P Palatini

..This increased risk may be attributed to worsening of their lifestyle profiles over time. Healthy lifestyles should be emphasized to all hypertensive individuals including patients with favorable lifestyle profiles...

..In conclusion, our findings indicate that carotid IMT is greater and grows faster in white-coat hypertensive subjects than in normotensive subjects without significant differences with sustained hypertensive patients...

..To examine the impact of overweight and obesity on development of target organ damage in the early stage of hypertension...

..We studied the effect of two phosducin polymorphisms on risk of hypertension in 273 overweight or obese (Ov-Ob) young-to-middle-age participants from the HARVEST and 287 normal weight (NW) participants...

..Whether glomerular hyperfiltration is implicated in the development of microalbuminuria in hypertension is not well known. This prospective study investigated the relationship between changes in GFR and microalbuminuria in hypertension...

..Caution should be used in subjects with more severe hypertension and every hypertensive athlete should be thoroughly investigated to exclude target organ damage and coronary artery disease...

..Aim of this study was to examine which clinical variables influence GFR in the early stage of hypertension...

..Continuous technology improvement of instrumentation for SBPM can be achieved through close cooperation between manufacturers and validation centers...

..The aim of this study was to ascertain whether cylindrical and tronco-conical cuffs provide different readings according to arm size and shape...

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..We did a prospective study to investigate whether glomerular hyperfiltration assessed from serum cystatin C predicts development of microalbuminuria in hypertension...

..The many methodological problems associated with the use of this technique suggest that ABPM is performed only by experienced doctors...

..Treatment of high heart rate in healthy subjects appears to be premature, but in clinical conditions such as hypertension or diabetes, the reduction of elevated heart rate appears a desirable additional goal of therapy...

..The impressive amount of available epidemiologic data show support for the continued effort to raise awareness of the clinical importance of resting heart rate among health care professionals...

..8%). Aliskiren 300 mg provided a sustained BP-lowering effect beyond the 24-h dosing interval, with a significantly smaller loss of BP-lowering effect in the 24-48 h period after dose than irbesartan 300 mg or ramipril 10 mg...

..The objective of this study was to investigate the effect of regular physical activity on the haemodynamic response to public speaking and to evaluate the long-term effect of exercise on development of hypertension...

..To compare the blood pressure (BP) response to doctor's visit with the BP reaction to a psycho-social challenge and with the difference between clinic and daytime BP (DeltaC-D)...

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..To study the effect of leisure-time physical activity on the progression of carotid intima-media thickness (IMT) in the early stage of hypertension...

..They performed three speech tasks with neutral, anger and anxiety scenarios. BP was assessed with the Finometer beat-to-beat non-invasive recording system throughout the test procedure...

..To examine the association of clinic and ambulatory heart rate with total, cardiovascular, and noncardiovascular death in a cohort of elderly subjects with isolated systolic hypertension from the Systolic Hypertension in Europe Trial...

..The purpose of this study was to describe gender differences in TO involvement in a cohort of young-to-middle-aged subjects screened for stage 1 hypertension and followed for 8.2 years...

..The aim of this study was to compare the BP readings obtained at the arm with those obtained at the forearm and to assess whether the wrist-arm discrepancies were related to subjects' clinical characteristics...

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..The aim of the present study was to investigate the effect of coffee intake on the risk of developing hypertension needing antihypertensive treatment in individuals stratified by CYP1A2 genotype...

..In light of this evidence, heart rate should be included among the major risk factors for coronary heart disease...

..We carried out a prospective study to investigate whether clinic and ambulatory heart rates assessed at baseline and changes in clinic heart rate during 6 months of follow-up were independent predictors of subsequent blood pressure (BP)...

..Early intervention with medical therapy may be beneficial in these subjects even if their blood pressure falls below normal limits during follow-up...

..The f-channel blockers, selective heart rate-lowering agents with no effect on blood pressure, could also be profitably used in hypertensive subjects with fast heart rate...

..Unfortunately, lowering of the heart rate is not a clinically recognised goal. Prospective trials investigating whether treatment of high heart rate can prevent cardiovascular events, notably in hypertensive patients, are warranted...

..Data obtained with ambulatory or home measurement did not show any advantage of heart rate measured out of the office over clinic heart rate, but the available evidence is still limited and more research is needed...

..The BP W200-1 model features a 'Microlife Average Mode', which uses a 'weighted' average of a minimum of three consecutive blood pressure (BP) readings taken 15 s apart...

..Recent studies have shown that angiotensin II receptor blockers, given alone or combined with a diuretic, may prevent some cardiovascular outcomes independent of their blood pressure-lowering efficacy...

..The aim of the study was to investigate the effect of polymorphism A1166C for AGTR1 and -1332G/A for AGTR2 on the incidence of sustained hypertension (HT) and metabolic syndrome in a cohort of young patients screened for stage 1 HT...

..We did a prospective study to investigate the long-term effect of regular physical activity on development of LV hypertrophy (LVH) in a cohort of young subjects screened for Stage 1 hypertension...

..Further research is needed to determine whether the use of ambulatory blood pressure monitoring is cost-effective in these subjects...

..Several studies have found that measurement of blood pressure (BP) in the clinical setting may lead to overestimation of hypertension and may yield inaccurate assessments of the efficacy of antihypertensive treatment...

..In conclusion, these data show that the Microlife BP W100 wrist monitor satisfied the recommended ESH accuracy levels and achieved A/A grade of the BHS protocol across a wide range of blood pressure...

..Autonomic nervous system abnormality is also associated with such pressure-unrelated cardiovascular risk factors as tachycardia, high hematocrit, insulin resistance, and obesity. Mechanisms of this association are discussed...

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..The longitudinal relationship between coffee use and hypertension is not well known. Aim. We did a prospective study to investigate if there is a temporal relationship between coffee consumption and development of sustained hypertension...

..Arterial stiffness and its consequences represent the great challenge of the twenty-first century for affluent countries, and "de-stiffening" will be the goal of the next decades...

..Little is known about the determinants of atrial size, and no study has analyzed whether genetic factors are involved in the pathogenesis of LA enlargement...

..To focus on the reliability of ambulatory blood pressure monitoring and on its limitations in clinical practice, and to construct adequate strategies to improve ambulatory monitoring performance...

..Thus, ABPM appears mandatory to better define the hypertensive status in these subjects because it provides information on diurnal BP rhythm and variability and allows identification of subjects with white-coat and masked hypertension...

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..Blood pressure levels are a main determinant of m-IMT while the interaction of BP with other risk factors such as age and plasma lipids is more relevant for advanced intima-media thickening such as M-MAX...

..In conclusion, survival of diabetic patients is worse than that of non-diabetic coeval subjects. Only few items are able to predict cardiovascular mortality in the diabetics, namely age, hypertension, CAD, macro- and microalbuminuria...

..Finally, the lack of correlation between AER and left ventricular mass suggests that renal and cardiac involvement do not occur in a parallel fashion in the initial phase of hypertension...

..We speculate that the degree of beta-adrenergic responsiveness may be a major determinant of the phenotypic differences between the parents and offspring found in this study...

..To determine whether the prediction of target-organ damage varies according to the reproducibility of 24 h blood pressure...

..In this study, we tested the hypothesis that sympathetic over-activity may cause metabolic abnormalities and affect left ventricular (LV) structure and mass early in life...

..Results indicate that heart rate recorded over the 24 hours has a better reproducibility than office heart rate, and could thus be a better prognostic indicator than traditional measurement of resting heart rate in the hospital setting...

..0001). In conclusion, the present results indicated that in mildly hypertensive subjects an increased left ventricular wall thickness is crucial in preserving left ventricular pump function during exercise...

..This paper is aimed at demonstrating that leg peripheral resistance has circadian fluctuations which are modulated by spinal neural traffic...

..The evolution of hypertension (HT) subtypes in young-to-middle-age subjects is unclear...

..The present data indicate that changes in LV anatomy are the earliest signs of hypertensive cardiac involvement. Left ventricular filling is affected only marginally in the initial phase of hypertension...

..Peripheral resistance measured in the leg and in the forearm was greater in the former than in the latter, both during sleep and during waking...

..Left ventricular diastolic function is only marginally affected, even when multiple parameters of left ventricular filling are taken into account...

..This factor should be taken into consideration in population-based studies aimed at investigating supraortic vessels as it can act as a confounder...

..Alcohol's effect on LV wall thickness appears to be direct, whereas its action on albumin excretion rate seems to be mediated mainly by its effect on BP...

..To estimate the contribution of heredity to the variance in left ventricular mass (LVM), and to ascertain whether genetic factors may interact with non-genetic factors in promoting LVM growth...

..To compare the antihypertensive efficacy and tolerability of a once-daily fixed valsartan/hydrochlorothiazide (HCTZ) combination and amlodipine in subjects with mild-to-moderate hypertension...

..Since hyperaldosteronism has been experimentally related to myocardial interstitial fibrosis, we investigated the effects of hypertension and excess aldosterone due to aldosterone-producing adenomas (APAs) on the heart...

..This study was aimed at investigating whether a circadian rhythm of peripheral resistance exists in patients with orthotopic cardiac transplantation (OCT) and whether it parallels that of blood pressure (BP)...

..CONCLUSION: Urinary albumin assessed in the first week after acute myocardial infarction is a strong prognostic marker for 1-year mortality...

..To examine the association between heart rate and 12-year incidence rates of total and cardiovascular death in a cohort of elderly subjects stratified by sex...

..Hyperreactors were characterized by higher whole-day BP and by a hyperkinetic hemodynamic pattern as a result of increased sympathetic tone...

..001). These data show that the UA-85X satisfies the recommended ESH and Advancement of Medical Instrumentation accuracy levels for both systolic BP and diastolic BP...

..This dual action may represent an important advance in treatment of elevated blood pressure...

..CONCLUSIONS: These data show that the A&D UA-631 device satisfies the new recommended ESH accuracy levels for both SBP and DBP. Its performance seems to be better in subjects with stiffer arteries...

..All current trials investigate the effect of the treatment on secondary prevention of CV events among patients with advanced complicated diabetes and hypertension...

..Antihypertensive drugs that lower the heart rate seem to have a good potential for prolonging life expectancy in humans...

..This may account for the higher risk of stroke that has been described in this condition...

..Therefore we explored whether the GNB3 825T allele is associated with increased left ventricular mass index in a selected and homogeneous group of young, never treated, mild hypertensives...

..The numerous advantages summarized above make ABP monitoring an accepted method of BP measurement in hypertension therapy trials. Self-measurement of BP may be a valid and less expensive alternative to ABP monitoring...

..Taken together, these results demonstrate that cardiac DT-diaphorase does not contribute to ROS generation, but represents a detoxification system...

..Although a greater effect is expected in men, cardiac slowing could counteract the detrimental haemodynamic effect of tachycardia also in women...

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..In patients with tachycardia the reduction of HR appears a desirable additional goal of therapy...

..In this tissue, the GSH concentration determined by the fluorometric method was shown to be inversely correlated with the size of the sample, suggesting the presence of some quenching material...

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..We tested the hypothesis that a condition characterized by sympathetic predominance may affect the evolution of blood pressure and lipids in the early stage of hypertension...

..To determine the accuracy of the UA-787 oscillometric blood pressure monitor developed by the A&D Company...

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..Our results support the opinion that alternative methods of contraception should be considered for hypertensive women in place of oral contraceptives...

..7+/-6.9 mmHg for SBP and -1.1+/-4.3 mmHg for DBP. In conclusion, these results indicate that the Microlife WatchBP O3 monitor can be recommended for clinical use in the adult population...

..CONCLUSIONS: A diet rich in fish is associated with lower plasma leptin, independent of body fat. These findings may have implications for understanding the reduced cardiovascular risk in subjects on a high-fish diet...

..In conclusion, these results indicate that the UEBE Visomat Comfort form monitor can be recommended for clinical use in the adult population over a wide range of arm circumferences...

..7 +/- 5.3 mmHg for DBP, respectively. These data show that the UEBE visocor HM40 wrist monitor met the requirements for validation by the International Protocol and can be recommended for clinical use in the adult population...

..To determine whether the use of ambulatory blood pressure monitoring is cost-effective in these individuals, further research is needed...

..In conclusion, the present results indicate that the Microlife BP A100 monitor coupled with a single cuff with standard size bladder provides accurate blood pressure readings over a wide range of arm circumferences...

..5+/-5.7 mmHg for SBP and -1.4+/-5.3 mmHg for DBP. In conclusion, the present results show that the UEBE visomat comfort eco monitor can be recommended for clinical use in the adult population...

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..These data show that the Panasonic EW3106 and EW 3109 monitors satisfy the recommended European Society of Hypertension accuracy levels for SBP and DBP...

..We evaluated the relationship between decrease in BW and BP over time in 796 stage 1 hypertensives...

..The GNB3 825T allele may be considered a genetic marker of predisposition for hypertension...

..These pressure waves were added by computer to the sphygmic waves recorded intraarterially in the same subject during bicycle ergometry: the resultant tracing showed a beat-shaped pattern similar to that recorded during running...