Leonardo Pantoni

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
  2. doi request reprint Leukoaraiosis: from an ancient term to an actual marker of poor prognosis
    Leonardo Pantoni
    Stroke 39:1401-3. 2008
  3. ncbi request reprint Not-so-silent infarcts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Lancet Neurol 2:335. 2003
  4. ncbi request reprint Pathological lesions in vascular dementia
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Ann N Y Acad Sci 977:279-91. 2002
  5. ncbi request reprint The relation between white-matter lesions and cognition
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Curr Opin Neurol 20:390-7. 2007
  6. ncbi request reprint Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
  7. ncbi request reprint Thrombophilic risk factors and unusual clinical features in three Italian CADASIL patients
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Eur J Neurol 11:782-7. 2004
  8. ncbi request reprint Treatment of vascular dementia: evidence from trials with non-cholinergic drugs
    Leonardo Pantoni
    Azienda Ospedaliera Careggi and University of Florence, Florence, Italy
    J Neurol Sci 226:67-70. 2004
  9. ncbi request reprint Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 35, 50134 Florence, Italy
    Stroke 36:619-24. 2005
  10. ncbi request reprint Clinical features, risk factors, and prognosis in transient global amnesia: a follow-up study
    L Pantoni
    Azienda Ospedaliera Careggi, Florence, Italy
    Eur J Neurol 12:350-6. 2005

Detail Information

Publications78

  1. ncbi request reprint Small vessel disease and general cognitive function in nondisabled elderly: the LADIS study
    Wiesje M van der Flier
    Alzheimer Center, Department of Neurology, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 36:2116-20. 2005
    ..We investigated the independent contribution of WMH and lacunes to general cognitive function in a group of independently living elderly with varying degrees of small vessel disease...
  2. doi request reprint Leukoaraiosis: from an ancient term to an actual marker of poor prognosis
    Leonardo Pantoni
    Stroke 39:1401-3. 2008
  3. ncbi request reprint Not-so-silent infarcts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Lancet Neurol 2:335. 2003
  4. ncbi request reprint Pathological lesions in vascular dementia
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Ann N Y Acad Sci 977:279-91. 2002
    ..An ongoing survey aimed at collecting information about the procedures used in different pathological laboratories in the assessment of lesions possibly associated with dementia is finally presented...
  5. ncbi request reprint The relation between white-matter lesions and cognition
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Curr Opin Neurol 20:390-7. 2007
    ..To summarize recent findings and developments in the field of the relation between white-matter lesions and cognition...
  6. ncbi request reprint Impact of age-related cerebral white matter changes on the transition to disability -- the LADIS study: rationale, design and methodology
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Neuroepidemiology 24:51-62. 2005
    ..The study results may also help to standardize, on an international basis, tools and criteria to identify early stages of disability...
  7. ncbi request reprint Thrombophilic risk factors and unusual clinical features in three Italian CADASIL patients
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Eur J Neurol 11:782-7. 2004
    ..We conclude that a diagnosis of CADASIL should not be disregarded in patients with vascular risk factors and presenting with symptoms not immediately referable to subcortical damage at ages more advanced than commonly reported...
  8. ncbi request reprint Treatment of vascular dementia: evidence from trials with non-cholinergic drugs
    Leonardo Pantoni
    Azienda Ospedaliera Careggi and University of Florence, Florence, Italy
    J Neurol Sci 226:67-70. 2004
    ..This selective focus seems to be better suited for disclosing specific treatments in the field of VaD...
  9. ncbi request reprint Efficacy and safety of nimodipine in subcortical vascular dementia: a randomized placebo-controlled trial
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 35, 50134 Florence, Italy
    Stroke 36:619-24. 2005
    ..Evidence of drug efficacy in vascular dementia (VaD) is scanty. Therapeutic trials should address VaD subtypes. We studied the efficacy and safety of the calcium antagonist nimodipine in subcortical VaD...
  10. ncbi request reprint Clinical features, risk factors, and prognosis in transient global amnesia: a follow-up study
    L Pantoni
    Azienda Ospedaliera Careggi, Florence, Italy
    Eur J Neurol 12:350-6. 2005
    ..These results have therapeutic implications and reinforce the hypothesis that TGA is a benign disorder...
  11. ncbi request reprint Leukoaraiosis predicts hidden global functioning impairment in nondisabled older people: the LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 54:1095-101. 2006
    ..To determine whether leukoaraiosis severity is independently associated with differences in global functioning in nondisabled elderly patients...
  12. ncbi request reprint Postmortem examination of vascular lesions in cognitive impairment: a survey among neuropathological services
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 37:1005-9. 2006
    ..We aimed at surveying the postmortem neuropathological procedures used in different centers in examining brain lesions of presumable or possible vascular origin in cognitively impaired patients...
  13. ncbi request reprint Pathophysiology of cerebral small vessels in vascular cognitive impairment
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Int Psychogeriatr 15:59-65. 2003
    ..Modern magnetic resonance techniques such as diffusion, perfusion, and spectroscopy may allow the in vivo study of the pathophysiology of small-vessel diseases and the consequences on the brain parenchyma...
  14. ncbi request reprint Visual rating scales for age-related white matter changes (leukoaraiosis): can the heterogeneity be reduced?
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Stroke 33:2827-33. 2002
    ..We aimed to compare 6 widely used rating scales for leukoaraiosis and to calculate conversion coefficients of the score of 1 scale in the score of a second scale...
  15. ncbi request reprint Abulia and cognitive impairment in two patients with capsular genu infarct
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Acta Neurol Scand 104:185-90. 2001
    ..We report 2 previously non-demented patients who developed acute confusional state, abulia, and moderate cognitive decline after the occurrence of an infarct in the capsular genu...
  16. ncbi request reprint Transient global amnesia: a review emphasizing pathogenic aspects
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Acta Neurol Scand 102:275-83. 2000
    ..Our conclusion has relevant consequences in the evaluation of patients with TGA...
  17. ncbi request reprint The Scandinavian Multi-Infarct Dementia Trial: a double-blind, placebo-controlled trial on nimodipine in multi-infarct dementia
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    J Neurol Sci 175:116-23. 2000
    ..A post-hoc analysis (presented in an accompanying paper) suggests that nimodipine may have a favorable effect in the subgroup of patients defined as affected by subcortical (small vessel) vascular dementia...
  18. ncbi request reprint Pathophysiology of age-related cerebral white matter changes
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Cerebrovasc Dis 13:7-10. 2002
    ..It is possible that other genetic factors contribute, by interaction with conventional risk factors, to the development of white matter injury in nonfamilial cases...
  19. ncbi request reprint Efficacy and safety of nimodipine in subcortical vascular dementia: a subgroup analysis of the Scandinavian Multi-Infarct Dementia Trial
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    J Neurol Sci 175:124-34. 2000
    ....
  20. doi request reprint Cerebral white matter changes are associated with abnormalities on neurological examination in non-disabled elderly: the LADIS study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 260:1014-21. 2013
    ..In our cohort of non-disabled elders, severe WMC were associated with the presence and the occurrence of neurological signs, independently of other vascular brain lesions, confirming that these lesions have clinical relevance...
  21. ncbi request reprint Age, hypertension, and lacunar stroke are the major determinants of the severity of age-related white matter changes. The LADIS (Leukoaraiosis and Disability in the Elderly) Study
    Anna Maria Basile
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy, and Department of Neurology, Hopital Lariboisiere, Paris, France
    Cerebrovasc Dis 21:315-22. 2006
    ..We sought whether such a trend existed in the association of vascular risk factors or comorbidities with the severity of ARWMC aiming particularly at further elucidating the relative roles of hypertension and stroke in this regard...
  22. ncbi request reprint Risk of rapid global functional decline in elderly patients with severe cerebral age-related white matter changes: the LADIS study
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Intern Med 167:81-8. 2007
    ..The LADIS (LeukoAraiosis and DISability) Study primarily aims to assess ARWMCs as a determinant of global functional decline in the elderly population...
  23. pmc Changes in white matter as determinant of global functional decline in older independent outpatients: three year follow-up of LADIS (leukoaraiosis and disability) study cohort
    Domenico Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    BMJ 339:b2477. 2009
    ..To assess the impairment in daily living activities in older people with age related changes in white matter according to the severity of these changes...
  24. doi request reprint Cerebral hemorrhages in CADASIL: report of four cases and a brief review
    Valentina Rinnoci
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    J Neurol Sci 330:45-51. 2013
    ..Strokes are typically ischemic, while hemorrhagic events have been only sporadically described. However, cerebral microbleeds have been found in 31-69% of CADASIL patients...
  25. doi request reprint First report of a pathogenic mutation on exon 24 of the NOTCH3 gene in a CADASIL family
    Raffaella Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    J Neurol 258:1632-6. 2011
    ..This report underlines that when CADASIL is suspected the genetic analysis should be performed on all the NOTCH3 exons coding for EGF-like repeats including exon 24 and confirms that CADASIL may have heterogeneous phenotypes...
  26. doi request reprint Urinary complaints in nondisabled elderly people with age-related white matter changes: the Leukoaraiosis And DISability (LADIS) Study
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Am Geriatr Soc 56:1638-43. 2008
    ..To investigate, in a cohort of nondisabled elderly people, the association between urinary complaints and severity of age-related white matter changes (ARWMC)...
  27. doi request reprint The VAS-COG clinic: an out-patient service for patients with cognitive and behavioral consequences of cerebrovascular diseases
    Laura Ciolli
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    Neurol Sci 33:1277-83. 2012
    ..The VAS-COG clinic may represent a model in this regard and might be important for improving the care of patients and offering counseling to their families. The efficacy of this service needs, however, to be proved by successive work...
  28. doi request reprint Familial cerebral cavernous malformation: report of a further Italian family
    Serena Nannucci
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134, Florence, Italy
    Neurol Sci 30:143-7. 2009
    ..This report underlines that a familial form of CCM could be suspected when a patient presents with multiple CCMs; neurologists and neurosurgeons should be aware that genetic testing for these forms is available...
  29. doi request reprint Facial affect recognition in CADASIL patients
    Raffaella Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Arch Clin Neuropsychol 28:65-71. 2013
    ..This effect was not mediated by depression, cognitive impairment, and MMSE score. Facial affect recognition is reduced in the CADASIL patients and this impairment might represent an early manifestation of the disease...
  30. doi request reprint The Cerebral Autosomal-Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Scale: a screening tool to select patients for NOTCH3 gene analysis
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, University of Florence, and Department of Radiology, Neuroradiology Unit, Careggi University Hospital, Largo Brambilla 3, 50134 Florence, Italy
    Stroke 43:2871-6. 2012
    ..We aimed at developing the CADASIL scale, a screening tool to be applied in the clinical setting...
  31. doi request reprint Cognitive decline and dementia related to cerebrovascular diseases: some evidence and concepts
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Cerebrovasc Dis 27:191-6. 2009
    ..Despite impressive epidemiological data, the actual burden of CVDs in terms of cognitive decline is still incompletely appreciated by physicians and health regulators...
  32. ncbi request reprint Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models
    Cristina Sarti
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    J Neurol Sci 203:263-6. 2002
    ..We propose this model to investigate subcortical vascular dementia...
  33. doi request reprint Factors predicting the Montreal cognitive assessment (MoCA) applicability and performances in a stroke unit
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134, Florence, Italy
    J Neurol 260:1518-26. 2013
    ..MoCA seems to reveal some degree of cognitive deficit even in patients with mild stroke...
  34. pmc Acetazolamide for the prophylaxis of migraine in CADASIL: a preliminary experience
    Ida Donnini
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, Florence, Italy
    J Headache Pain 13:299-302. 2012
    ..Based on these data, a randomized controlled trial seems worthy to be carried out to test the efficacy and safety of this drug...
  35. doi request reprint Bone marrow-derived progenitor cells in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, Thrombosis Center, University of Florence, Florence, Italy
    Stroke 41:218-23. 2010
    ..No data are available about these cells in CADASIL. Our objective in this study was to evaluate endothelial progenitor cells and CPCs role in CADASIL...
  36. ncbi request reprint A pathogenic mutation on exon 21 of the NOTCH3 gene causing CADASIL in an octogenarian paucisymptomatic patient
    Francesca Pescini
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    J Neurol Sci 267:170-3. 2008
    ..The newly reported mutation might sustain a milder expressivity of the disease...
  37. doi request reprint Post-stroke dementia and cognitive impairment
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Front Neurol Neurosci 30:65-9. 2012
    ..The detection of cognitive impairment in the acute phase of stroke can offer valid information to the clinician on whether to set an early cognitive rehabilitation and to plan a more focused follow-up...
  38. pmc Risk and Determinants of Dementia in Patients with Mild Cognitive Impairment and Brain Subcortical Vascular Changes: A Study of Clinical, Neuroimaging, and Biological Markers-The VMCI-Tuscany Study: Rationale, Design, and Methodology
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Largo Brambilla 3, 50134 Florence, Italy
    Int J Alzheimers Dis 2012:608013. 2012
    ..This paper summarizes the main aims and methodological aspects of this multicenter, ongoing, observational study enrolling patients affected by VMCI with SVD...
  39. doi request reprint Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Lancet Neurol 9:689-701. 2010
    ..Small vessel disease should be a main target for preventive and treatment strategies, but all types of presentation and complications should be taken into account...
  40. doi request reprint Predictive value of MoCA in the acute phase of stroke on the diagnosis of mid-term cognitive impairment
    Emilia Salvadori
    NEUROFARBA Department, Neuroscience Section, University of Florence, Florence, Italy
    J Neurol 260:2220-7. 2013
    ..3 % negative predictive value. In a sample of mild stroke patients, MoCA seems to be a good predictor of mid-term PSCI, making it a possible candidate for a brief cognitive screening in the acute stroke setting...
  41. ncbi request reprint [New evidence in the field of white matter changes]
    Leonardo Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    No To Shinkei 58:298-302. 2006
  42. ncbi request reprint Emotional arousal and phobia in transient global amnesia
    D Inzitari
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Arch Neurol 54:866-73. 1997
    ..To evaluate the role of emotionally stressful or phobogenic events and phobic personality traits in transient global amnesia (TGA)...
  43. doi request reprint The contribution of cerebrospinal fluid oligoclonal bands to the early diagnosis of multiple sclerosis
    V Zipoli
    Department of Neurology, University of Florence, Florence, Italy
    Mult Scler 15:472-8. 2009
    ..McDonald Criteria (MDC) have been validated in selected patients at high risk for multiple sclerosis (MS). However, possible overdiagnosis of MS can represent critical issues in less controlled clinical settings...
  44. doi request reprint Comparison of clinical, familial, and MRI features of CADASIL and NOTCH3-negative patients
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Florence, Italy
    Neurology 74:57-63. 2010
    ..To report the characteristics of patients suspected to have cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) but in whom no NOTCH3 gene pathogenic mutation was found...
  45. ncbi request reprint Cytokines and cell adhesion molecules in cerebral ischemia: experimental bases and therapeutic perspectives
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Arterioscler Thromb Vasc Biol 18:503-13. 1998
    ..Our analysis suggests that until sufficient knowledge of the underlying disease mechanisms is acquired, more care should be taken when testing new and potentially efficacious drugs in stroke patients...
  46. ncbi request reprint Longitudinal evaluation of leukoaraiosis with whole brain ADC histograms
    M Mascalchi
    Radiodiagnostic Section, Department of Clinical Physiopathology, University of Florence, USA
    Neurology 59:938-40. 2002
    ..008) and brain volume index (BVI) was decreased (p = 0.006). WB-ADC histogram and BVI are sensitive to leukoaraiosis and might be considered for monitoring progression of the disease...
  47. ncbi request reprint Experimental approaches to white matter disease
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Dement Geriatr Cogn Disord 9:20-4. 1998
    ..Opportune modifications of these animal models may represent a valuable source of information on the pathogenesis and pathophysiology of human vascular disease of the WM...
  48. ncbi request reprint Vascular mild cognitive impairment: concept, definition, and directions for future studies
    Arturo Consoli
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Aging Clin Exp Res 24:113-6. 2012
    ..Longitudinal studies on the natural history of vascular MCI, with investigation of the factors responsible for the transition to dementia, are worthy of being planned and carried out...
  49. doi request reprint The use of CT in dementia
    Marco Pasi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Int Psychogeriatr 23:S6-12. 2011
    ....
  50. ncbi request reprint Persistent impairment of gait performances and working memory after bilateral common carotid artery occlusion in the adult Wistar rat
    Cristina Sarti
    Department of Neurological and Psychiatric Sciences, University of Florence, Viale Morgagni 85, 50134 Firenze, Italy
    Behav Brain Res 136:13-20. 2002
    ..We investigated whether rats subjected to bilateral common carotid artery occlusion (bCCA-o) developed focal neurological deficits, gait dysfunction, and working memory alterations...
  51. doi request reprint Investigations in primary care
    Anna Poggesi
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Front Neurol Neurosci 24:66-78. 2009
    ....
  52. ncbi request reprint The selective A2A receptor antagonist SCH 58261 reduces striatal transmitter outflow, turning behavior and ischemic brain damage induced by permanent focal ischemia in the rat
    Alessia Melani
    Department of Preclinical and Clinical Pharmacology, University of Florence, V le Pieraccini 6, 50139, Florence, Italy
    Brain Res 959:243-50. 2003
    ..Furthermore, this study, for the first time, proposes that turning behavior after permanent intraluminal MCAo, be used as a precocious index of neurological deficit and neuronal damage...
  53. doi request reprint Prevalence of CT-detected cerebral abnormalities in an elderly Swedish population sample
    M Simoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Acta Neurol Scand 118:260-7. 2008
    ..To measure the prevalence of computed tomography (CT)-detected cerebral lesions in a population-based sample of elderly persons living in Göteborg, Sweden...
  54. ncbi request reprint Lipoprotein(a) and cognitive performances in an elderly white population: Cross-sectional and follow-up data
    C Sarti
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Stroke 32:1678-83. 2001
    ..Elevated Lp(a) levels do not appear to be a major determinant of cognitive impairment in the elderly...
  55. ncbi request reprint Clinically relevant cognitive impairment after cardiac surgery: a 6-month follow-up study
    A Di Carlo
    National Research Council of Italy CNR CSFET, Italian Longitudinal Study on Aging, Via L Pancaldo, 21, 50127, Florence, Italy
    J Neurol Sci 188:85-93. 2001
    ..We prospectively estimated the frequency of cognitive impairment after cardiac surgery, with a particular emphasis on persistent and clinically relevant cognitive decline. Possible baseline and operative predictors were also evaluated...
  56. doi request reprint Psychiatric disturbances in CADASIL: a brief review
    R Valenti
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    Acta Neurol Scand 118:291-5. 2008
    ..However, the assessment of psychiatric disturbances in this disease has never been carried out systematically...
  57. ncbi request reprint Lipoprotein(a) serum levels and vascular diseases in an older Caucasian population cohort. Italian Longitudinal Study on Aging (ILSA)
    L Pantoni
    Department of Neurological and Psychiatric Sciences, University of Florence, Italy
    J Am Geriatr Soc 49:117-25. 2001
    ....
  58. ncbi request reprint Cerebellar arteriovenous malformation and vertebral artery aneurysm in a CADASIL patient
    F Pescini
    Department of Neurological and Psychiatric Sciences, University of Florence, Florence, Italy
    Acta Neurol Scand 113:62-3. 2006
    ..In one of these (the Alagille syndrome) intracranial aneurysms are reported. This hypothesis contrasts however with the absence of similar reports in other CADASIL cases and needs corroboration in large series...
  59. ncbi request reprint Pathological examination in vascular dementia
    Leonardo Pantoni
    Am J Psychiatry 159:1439-40; author reply 1440-1. 2002
  60. ncbi request reprint Development of a neuropsychological battery for the Leukoaraiosis and Disability in the Elderly Study (LADIS): experience and baseline data
    Sofia Madureira
    Servico de Neurologia, Centro de Estudos Egas Moniz, Hospital de Santa Maria, Lisboa, Portugal
    Neuroepidemiology 27:101-16. 2006
    ..In the LADIS population baseline data, older age and lower educational levels negatively influence neuropsychological performance...
  61. pmc Differential impact of cerebral white matter changes, diabetes, hypertension and stroke on cognitive performance among non-disabled elderly. The LADIS study
    Ana Verdelho
    Neurology Department, Centro de Estudos Egas Moniz, Santa Maria Hospital, Lisbon, Portugal
    J Neurol Neurosurg Psychiatry 78:1325-30. 2007
    ..Our aim was to study the influence of vascular risk factors and ARWMC on the neuropsychological performance of an independent elderly population, to see if vascular risk factors impair cognition in addition to the effects of ARWMC...
  62. ncbi request reprint Comparison of the Alzheimer's Disease Assessment Scale Cognitive Subscale and the Vascular Dementia Assessment Scale in differentiating elderly individuals with different degrees of white matter changes. The LADIS Study
    Raija Ylikoski
    Memory Research Unit, Department of Neurology, University of Helsinki, Helsinki, Finland
    Dement Geriatr Cogn Disord 24:73-81. 2007
    ..The objective of this study was to compare the results of the two scales among subjects with various degrees of white matter hyperintensities (WMHs)...
  63. ncbi request reprint Subcortical ischaemic vascular dementia
    Gustavo C Roman
    University of Texas at San Antonio and the Audie L Murphy Memorial Veterans Hospital, San Antonio, Texas 78284 7883, USA
    Lancet Neurol 1:426-36. 2002
    ..Treatment is symptomatic and prevention requires control of treatable risk factors...
  64. ncbi request reprint Postpartum psychiatric disturbances as an unrecognized onset of CADASIL
    Leonardo Pantoni
    Acta Psychiatr Scand 112:241; author reply 242. 2005
  65. ncbi request reprint Vascular cognitive impairment
    John T O'Brien
    Institute for Aging and Health, Newcastle General Hospital, Newcastle upon Tyne, UK
    Lancet Neurol 2:89-98. 2003
    ..Clinical trials in vascular cognitive impairment are in their infancy but support the value of therapeutic interventions for symptomatic treatment...
  66. doi request reprint Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: the Leukoaraiosis and Disability study
    Alida A Gouw
    Department of Neurology, Alzheimer Center and Image Analysis Center, Vrije Universiteit Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Stroke 39:1414-20. 2008
    ..We studied the natural course of white matter hyperintensities (WMH) and lacunes, the main MRI representatives of small vessel disease, over time and evaluated possible predictors for their development...
  67. ncbi request reprint Impact of white matter hyperintensities scoring method on correlations with clinical data: the LADIS study
    Elisabeth C W van Straaten
    Department of Neurology and Alzheimer Center, VU Medical Center, Amsterdam, The Netherlands
    Stroke 37:836-40. 2006
    ..Associations may depend on the method used for measuring WMH. We investigated the ability of different WMH scoring methods to detect differences in WMH load between groups with and without symptoms...
  68. ncbi request reprint Midlife respiratory function related to white matter lesions and lacunar infarcts in late life: the Prospective Population Study of Women in Gothenburg, Sweden
    Xinxin Guo
    Neuropsychiatric Epidemiology Unit, Institute of Neurosciences and Physiology, Sahlgrenska Academy at Goteborg University, Sweden
    Stroke 37:1658-62. 2006
    ..We examined midlife and late-life respiratory function in relation to small-vessel disease on computed tomography (CT) in women followed for 26 years...
  69. ncbi request reprint Classification and subtypes of vascular dementia
    Anders Wallin
    Goteborg University, Institute of Clinical Neuroscience, Sahlgrenska University Hospital, Molndal, Sweden
    Int Psychogeriatr 15:27-37. 2003
    ..Subcortical VaD has a relatively homogeneous clinical picture for which detailed criteria are suggested. AD + VaD is more difficult to identify but is possible, sometimes with the aid of neuroimaging and/or biological markers...
  70. ncbi request reprint White matter ischemia: Time to begin integrating experimental and clinical data
    Leonardo Pantoni
    Eur Neurol 56:71-3. 2006
  71. ncbi request reprint White matter hyperintensities rather than lacunar infarcts are associated with depressive symptoms in older people: the LADIS study
    John T O'Brien
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Am J Geriatr Psychiatry 14:834-41. 2006
    ..This study investigates the relationship between location and burden of WMH and lacunes on depressive features in older people...
  72. pmc Corpus callosum atrophy is associated with mental slowing and executive deficits in subjects with age-related white matter hyperintensities: the LADIS Study
    Hanna Jokinen
    Department of Psychology, University of Helsinki, Helsinki, Finland
    J Neurol Neurosurg Psychiatry 78:491-6. 2007
    ..Previous research has indicated that corpus callosum atrophy is associated with global cognitive decline in neurodegenerative diseases, but few studies have investigated specific cognitive functions...
  73. ncbi request reprint White matter hyperintensities and depression--preliminary results from the LADIS study
    Michael J Firbank
    Institute for Ageing and Health, University of Newcastle upon Tyne, UK
    Int J Geriatr Psychiatry 20:674-9. 2005
    ..White matter hyperintensities have been associated with the development of depression in older subjects, though the details of this relationship are not fully understood...
  74. ncbi request reprint The effect of white matter lesions on cognition in the elderly--small but detectable
    Giovanni B Frisoni
    Laboratory of Epidemiology Neuroimaging and Telemedicine, IRCCS San Giovanni di Dio FBF, via Pilastroni 4, 25125 Brescia, Italy
    Nat Clin Pract Neurol 3:620-7. 2007
    ..This view has important implications for the development of drugs for the treatment and prevention of cognitive impairment and dementia...
  75. doi request reprint Reliability and sensitivity of visual scales versus volumetry for evaluating white matter hyperintensity progression
    A A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Cerebrovasc Dis 25:247-53. 2008
    ..However, the most suitable method for measuring WMH progression has not been established yet. We compared the reliability and sensitivity of cross-sectional and longitudinal visual scales with volumetry for measuring WMH progression...
  76. doi request reprint On the etiology of incident brain lacunes: longitudinal observations from the LADIS study
    Alida A Gouw
    Alzheimer Center, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Stroke 39:3083-5. 2008
    ..We investigated regional differences in MRI characteristics and risk factor profiles of incident lacunes over a 3-year period...
  77. doi request reprint Hearing loss and cortical atrophy in a population-based study on non-demented women
    Xinxin Guo
    Department of Psychiatry, Sahlgrenska University Hospital, SE 413 45 Goteborg, Sweden
    Age Ageing 37:333-6. 2008
  78. doi request reprint Segmentation of age-related white matter changes in a clinical multi-center study
    Tim B Dyrby
    Danish Research Centre for Magnetic Resonance, Copenhagen University Hospital, Hvidovre, Denmark
    Neuroimage 41:335-45. 2008
    ..Expert knowledge not available to the neural networks was a minor source of discrepancy, while variation in MR scan quality constituted the largest source of error...