Research Topics
| Uberto PagottoSummaryAffiliation: University of Bologna Country: Italy Publications
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Detail Information
Publications
[Pharmacological therapy of obesity]Uberto Pagotto
UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
G Ital Cardiol (Rome) 9:83S-93S. 2008..9 kg/m2 with major obesity-related comorbidities such as hypertension, diabetes, dyslipidemia, obstructive sleep apnea, and metabolic syndrome...- [Endocannabinoid system and energy metabolism: physiology and pathophysiology]Uberto Pagotto
UO di Endocrinologia e Centro di Ricerca Biomedica Applicata CRBA, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico S Orsola Malpighi, Università Alma Mater Studiorum, Bologna
G Ital Cardiol (Rome) 9:74S-82S. 2008.... - The emerging role of the endocannabinoid system in endocrine regulation and energy balanceUberto Pagotto
Endocrinology Unit, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Bologna, Italy, and Department of Physiological Chemistry, Johannes Gutenberg University Mainz, Germany
Endocr Rev 27:73-100. 2006..The relevance of the system is further strenghtened by the notion that drugs interfering with the activity of the endocannabinoid system are considered as promising candidates for the treatment of various diseases, including obesity... - Active and total ghrelin concentrations in the newbornPiero Pirazzoli
Department of Pediatrics, Center for Applied Biomedical Research, S Orsola Malpighi Hospital, Bologna, Italy
J Pediatr Endocrinol Metab 18:379-84. 2005..An acyl modification is indispensable for biological activity. Acylated and desacylated forms of ghrelin are both present in the blood. No data exist about the ratio between active ghrelin and total ghrelin in the first period of life... - Fighting obesity and associated risk factors by antagonising cannabinoid type 1 receptorsUberto Pagotto
Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, S Orsola-Malpighi General Hospital, , Bologna 40138, Italy
Lancet 365:1363-4. 2005 - The hypothalamic-pituitary-adrenal axis activity in obesity and the metabolic syndromeRenato Pasquali
Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research C R B A, S Orsola Malpighi Hospital, University of Bologna, 40138 Bologna, Italy
Ann N Y Acad Sci 1083:111-28. 2006.... 
Autonomic disturbances in narcolepsyGiuseppe Plazzi
Department of Neurological Sciences, University of Bologna Bologna, Italy
Sleep Med Rev 15:187-96. 2011..We review here studies on autonomic functions and clinical disturbances in narcoleptic patients, trying to shed light on the possible contribute of alterations of the hypocretin system in autonomic pathophysiology...- Heterogeneity in the responsiveness to long-term lifestyle intervention and predictability in obese women with polycystic ovary syndromeRenato Pasquali
Division of Endocrinology, Department of Clinical Medicine, St Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
Eur J Endocrinol 164:53-60. 2011..Objective This follow-up study aimed to investigate obese women with PCOS treated with a long-term lifestyle program to evaluate responsiveness and predictability... - I-123 MIBG scintigraphy and 68Ga-DOTANOC PET/CT negative but F-18 DOPA PET/CT positive pheochromocytoma: a case reportIlaria Grassi
Unità Operativa di Medicina Nucleare, Policlinico S Orsola Malpighi, Bologna, Italy
Clin Nucl Med 36:124-6. 2011..Traditionally, I-123 MIBG scintigraphy has been used in detecting chromaffin cell tumors, but more recently it had been demonstrated that a certain part of pheochromocytoma could be false-negative on scintigraphy... - The endocannabinoid system in the regulation of cardiometabolic risk factorsLuigi Bellocchio
Endocrinology Unit and Center for Applied Biomedical Research, Department of Internal Medicine and Gastroenterology, Sant Orsola Malpighi Hospital, Alma Mater Studiorum, University of Bologna, Bologna, Italy
Am J Cardiol 100:7P-17P. 2007..In addition, we provide evidence that supports the recently proposed hypothesis that a close association exists between obesity and overactivation of the EC system... - Here, there and everywhere: the endocannabinoid systemRoberto Vettor
J Neuroendocrinol 20:iv-vi. 2008 - Cannabinoid receptors as therapeutic targets for obesity and metabolic diseasesLuigi Bellocchio
Endocrinology Unit and CRBA, Department of Internal Medicine and Gastroenterology, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
Curr Opin Pharmacol 6:586-91. 2006.... - Regulation, function, and dysregulation of endocannabinoids in models of adipose and beta-pancreatic cells and in obesity and hyperglycemiaIsabel Matias
Endocannabinoid Research Group, Institute of Biomolecular Chemistry of the National Research Council, Via Campi Flegrei 34, 80078 Pozzuoli (Naples, Italy
J Clin Endocrinol Metab 91:3171-80. 2006..CONCLUSIONS: Peripheral endocannabinoid overactivity might explain why CB(1) blockers cause weight-loss independent reduction of lipogenesis, of hypoadiponectinemia, and of hyperinsulinemia in obese animals and humans... - Sex difference in the relationship between the hypothalamic-pituitary-adrenal axis and sex hormones in obesityValentina Vicennati
Division of Endocrinology, S. Orsola-Malpighi Hospital, University Alma Mater Studiorum, Bologna, Italy
Obesity (Silver Spring) 14:235-43. 2006..In addition, it clearly seems that, as reported in normal weight subjects, a sex difference in the HPA axis activity still persists even in the presence of obesity... - The negative association between total ghrelin levels, body mass and insulin secretion is lost in hypercortisolemic patients with Cushing's diseaseRoberta Giordano
Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
Eur J Endocrinol 153:535-43. 2005..The stomach is the major source of circulating ghrelin levels that are negatively associated with body mass, insulin and glucose levels. The role of glucocorticoids in ghrelin secretion and action is still unclear... - Ghrelin as a potential anti-obesity targetTamas L Horvath
Dept. of Ob/Gyn, Yale University School of Medicine, New Haven, CT, USA
Curr Pharm Des 9:1383-95. 2003..g. cardiovascular mechanisms, anti-proliferative effects, reproduction)... 
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesisDaniela Cota
Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
J Clin Invest 112:423-31. 2003....- Testosterone replacement therapy restores normal ghrelin in hypogonadal menUberto Pagotto
Endocrine Unit, Department of Internal Medicine and Gastroenterology, and Center for Applied Biomedical Research, Sant'Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy 40138
J Clin Endocrinol Metab 88:4139-43. 2003..This may be consistent with the concept that ghrelin may exert a relevant role in the endocrine network connecting the control of the reproductive system with the regulation of energy balance... - Plasma ghrelin, obesity, and the polycystic ovary syndrome: correlation with insulin resistance and androgen levelsUberto Pagotto
Endocrine Unit, Department of Internal Medicine and Gastroenterology, Center for Applied Biomedical Research, S. Orsola-Malpighi Hospital, 40138 Bologna, Italy
J Clin Endocrinol Metab 87:5625-9. 2002..In addition, regardless of the presence of PCOS, a marked negative correlation exists between ghrelin and androstenedione levels, suggestive of an interaction between ghrelin and steroid synthesis or action... - The endocannabinoid system and the treatment of obesityUberto Pagotto
Endocrinology Unit and Center for Applied Biomedical Research, Dept of Internal Medicine and Gastroenterology, S Orsola Malpighi General Hospital, Bologna, Italy
Ann Med 37:270-5. 2005.... - Glucose intolerance in a large cohort of mediterranean women with polycystic ovary syndrome: phenotype and associated factorsAlessandra Gambineri
U.O. di Endocrinologia, Dipartimento di Medicina Interna e Gastroenterologia, Policlinico Sant' Orsola-Malpighi, Via Massarenti 9, 40138 Bologna, Italy
Diabetes 53:2353-8. 2004..Our findings indicate that PCOS patients with GI represent a subgroup with specific clinical and hormonal characteristics. Our observations may have an important impact in preventative and therapeutic strategies... - Efficacy of octreotide-LAR in dieting women with abdominal obesity and polycystic ovary syndromeAlessandra Gambineri
Division of Endocrinology, Department of Internal Medicine, Center for Applied Biomedical Research, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
J Clin Endocrinol Metab 90:3854-62. 2005..Restoration of ovulatory menstrual cycles appears to be another advantage of this treatment... - In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cellsIlaria Cavallari
Department of Oncology and Surgical Sciences, University of Padova, I 35128 Padova, Italy
J Clin Endocrinol Metab 88:3893-901. 2003..This report thus provides the first description of the expression pattern of menin in human pancreas in situ and lays the groundwork for further studies of other tissues and tumors... - Treatment with flutamide, metformin, and their combination added to a hypocaloric diet in overweight-obese women with polycystic ovary syndrome: a randomized, 12-month, placebo-controlled studyAlessandra Gambineri
Division of Endocrinology, Department of Internal Medicine, S. Orsola-Malpighi Hospital, Via Massarenti 9, 40138 Bologna, Italy
J Clin Endocrinol Metab 91:3970-80. 2006.... - Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytesLaura Tedesco
Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
Diabetes 57:2028-36. 2008..This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes... - Central effects of the somatotropic systemHarald Jorn Schneider
Max Planck Institute of Psychiatry, Department of Endocrinology, Kraepelinstr 10, 80804 Munich, Germany
Eur J Endocrinol 149:377-92. 2003..Pulsatile GH secretion is closely related to slow wave sleep (SWS) with SWS being stimulated by GH releasing hormone and rapid eye movement (REM) sleep by GH... - Effect of flutamide and metformin administered alone or in combination in dieting obese women with polycystic ovary syndromeAlessandra Gambineri
Division of Endocrinology, Department of Internal Medicine, S. Orsola-Malpighi Hospital, University of Bologna, Italy
Clin Endocrinol (Oxf) 60:241-9. 2004..Therefore, this study provides a rationale for specifically targeting different therapeutical options for PCOS according to the required outcomes... - Plasma adiponectin in nonalcoholic fatty liver is related to hepatic insulin resistance and hepatic fat content, not to liver disease severityElisabetta Bugianesi
Division of Gastroenterology, University of Turin, Ospedale San Giovanni Battista, Corso Bramante 88, I 10126 Torino, Italy
J Clin Endocrinol Metab 90:3498-504. 2005..Hypoadiponectinemia in NAFLD is part of a metabolic disturbance characterized by ectopic fat accumulation in the central compartment... - Insulin-like factor 3: a new circulating hormone related to luteinizing hormone-dependent ovarian hyperandrogenism in the polycystic ovary syndromeAlessandra Gambineri
Division of Endocrinology, Department of Internal Medicine, S Orsola Malpighi Hospital, Via Massarenti 9, Bologna, Italy
J Clin Endocrinol Metab 92:2066-73. 2007.... - Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis functionDaniela Cota
Group of Clinical Neuroendocrinology, Max Planck Institute of Psychiatry, Munich, Germany
Endocrinology 148:1574-81. 2007.... - Circulating obestatin levels and the ghrelin/obestatin ratio in obese womenValentina Vicennati
Division of Endocrinology, Department of Internal Medicine, Centre for Applied Biomedical Research CRBA, S Orsola Malpighi Hospital, University Alma Mater Studiorum, Via Massarenti 9, 40138, Bologna, Italy
Eur J Endocrinol 157:295-301. 2007..We measured blood levels of obestatin, total ghrelin, and the ghrelin/obestatin ratio and their relationship with anthropometric and metabolic parameters, adiponectin and insulin resistance, in overweight/obese and normal-weight women...