Research Topics
Genomes and Genes | L PalmieriSummaryAffiliation: University of Bari Country: Italy Publications
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Publications
Arabidopsis mitochondria have two basic amino acid transporters with partially overlapping specificities and differential expression in seedling developmentLuigi Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari and CNR Institute of Biomembranes and Bioenergetics, Via E Orabona 4, 70125 Bari, Italy
Biochim Biophys Acta 1757:1277-83. 2006..Increase of BAC2 transcript levels later in seedling development is consistent with roles in NO, polyamine or proline metabolism--processes involving arginine, citrulline and/or ornithine...- Identification and functions of new transporters in yeast mitochondriaL Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
Biochim Biophys Acta 1459:363-9. 2000..Furthermore, the yeast carrier sequences can be used to identify the orthologous proteins in other organisms, including man... 
Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1L Palmieri
Department of Pharmaco Biology, University of Bari, Bari, Italy
Mol Psychiatry 15:38-52. 2010..AGC and altered Ca(2+) homeostasis play a key interactive role in the cascade of signaling events leading to autism: their modulation could provide new preventive and therapeutic strategies...- Mitochondrial dysfunction in autism spectrum disorders: cause or effect?Luigi Palmieri
Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125, Bari, Italy
Biochim Biophys Acta 1797:1130-7. 2010..Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca(2+)) signalling... - Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significanceL Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
J Bioenerg Biomembr 32:67-77. 2000..The yeast dicarboxylate carrier sequence has been used to identify the orthologous protein in Caenorhabditis elegans and, in turn, this latter sequence has been used to establish the sequence of the human ortholog... - The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegansG Fiermonte
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
J Biol Chem 273:24754-9. 1998.... 
Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondriaL Palmieri
Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
EMBO J 20:5060-9. 2001..These results show that the aspartate/glutamate carrier is regulated by Ca(2+) through a mechanism independent of Ca(2+) entry into mitochondria, and suggest a novel mechanism of Ca(2+) regulation of the aspartate/malate shuttle...- Identification of the yeast mitochondrial transporter for oxaloacetate and sulfateL Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
J Biol Chem 274:22184-90. 1999..The main physiological role of OAC appears to be to use the proton-motive force to take up into mitochondria oxaloacetate produced from pyruvate by cytoplasmic pyruvate carboxylase... - Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal locationG Fiermonte
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
J Biol Chem 276:8225-30. 2001..It is transported from the cytoplasm into mitochondria where it is converted into acetyl-CoA. Defects in human ODC are likely to be a cause of 2-oxoadipate acidemia, an inborn error of metabolism of lysine, tryptophan, and hydroxylysine... - Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarateL Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
J Biol Chem 276:1916-22. 2001.... - Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporterL Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
EMBO J 20:5049-59. 2001..The physiological role of Ant1p in S.cerevisiae is probably to transport cytoplasmic ATP into the peroxisomal lumen in exchange for AMP generated in the activation of fatty acids... - Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiaeAlessandra Castegna
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
J Biol Chem 285:17359-70. 2010..Our proposal is also supported by the growth defect displayed by the DeltaYHM2 strain and more so by the DeltaYHM2DeltaZWF1 strain upon H(2)O(2) exposure, implying that Yhm2p has an antioxidant function... - Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiaeAngelo Vozza
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
J Biol Chem 279:20850-7. 2004..The physiological role of Ggc1p in S. cerevisiae is probably to transport GTP into mitochondria, where it is required for important processes such as nucleic acid and protein synthesis, in exchange for intramitochondrially generated GDP... - Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitisA Castegna
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
Neuroscience 185:97-105. 2011..These findings indicate that oxidative stress occurs in brain areas that are not actively undergoing inflammation in EAE and that this can lead to a neurodegenerative process due to the susceptibility of GS to oxidative inactivation... - Molecular identification of an Arabidopsis S-adenosylmethionine transporter. Analysis of organ distribution, bacterial expression, reconstitution into liposomes, and functional characterizationLuigi Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
Plant Physiol 142:855-65. 2006..These findings suggest that the provision of cytosolically synthesized SAM to mitochondria and possibly also to plastids is mediated by SAMC1 according to the relative demands for this metabolite in the organelles... - Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: organ distribution, bacterial expression, reconstitution into liposomes and functional characterizationLuigi Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
Biochem J 410:621-9. 2008..It is proposed that plant DICs constitute the membrane component of several metabolic processes including the malate-oxaloacetate shuttle, the most important redox connection between the mitochondria and the cytosol... - Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distributionGiuseppe Fiermonte
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, Italy
J Biol Chem 279:30722-30. 2004.... - Identification and characterization of ADNT1, a novel mitochondrial adenine nucleotide transporter from ArabidopsisLuigi Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
Plant Physiol 148:1797-808. 2008..These findings are discussed in the context of a potential function for ADNT1 in the provision of the energy required to support growth in heterotrophic plant tissues... - Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoformsGiuseppe Fiermonte
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
J Biol Chem 277:19289-94. 2002.... - Identification of mitochondrial carriers in Saccharomyces cerevisiae by transport assay of reconstituted recombinant proteinsFerdinando Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
Biochim Biophys Acta 1757:1249-62. 2006..The roles of eight yeast mitochondrial carriers remain to be established... - The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in DeltapH formation across peroxisomal membranesFrancesco M Lasorsa
Department of Pharmaco-Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
Biochem J 381:581-5. 2004..Furthermore, microscopic fluorescence imaging of a pH-sensitive green fluorescent protein targeted to peroxisomes shows that Ant1p is involved in the formation of a DeltapH across the peroxisomal membrane, acidic inside... - Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathyLuigi Palmieri
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
Hum Mol Genet 14:3079-88. 2005.... - Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cellsFrancesco Massimo Lasorsa
Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari and CNR Institute of Biomembranes and Bioenergetics, Via Orabona 4, 70125 Bari, Italy
J Biol Chem 278:38686-92. 2003.... - Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distributionNathalie Picault
Institut de Biotechnologie des Plantes, CNRS UMR8618, Universite de Paris Sud, 91405 Orsay, Cedex, France
J Biol Chem 277:24204-11. 2002.... - The mitochondrial oxoglutarate carrier: structural and dynamic properties of transmembrane segment IV studied by site-directed spin labelingBlasco Morozzo della Rocca
INFM and Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica snc, 00133 Rome, Italy
Biochemistry 42:5493-9. 2003..The helix is strongly packed, as indicated by the values of normalized mobility, which also suggest that the conformational changes occurring during transport probably involve the N-terminal region of the helix... - Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stabilityFlavia Fontanesi
Department of Genetics Anthropology Evolution, University of Parma, 43100 Parma, Italy
Hum Mol Genet 13:923-34. 2004..cerevisiae is a suitable in vivo model to study the pathogenicity of the human ANT1 mutations and the pathophysiology leading to impairment of oxidative phosphorylation and damage of mtDNA integrity, as found in adPEO... - The growing family of mitochondrial carriers in ArabidopsisNathalie Picault
Institut de Biotechnologie des Plantes, CNRS UMR8618, , , 91405 Orsay Cedex, France
Trends Plant Sci 9:138-46. 2004 - Identification of a mitochondrial transporter for basic amino acids in Arabidopsis thaliana by functional reconstitution into liposomes and complementation in yeastMary Elizabeth Hoyos
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
Plant J 33:1027-35. 2003..e. delivery of Arg to mitochondrial arginase. The Km (0.19 mm) for Arg uptake by AtmBAC1 was close to the value we previously determined for the saturable component of Arg uptake into intact mitochondria from soybean seedling cotyledons... - Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsyFlorence Molinari
INSERM U393, Hopital Necker Enfants Malades, Paris, France
Am J Hum Genet 76:334-9. 2005.... - The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid inductionHanspeter Rottensteiner
FU Berlin, FB Biologie, Chemie, Pharmazie, Thielallee 63, D-14195 Berlin, Germany
Biochem J 365:109-17. 2002..Generation of the signal was also independent of protein synthesis, as demonstrated by cycloheximide treatment... - Adenine nucleotide translocator 1 deficiency associated with Sengers syndromeEric Z Jordens
Department of Pediatrics, University Medical Center Nijmegen, Nijmegen, The Netherlands
Ann Neurol 52:95-9. 2002..We propose that transcriptional, translational, or posttranslational events are responsible for the ANT1 deficiency associated with the syndrome...