Giuseppe Paglietti

Summary

Affiliation: University of Sassari
Country: Italy

Publications

  1. ncbi request reprint Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxides
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 39:195-203. 2004
  2. ncbi request reprint Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari Italy
    Med Chem 2:113-22. 2006
  3. ncbi request reprint Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, Universita di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Med Chem 2:577-89. 2006
  4. ncbi request reprint Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Bioorg Med Chem 15:1914-27. 2007
  5. ncbi request reprint Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities
    Paola Corona
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 43:189-203. 2008
  6. ncbi request reprint [1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100, Sassari, Italy
    Bioorg Med Chem Lett 17:4791-4. 2007
  7. ncbi request reprint 2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: a new class of P-glycoprotein-mediated drug efflux inhibitors
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
    Med Chem 4:194-205. 2008
  8. doi request reprint Synthesis and in vitro antitumor activity of new quinoxaline derivatives
    Paola Corona
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 44:1579-91. 2009
  9. ncbi request reprint Styrylbenzimidazoles. Synthesis and biological activity - part 3
    Gabriella Vitale
    Dipartimento Farmaco Chimico Tossicologico, University of Sassari, Via Muroni, 23 07100 Sassari, Italy
    Med Chem 6:70-8. 2010

Collaborators

  • Sabrina Pricl
  • Paola Corona
  • Stefania Ferrari
  • Paola Molicotti
  • Antonio Carta
  • Paolo La Colla
  • Roberta Loddo
  • Mario Loriga
  • Sandra Piras
  • Gabriella Vitale
  • Cristina Ibba
  • Bernardetta Busonera
  • Maurizio Fermeglia
  • Marco Ferrone
  • Gabriella Collu
  • Stefania Zanetti
  • Gabriele Giliberti
  • Esther Marongiu
  • Bianca Paglietti
  • Michele Palomba
  • Tiziana Sanna
  • Sara Cannas
  • Giovanni Loriga
  • Barbara Secci
  • Paola Mollicotti
  • Leonardo Sechi
  • Antonella Mattana
  • Pier Luigi Fiori

Detail Information

Publications9

  1. ncbi request reprint Synthesis, anti-mycobacterial, anti-trichomonas and anti-candida in vitro activities of 2-substituted-6,7-difluoro-3-methylquinoxaline 1,4-dioxides
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 39:195-203. 2004
    ..5 microg/ml against representative strains of Gram-positive and Gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, Vibrio alginolyticus and Pseudomonas aeruginosa)...
  2. ncbi request reprint Synthesis of variously substituted 3-phenoxymethyl quinoxalin-2-ones and quinoxalines capable to potentiate in vitro the antiproliferative activity of anticancer drugs in multi-drug resistant cell lines
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari Italy
    Med Chem 2:113-22. 2006
    ..In this series, 17a turned out to be the most potent quinoxaline derivative in potentiating the antiproliferative activity of doxorubicin and vincristine against KB(MDR) and KB(V20C) resistant cell lines, respectively...
  3. ncbi request reprint Synthesis and in vitro evaluation of the anti-viral activity of N-[4-(1H(2H)-benzotriazol-1(2)-yl)phenyl]alkylcarboxamides
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Facolta di Farmacia, Universita di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Med Chem 2:577-89. 2006
    ..Title compounds were evaluated in silico against the Sb-1 helicase, as the crystal structure of this enzyme was not available, the corresponding 3D model was obtained by homology techniques (see Fig. 2)...
  4. ncbi request reprint Design, synthesis, and preliminary in vitro and in silico antiviral activity of [4,7]phenantrolines and 1-oxo-1,4-dihydro-[4,7]phenantrolines against single-stranded positive-sense RNA genome viruses
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Bioorg Med Chem 15:1914-27. 2007
    ..According to molecular dynamics simulations, compounds (15) and (17) emerged for its potency against the HCV NS5B, with a calculated IC50 of 11-12 microM...
  5. ncbi request reprint Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: evaluation of in vitro anti-cancer and anti-folate activities
    Paola Corona
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 43:189-203. 2008
    ..03microM), respectively, with comparable/better activities than Methotrexate (MTX). Docking calculations of the complexes of hDHFR with the most active compounds identified the binding mode of the described molecules with respect to MTX...
  6. ncbi request reprint [1,2,3]Triazolo[4,5-h]quinolones. A new class of potent antitubercular agents against multidrug resistant Mycobacterium tuberculosis strains
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100, Sassari, Italy
    Bioorg Med Chem Lett 17:4791-4. 2007
    ..5-3.2 microg/mL. 3c showed no cytotoxicity and proved to be the most potent derivative exhibiting MIC(90)=0.5 microg/mL against all M. tuberculosis strains and infected human macrophages (J774-A1) tested...
  7. ncbi request reprint 2(3)-Aryl-thio(oxy)-methylquinoxaline derivatives: a new class of P-glycoprotein-mediated drug efflux inhibitors
    Antonio Carta
    Dipartimento Farmaco Chimico Tossicologico, Via Muroni 23 A, 07100 Sassari, Italy
    Med Chem 4:194-205. 2008
    ..Furthermore, we can conclude that replacement of oxygen with sulphur atom did not improve the biological activity...
  8. doi request reprint Synthesis and in vitro antitumor activity of new quinoxaline derivatives
    Paola Corona
    Dipartimento Farmaco Chimico Tossicologico, Universita degli Studi di Sassari, Via Muroni 23 A, 07100 Sassari, Italy
    Eur J Med Chem 44:1579-91. 2009
    ..Within this series the benzylamino quinoxaline derivatives 1b-7b were the most active, whereas compound 2c showed the highest MG_MD value (-5.66)...
  9. ncbi request reprint Styrylbenzimidazoles. Synthesis and biological activity - part 3
    Gabriella Vitale
    Dipartimento Farmaco Chimico Tossicologico, University of Sassari, Via Muroni, 23 07100 Sassari, Italy
    Med Chem 6:70-8. 2010
    ..7 microM. Compounds 18 and 21 were equally active against CVB-2, with EC(50) values of 7 - 8 microM, while the derivative 30 was active against RSV with EC(50)= 1 microM and represents a new lead compound...