M Papotti

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preoperative octreotide scintigraphy
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Virchows Arch 439:787-97. 2001
  2. ncbi Large cell neuroendocrine carcinoma of the gallbladder: report of two cases
    M Papotti
    Department of Pathology, University of Turin, Italy
    Am J Surg Pathol 24:1424-8. 2000
  3. ncbi RET/PTC activation in hyalinizing trabecular tumors of the thyroid
    M Papotti
    Dipartimenti di Anatomia Patologica, Universita di Torino, Italy
    Am J Surg Pathol 24:1615-21. 2000
  4. ncbi Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Mod Pathol 14:768-76. 2001
  5. ncbi Biologic activities of growth hormone secretagogues in humans
    E Ghigo
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:87-93. 2001
  6. ncbi Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1738-45. 2001
  7. ncbi Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Endocrinol Invest 29:781-90. 2006
  8. ncbi Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
    E Arvat
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1169-74. 2001
  9. ncbi Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: focus on reproductive system
    E Arvat
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:35-43. 2001
  10. ncbi Ghrelin-producing endocrine tumors of the stomach and intestine
    M Papotti
    Department of Biomedical Sciences, University of Turin, Via Santena 7, I 10126 Turin, Italy
    J Clin Endocrinol Metab 86:5052-9. 2001

Collaborators

Detail Information

Publications45

  1. ncbi Expression of somatostatin receptor types 2, 3 and 5 in biopsies and surgical specimens of human lung tumours. Correlation with preoperative octreotide scintigraphy
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Virchows Arch 439:787-97. 2001
    ..IHC can therefore be usefully coupled to radionuclear investigations to better characterize the sst cellular location and subtype in lung tumors...
  2. ncbi Large cell neuroendocrine carcinoma of the gallbladder: report of two cases
    M Papotti
    Department of Pathology, University of Turin, Italy
    Am J Surg Pathol 24:1424-8. 2000
    ..More importantly, however, the recognition of this rare tumor type carries important clinical implications in regard to the use of chemotherapeutic agents and supplemental treatments (for example, somatostatin analogs)...
  3. ncbi RET/PTC activation in hyalinizing trabecular tumors of the thyroid
    M Papotti
    Dipartimenti di Anatomia Patologica, Universita di Torino, Italy
    Am J Surg Pathol 24:1615-21. 2000
    ..6%) of HTTs and papillary carcinomas exhibit the same RET proto-oncogene alterations. Thus, HTT may represent the "hyalinizing trabecular" variant of papillary carcinoma rather than a separate entity...
  4. ncbi Expression of apocrine differentiation markers in neuroendocrine breast carcinomas of aged women
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Mod Pathol 14:768-76. 2001
    ..In addition, the possibility for using Chs or GCDFP-15 serum values in the follow-up of these patients, as demonstrated in two cases of the present series, can justify the immunophenotyping of the tumors...
  5. ncbi Biologic activities of growth hormone secretagogues in humans
    E Ghigo
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:87-93. 2001
    ..The discovery of ghrelin, a 28 amino acid peptide synthesized in the stomach but also in other tissues, has opened new fascinating perspectives of research in this field...
  6. ncbi Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1738-45. 2001
    ..In conclusion, this study provides the first demonstration of specific GHS binding sites, other than GHS-R1, in breast cancer. These receptors probably mediate growth inhibitory effects on breast carcinoma cells in vitro...
  7. ncbi Ghrelin and cortistatin in lung cancer: expression of peptides and related receptors in human primary tumors and in vitro effect on the H345 small cell carcinoma cell line
    P Cassoni
    Department of Biomedical Sciences and Human Oncology, University of Turin, Turin, Italy
    J Endocrinol Invest 29:781-90. 2006
    ....
  8. ncbi Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone
    E Arvat
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:1169-74. 2001
    ..Thus, ghrelin is a new hormone playing a major role in the control of somatotroph secretion in humans, and its effects are imitated by nonnatural GHS...
  9. ncbi Growth hormone-releasing hormone and growth hormone secretagogue-receptor ligands: focus on reproductive system
    E Arvat
    Department of Internal Medicine, University of Turin, Italy
    Endocrine 14:35-43. 2001
    ..Because GHRH and GHS receptors share the same localization in some peripheral tissues, they may have some interactions even at this level...
  10. ncbi Ghrelin-producing endocrine tumors of the stomach and intestine
    M Papotti
    Department of Biomedical Sciences, University of Turin, Via Santena 7, I 10126 Turin, Italy
    J Clin Endocrinol Metab 86:5052-9. 2001
    ..These hyperplastic/neoplastic conditions could represent the clinical model to clarify the existence and impact of ghrelin hypersecretion on endocrine and nonendocrine functions...
  11. ncbi Clinical significance of neuroendocrine carcinoma of the breast
    A Sapino
    Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
    Ann Oncol 12:S115-7. 2001
    ..In the present work, the clinical significance of pure' NE differentiation in breast carcinoma and of its 'variants' will be analyzed...
  12. ncbi Characterization of thyroid 'follicular neoplasms' in fine-needle aspiration cytological specimens using a panel of immunohistochemical markers: a proposal for clinical application
    E Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, Regione Gonzole 10, 10043 Orbassano TO, Italy
    Endocr Relat Cancer 12:305-17. 2005
    ..The combination of three or more markers did not substantially improve the diagnostic accuracy of the test...
  13. doi Somatostatin, cortistatin and their receptors in tumours
    M Volante
    Department of Clinical and Biological Sciences, University of Turin at San Luigi Hospital, Orbassano, University of Turin, Torino, Italy
    Mol Cell Endocrinol 286:219-29. 2008
    ..Thus, in comparison to SS analogs, CST synthetic analogs may represent additional diagnostic/therapeutic tools in those tumours expressing the receptors for SS, for ghrelin or for both peptides...
  14. ncbi Ghrelin, a natural GH secretagogue produced by the stomach, induces hyperglycemia and reduces insulin secretion in humans
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 86:5083-6. 2001
    ....
  15. ncbi Oxyphilic and non-oxyphilic thyroid carcinoma cell lines differ in expressing apoptosis-related genes
    E Allia
    Department of Biomedical Sciences and Oncology, University of Torino, Torino, Italy
    J Endocrinol Invest 26:660-7. 2003
    ....
  16. ncbi Galectin-3: presurgical marker of thyroid follicular epithelial cell-derived carcinomas
    E Saggiorato
    Section of Endocrinology, Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Endocrinol Invest 27:311-7. 2004
    ..The routine correct use of galectin-3, by increasing the diagnostic accuracy of conventional cytology, improves the management of thyroid nodules and can lead to a sensitive reduction of useless thyroid surgeries...
  17. ncbi Extensive DNA fragmentation in oxyphilic cell lesions of the thyroid
    M Volante
    Departments of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    J Histochem Cytochem 49:1003-11. 2001
    ..These findings are consistent with an extensive DNA fragmentation peculiar to oxyphilic cells, which is not directly related to apoptosis and whose origin and biological significance are presently unknown...
  18. ncbi Presence of cortistatin in the human pancreas
    M Papotti
    Department of Biomedical Sciences, Pharmacology and Forensic Medicine, University of Turin, Torino, Italy
    J Endocrinol Invest 26:RC15-8. 2003
    ..Thus, our findings show the presence of CST in the human endocrine pancreas. Local autocrine or paracrine circuits, only in part overlapped with those of SRIF, may be active to modulate insulin and/or glucagon levels...
  19. ncbi Natural and synthetic growth hormone secretagogues: do they have therapeutic potential?
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    Treat Endocrinol 2:153-63. 2003
    ....
  20. ncbi Cortistatin-14 inhibits cell proliferation of human thyroid carcinoma cell lines of both follicular and parafollicular origin
    P Cassoni
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    J Endocrinol Invest 25:362-8. 2002
    ..Taken together, these data firstly demonstrate that EP-80874 has a mixed SRIH/CST antagonist activity and suggest that the oncostatic effect of CST-14 on thyroid cancer cells could be mediated by both sst and/or GHS-R...
  21. ncbi Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, 10126 Turin, Italy
    Virchows Arch 440:461-75. 2002
    ..It is concluded that SSTRs 1-5 are heterogeneously expressed in GEP endocrine tumors and that IHC is a reliable tool to detect SSTR types 2, 3 and 5 in surgical and biopsy specimens...
  22. ncbi Immunohistochemical detection of somatostatin receptor types 1-5 in medullary carcinoma of the thyroid
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Italy
    Clin Endocrinol (Oxf) 54:641-9. 2001
    ....
  23. doi New strategies for targeting the therapy of NSCLC: the role of ERCC1 and TS
    P Ceppi
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    Adv Med Sci 55:22-5. 2010
    ..Here is presented a brief overview of the literature regarding these two genes that are currently under prospective investigation as predictive markers of treatment efficacy in NSCLC...
  24. ncbi Classic and recent special stains used in differential diagnosis of endocrine tumors
    G Bussolati
    Department of Biomedical Sciences and Oncology, University of Turin, Via Santena 7, I 10126 Turin, Italy
    Endocr Pathol 12:379-87. 2001
    ....
  25. ncbi Ectopic secretion of LH by an endocrine pancreatic tumor
    E Brignardello
    Division of Endocrine Oncology, COES, University of Turin, Turin, Italy
    J Endocrinol Invest 27:361-5. 2004
    ..Testosterone was slightly below normal, but the patient reported an increase of libido. This is an unusual case of ectopic secretion of LH from an endocrine tumor of the pancreas...
  26. ncbi Argyrophilic neuroendocrine carcinoma of the male breast
    M Papotti
    Department of Human Oncology, University of Turin, Torino, Italy
    Ultrastruct Pathol 17:115-21. 1993
    ..Argyrophilia, expression of chromogranins at both protein and gene level, and the presence of dense granules of the neurosecretory type by electron microscopy were demonstrated...
  27. ncbi Ghrelin: more than a natural GH secretagogue and/or an orexigenic factor
    E Ghigo
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Italy
    Clin Endocrinol (Oxf) 62:1-17. 2005
    ....
  28. ncbi 34betaE12 cytokeratin immunodetection in the differential diagnosis of neuroendocrine carcinomas of the breast
    M Papotti
    Department of Biomedical Sciences and Oncology, University of Turin, Torino, Italy
    Appl Immunohistochem Mol Morphol 9:229-33. 2001
    ..HMW CK can be added to the list of markers useful in the differential diagnosis of NE from non-NE tumors...
  29. ncbi ERCC1 and RRM1 gene expressions but not EGFR are predictive of shorter survival in advanced non-small-cell lung cancer treated with cisplatin and gemcitabine
    P Ceppi
    Thoracic Oncology Unit, Orbassano, Torino, Italy
    Ann Oncol 17:1818-25. 2006
    ....
  30. ncbi Acromegaly due to ectopic secretion of GHRH by bronchial carcinoid in a patient with empty sella
    G Osella
    Department of Biological and Clinical Sciences, University of Turin, Turin, Italy
    J Endocrinol Invest 26:163-9. 2003
    ..Pituitary radiology showed an empty sella demonstrating for the first time its association with ectopic GHRH syndrome...
  31. doi Pathological and molecular features of adrenocortical carcinoma: an update
    M Volante
    Department of Clinical and Biological Sciences, Division of Pathology, University of Turin at San Luigi Hospital, Orbassano, Torino, Italy
    J Clin Pathol 61:787-93. 2008
    ..However, these markers are not sufficiently sensitive and specific to replace conventional morphological criteria...
  32. ncbi Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death
    N Filigheddu
    Department of Genetics, Biology and Biochemistry, University of Torino, Italy
    Endocrine 14:113-9. 2001
    ..These findings suggest that the inhibitory activity of hexarelin on cardiomyocytes and endothelial cell death could explain, at least partially, its cardioprotective effect against ischemia recorded in rats in vivo...
  33. ncbi Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland
    G Muccioli
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Italy
    J Endocrinol Invest 24:RC7-9. 2001
    ..These receptors are the specific binding sites for GHS and their antagonists, as well as for SRIH analogs (vapreotide and cortistatin- 14), but not for native SRIH...
  34. ncbi Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland
    R Deghenghi
    Europeptides, Argenteuil, France
    J Endocrinol Invest 24:RC1-3. 2001
    ..Our data demonstrate for the first time that cortistatin, a natural peptide related to SRIH, binds to GHS-R and suggest that this factor may play a role in modulating the activity of these receptors...
  35. pmc Accumulation of p27(kip1) is associated with cyclin D3 overexpression in the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma
    G Troncone
    Dipartimento di Scienze Biomorfologiche e Funzionali, Universita di Napoli Federico II, Napoli, Italy
    J Clin Pathol 60:377-81. 2007
    ..However, the oxyphilic (Hurthle cell) variant of follicular thyroid carcinoma expresses more p27 than benign oxyphilic lesions do...
  36. ncbi Growth hormone secretagogue binding sites in peripheral human tissues
    M Papotti
    Department of Biomedical Sciences, University of Turin, Italy
    J Clin Endocrinol Metab 85:3803-7. 2000
    ..This study provides the first detailed analysis of the tissue localization of GHS receptors and suggests that a still unknown receptor subtype, specific for peptidyl GHS, may exist in the heart and in other tissues...
  37. ncbi 34BetaE12 expression along the whole spectrum of neuroendocrine proliferations of the lung, from neuroendocrine cell hyperplasia to small cell carcinoma
    N Sturm
    Laboratoire de Pathologie Cellulaire, INSERM 9924, Centre Hospitalo Universitaire Albert Michallon, Grenoble, France
    Histopathology 42:156-66. 2003
    ..We have now examined the role of Ck34betaE12 in discriminating between neuroendocrine and non-neuroendocrine proliferations...
  38. ncbi Adrenal pseudocyst mimicking cancer: a case report
    S Bovio
    Division of Internal Medicine I, Department of Biological and Clinical Science, A S O San Luigi, Orbassano, Italy
    J Endocrinol Invest 30:256-8. 2007
    ..We report herein the case of an adrenal hemorrhagic pseudocyst that simulated adrenocortical cancer and argue on the clinical clues for a differential diagnosis with other adrenal tumors...
  39. ncbi [Immunohistochemistry in thyroid needle aspiration samples]
    M Papotti
    Dipartimento di Scienze Cliniche e Biologiche, Ospedale San Luigi di Orbassano
    Pathologica 97:201-2. 2005
  40. pmc Specific haplotypes of the RET proto-oncogene are over-represented in patients with sporadic papillary thyroid carcinoma
    F Lesueur
    International Agency for Research on Cancer, Lyon, France
    J Med Genet 39:260-5. 2002
    ..Somatic rearrangements of the RET proto-oncogene are present in up to 66% of sporadic tumours, while they are rarely found in familial cases...
  41. pmc Detection and molecular characterisation of thyroid cancer precursor lesions in a specific subset of Hashimoto's thyroiditis
    A Gasbarri
    1Department of Pathology, St Andrea Hospital, University La Sapienza, Via di Grottarossa 1035, 00189 Rome, Italy
    Br J Cancer 91:1096-104. 2004
    ....
  42. ncbi Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans
    F Broglio
    Division of Endocrinology, Department of Internal Medicine, Erasmus University of Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3062-5. 2004
    ..As GHS-R1a is not bound by unacylated ghrelin, these findings suggest that GHS receptor subtypes mediate the metabolic actions of both acylated and unacylated ghrelin...
  43. ncbi Is high-grade adenomatous hyperplasia an early bronchioloalveolar adenocarcinoma?
    R Ullmann
    Institute of Pathology, Laboratory for Molecular Genetics, University of Graz, Graz, Austria
    J Pathol 201:371-6. 2003
    ..In addition, in view of the monoclonal origin of multiple foci within the same patient, AAH may not be a precursor of AC in some cases, but rather may represent intraepithelial spread...
  44. ncbi Thyroid transcription factor 1 and cytokeratins 1, 5, 10, 14 (34betaE12) expression in basaloid and large-cell neuroendocrine carcinomas of the lung
    N Sturm
    Laboratoire de Pathologie Cellulaire, Service de Chirurgie Thoracique, and Lung Cancer Research Group, INSERM 9924, Centre Hospitalo-Universitaire Albert Michallon, Grenoble, France
    Hum Pathol 32:918-25. 2001
    ....
  45. ncbi Peptide receptors in neuroendocrine tumors of the lung as potential tools for radionuclide diagnosis and therapy
    G Pelosi
    Division of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy
    Q J Nucl Med Mol Imaging 50:272-87. 2006
    ....