Francesco Panza

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. pmc Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
    Int J Alzheimers Dis 2011:721457. 2011
  2. doi request reprint Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Int J Geriatr Psychiatry 27:1218-38. 2012
  3. doi request reprint Current epidemiological approaches to the metabolic-cognitive syndrome
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Alzheimers Dis 30:S31-75. 2012
  4. doi request reprint Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
    Grazia D'Onofrio
    IRCCS Casa Sollievo della Sofferenza, Geriatric Unit and Gerontology Geriatric Research Laboratory, San Giovanni Rotondo, Foggia, Italy
    Expert Opin Drug Discov 7:19-37. 2012
  5. doi request reprint Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
    Immunotherapy 4:213-38. 2012
  6. ncbi request reprint Lipoproteins, vascular-related genetic factors, and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Rejuvenation Res 10:441-58. 2007
  7. doi request reprint Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Immunotherapy 2:767-82. 2010
  8. ncbi request reprint Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Am J Med Genet B Neuropsychiatr Genet 126:69-73. 2004
  9. ncbi request reprint S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Neurobiol Aging 29:478-80. 2008
  10. ncbi request reprint Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy
    Curr Med Chem 18:5430-47. 2011

Collaborators

Detail Information

Publications76

  1. pmc Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late-Onset Alzheimer's Disease: Focus on APOE Gene
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, 71013 Foggia, Italy
    Int J Alzheimers Dis 2011:721457. 2011
    ....
  2. doi request reprint Alcohol consumption in mild cognitive impairment and dementia: harmful or neuroprotective?
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Int J Geriatr Psychiatry 27:1218-38. 2012
    ..However, contrasting findings also exist...
  3. doi request reprint Current epidemiological approaches to the metabolic-cognitive syndrome
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Alzheimers Dis 30:S31-75. 2012
    ....
  4. doi request reprint Advances in the identification of γ-secretase inhibitors for the treatment of Alzheimer's disease
    Grazia D'Onofrio
    IRCCS Casa Sollievo della Sofferenza, Geriatric Unit and Gerontology Geriatric Research Laboratory, San Giovanni Rotondo, Foggia, Italy
    Expert Opin Drug Discov 7:19-37. 2012
    ..APP is believed to be involved in the pathophysiological cascade of AD...
  5. doi request reprint Immunotherapy for Alzheimer's disease: from anti-β-amyloid to tau-based immunization strategies
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Foggia, Italy
    Immunotherapy 4:213-38. 2012
    ....
  6. ncbi request reprint Lipoproteins, vascular-related genetic factors, and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Lipoprotein Metabolism and Atherosclerosis, University of Bari, Policlinico, Piazza Giulio Cesare 11, Bari, Italy
    Rejuvenation Res 10:441-58. 2007
    ..While further studies are needed to confirm the possible role of apolipoprotein E concentration as putative longevity factor this paper provides an overview of many of the investigated vascular factors with respect to longevity...
  7. doi request reprint Bapineuzumab: anti-β-amyloid monoclonal antibodies for the treatment of Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Immunotherapy 2:767-82. 2010
    ..The results of four ongoing large Phase III trials on bapineuzumab will provide answers regarding whether passive anti-Aβ immunization is able to alter the course of this devastating disease...
  8. ncbi request reprint Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Am J Med Genet B Neuropsychiatr Genet 126:69-73. 2004
    ..We suggest that these regional variations in LRP1 genotype and allele frequencies in AD could be related to the different patterns of association between this polymorphism and the disease in various European studies...
  9. ncbi request reprint S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in predementia syndromes and Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Neurobiol Aging 29:478-80. 2008
    ....
  10. ncbi request reprint Interacting with γ-secretase for treating Alzheimer's disease: from inhibition to modulation
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy
    Curr Med Chem 18:5430-47. 2011
    ..Further understanding of the reasons of the failures of these γ-secretase-based drugs in AD may be important for the future research on effective treatments for this devastating disease...
  11. doi request reprint Impact of depressive symptoms on the rate of progression to dementia in patients affected by mild cognitive impairment. The Italian Longitudinal Study on Aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Int J Geriatr Psychiatry 23:726-34. 2008
    ..5-year follow-up; and the interaction between depressive symptoms and vascular risk factors for conversion to dementia...
  12. ncbi request reprint Beyond the neurotransmitter-focused approach in treating Alzheimer's disease: drugs targeting beta-amyloid and tau protein
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, 70124, Bari, Italy
    Aging Clin Exp Res 21:386-406. 2009
    ..With all these approaches on their way, the hope for disease-modifying therapy in this devastating disease may become a reality in the next 5 years...
  13. doi request reprint Depressive symptoms, vascular risk factors and mild cognitive impairment. The Italian longitudinal study on aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Dement Geriatr Cogn Disord 25:336-46. 2008
    ..We evaluated the impact of depressive symptoms on the rate of incident mild cognitive impairment (MCI) after a 3.5-year follow-up, and we assessed the interaction between depressive symptoms and vascular risk factors for incident MCI...
  14. ncbi request reprint Disease-modifying approach to the treatment of Alzheimer's disease: from alpha-secretase activators to gamma-secretase inhibitors and modulators
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Drugs Aging 26:537-55. 2009
    ..All these therapeutic approaches increase the hope of slowing the rate of decline in patients with AD and modifying the natural history of this devastating disease within the next 5 years...
  15. ncbi request reprint Vascular risk factors, alcohol intake, and cognitive decline
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Bari, Italy
    J Nutr Health Aging 12:376-81. 2008
    ..At present, vascular risk factor management, lifestyle changes, and drugs could be employed together to delay the onset of dementia syndromes...
  16. doi request reprint Possible role of S-adenosylmethionine, S-adenosylhomocysteine, and polyunsaturated fatty acids in predementia syndromes and Alzheimer's disease
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 16:467-70. 2009
    ....
  17. doi request reprint Polyunsaturated fatty acid and S-adenosylmethionine supplementation in predementia syndromes and Alzheimer's disease: a review
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    ScientificWorldJournal 9:373-89. 2009
    ..g., 3-5 years of follow-up)...
  18. doi request reprint Temporal relationship between depressive symptoms and cognitive impairment: the Italian Longitudinal Study on Aging
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 17:899-911. 2009
    ..Global cognitive function and episodic memory at baseline were not associated with the course of depressive symptoms during the follow-up...
  19. ncbi request reprint Peripheral antioxidant markers in mild cognitive impairment and its progression to dementia
    Francesco Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 21:1179-83. 2010
    ....
  20. ncbi request reprint Heterogeneity of mild cognitive impairment and other predementia syndromes in progression to dementia
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Neurobiol Aging 28:1631-2; discussion 1633-4. 2007
    ....
  21. ncbi request reprint Monoclonal antibodies against β-amyloid (Aβ) for the treatment of Alzheimer's disease: the Aβ target at a crossroads
    Francesco Panza
    Expert Opin Biol Ther 11:679-86. 2011
    ....
  22. ncbi request reprint [Genetics of late-onset Alzheimer's disease: vascular risk and beta-amyloid metabolism]
    Francesco Panza
    Cattedra di Geriatria, Centro Universitario per lo Studio dell Invecchiamento Cerebrale, Unità di Ricerca per la Memoria, Universita, Bari
    Recenti Prog Med 93:489-97. 2002
    ....
  23. ncbi request reprint Apolipoprotein E (APOE) polymorphism influences serum APOE levels in Alzheimer's disease patients and centenarians
    Francesco Panza
    Department of Geriatrics, Center for Agin Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, Bari, Italy
    Neuroreport 14:605-8. 2003
    ..In these highly selected populations, APOE genotype distribution strongly influences serum APOE concentration, not suggesting, at present, a possible role as a biochemical marker for AD, but only as a putative longevity factor...
  24. ncbi request reprint Angiotensin I converting enzyme (ACE) gene polymorphism in centenarians: different allele frequencies between the North and South of Europe
    Francesco Panza
    Department of Geriatrics, Centre for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, Bari 70124, Italy
    Exp Gerontol 38:1015-20. 2003
    ..Such genetic differences in conjunction with differing environmental factors may explain in part previous results suggesting a role of this polymorphism in longevity...
  25. ncbi request reprint Vascular risk and genetics of sporadic late-onset Alzheimer's disease
    F Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Neural Transm 111:69-89. 2004
    ..This review will focus on the current knowledge on genetic and nongenetic vascular factors likely to be involved in LOAD, with special emphasis placed on the APOE and ACE1 genes...
  26. ncbi request reprint Vascular genetic factors and human longevity
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Mech Ageing Dev 125:169-78. 2004
    ..While further studies are needed to confirm the possible role of APOE concentration as putative longevity factor, this paper provides an overview of genetic vascular factors potentially involved in human longevity...
  27. ncbi request reprint Metabolic syndrome, mild cognitive impairment, and dementia
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Curr Alzheimer Res 8:492-509. 2011
    ..At present, vascular risk factor management could be decisive in delaying the onset of dementia syndromes or in preventing the progression of predementia syndromes...
  28. ncbi request reprint Different models of frailty in predementia and dementia syndromes
    F Panza
    Geriatric Unit and Gerontology Geriatric Research Laboratory, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo, Foggia, Italy
    J Nutr Health Aging 15:711-9. 2011
    ....
  29. ncbi request reprint Cognitive frailty: Predementia syndrome and vascular risk factors
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 27:933-40. 2006
    ..This review will focus on the possible role of vascular risk factors in modulating the risk of age-related cognitive decline, and the progression of predementia syndrome such as MCI to dementia...
  30. ncbi request reprint Candidate genes for late-onset Alzheimer's disease: focus on chromosome 12
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Mech Ageing Dev 127:36-47. 2006
    ..In this article, we focused on the current knowledge of the genetics of familial late-onset and sporadic AD linked to the chromosome 12, and the future search for other candidate genes...
  31. doi request reprint REVIEW: γ-Secretase inhibitors for the treatment of Alzheimer's disease: The current state
    Francesco Panza
    IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    CNS Neurosci Ther 16:272-84. 2010
    ..This article briefly reviews the profile of γ-secretase inhibitors, compounds that inhibit γ-secretase, the pivotal enzyme that generates Aβ, and that have reached the clinic...
  32. ncbi request reprint Lipid metabolism in cognitive decline and dementia
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    Brain Res Rev 51:275-92. 2006
    ..Thus, more studies with long-term follow-up and serial assessments of TC are needed to further clarify the causal relationship between cholesterol and dementia...
  33. ncbi request reprint Current epidemiology of mild cognitive impairment and other predementia syndromes
    Francesco Panza
    Dept of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 13:633-44. 2005
    ..To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia...
  34. doi request reprint Late-life depression, mild cognitive impairment, and dementia: possible continuum?
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Am J Geriatr Psychiatry 18:98-116. 2010
    ..In this scenario, at least in certain subsets of elderly patients, late-life depression, MCI, and dementia could represent a possible clinical continuum...
  35. pmc Possible role of alpha-lipoic acid in the treatment of peripheral nerve injuries
    Maurizio Ranieri
    Department of Physical Medicine and Rehabilitation, University of Foggia, Foggia, Italy
    J Brachial Plex Peripher Nerve Inj 5:15. 2010
    ....
  36. doi request reprint Interleukin 6-174 G/C promoter and variable number of tandem repeats (VNTR) gene polymorphisms in sporadic Alzheimer's disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Prog Neuropsychopharmacol Biol Psychiatry 34:177-82. 2010
    ..Furthermore, the C allele of the IL-6 variable number of tandem repeats (VNTR) polymorphism was associated with a delayed onset and a decreased risk of AD...
  37. ncbi request reprint Polymorphism C in the serotonin transporter gene in depression-free elderly patients with vascular dementia
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy dseripa operapadrepio it
    Dement Geriatr Cogn Disord 29:424-31. 2010
    ..Less clear are data regarding their association with severe dementia, in particular with vascular dementia (VaD)...
  38. doi request reprint Short arm of chromosome 11 and sporadic Alzheimer's disease: catalase and cathepsin D gene polymorphisms
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti, viale L Pinto, 71100 Foggia, Italy
    Neurosci Lett 432:237-42. 2008
    ..Our data, at present, do not support a role of two gene polymorphisms of the short arm of the chromosome 11, the CAT rs1001179 and CTSD rs17571, as a possible susceptibility factors for sporadic AD...
  39. doi request reprint The APOE polymorphism in Alzheimer's disease patients with neuropsychiatric symptoms and syndromes
    Grazia D'Onofrio
    Geriatrics Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, FG, Italy
    Int J Geriatr Psychiatry 26:1062-70. 2011
    ..Neuropsychiatric symptoms (NPS) are a common feature of Alzheimer's disease (AD), resulting in particular AD endophenotypes. The common AD genetic risk factor apolipoprotein E (APOE) has been suggested underlying these AD endophenotypes...
  40. doi request reprint Alpha-2-macroglobulin gene, oxidized low-density lipoprotein receptor-1 locus, and sporadic Alzheimer's disease
    Anna Maria Colacicco
    Department of Geriatrics, Center for Aging Brain, University of Bari, Italy
    Neurobiol Aging 30:1518-20. 2009
    ....
  41. pmc Frailty syndrome and all-cause mortality in demented patients: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari Policlinico, Italy
    Age (Dordr) 34:507-17. 2012
    ..89, 95% CI 1.10-3.44), but not of disability. Frailty syndrome was a short-term predictor of disability in nondemented older subjects and short- and long-term predictor of all-cause mortality in nondemented and demented patients...
  42. ncbi request reprint The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in European populations
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Foggia, Italy
    J Gerontol A Biol Sci Med Sci 60:991-6. 2005
    ..The regional differences in CTSD allele frequencies could be related to the different patterns of association between this polymorphism and AD in various European studies...
  43. doi request reprint Metabolic-cognitive syndrome: a cross-talk between metabolic syndrome and Alzheimer's disease
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Ageing Res Rev 9:399-417. 2010
    ....
  44. ncbi request reprint The serotonin transporter gene locus in late-life major depressive disorder
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, Institute of Care and Scientific Research Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Am J Geriatr Psychiatry 21:67-77. 2013
    ..The aim of this study was to explore the possible involvement of the SLC6A4 locus in patients with late-life MDD by means of a haplotype-tagged approach...
  45. doi request reprint Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, Viale Cappuccini 1, 71013 San Giovanni Rotondo FG, Italy
    Neurosci Lett 438:335-9. 2008
    ..No further differences among the three groups of subjects were found, also when they were compared with the community-dwelling sample. These findings suggest that SLC6A4 gene variation may have only a minor role, if any, in AD or QD...
  46. ncbi request reprint Dietary fatty acids intakes and rate of mild cognitive impairment. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Exp Gerontol 41:619-27. 2006
    ..34-1.13, p=0.12). In our population, dietary fatty acids intakes were not associated with incident MCI in older age, only high PUFA intake evidenced a borderline nonsignificant trend for a protective effect against the development of MCI...
  47. doi request reprint Metabolic syndrome, mild cognitive impairment, and progression to dementia. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 32:1932-41. 2011
    ..In our population, among MCI patients the presence of MetS independently predicted an increased risk of progression to dementia over 3.5 years of follow-up...
  48. ncbi request reprint Polymorphisms in the oxidized low-density lipoprotein receptor-1 gene and risk of Alzheimer's disease
    Alessia D'Introno
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    J Gerontol A Biol Sci Med Sci 60:280-4. 2005
    ..In our population, the +1073 C/T OLR1 polymorphism exhibited a significant association with Alzheimer's disease, further supporting the role of OLR1 as a candidate risk gene for sporadic Alzheimer's disease...
  49. pmc Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124, Bari, Italy
    Age (Dordr) 35:441-53. 2013
    ..However, within-class differences linked to different chemical structures and/or drug potencies may exist, with a possible effect of the enalapril and lisinopril sub-groups in reducing the risk of incident MCI...
  50. ncbi request reprint Cerebrovascular disease in the elderly: lipoprotein metabolism and cognitive decline
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    Aging Clin Exp Res 18:144-8. 2006
    ..In conclusion, in our population, among MCI patients who progressed to dementia, 60% progressed to AD and 33% to VaD. Vascular risk factors and CVD may influence the development of MCI and the rate of progression to dementia...
  51. pmc Klotho locus, metabolic traits, and serum hemoglobin in hospitalized older patients: a genetic association analysis
    Giulia Paroni
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo, Foggia, Italy
    Age (Dordr) 34:949-68. 2012
    ....
  52. ncbi request reprint Selective attention skills in differentiating between Alzheimer's disease and normal aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, University of Bari Policlinico, Italy
    J Geriatr Psychiatry Neurol 15:99-109. 2002
    ..62 and 0.91, respectively. The SCT is a valid and reliable test to assess selective attention in elderly subjects, in whom dementing illness must be diagnosed and clinically distinct from age-related cognitive decline...
  53. doi request reprint Apolipoprotein E genotypes and neuropsychiatric symptoms and syndromes in late-onset Alzheimer's disease
    Francesco Panza
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Ageing Res Rev 11:87-103. 2012
    ..In fact, identifying predisposing genetic risk factors may allow us to understand the pathophysiological features of neuropsychiatric syndromes or symptoms in AD, so optimizing possible therapeutic options...
  54. ncbi request reprint Dietary intake of unsaturated fatty acids and age-related cognitive decline: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza G Cesare 11, 70124 Bari, Italy
    Neurobiol Aging 27:1694-704. 2006
    ..5-year follow-up. In this prospective population-based study on older nondemented subjects with a typical Mediterranean diet, high MUFA and PUFA intakes appeared to be protective against ARCD...
  55. ncbi request reprint Incident occurrence of depressive symptoms among patients with mild cognitive impairment - the Italian longitudinal study on aging
    Vincenzo Solfrizzi
    Memory Unit, Center for Aging Brain, Department of Geriatrics, University of Bari, Bari, Italy
    Dement Geriatr Cogn Disord 24:55-64. 2007
    ..We estimated the prevalence and incidence rates of depressive symptoms and the role of vascular risk factors and sociodemographic variables on the occurrence of depressive symptoms in mild cognitive impairment (MCI)...
  56. doi request reprint Alcohol drinking, cognitive functions in older age, predementia, and dementia syndromes
    Francesco Panza
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 17:7-31. 2009
    ..At present, there is no indication that light to moderate alcohol drinking would be harmful to cognition and dementia, and it is not possible to define a specific beneficial level of alcohol intake...
  57. doi request reprint Dietary fatty acids in dementia and predementia syndromes: epidemiological evidence and possible underlying mechanisms
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Ageing Res Rev 9:184-99. 2010
    ....
  58. doi request reprint Metabolic syndrome and cognitive impairment: current epidemiology and possible underlying mechanisms
    Francesco Panza
    Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    J Alzheimers Dis 21:691-724. 2010
    ..In the future, trials could be undertaken to determine whether modifications of these risk factors, including inflammation, could lower risk of developing cognitive decline...
  59. ncbi request reprint Macronutrients, aluminium from drinking water and foods, and other metals in cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    J Alzheimers Dis 10:303-30. 2006
    ....
  60. doi request reprint Frailty syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Alzheimers Dement 9:113-22. 2013
    ..We estimated the predictive role of frailty syndrome on incident dementia and its subtypes in a nondemented, Italian, older population...
  61. ncbi request reprint Neuropsychiatric symptoms and functional status in Alzheimer's disease and vascular dementia patients
    Grazia D'Onofrio
    Geriatric Unit and Laboratory of Gerontology and Geriatrics, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, San Giovanni Rotondo, Foggia, Italy
    Curr Alzheimer Res 9:759-71. 2012
    ....
  62. ncbi request reprint Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: a population-based study from Southern Italy
    Davide Seripa
    Laboratory of Geriatrics and Gerontology, Research Department, IRCCS Casa Sollievo della Sofferenza, Viale San Giovanni Rotondo, Italy
    J Gerontol A Biol Sci Med Sci 61:918-23. 2006
    ..636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity...
  63. pmc The Multidimensional Prognostic Index (MPI), based on a comprehensive geriatric assessment predicts short- and long-term mortality in hospitalized older patients with dementia
    Alberto Pilotto
    Department of Medical Sciences, Geriatric Unit and Gerontology Geriatrics Research Laboratory, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    J Alzheimers Dis 18:191-9. 2009
    ..In conclusion, the MPI, calculated from information collected in a standardized CGA, accurately stratified hospitalized elderly patients with dementia into groups at varying risk of short- and long-term mortality...
  64. doi request reprint Dietary fatty acids and predementia syndromes
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Italy
    ScientificWorldJournal 9:792-810. 2009
    ..Therefore, at present, no definitive dietary recommendations on fish and unsaturated fatty acids consumption, or lower intake of saturated fat, in relation to the risk for dementia and cognitive decline are possible...
  65. ncbi request reprint Circulating biomarkers of cognitive decline and dementia
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    Clin Chim Acta 364:91-112. 2006
    ....
  66. doi request reprint Metabolic syndrome and the risk of vascular dementia: the Italian Longitudinal Study on Ageing
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Ageing Brain, Memory Unit, University of Bari, Policlinico, Piazza Giulio Cesare, 11 70124 Bari, Italy
    J Neurol Neurosurg Psychiatry 81:433-40. 2010
    ..The authors investigated the relationship of metabolic syndrome (MetS) and its individual components with incident dementia in a prospective population-based study with a 3.5-year follow-up...
  67. doi request reprint Polymorphisms in glutathione S-transferase omega-1 gene and increased risk of sporadic Alzheimer disease
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Foggia, Italy
    Rejuvenation Res 13:645-52. 2010
    ..014,; 95% CI, 2.528-6.382). Our findings supported a role of the GSTO1 rs4925 SNP in the risk of sporadic AD in southern Italy, suggesting that this and other variants of the GSTO1 gene could be implicated in AD pathogenesis...
  68. doi request reprint Diet and Alzheimer's disease risk factors or prevention: the current evidence
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Aging Brain, Memory Unit, University of Bari, Bari, Italy
    Expert Rev Neurother 11:677-708. 2011
    ..Hopefully this will open new opportunities for the prevention and management of dementia and AD...
  69. ncbi request reprint Apolipoprotein E genotypes in hospitalized elderly patients with vascular dementia
    Giuseppe Orsitto
    Geriatric Unit, Medical Sciences Department, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 23:327-33. 2007
    ..However, it is still unclear if a relationship exists between the APOE epsilon4 allele and vascular dementia (VaD) in elderly subjects...
  70. ncbi request reprint Unsaturated fatty acids intake and all-causes mortality: a 8.5-year follow-up of the Italian Longitudinal Study on Aging
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari Policlinico, Piazza G Cesare, 11 70124 Bari, Italy
    Exp Gerontol 40:335-43. 2005
    ..In conclusion, in this prospective study on older nondemented subjects with a typical Mediterranean diet, a higher MUFA intake increased survival, while a higher UFA/SFA ratio increased total mortality, but only marginally...
  71. doi request reprint Aluminum in the diet and Alzheimer's disease: from current epidemiology to possible disease-modifying treatment
    Vincenza Frisardi
    Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy
    J Alzheimers Dis 20:17-30. 2010
    ....
  72. ncbi request reprint The RELN locus in Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatric Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo dalla Sofferenza, San Giovanni Rotondo FG, I 71013, Italy
    J Alzheimers Dis 14:335-44. 2008
    ..These findings suggest that RELN gene variants may play a role in the pathogenesis of AD, particularly in females...
  73. doi request reprint All-cause mortality and competing risks of fatal and nonfatal vascular events in the Italian longitudinal study on aging: impact of lipoprotein(a)
    Vincenzo Solfrizzi
    Department of Geriatrics, Center for Lipoprotein Metabolism, University of Bari, Bari, Italy
    Rejuvenation Res 12:395-402. 2009
    ..Finally competing risk, conditioning the timing and occurrence of vascular events in our study population, could be a correct approach for evaluating the role of Lp(a) lipoprotein in vascular disease among elderly people...
  74. doi request reprint Association analysis of GRIN2B, encoding N-methyl-D-aspartate receptor 2B subunit, and Alzheimer's disease
    Davide Seripa
    Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, San Giovanni Rotondo, Italy
    Dement Geriatr Cogn Disord 25:287-92. 2008
    ..Glutamate transmits signals via the N-methyl-D-aspartate receptors (NMDARs). Aims: The potential involvement of polymorphisms in the GRIN2B gene, encoding subunit 2B of the NMDA receptor, in the risk for AD was evaluated...
  75. ncbi request reprint Interleukin 6-174 G/C promoter gene polymorphism and sporadic Alzheimer's disease: geographic allele and genotype variations in Europe
    Cristiano Capurso
    Department of Geriatrics, University of Foggia, Ospedali Riuniti Viale L Pinto, 71100 Foggia, Italy
    Exp Gerontol 39:1567-73. 2004
    ..We suggest that regional European differences in genotype and allele frequencies of the IL-6-174 G/C promoter polymorphism may explain in part controversial findings on this polymorphism in AD in various European studies...
  76. doi request reprint The APOE gene locus in frontotemporal dementia and primary progressive aphasia
    Davide Seripa
    BiolD, Geriatric Unit and Gerontology Geriatrics Research Laboratory, Department of Medical Sciences, I R C C S Casa Sollievo della Sofferenza, Viale Cappuccini 1, San Giovanni Rotondo
    Arch Neurol 68:622-8. 2011
    ..To investigate the role of the apolipoprotein E (APOE) locus in frontotemporal dementia (FTD) and primary progressive aphasia (PPA)...