ischemia/reperfusion and chronic degenerative diseases... - Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusionG Paradies
Department of Biochemistry and Molecular Biology and C N R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy
Free Radic Biol Med 27:42-50. 1999..These findings may provide an explanation for some of the factors that lead to myocardial reperfusion injury... - In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c releaseG Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
Free Radic Biol Med 50:477-83. 2011..Thus, in vivo hyperoxic PC may represent a useful strategy for the treatment of cardiac I/R injury and could have potential applications in clinical practice... - Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosisG Petrosillo
Department of Biochemistry and Molecular Biology and C.N.R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Via E, Orabona 4, 70126, Bari, Italy
FEBS Lett 509:435-8. 2001..The data may prove useful in clarifying the molecular mechanism underlying the release of cytochrome c from the mitochondria to the cytosol... - Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipinG Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari Italy
FASEB J 20:269-76. 2006..Melatonin had also strong protective effect against oxidative alterations to complex I and III as well as to cardiolipin in isolated mitochondria... - Mitochondrial dysfunction associated with cardiac ischemia/reperfusion can be attenuated by oxygen tension control. Role of oxygen-free radicals and cardiolipinG Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, Via E. Orabona, 4, 70126 Bari, Italy
Biochim Biophys Acta 1710:78-86. 2005.... - Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipinG Petrosillo
Department of Biochemistry and Molecular Biology, C N R Institute of Biomembranes and Bioenergetics, University of Bari, Via E Orabona 4, 70126 Bari, Italy
Neurochem Int 53:126-31. 2008..These findings may prove useful in elucidating the mechanism underlying mitochondrial dysfunction associated with brain aging... - Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore openingGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, Section of Anaesthesia, University of Bari, Bari, Italy
Am J Physiol Heart Circ Physiol 297:H1487-93. 2009..Together, these results demonstrate that melatonin protects heart from reperfusion injury by inhibiting MPTP opening, probably via prevention of cardiolipin peroxidation... - Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protectionGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari Italy
Rejuvenation Res 11:935-43. 2008..In summary, this study documents a decline of mitochondrial bioenergetic functions in brain with aging and the beneficial effect of melatonin... - Stimulation of phosphate transport in rat-liver mitochondria by thyroid hormonesG Paradies
Department of Biochemistry and Molecular Biology, University of Bari, Italy
Biochim Biophys Acta 1019:133-6. 1990..The thyroid hormone induced change in the activity of the phosphate carrier appears to be due to a more favorable lipid microenvironment (cardiolipin content) surrounding the carrier molecule in the mitochondrial membrane... - Interaction of peroxidized cardiolipin with rat-heart mitochondrial membranes: induction of permeability transition and cytochrome c releaseGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and Consiglio Nazionale delle Ricerche, Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
FEBS Lett 580:6311-6. 2006.... - Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c releaseGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
Free Radic Biol Med 47:969-74. 2009.... - Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipinGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
Biochim Biophys Acta 1767:1260-7. 2007..It is concluded that CD diet causes mitochondrial complex I dysfunction which can be attributed to ROS-induced cardiolipin oxidation. These findings provide new insights into the alterations underlying mitochondrial dysfunction in NAFLD... - Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipinGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics, University of Bari, Via E Orabona, 4, 70126 Bari, Italy
J Biol Chem 279:53103-8. 2004..The data may help to clarify the molecular mechanism underlying the Ca(2+)-induced release of cytochrome c from rat liver mitochondria and the role played by ROS and cardiolipin in this process... - Synergistic effect of Ca2+ and peroxidized cardiolipin in the induction of permeability transition and cytochrome c release in rat heart mitochondriaGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, University of Bari, Italy
Ital J Biochem 56:307-9. 2007..This synergistic effect of Ca2+ and CLOOH on MPT induction and cytochrome c release in mitochondria might have important implications in the apoptotic process as well as in several pathophysiological situations... - Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damageGiuseppe Paradies
Department of Biochemistry and Molecular Biology and C N R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, VIA E Oraboni 4, 70126 Bari, Italy
Gene 286:135-41. 2002.... - Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondriaG Paradies
Department of Biochemistry and Molecular Biology, Universita degli Studi di Bari, Italy
Arch Biochem Biophys 284:332-7. 1991..The age-related decrement in the activity of the phosphate carrier appears to be dependent on changes in the lipid domain surrounding the carrier protein molecule in the mitochondrial membrane... - Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondriaGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
FASEB J 17:2202-8. 2003..The data may help clarify the molecular mechanism underlying the release of cytochrome c from the mitochondria to the cytosol and the role of ROS and cardiolipin in this release... - Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipinGiuseppe Petrosillo
Department of Biochemistry and Molecular Biology, CNR Unit for the Study of Mitochondria and Bioenergetics, Bari, Italy
FASEB J 17:714-6. 2003..It is proposed that the loss of complex III activity in reperfused rat hearts can be mainly ascribed to a loss of cardiolipin content, due to oxidative attack by oxygen free radicals... - Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotypeConsiglia Pacelli
Department of Medical Biochemistry, Biology and Physics, University of Bari, Bari, Italy
J Nutr 140:1072-9. 2010..The results suggest that CD-induced dysfunction in brain mitochondria may be responsible for impairment in cognition and underline that, similar to the liver, the brain also needs an adequate choline supply for its normal functioning...