Uberto Pagotto

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi request reprint [Pharmacological therapy of obesity]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:83S-93S. 2008
  2. ncbi request reprint [Endocannabinoid system and energy metabolism: physiology and pathophysiology]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:74S-82S. 2008
  3. ncbi request reprint The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    Uberto Pagotto
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy, and Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Germany
    Endocr Rev 27:73-100. 2006
  4. doi request reprint Autonomic disturbances in narcolepsy
    Giuseppe Plazzi
    Department of Neurological Sciences, University of Bologna Bologna, Italy
    Sleep Med Rev 15:187-96. 2011
  5. ncbi request reprint Active and total ghrelin concentrations in the newborn
    Piero Pirazzoli
    Department of Pediatrics, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Bologna, Italy
    J Pediatr Endocrinol Metab 18:379-84. 2005
  6. ncbi request reprint Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, S Orsola Malpighi General Hospital, Università Alma Mater Studiorum, Bologna 40138, Italy
    Lancet 365:1363-4. 2005
  7. ncbi request reprint The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
    Ann N Y Acad Sci 1083:111-28. 2006
  8. doi request reprint Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, St Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Endocrinol 164:53-60. 2011
  9. doi request reprint I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case report
    Ilaria Grassi
    Unità Operativa di Medicina Nucleare, Policlinico S Orsola Malpighi, Bologna, Italy
    Clin Nucl Med 36:124-6. 2011
  10. ncbi request reprint Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases
    Luigi Bellocchio
    Endocrinology Unit and CRBA, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Curr Opin Pharmacol 6:586-91. 2006

Collaborators

Detail Information

Publications32

  1. ncbi request reprint [Pharmacological therapy of obesity]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:83S-93S. 2008
    ..9 kg/m2 with major obesity-related comorbidities such as hypertension, diabetes, dyslipidemia, obstructive sleep apnea, and metabolic syndrome...
  2. ncbi request reprint [Endocannabinoid system and energy metabolism: physiology and pathophysiology]
    Uberto Pagotto
    UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
    G Ital Cardiol (Rome) 9:74S-82S. 2008
    ....
  3. ncbi request reprint The emerging role of the endocannabinoid system in endocrine regulation and energy balance
    Uberto Pagotto
    Endocrinology Unit, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy, and Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Germany
    Endocr Rev 27:73-100. 2006
    ..The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases, including obesity...
  4. doi request reprint Autonomic disturbances in narcolepsy
    Giuseppe Plazzi
    Department of Neurological Sciences, University of Bologna Bologna, Italy
    Sleep Med Rev 15:187-96. 2011
    ..We review here studies on autonomic functions and clinical disturbances in narcoleptic patients, trying to shed light on the possible contribute of alterations of the hypocretin system in autonomic pathophysiology...
  5. ncbi request reprint Active and total ghrelin concentrations in the newborn
    Piero Pirazzoli
    Department of Pediatrics, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Bologna, Italy
    J Pediatr Endocrinol Metab 18:379-84. 2005
    ..An acyl modification is indispensable for biological activity. Acylated and desacylated forms of ghrelin are both present in the blood. No data exist about the ratio between active ghrelin and total ghrelin in the first period of life...
  6. ncbi request reprint Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptors
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, S Orsola Malpighi General Hospital, Università Alma Mater Studiorum, Bologna 40138, Italy
    Lancet 365:1363-4. 2005
  7. ncbi request reprint The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
    Ann N Y Acad Sci 1083:111-28. 2006
    ....
  8. doi request reprint Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndrome
    Renato Pasquali
    Division of Endocrinology, Department of Clinical Medicine, St Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Eur J Endocrinol 164:53-60. 2011
    ..Objective This follow-up study aimed to investigate obese women with PCOS treated with a long-term lifestyle program to evaluate responsiveness and predictability...
  9. doi request reprint I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case report
    Ilaria Grassi
    Unità Operativa di Medicina Nucleare, Policlinico S Orsola Malpighi, Bologna, Italy
    Clin Nucl Med 36:124-6. 2011
    ..Traditionally, I-123 MIBG scintigraphy has been used in detecting chromaffin cell tumors, but more recently it had been demonstrated that a certain part of pheochromocytoma could be false-negative on scintigraphy...
  10. ncbi request reprint Cannabinoid receptors as therapeutic targets for obesity and metabolic diseases
    Luigi Bellocchio
    Endocrinology Unit and CRBA, Department of Internal Medicine and Gastroenterology, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    Curr Opin Pharmacol 6:586-91. 2006
    ....
  11. doi request reprint Here, there and everywhere: the endocannabinoid system
    Roberto Vettor
    J Neuroendocrinol 20:iv-vi. 2008
  12. ncbi request reprint Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemia
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry of the National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli Naples, Italy
    J Clin Endocrinol Metab 91:3171-80. 2006
    ..Cannabinoid CB(1) receptor blockade decreases weight and hyperinsulinemia in obese animals and humans in a way greatly independent from food intake...
  13. ncbi request reprint Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesity
    Valentina Vicennati
    Division of Endocrinology, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
    Obesity (Silver Spring) 14:235-43. 2006
    ..This study was carried out to investigate the role of sex in the regulation of the hypothalamic-pituitary-adrenal (HPA) axis and its relationship with testosterone levels in male and female obesity...
  14. ncbi request reprint The endocannabinoid system in the regulation of cardiometabolic risk factors
    Luigi Bellocchio
    Endocrinology Unit and Center for Applied Biomedical Research, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Am J Cardiol 100:7P-17P. 2007
    ..In addition, we provide evidence that supports the recently proposed hypothesis that a close association exists between obesity and overactivation of the EC system...
  15. ncbi request reprint The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's disease
    Roberta Giordano
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    Eur J Endocrinol 153:535-43. 2005
    ..The stomach is the major source of circulating ghrelin levels that are negatively associated with body mass, insulin and glucose levels. The role of glucocorticoids in ghrelin secretion and action is still unclear...
  16. ncbi request reprint Ghrelin as a potential anti-obesity target
    Tamas L Horvath
    Dept of Ob Gyn, Yale University School of Medicine, New Haven, CT, USA
    Curr Pharm Des 9:1383-95. 2003
    ..g. cardiovascular mechanisms, anti-proliferative effects, reproduction)...
  17. pmc The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    Daniela Cota
    Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 112:423-31. 2003
    ....
  18. ncbi request reprint Testosterone replacement therapy restores normal ghrelin in hypogonadal men
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, Sant Orsola Malpighi Hospital, University of Bologna, Bologna, Italy 40138
    J Clin Endocrinol Metab 88:4139-43. 2003
    ..This may be consistent with the concept that ghrelin may exert a relevant role in the endocrine network connecting the control of the reproductive system with the regulation of energy balance...
  19. ncbi request reprint Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levels
    Uberto Pagotto
    Endocrine Unit, Department of Internal Medicine and Gastroenterology, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, 40138 Bologna, Italy
    J Clin Endocrinol Metab 87:5625-9. 2002
    ..In addition, regardless of the presence of PCOS, a marked negative correlation exists between ghrelin and androstenedione levels, suggestive of an interaction between ghrelin and steroid synthesis or action...
  20. ncbi request reprint The endocannabinoid system and the treatment of obesity
    Uberto Pagotto
    Endocrinology Unit and Center for Applied Biomedical Research, Dept of Internal Medicine and Gastroenterology, S Orsola Malpighi General Hospital, Bologna, Italy
    Ann Med 37:270-5. 2005
    ....
  21. ncbi request reprint Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function
    Daniela Cota
    Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
    Endocrinology 148:1574-81. 2007
    ....
  22. ncbi request reprint Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled study
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 91:3970-80. 2006
    ..All these studies are, however, characterized by a short to medium period of treatment...
  23. ncbi request reprint In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells
    Ilaria Cavallari
    Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
    J Clin Endocrinol Metab 88:3893-901. 2003
    ..This report thus provides the first description of the expression pattern of menin in human pancreas in situ and lays the groundwork for further studies of other tissues and tumors...
  24. ncbi request reprint Efficacy of octreotide-LAR in dieting women with abdominal obesity and polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
    J Clin Endocrinol Metab 90:3854-62. 2005
    ..Somatostatin reduces LH, GH, and insulin, and somatostatin receptors are present at the ovarian level; somatostatin analogs are thus potential candidates for treatment of the polycystic ovary syndrome (PCOS)...
  25. ncbi request reprint Central effects of the somatotropic system
    Harald Jorn Schneider
    Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstr 10, 80804 Munich, Germany
    Eur J Endocrinol 149:377-92. 2003
    ..Pulsatile GH secretion is closely related to slow wave sleep (SWS) with SWS being stimulated by GH releasing hormone and rapid eye movement (REM) sleep by GH...
  26. pmc Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
    Laura Tedesco
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Diabetes 57:2028-36. 2008
    ..This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes...
  27. ncbi request reprint Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, University of Bologna, Italy
    Clin Endocrinol (Oxf) 60:241-9. 2004
    ....
  28. ncbi request reprint Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severity
    Elisabetta Bugianesi
    Division of Gastroenterology, University of Turin, Ospedale San Giovanni Battista, Corso Bramante 88, I 10126 Torino, Italy
    J Clin Endocrinol Metab 90:3498-504. 2005
    ..Hypoadiponectinemia in NAFLD is part of a metabolic disturbance characterized by ectopic fat accumulation in the central compartment...
  29. ncbi request reprint Circulating obestatin levels and the ghrelin/obestatin ratio in obese women
    Valentina Vicennati
    Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research CRBA, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138, Bologna, Italy
    Eur J Endocrinol 157:295-301. 2007
    ..We measured blood levels of obestatin, total ghrelin, and the ghrelin/obestatin ratio and their relationship with anthropometric and metabolic parameters, adiponectin and insulin resistance, in overweight/obese and normal-weight women...
  30. ncbi request reprint Insulin-like factor 3: a new circulating hormone related to luteinizing hormone-dependent ovarian hyperandrogenism in the polycystic ovary syndrome
    Alessandra Gambineri
    Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, Bologna, Italy
    J Clin Endocrinol Metab 92:2066-73. 2007
    ....
  31. ncbi request reprint Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factors
    Alessandra Gambineri
    U O di Endocrinologia, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico Sant Orsola Malpighi, Via Massarenti 9, 40138 Bologna, Italy
    Diabetes 53:2353-8. 2004
    ..Our findings indicate that PCOS patients with GI represent a subgroup with specific clinical and hormonal characteristics. Our observations may have an important impact in preventative and therapeutic strategies...