L Palmieri

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. ncbi request reprint Arabidopsis mitochondria have two basic amino acid transporters with partially overlapping specificities and differential expression in seedling development
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari and CNR Institute of Biomembranes and Bioenergetics, Via E Orabona 4, 70125 Bari, Italy
    Biochim Biophys Acta 1757:1277-83. 2006
  2. ncbi request reprint Identification and functions of new transporters in yeast mitochondria
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
    Biochim Biophys Acta 1459:363-9. 2000
  3. doi request reprint Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1
    L Palmieri
    Department of Pharmaco Biology, University of Bari, Bari, Italy
    Mol Psychiatry 15:38-52. 2010
  4. doi request reprint Mitochondrial dysfunction in autism spectrum disorders: cause or effect?
    Luigi Palmieri
    Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125, Bari, Italy
    Biochim Biophys Acta 1797:1130-7. 2010
  5. ncbi request reprint Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
    J Bioenerg Biomembr 32:67-77. 2000
  6. ncbi request reprint The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans
    G Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 273:24754-9. 1998
  7. pmc Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria
    L Palmieri
    Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    EMBO J 20:5060-9. 2001
  8. ncbi request reprint Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 274:22184-90. 1999
  9. ncbi request reprint Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location
    G Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Biol Chem 276:8225-30. 2001
  10. ncbi request reprint Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 276:1916-22. 2001

Collaborators

  • F Palmieri
  • Massimo Zeviani
  • Hanspeter Rottensteiner
  • A R Fernie
  • M Iijima
  • C Schneider
  • Christopher D Todd
  • M Elia
  • D C Hooper
  • Antonio M Persico
  • R Rizzuto
  • Tiziana Lodi
  • K Kobayashi
  • R Erdmann
  • Aner Gurvitz
  • Andrea Dorner
  • Jan A Smeitink
  • Giuseppe Fiermonte
  • Nathalie Picault
  • Pasquale Scarcia
  • A Castegna
  • Alessandra Castegna
  • Francesco Massimo Lasorsa
  • G Fiermonte
  • Gennaro Agrimi
  • Florence Molinari
  • Angelo Vozza
  • Francesco M Lasorsa
  • Flavia Fontanesi
  • Blasco Morozzo della Rocca
  • Mary Elizabeth Hoyos
  • Simona Todisco
  • Michael Hodges
  • Eric Z Jordens
  • M T Curtis
  • D A Barkhouse
  • M J Fabis-Pedrini
  • R B Kean
  • I Spera
  • V Porcelli
  • Iolanda Spera
  • Lucrezia Germinario
  • M J Runswick
  • V Dolce
  • J E Walker
  • Michel Vekemans
  • Annick Raas-Rothschild
  • Ziva Ben-Neriah
  • Noman Kadhom
  • Laurence Colleaux
  • Ferechte Encha-Razavi
  • Tania Attie-Bitach
  • Pierre Rustin
  • Arnold Munnich
  • Marlene Rio
  • Anna Maria Viola
  • Valeria Tiranti
  • Emanuela Blanco
  • Anna Limongelli
  • Francesco De Leonardis
  • Iliana Ferrero
  • Claudia Donnini
  • Anna Rita Cappello
  • Graziantonio Lauria
  • Timothy Wertin
  • Joseph C Polacco
  • Francesca Polizio
  • Francesca Venerini
  • Jens Pedersen
  • Valentina Stipani
  • Roberto Arrigoni
  • Alessandro Desideri
  • Loredana Capobianco
  • Paolo Pinton
  • Jullius Valsson
  • Wim Ruitenbeek
  • John E Walker
  • Frans J Trijbels
  • Lambert P van den Heuvel
  • Rob C A Sengers
  • Isabella Pisano
  • Marjan Huizing
  • Gunnlaugur Sigfusson
  • M Ventura
  • F M Lasorsa

Detail Information

Publications31

  1. ncbi request reprint Arabidopsis mitochondria have two basic amino acid transporters with partially overlapping specificities and differential expression in seedling development
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari and CNR Institute of Biomembranes and Bioenergetics, Via E Orabona 4, 70125 Bari, Italy
    Biochim Biophys Acta 1757:1277-83. 2006
    ..Increase of BAC2 transcript levels later in seedling development is consistent with roles in NO, polyamine or proline metabolism--processes involving arginine, citrulline and/or ornithine...
  2. ncbi request reprint Identification and functions of new transporters in yeast mitochondria
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
    Biochim Biophys Acta 1459:363-9. 2000
    ..Furthermore, the yeast carrier sequences can be used to identify the orthologous proteins in other organisms, including man...
  3. doi request reprint Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1
    L Palmieri
    Department of Pharmaco Biology, University of Bari, Bari, Italy
    Mol Psychiatry 15:38-52. 2010
    ..AGC and altered Ca(2+) homeostasis play a key interactive role in the cascade of signaling events leading to autism: their modulation could provide new preventive and therapeutic strategies...
  4. doi request reprint Mitochondrial dysfunction in autism spectrum disorders: cause or effect?
    Luigi Palmieri
    Laboratory of Biochemistry and Molecular Biology, Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125, Bari, Italy
    Biochim Biophys Acta 1797:1130-7. 2010
    ..Recent evidence from post-mortem studies of autistic brains points toward abnormalities in mitochondrial function as possible downstream consequences of dysreactive immunity and altered calcium (Ca(2+)) signalling...
  5. ncbi request reprint Yeast mitochondrial carriers: bacterial expression, biochemical identification and metabolic significance
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
    J Bioenerg Biomembr 32:67-77. 2000
    ..The yeast dicarboxylate carrier sequence has been used to identify the orthologous protein in Caenorhabditis elegans and, in turn, this latter sequence has been used to establish the sequence of the human ortholog...
  6. ncbi request reprint The sequence, bacterial expression, and functional reconstitution of the rat mitochondrial dicarboxylate transporter cloned via distant homologs in yeast and Caenorhabditis elegans
    G Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 273:24754-9. 1998
    ....
  7. pmc Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria
    L Palmieri
    Department of Pharmaco Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    EMBO J 20:5060-9. 2001
    ..These results show that the aspartate/glutamate carrier is regulated by Ca(2+) through a mechanism independent of Ca(2+) entry into mitochondria, and suggest a novel mechanism of Ca(2+) regulation of the aspartate/malate shuttle...
  8. ncbi request reprint Identification of the yeast mitochondrial transporter for oxaloacetate and sulfate
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 274:22184-90. 1999
    ..The main physiological role of OAC appears to be to use the proton-motive force to take up into mitochondria oxaloacetate produced from pyruvate by cytoplasmic pyruvate carboxylase...
  9. ncbi request reprint Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location
    G Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Biol Chem 276:8225-30. 2001
    ..It is transported from the cytoplasm into mitochondria where it is converted into acetyl-CoA. Defects in human ODC are likely to be a cause of 2-oxoadipate acidemia, an inborn error of metabolism of lysine, tryptophan, and hydroxylysine...
  10. ncbi request reprint Identification in Saccharomyces cerevisiae of two isoforms of a novel mitochondrial transporter for 2-oxoadipate and 2-oxoglutarate
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 276:1916-22. 2001
    ....
  11. pmc Identification and functional reconstitution of the yeast peroxisomal adenine nucleotide transporter
    L Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    EMBO J 20:5049-59. 2001
    ..The physiological role of Ant1p in S.cerevisiae is probably to transport cytoplasmic ATP into the peroxisomal lumen in exchange for AMP generated in the activation of fatty acids...
  12. pmc Identification and functional characterization of a novel mitochondrial carrier for citrate and oxoglutarate in Saccharomyces cerevisiae
    Alessandra Castegna
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
    J Biol Chem 285:17359-70. 2010
    ..Our proposal is also supported by the growth defect displayed by the DeltaYHM2 strain and more so by the DeltaYHM2DeltaZWF1 strain upon H(2)O(2) exposure, implying that Yhm2p has an antioxidant function...
  13. ncbi request reprint Identification of the mitochondrial GTP/GDP transporter in Saccharomyces cerevisiae
    Angelo Vozza
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Biol Chem 279:20850-7. 2004
    ..The physiological role of Ggc1p in S. cerevisiae is probably to transport GTP into mitochondria, where it is required for important processes such as nucleic acid and protein synthesis, in exchange for intramitochondrially generated GDP...
  14. doi request reprint Oxidative stress and reduced glutamine synthetase activity in the absence of inflammation in the cortex of mice with experimental allergic encephalomyelitis
    A Castegna
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    Neuroscience 185:97-105. 2011
    ..These findings indicate that oxidative stress occurs in brain areas that are not actively undergoing inflammation in EAE and that this can lead to a neurodegenerative process due to the susceptibility of GS to oxidative inactivation...
  15. pmc Molecular identification of an Arabidopsis S-adenosylmethionine transporter. Analysis of organ distribution, bacterial expression, reconstitution into liposomes, and functional characterization
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
    Plant Physiol 142:855-65. 2006
    ..These findings suggest that the provision of cytosolically synthesized SAM to mitochondria and possibly also to plastids is mediated by SAMC1 according to the relative demands for this metabolite in the organelles...
  16. ncbi request reprint Molecular identification of three Arabidopsis thaliana mitochondrial dicarboxylate carrier isoforms: organ distribution, bacterial expression, reconstitution into liposomes and functional characterization
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, 70125 Bari, Italy
    Biochem J 410:621-9. 2008
    ..It is proposed that plant DICs constitute the membrane component of several metabolic processes including the malate-oxaloacetate shuttle, the most important redox connection between the mitochondria and the cytosol...
  17. ncbi request reprint Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution
    Giuseppe Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via Orabona 4, Italy
    J Biol Chem 279:30722-30. 2004
    ....
  18. pmc Identification and characterization of ADNT1, a novel mitochondrial adenine nucleotide transporter from Arabidopsis
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
    Plant Physiol 148:1797-808. 2008
    ..These findings are discussed in the context of a potential function for ADNT1 in the provision of the energy required to support growth in heterotrophic plant tissues...
  19. ncbi request reprint Identification of the mitochondrial glutamate transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution of two human isoforms
    Giuseppe Fiermonte
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    J Biol Chem 277:19289-94. 2002
    ....
  20. ncbi request reprint Identification of mitochondrial carriers in Saccharomyces cerevisiae by transport assay of reconstituted recombinant proteins
    Ferdinando Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Via E Orabona 4, 70125 Bari, Italy
    Biochim Biophys Acta 1757:1249-62. 2006
    ..The roles of eight yeast mitochondrial carriers remain to be established...
  21. pmc The yeast peroxisomal adenine nucleotide transporter: characterization of two transport modes and involvement in DeltapH formation across peroxisomal membranes
    Francesco M Lasorsa
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, 70125 Bari, Italy
    Biochem J 381:581-5. 2004
    ..Furthermore, microscopic fluorescence imaging of a pH-sensitive green fluorescent protein targeted to peroxisomes shows that Ant1p is involved in the formation of a DeltapH across the peroxisomal membrane, acidic inside...
  22. ncbi request reprint Complete loss-of-function of the heart/muscle-specific adenine nucleotide translocator is associated with mitochondrial myopathy and cardiomyopathy
    Luigi Palmieri
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari, Italy
    Hum Mol Genet 14:3079-88. 2005
    ....
  23. ncbi request reprint Recombinant expression of the Ca(2+)-sensitive aspartate/glutamate carrier increases mitochondrial ATP production in agonist-stimulated Chinese hamster ovary cells
    Francesco Massimo Lasorsa
    Department of Pharmaco Biology, Laboratory of Biochemistry and Molecular Biology, University of Bari and CNR Institute of Biomembranes and Bioenergetics, Via Orabona 4, 70125 Bari, Italy
    J Biol Chem 278:38686-92. 2003
    ....
  24. ncbi request reprint Identification of a novel transporter for dicarboxylates and tricarboxylates in plant mitochondria. Bacterial expression, reconstitution, functional characterization, and tissue distribution
    Nathalie Picault
    Institut de Biotechnologie des Plantes, CNRS UMR8618, Universite de Paris Sud, 91405 Orsay, Cedex, France
    J Biol Chem 277:24204-11. 2002
    ....
  25. ncbi request reprint The mitochondrial oxoglutarate carrier: structural and dynamic properties of transmembrane segment IV studied by site-directed spin labeling
    Blasco Morozzo della Rocca
    INFM and Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica snc, 00133 Rome, Italy
    Biochemistry 42:5493-9. 2003
    ..The helix is strongly packed, as indicated by the values of normalized mobility, which also suggest that the conformational changes occurring during transport probably involve the N-terminal region of the helix...
  26. ncbi request reprint Mutations in AAC2, equivalent to human adPEO-associated ANT1 mutations, lead to defective oxidative phosphorylation in Saccharomyces cerevisiae and affect mitochondrial DNA stability
    Flavia Fontanesi
    Department of Genetics Anthropology Evolution, University of Parma, 43100 Parma, Italy
    Hum Mol Genet 13:923-34. 2004
    ..cerevisiae is a suitable in vivo model to study the pathogenicity of the human ANT1 mutations and the pathophysiology leading to impairment of oxidative phosphorylation and damage of mtDNA integrity, as found in adPEO...
  27. ncbi request reprint The growing family of mitochondrial carriers in Arabidopsis
    Nathalie Picault
    Institut de Biotechnologie des Plantes, CNRS UMR8618, Batiment 630, Universite de Paris Sud XI, 91405 Orsay Cedex, France
    Trends Plant Sci 9:138-46. 2004
  28. ncbi request reprint Identification of a mitochondrial transporter for basic amino acids in Arabidopsis thaliana by functional reconstitution into liposomes and complementation in yeast
    Mary Elizabeth Hoyos
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    Plant J 33:1027-35. 2003
    ..e. delivery of Arg to mitochondrial arginase. The Km (0.19 mm) for Arg uptake by AtmBAC1 was close to the value we previously determined for the saturable component of Arg uptake into intact mitochondria from soybean seedling cotyledons...
  29. pmc Impaired mitochondrial glutamate transport in autosomal recessive neonatal myoclonic epilepsy
    Florence Molinari
    INSERM U393, Hopital Necker Enfants Malades, Paris, France
    Am J Hum Genet 76:334-9. 2005
    ....
  30. pmc The peroxisomal transporter gene ANT1 is regulated by a deviant oleate response element (ORE): characterization of the signal for fatty acid induction
    Hanspeter Rottensteiner
    FU Berlin, FB Biologie, Chemie, Pharmazie, Thielallee 63, D 14195 Berlin, Germany
    Biochem J 365:109-17. 2002
    ..Generation of the signal was also independent of protein synthesis, as demonstrated by cycloheximide treatment...
  31. ncbi request reprint Adenine nucleotide translocator 1 deficiency associated with Sengers syndrome
    Eric Z Jordens
    Department of Pediatrics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Ann Neurol 52:95-9. 2002
    ..We propose that transcriptional, translational, or posttranslational events are responsible for the ANT1 deficiency associated with the syndrome...