E Palma

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le A Moro 5, I00185 Roma, Italy
    Proc Natl Acad Sci U S A 99:3950-5. 2002
  2. ncbi request reprint Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: new procedure for ion channel studies
    Ricardo Miledi
    Instituto de Neurobiologia, Campus UNAM Juriquilla, Mexico
    Methods Mol Biol 322:347-55. 2006
  3. ncbi request reprint Novel approaches to study the involvement of α7-nAChR in human diseases
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia e Farmacologia, Università di Roma LaSapienza, Rome, Italy
    Curr Drug Targets 13:579-86. 2012
  4. pmc Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
    E Palma
    Istituto Pasteur, Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 103:8465-8. 2006
  5. ncbi request reprint The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Roma, Italy
    Epilepsia 48:1842-9. 2007
  6. pmc GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 104:20944-8. 2007
  7. pmc Physiological characterization of human muscle acetylcholine receptors from ALS patients
    Eleonora Palma
    Dipartimento di Fisiologia e Farmacologia, Istituto Pasteur Fondazione Cenci Bolognetti, Universita Sapienza, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 108:20184-8. 2011
  8. pmc BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:1667-72. 2005
  9. pmc Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy
    D Ragozzino
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:15219-23. 2005
  10. pmc Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 101:10183-8. 2004

Collaborators

Detail Information

Publications22

  1. pmc Some properties of human neuronal alpha 7 nicotinic acetylcholine receptors fused to the green fluorescent protein
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le A Moro 5, I00185 Roma, Italy
    Proc Natl Acad Sci U S A 99:3950-5. 2002
    ..We also conclude that fused genes do not necessarily recapitulate all of the properties of the original receptors. This fact must be borne close in mind whenever reporter genes are attached to proteins...
  2. ncbi request reprint Microtransplantation of neurotransmitter receptors from cells to Xenopus oocyte membranes: new procedure for ion channel studies
    Ricardo Miledi
    Instituto de Neurobiologia, Campus UNAM Juriquilla, Mexico
    Methods Mol Biol 322:347-55. 2006
    ....
  3. ncbi request reprint Novel approaches to study the involvement of α7-nAChR in human diseases
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia e Farmacologia, Università di Roma LaSapienza, Rome, Italy
    Curr Drug Targets 13:579-86. 2012
    ..This review summarizes the current knowledge and recent findings obtained by these novel approaches...
  4. pmc Anomalous levels of Cl- transporters in the hippocampal subiculum from temporal lobe epilepsy patients make GABA excitatory
    E Palma
    Istituto Pasteur, Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 103:8465-8. 2006
    ....
  5. ncbi request reprint The antiepileptic drug levetiracetam stabilizes the human epileptic GABAA receptors upon repetitive activation
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Roma, Italy
    Epilepsia 48:1842-9. 2007
    ..Experiments were designed to investigate whether the antiepileptic drug, levetiracetam (LEV), which is used as an adjunctive treatment for medically intractable MTLE, counteracts the GABAA receptor run-down...
  6. pmc GABA(A)-current rundown of temporal lobe epilepsy is associated with repetitive activation of GABA(A) "phasic" receptors
    Eleonora Palma
    Dipartimento di Fisiologia Umana e Farmacologia Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 104:20944-8. 2007
    ..Our findings point to the rundown of GABA(A) receptors as a hallmark of TLE and suggest that modulating tonic and phasic mTLE GABA(A) receptor activity may represent a useful therapeutic approach to the disease...
  7. pmc Physiological characterization of human muscle acetylcholine receptors from ALS patients
    Eleonora Palma
    Dipartimento di Fisiologia e Farmacologia, Istituto Pasteur Fondazione Cenci Bolognetti, Universita Sapienza, 00185 Rome, Italy
    Proc Natl Acad Sci U S A 108:20184-8. 2011
    ..The two methods described here will be important tools for elucidating the role of muscle in ALS pathogenesis and for developing drugs to counter the effects of this disease...
  8. pmc BDNF modulates GABAA receptors microtransplanted from the human epileptic brain to Xenopus oocytes
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:1667-72. 2005
    ....
  9. pmc Rundown of GABA type A receptors is a dysfunction associated with human drug-resistant mesial temporal lobe epilepsy
    D Ragozzino
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:15219-23. 2005
    ....
  10. pmc Phosphatase inhibitors remove the run-down of gamma-aminobutyric acid type A receptors in the human epileptic brain
    E Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza di Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 101:10183-8. 2004
    ..Blockage of phosphatases stabilizes the TLE GABA(A) receptors and strengthens GABAergic inhibition. It may be that this process can be targeted to develop new treatments for intractable epilepsy...
  11. ncbi request reprint Properties of neuronal alpha7 mutant nicotinic acetylcholine receptors gated by bicuculline
    Raffaella Tonini
    Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, I 00185 Rome, Italy
    Neuropharmacology 44:765-71. 2003
    ..Therefore, the gating kinetics of both L248T and L247R-C189S-C190S receptor-channels change when BIC is replaced by ACh; and we conclude that both ACh and BIC activate mutant alpha7 receptors with different patterns of activation...
  12. ncbi request reprint Serotonin antagonizes the human neuronal alpha7 nicotinic acetylcholine receptor and becomes an agonist after L248T alpha7 mutation
    S Fucile
    Istituto Pasteur Fondazione Cenci Bolognetti, Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Viale Regina Elena 324, I 00161 Rome, Italy
    Neuroscience 110:169-79. 2002
    ....
  13. doi request reprint Microtransplantation of ligand-gated receptor-channels from fresh or frozen nervous tissue into Xenopus oocytes: a potent tool for expanding functional information
    F Eusebi
    Dipartimento di Fisiologia e Farmacologia Centro di Eccellenza BEMM, Universita di Roma Sapienza, Piazzale A Moro 5, I00185 Roma, Italy
    Prog Neurobiol 88:32-40. 2009
    ..This review focuses on recently obtained information and on some new lines of biological research using receptor microtransplantation into oocytes...
  14. pmc Two forms of acetylcholine receptor gamma subunit in mouse muscle
    A M Mileo
    Laboratorio di Biofisica, Centro Ricerca Sperimentale, IRE, Rome, Italy
    Proc Natl Acad Sci U S A 92:2686-90. 1995
    ..The gamma s subunit may, thus, contribute to the structural and functional diversity of nAcChoRs in muscle cells...
  15. pmc Abnormal GABAA receptors from the human epileptic hippocampal subiculum microtransplanted to Xenopus oocytes
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Centro di Eccellenza Biologia e Medicina Molecolare, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 102:2514-8. 2005
    ..This abnormal behavior of the subiculum GABAA receptors may contribute to epileptogenesis...
  16. pmc Blockage of A2A and A3 adenosine receptors decreases the desensitization of human GABA(A) receptors microtransplanted to Xenopus oocytes
    Cristina Roseti
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia Centro di Eccellenza BEMM, Universita di Roma La Sapienza, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 106:15927-31. 2009
    ....
  17. ncbi request reprint Visual event-related potentials in elite and amateur athletes
    Claudio Del Percio
    Istituto di Medicina e Scienza dello Sport, CONI Servizi, Via dei Campi Sportivi 46, Roma, Italy
    Brain Res Bull 74:104-12. 2007
    ..These results support the hypothesis that peculiar mechanisms of occipital neural synchronization can be observed in elite athletes during visuo-spatial demands, possibly to underlie sustained visuo-spatial attention and self-control...
  18. pmc Expression of functional neurotransmitter receptors in Xenopus oocytes after injection of human brain membranes
    Ricardo Miledi
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 99:13238-42. 2002
    ....
  19. pmc The single-channel properties of human acetylcholine alpha 7 receptors are altered by fusing alpha 7 to the green fluorescent protein
    Sergio Fucile
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, P le A Moro 5, I00185 Rome, Italy
    Proc Natl Acad Sci U S A 99:3956-61. 2002
    ..All this evidence shows that GFP-tagging can alter importantly receptor kinetics, a fact that has to be taken into account whenever tagged proteins are used to study their function...
  20. pmc Microtransplantation of membranes from cultured cells to Xenopus oocytes: a method to study neurotransmitter receptors embedded in native lipids
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale Aldo Moro 5, I 00185 Rome, Italy
    Proc Natl Acad Sci U S A 100:2896-900. 2003
    ..All this makes the Xenopus oocyte a powerful tool for detailed investigations of receptors and other proteins expressed in the membrane of cultured cells...
  21. pmc Expression of human epileptic temporal lobe neurotransmitter receptors in Xenopus oocytes: An innovative approach to study epilepsy
    Eleonora Palma
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Universita di Roma La Sapienza, Piazzale A Moro 5, Italy
    Proc Natl Acad Sci U S A 99:15078-83. 2002
    ..Our findings are in accord with the concept that both a depression of GABA inhibition and a dysfunction of the KAI-receptor system maintain a high neuronal excitability that results in epileptic seizures...
  22. pmc Amyloid beta(1-42) peptide alters the gating of human and mouse alpha-bungarotoxin-sensitive nicotinic receptors
    Francesca Grassi
    Istituto Pasteur Fondazione Cenci Bolognetti and Dipartimento di Fisiologia Umana e Farmacologia, Università La Sapienza Ple A Moro 5, I 00185 Roma, Italy
    J Physiol 547:147-57. 2003
    ..We also report that the inverse peptide Abeta(42-1), but not Abeta(40-1), partially mimicked the effects of the physiological Abeta(1-42) peptide. Possible implications for degenerative neuronal and muscular diseases are discussed...