G Paradies

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. doi request reprint Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
    Free Radic Biol Med 46:88-94. 2009
  2. ncbi request reprint Functional role of cardiolipin in mitochondrial bioenergetics
    Giuseppe Paradies
    Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy Electronic address
    Biochim Biophys Acta 1837:408-17. 2014
  3. doi request reprint Changes in the mitochondrial permeability transition pore in aging and age-associated diseases
    Giuseppe Paradies
    Department of Biosciences Biotechnologies and Biopharmaceutical, University of Bari and Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, Italy
    Mech Ageing Dev 134:1-9. 2013
  4. doi request reprint Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari 70126, Italy
    Free Radic Biol Med 48:1286-95. 2010
  5. doi request reprint Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
    J Pineal Res 48:340-6. 2010
  6. doi request reprint Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomebranes, Bioenergetics University of Bari, Italy
    J Pineal Res 48:297-310. 2010
  7. ncbi request reprint Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Circ Res 94:53-9. 2004
  8. doi request reprint Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Cell Calcium 45:643-50. 2009
  9. doi request reprint Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy
    Neurochem Int 58:447-57. 2011
  10. ncbi request reprint The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles
    G Paradies
    Department of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy
    FEBS Lett 466:323-6. 2000

Collaborators

Detail Information

Publications30

  1. doi request reprint Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
    Free Radic Biol Med 46:88-94. 2009
    ..These results may prove useful in elucidating the mechanism underlying mitochondrial dysfunction associated with heart aging...
  2. ncbi request reprint Functional role of cardiolipin in mitochondrial bioenergetics
    Giuseppe Paradies
    Department of Biosciences, Biotechnologies and Biopharmaceutics, University of Bari, Bari, Italy Electronic address
    Biochim Biophys Acta 1837:408-17. 2014
    ..This article is part of a Special Issue entitled: Dynamic and ultrastructure of bioenergetic membranes and their components. ..
  3. doi request reprint Changes in the mitochondrial permeability transition pore in aging and age-associated diseases
    Giuseppe Paradies
    Department of Biosciences Biotechnologies and Biopharmaceutical, University of Bari and Institute of Biomembranes and Bioenergetics, National Research Council of Italy, Bari, Italy
    Mech Ageing Dev 134:1-9. 2013
    ..This article examines data relevant to this issue. The important role of a principal lipidic counter-partner of the MPTP, cardiolipin, will also be discussed...
  4. doi request reprint Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari 70126, Italy
    Free Radic Biol Med 48:1286-95. 2010
    ..In this review, we discuss several aspects of mitochondrial bioenergetic alterations in aging and the role played by reactive oxygen species and cardiolipin in these alterations...
  5. doi request reprint Increased susceptibility to Ca(2+)-induced permeability transition and to cytochrome c release in rat heart mitochondria with aging: effect of melatonin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Italy
    J Pineal Res 48:340-6. 2010
    ..Our results might have implications in the necrotic and apoptotic myocytes cell death in aged myocardium, particularly in ischemia/reperfusion injury...
  6. doi request reprint Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomebranes, Bioenergetics University of Bari, Italy
    J Pineal Res 48:297-310. 2010
    ..In this review, we discuss the role of melatonin in preventing mitochondrial dysfunction and disease...
  7. ncbi request reprint Decrease in mitochondrial complex I activity in ischemic/reperfused rat heart: involvement of reactive oxygen species and cardiolipin
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Circ Res 94:53-9. 2004
    ..These findings may provide an explanation for some of the factors responsible for myocardial reperfusion injury...
  8. doi request reprint Role of cardiolipin peroxidation and Ca2+ in mitochondrial dysfunction and disease
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Cell Calcium 45:643-50. 2009
    ..In this review, we provide an overview of the role of CL peroxidation and Ca(2+) in mitochondrial dysfunction and disease...
  9. doi request reprint Mitochondrial dysfunction in brain aging: role of oxidative stress and cardiolipin
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology, University of Bari, Bari, Italy
    Neurochem Int 58:447-57. 2011
    ..In this review, we focus on the role played by oxidative stress and cardiolipin in mitochondrial bioenergetic alterations associated with brain aging...
  10. ncbi request reprint The effect of reactive oxygen species generated from the mitochondrial electron transport chain on the cytochrome c oxidase activity and on the cardiolipin content in bovine heart submitochondrial particles
    G Paradies
    Department of Biochemistry and Molecular Biology and CNR Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy
    FEBS Lett 466:323-6. 2000
    ..These results may prove useful in probing molecular mechanism of ROS-induced peroxidative damage to mitochondria which have been proposed to contribute to aging, ischemia/reperfusion and chronic degenerative diseases...
  11. ncbi request reprint Lipid peroxidation and alterations to oxidative metabolism in mitochondria isolated from rat heart subjected to ischemia and reperfusion
    G Paradies
    Department of Biochemistry and Molecular Biology and C N R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Italy
    Free Radic Biol Med 27:42-50. 1999
    ..These findings may provide an explanation for some of the factors that lead to myocardial reperfusion injury...
  12. ncbi request reprint The effect of aging and acetyl-L-carnitine on the pyruvate transport and oxidation in rat heart mitochondria
    G Paradies
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    FEBS Lett 454:207-9. 1999
    ....
  13. ncbi request reprint Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation. Possible role in the apoptosis
    G Petrosillo
    Department of Biochemistry and Molecular Biology and C.N.R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, Via E, Orabona 4, 70126, Bari, Italy
    FEBS Lett 509:435-8. 2001
    ..The data may prove useful in clarifying the molecular mechanism underlying the release of cytochrome c from the mitochondria to the cytosol...
  14. doi request reprint In vivo hyperoxic preconditioning protects against rat-heart ischemia/reperfusion injury by inhibiting mitochondrial permeability transition pore opening and cytochrome c release
    G Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
    Free Radic Biol Med 50:477-83. 2011
    ..Thus, in vivo hyperoxic PC may represent a useful strategy for the treatment of cardiac I/R injury and could have potential applications in clinical practice...
  15. ncbi request reprint Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin
    G Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari Italy
    FASEB J 20:269-76. 2006
    ..Melatonin had also strong protective effect against oxidative alterations to complex I and III as well as to cardiolipin in isolated mitochondria...
  16. ncbi request reprint Mitochondrial dysfunction associated with cardiac ischemia/reperfusion can be attenuated by oxygen tension control. Role of oxygen-free radicals and cardiolipin
    G Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, Via E Orabona, 4, 70126 Bari, Italy
    Biochim Biophys Acta 1710:78-86. 2005
    ....
  17. doi request reprint Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin
    G Petrosillo
    Department of Biochemistry and Molecular Biology, C N R Institute of Biomembranes and Bioenergetics, University of Bari, Via E Orabona 4, 70126 Bari, Italy
    Neurochem Int 53:126-31. 2008
    ..These findings may prove useful in elucidating the mechanism underlying mitochondrial dysfunction associated with brain aging...
  18. doi request reprint Melatonin protects against heart ischemia-reperfusion injury by inhibiting mitochondrial permeability transition pore opening
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, Section of Anaesthesia, University of Bari, Bari, Italy
    Am J Physiol Heart Circ Physiol 297:H1487-93. 2009
    ..Together, these results demonstrate that melatonin protects heart from reperfusion injury by inhibiting MPTP opening, probably via prevention of cardiolipin peroxidation...
  19. doi request reprint Melatonin prevents age-related mitochondrial dysfunction in rat brain via cardiolipin protection
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari Italy
    Rejuvenation Res 11:935-43. 2008
    ..In summary, this study documents a decline of mitochondrial bioenergetic functions in brain with aging and the beneficial effect of melatonin...
  20. ncbi request reprint Stimulation of phosphate transport in rat-liver mitochondria by thyroid hormones
    G Paradies
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Biochim Biophys Acta 1019:133-6. 1990
    ..The thyroid hormone induced change in the activity of the phosphate carrier appears to be due to a more favorable lipid microenvironment (cardiolipin content) surrounding the carrier molecule in the mitochondrial membrane...
  21. doi request reprint Melatonin inhibits cardiolipin peroxidation in mitochondria and prevents the mitochondrial permeability transition and cytochrome c release
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
    Free Radic Biol Med 47:969-74. 2009
    ....
  22. ncbi request reprint Interaction of peroxidized cardiolipin with rat-heart mitochondrial membranes: induction of permeability transition and cytochrome c release
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and Consiglio Nazionale delle Ricerche, Institute of Biomembranes and Bioenergetics, University of Bari, 70126 Bari, Italy
    FEBS Lett 580:6311-6. 2006
    ....
  23. ncbi request reprint Ca2+-induced reactive oxygen species production promotes cytochrome c release from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mechanisms: role of cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and Consiglio Nazionale delle Ricerche Institute of Biomembranes and Bioenergetics, University of Bari, Via E Orabona, 4, 70126 Bari, Italy
    J Biol Chem 279:53103-8. 2004
    ..The data may help to clarify the molecular mechanism underlying the Ca(2+)-induced release of cytochrome c from rat liver mitochondria and the role played by ROS and cardiolipin in this process...
  24. ncbi request reprint Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    Biochim Biophys Acta 1767:1260-7. 2007
    ..It is concluded that CD diet causes mitochondrial complex I dysfunction which can be attributed to ROS-induced cardiolipin oxidation. These findings provide new insights into the alterations underlying mitochondrial dysfunction in NAFLD...
  25. ncbi request reprint Reactive oxygen species affect mitochondrial electron transport complex I activity through oxidative cardiolipin damage
    Giuseppe Paradies
    Department of Biochemistry and Molecular Biology and C N R Unit for the Study of Mitochondria and Bioenergetics, University of Bari, VIA E Oraboni 4, 70126 Bari, Italy
    Gene 286:135-41. 2002
    ....
  26. ncbi request reprint Synergistic effect of Ca2+ and peroxidized cardiolipin in the induction of permeability transition and cytochrome c release in rat heart mitochondria
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, University of Bari, Italy
    Ital J Biochem 56:307-9. 2007
    ..This synergistic effect of Ca2+ and CLOOH on MPT induction and cytochrome c release in mitochondria might have important implications in the apoptotic process as well as in several pathophysiological situations...
  27. ncbi request reprint Effect of aging on the activity of the phosphate carrier and on the lipid composition in rat liver mitochondria
    G Paradies
    Department of Biochemistry and Molecular Biology, Universita degli Studi di Bari, Italy
    Arch Biochem Biophys 284:332-7. 1991
    ..The age-related decrement in the activity of the phosphate carrier appears to be dependent on changes in the lipid domain surrounding the carrier protein molecule in the mitochondrial membrane...
  28. ncbi request reprint Role of reactive oxygen species and cardiolipin in the release of cytochrome c from mitochondria
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology and CNR Institute of Biomembranes and Bioenergetics, University of Bari, Bari, Italy
    FASEB J 17:2202-8. 2003
    ..The data may help clarify the molecular mechanism underlying the release of cytochrome c from the mitochondria to the cytosol and the role of ROS and cardiolipin in this release...
  29. ncbi request reprint Decreased complex III activity in mitochondria isolated from rat heart subjected to ischemia and reperfusion: role of reactive oxygen species and cardiolipin
    Giuseppe Petrosillo
    Department of Biochemistry and Molecular Biology, CNR Unit for the Study of Mitochondria and Bioenergetics, Bari, Italy
    FASEB J 17:714-6. 2003
    ..It is proposed that the loss of complex III activity in reperfused rat hearts can be mainly ascribed to a loss of cardiolipin content, due to oxidative attack by oxygen free radicals...
  30. doi request reprint Dietary choline deprivation impairs rat brain mitochondrial function and behavioral phenotype
    Consiglia Pacelli
    Department of Medical Biochemistry, Biology and Physics, University of Bari, Bari, Italy
    J Nutr 140:1072-9. 2010
    ..The results suggest that CD-induced dysfunction in brain mitochondria may be responsible for impairment in cognition and underline that, similar to the liver, the brain also needs an adequate choline supply for its normal functioning...