P Pagliaro

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. ncbi Coronary endothelial dysfunction after ischemia and reperfusion and its prevention by ischemic preconditioning
    Pasquale Pagliaro
    Department of Biological and Clinical Sciences, University of Turin, Turin, Italy
    Ital Heart J 4:383-94. 2003
  2. ncbi Role of the fuel utilized by tissues on coronary vessel response to physical stimuli in isolated rat hearts
    P Pagliaro
    Laboratory of Physiology, Department of Clinical and Biological Sciences, University of Torino, Italy
    Physiol Res 53:27-34. 2004
  3. ncbi Rethinking the renin-angiotensin system and its role in cardiovascular regulation
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Italy
    Cardiovasc Drugs Ther 19:77-87. 2005
  4. ncbi Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
    Free Radic Biol Med 34:33-43. 2003
  5. ncbi Mitochondrial ATP-sensitive channel opener does not induce vascular preconditioning, but potentiates the effect of a preconditioning ischemia on coronary reactive hyperemia in the anesthetized goat
    P Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Ospedale S Luigi, Regione Gonzole, 10043 Orbassano, TO, Italy
    Pflugers Arch 443:166-74. 2001
  6. ncbi Involvement of nitric oxide in ischemic preconditioning
    P Pagliaro
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Ital Heart J 2:660-8. 2001
  7. doi Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling
    Pasquale Pagliaro
    Department of Clinical and Biological Sciences, Universita di Torino, Regione Gonzole 10, Orbassano, Turin, Italy
    Antioxid Redox Signal 14:833-50. 2011
  8. ncbi The endothelium-derived hyperpolarizing factor: does it play a role in vivo and is it involved in the regulation of vascular tone only?
    P Pagliaro
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Ital Heart J 1:264-8. 2000
  9. ncbi Differential biological effects of products of nitric oxide (NO) synthase: it is not enough to say NO
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, 10041 Orbassano, Italy
    Life Sci 73:2137-49. 2003
  10. ncbi Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect
    R Rastaldo
    Dipartimento di Neuroscienze, Sezione di Fisiologia, , 10043 Orbassano, TO, Italy
    Am J Physiol Heart Circ Physiol 280:H2823-32. 2001

Collaborators

Detail Information

Publications58

  1. ncbi Coronary endothelial dysfunction after ischemia and reperfusion and its prevention by ischemic preconditioning
    Pasquale Pagliaro
    Department of Biological and Clinical Sciences, University of Turin, Turin, Italy
    Ital Heart J 4:383-94. 2003
    ....
  2. ncbi Role of the fuel utilized by tissues on coronary vessel response to physical stimuli in isolated rat hearts
    P Pagliaro
    Laboratory of Physiology, Department of Clinical and Biological Sciences, University of Torino, Italy
    Physiol Res 53:27-34. 2004
    ..It follows that the resulting shear stress is substrate-sensitive...
  3. ncbi Rethinking the renin-angiotensin system and its role in cardiovascular regulation
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Italy
    Cardiovasc Drugs Ther 19:77-87. 2005
    ..This mini review will summarize some new aspects concerning the recently discovered biological functions of RAS and in particular of ACE, ACE(2) and ACE-inhibitors in cardiovascular system...
  4. ncbi Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, Orbassano, Italy
    Free Radic Biol Med 34:33-43. 2003
    ....
  5. ncbi Mitochondrial ATP-sensitive channel opener does not induce vascular preconditioning, but potentiates the effect of a preconditioning ischemia on coronary reactive hyperemia in the anesthetized goat
    P Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Ospedale S Luigi, Regione Gonzole, 10043 Orbassano, TO, Italy
    Pflugers Arch 443:166-74. 2001
    ..01). In conclusion, PI alters CRH by decreasing THF and reducing the ttp of CRH. Whilst diazoxide does not reproduce the effects of PI on CRH, pre-treatment with diazoxide potentiates the effects of PI on THF...
  6. ncbi Involvement of nitric oxide in ischemic preconditioning
    P Pagliaro
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Ital Heart J 2:660-8. 2001
    ..It has been suggested that the activation of PKC-epsilon is mediated by peroxynitrite produced by the combination of NO and the superoxide anion, the latter being generated during reperfusion which follows preconditioning ischemia...
  7. doi Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling
    Pasquale Pagliaro
    Department of Clinical and Biological Sciences, Universita di Torino, Regione Gonzole 10, Orbassano, Turin, Italy
    Antioxid Redox Signal 14:833-50. 2011
    ..The cardioprotective signaling pathways are thought to converge on mitochondria, and various mitochondrial proteins have been identified as targets of these post-transitional modifications in both pre- and postconditioning...
  8. ncbi The endothelium-derived hyperpolarizing factor: does it play a role in vivo and is it involved in the regulation of vascular tone only?
    P Pagliaro
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Ital Heart J 1:264-8. 2000
    ....
  9. ncbi Differential biological effects of products of nitric oxide (NO) synthase: it is not enough to say NO
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Universita degli Studi di Torino, 10041 Orbassano, Italy
    Life Sci 73:2137-49. 2003
    ..In the light of the multitude of effects of NO, the role of this gas, their siblings and their derivatives in cardiac ischemic preconditioning scenario is more extensively analyzed...
  10. ncbi Cytochrome P-450 metabolite of arachidonic acid mediates bradykinin-induced negative inotropic effect
    R Rastaldo
    Dipartimento di Neuroscienze, Sezione di Fisiologia, , 10043 Orbassano, TO, Italy
    Am J Physiol Heart Circ Physiol 280:H2823-32. 2001
    ..One of these mediators appears to be 14,15-EET...
  11. ncbi Ischemic preconditioning: from the first to the second window of protection
    P Pagliaro
    , Orbassano, Italy
    Life Sci 69:1-15. 2001
    ..The production of heat shock proteins is considered a marker rather than a mechanism of SWOP...
  12. doi Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor
    C Penna
    Laboratories of Physiology and Pharmacology, Department of Clinical and Biological Sciences, University of Torino, Torino, Italy
    Acta Physiol (Oxf) 197:175-85. 2009
    ..The actual protection of ischaemic pre-conditioning occurs in the reperfusion phase. Therefore, we studied in this phase the kinases involved in PAF-induced pre-conditioning...
  13. doi Ischemia/reperfusion injury is increased and cardioprotection by a postconditioning protocol is lost as cardiac hypertrophy develops in nandrolone treated rats
    C Penna
    Department of Clinical and Biological Sciences, S Luigi Gonzaga Hospital, University of Turin, Orbassano, TO, Italy
    Basic Res Cardiol 106:409-20. 2011
    ..This increased susceptibility might be related to steroid-induced hypertrophy and/or to altered enzyme expression/phosphorylation...
  14. ncbi Cardioprotection against ischemia/reperfusion injury and chromogranin A-derived peptides
    C Penna
    Department of Clinical and Biological Sciences, University of Turin, Torino, Italy
    Curr Med Chem 19:4074-85. 2012
    ..Here, we review the literature about the cardiac effects of catestatin and vasostatin, the mechanisms of myocardial injury and protection and the role of CgA derived peptides in cardioprotection...
  15. ncbi The platelet activating factor triggers preconditioning-like cardioprotective effect via mitochondrial K-ATP channels and redox-sensible signaling
    C Penna
    Laboratories of Physiology, Department of Clinical and Biological Sciences, University of Turin, Italy
    J Physiol Pharmacol 59:47-54. 2008
    ..Infarct-sparing effect of PAF was abolished by N-acetyl-L-cysteine and 5-hydroxydecanoate. Thus, the cardioprotective effect exerted by PAF-pretreatment involves activation of mK(ATP) channels and redox signaling in pre-ischemic phase...
  16. ncbi Comparison between the effects of pentobarbital or ketamine/nitrous oxide anesthesia on metabolic and endothelial components of coronary reactive hyperemia
    R Rastaldo
    Dipartimento di Scienze Cliniche e Biologiche, Sezione di Fisiologia, , Italy
    Life Sci 69:729-38. 2001
    ..153+/-45 s, p<0.05). It is suggested that pentobarbital decreases the indices of CRH related to metabolic activity, whereas ketamine reduces the duration of the hyperemic response, which suggests an impairment of endothelial function...
  17. ncbi Fatty acids are important for the Frank-Starling mechanism and Gregg effect but not for catecholamine response in isolated rat hearts
    P Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche, Laboratorio di Fisiologia, dell Università di Torino, Torino, Italy
    Acta Physiol Scand 176:167-76. 2002
    ....
  18. ncbi Nitric oxide and cardiac function
    R Rastaldo
    Department of Neurosciences, Physiology Division, University of Turin, Turin, Italy
    Life Sci 81:779-93. 2007
    ..In particular, while in the basal control of contractility, endothelial synthase has a predominant role, the inducible isoform is mainly responsible for the cardiodepression in septic shock...
  19. doi The paradigm of postconditioning to protect the heart
    C Penna
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, Torino, Italy
    J Cell Mol Med 12:435-58. 2008
    ..Pharmacological PostC and possibly remote PostC may have a promising future in clinical scenario...
  20. ncbi Low concentrations of an nitric oxide-donor combined with a liposoluble antioxidant compound enhance protection against reperfusion injury in isolated rat hearts
    R Rastaldo
    University of Turin, Department of Clinical and Biological Sciences, Turin, Italy
    J Physiol Pharmacol 61:21-7. 2010
    ..It is likely that a different NO-induced release of reactive oxygen species via mKATP channel activation may play a pivotal role in affecting infarct size and post-ischemic contractile recovery...
  21. ncbi Synergistic effects against post-ischemic cardiac dysfunction by sub-chronic nandrolone pretreatment and postconditioning: role of beta2-adrenoceptor
    C Penna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Italy
    J Physiol Pharmacol 59:645-59. 2008
    ..Intriguingly, ND-pretreatment potentiates the improvement of systolic function induced by postconditioning via beta(2)-adrenoreceptor activation...
  22. ncbi Post-conditioning reduces infarct size in the isolated rat heart: role of coronary flow and pressure and the nitric oxide/cGMP pathway
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, TO, Italy
    Basic Res Cardiol 101:168-79. 2006
    ..The benefits of M- and CPost-con are similar. However, protection by Post-con is greater in the constant-flow than in the constant-pressure model...
  23. ncbi The effects of ischemic preconditioning on resting coronary flow and reactive hyperemia: involvement of A1 adenosine receptors
    P Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, Italy
    Life Sci 64:1071-8. 1999
    ..The results suggest that ischemic preconditioning reduces the coronary hyperemic response by decreasing the myocardial metabolism through the activation of the A1 adenosine receptors...
  24. ncbi Model-based assessment of pressure and flow-dependent coronary responses following abrupt pressure drops
    C Guiot
    Dip Neuroscienze sez Fisiologia, dell Università di Torino, Torino, Italy
    Comput Biol Med 30:111-26. 2000
    ..The parameter values were assessed by comparing the model predicted coronary flow with the one actually measured in animals...
  25. ncbi Systolic coronary flow impediment in the dog: role of ventricular pressure and contractility
    P Pagliaro
    Division of Biomedical Sciences, King s College London, London WC2R 2LS, UK
    Exp Physiol 83:821-31. 1998
    ..When systolic pressure exceeds 100 mmHg the shielding effect is overcome and the amplitude of the systolic flow reduction varies with ventricular pressure...
  26. ncbi Intermittent activation of bradykinin B2 receptors and mitochondrial KATP channels trigger cardiac postconditioning through redox signaling
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, dell Università di Torino, Italy
    Cardiovasc Res 75:168-77. 2007
    ..Postconditioning (PostC) maneuvers allow post-ischemic accumulation of autacoids, which trigger protection. We tested if PostC-triggering includes bradykinin (BK) B2 receptor activation and its downstream pathway...
  27. ncbi [Ischemic postconditioning: an effective strategy of myocardial protection?]
    Raffaella Rastaldo
    Sezione di Fisiologia, Dipartimento di Neuroscienze, Universita degli Studi, Torino
    G Ital Cardiol (Rome) 7:464-73. 2006
    ..In the rat, such a procedure reduced the infarct size to a greater extent than post-conditioning. Moreover, an additive effect of NO donors and antioxidant compounds is possible...
  28. doi Omega 3 has a beneficial effect on ischemia/reperfusion injury, but cannot reverse the effect of stressful forced exercise
    Daniele Mancardi
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Orbassano, Torino, Italy
    Nutr Metab Cardiovasc Dis 19:20-6. 2009
    ..Here, we investigate the impact of stressful FE and an omega 3-FFA-enriched diet on cardiac tolerance to ischemic events over one month...
  29. ncbi Limited plasticity of mesenchymal stem cells cocultured with adult cardiomyocytes
    Maria Pia Gallo
    Department of Animal and Human Biology, University of Torino, Torino, Italy
    J Cell Biochem 100:86-99. 2007
    ....
  30. ncbi [Activity of apelin and APJ receptors on myocardial contractility and vasomotor tone]
    Gianni Losano
    Sezione di Fisiologia, Dipartimento di Neuroscienze, Universita degli Studi, Torino
    Ital Heart J Suppl 6:272-8. 2005
    ..On the contrary, when the peptide is administered for 2 weeks, cardiac output increases significantly without the occurrence of cardiac hypertrophy. It is not excluded that hypertrophy might occur after a longer administration...
  31. pmc Physiological and pharmacological features of the novel gasotransmitter: hydrogen sulfide
    Daniele Mancardi
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Biochim Biophys Acta 1787:864-72. 2009
    ..We will also provide available information on H(2)S-donating drugs which have so far been tested in order to conjugate the beneficial effect of H(2)S with other pharmaceutical properties...
  32. doi Diazoxide postconditioning induces mitochondrial protein S-Nitrosylation and a redox-sensitive mitochondrial phosphorylation/translocation of RISK elements: no role for SAFE
    C Penna
    Dipartimento di Scienze Cliniche e Biologiche, Facoltà di Medicina e Chirurgia S Luigi Gonzaga, Universita di Torino, Regione Gonzole 10, 10043, Orbassano, TO, Italy
    Basic Res Cardiol 108:371. 2013
    ..Intriguingly, phospho-STAT3 translocation is induced by I-PostC, but not by P-PostC, thus suggesting a redox-independent mechanism in the SAFE pathway. ..
  33. doi Postconditioning induces an anti-apoptotic effect and preserves mitochondrial integrity in isolated rat hearts
    Claudia Penna
    Department of Clinical and Biological Sciences, University of Turin, Italy
    Biochim Biophys Acta 1787:794-801. 2009
    ..g. cytochrome c, iii) preserves the mitochondrial structure, and iv) limits the migration of phospho-Cx43 to mitochondria...
  34. doi Early homing of adult mesenchymal stem cells in normal and infarcted isolated beating hearts
    Claudia Penna
    Department of Clinical and Biological Sciences, University of Turin, Italy
    J Cell Mol Med 12:507-21. 2008
    ..The results show (i) that MSCs start to change marker expression few hours after injection into a beating heart and (ii) that infarcted myocardium influences transplanted MSC morphology and mobility within the heart...
  35. ncbi Human recombinant chromogranin A-derived vasostatin-1 mimics preconditioning via an adenosine/nitric oxide signaling mechanism
    Sandra Cappello
    Dipartimento di Neuroscienze, Sezione di Fisiologia, Universita di Torino, Corso Raffaello 30, 10125 Turin, Italy
    Am J Physiol Heart Circ Physiol 293:H719-27. 2007
    ..As with repeated brief preconditioning ischemia, hrSTA-CgA(1-78) may be considered a stimulus strong enough to trigger both pathways, which may converge on PKC...
  36. ncbi Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, ASO S Luigi, Orbassano, Italy
    Am J Physiol Heart Circ Physiol 288:H2512-20. 2005
    ..Moreover, the study suggests that endogenous release of PAF, induced by brief periods of ischemia and reperfusion, may participate to the triggering of the IP of the heart...
  37. doi Intermittent adenosine at the beginning of reperfusion does not trigger cardioprotection
    Claudia Penna
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    J Surg Res 153:231-8. 2009
    ..Intermittent infusion of either bradykinin or diazoxide during early reperfusion triggered PostC protection via redox signaling. Here we tested whether intermittent adenosine (ADO) may trigger PostC-like cardioprotection...
  38. ncbi Post-conditioning induced cardioprotection requires signaling through a redox-sensitive mechanism, mitochondrial ATP-sensitive K+ channel and protein kinase C activation
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Ospedale S Luigi, Regione Gonzole, 10043, Orbassano, TO, Italy
    Basic Res Cardiol 101:180-9. 2006
    ..Our data show that Post-C induced protection involves an early redox-sensitive mechanism as well as a persistent activation of mK(ATP) and PKC, suggesting that the mK(ATP)/ROS/PKC pathway is involved in post-conditioning...
  39. doi Postconditioning cardioprotection against infarct size and post-ischemic systolic dysfunction is influenced by gender
    Claudia Penna
    Dip to di Scienze Cliniche e Biologiche, Universita di Torino, Regione Gonzole 10, 10043, Orbassano, TO, Italy
    Basic Res Cardiol 104:390-402. 2009
    ..Results suggest that improvement of systolic function is mainly due to the anti-necrotic rather than to the anti-stunning effect exerted by PostC...
  40. ncbi Effect of endothelins on the cardiovascular system
    Claudia Penna
    Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
    J Cardiovasc Med (Hagerstown) 7:645-52. 2006
    ..The chronic effect of ETs on the myocardium results in hypertrophy and prevention of apoptosis, two processes that are together responsible for the contradictory effect of ETs in heart failure...
  41. doi Postconditioning and intermittent bradykinin induced cardioprotection require cyclooxygenase activation and prostacyclin release during reperfusion
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Regione Gonzole 10, 10043, Orbassano, TO, Italy
    Basic Res Cardiol 103:368-77. 2008
    ..These data suggest that COX must not be inhibited to have PostC protection. This finding should be kept present by future clinical studies on PostC...
  42. ncbi F0F1 ATP synthase activity is differently modulated by coronary reactive hyperemia before and after ischemic preconditioning in the goat
    Claudia Penna
    Sezione di Fisiologia, Dipartimento di Neuroscienze and Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, 10100 Turin, Italy
    Am J Physiol Heart Circ Physiol 287:H2192-200. 2004
    ..The increase in ATP concentration after preconditioning is in agreement with previous reports of reduced ATP hydrolysis by cytoplasmic ATPases...
  43. doi Effects of a protocol of ischemic postconditioning and/or captopril in hearts of normotensive and hypertensive rats
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, dell Università di Torino, Regione Gonzole 10, 10043 Orbassano TO, Italy
    Basic Res Cardiol 105:181-92. 2010
    ..Data show that PostC protection against infarct size is blunted in SHR and that PostC is unable to add its protective effect to those of chronic Captopril, which per se reduces cardiac hypertrophy and heart susceptibility to I/R insult...
  44. ncbi Ischemic preconditioning changes the pattern of coronary reactive hyperemia regardless of mitochondrial ATP-sensitive K(+) channel blockade
    Pasquale Pagliaro
    Dipartimento di Scienze Cliniche e Biologiche dell Università di Torino, Orbassano, Italy
    Life Sci 71:2299-309. 2002
    ..These results demonstrate that the changes induced in CRH by preconditioning are independent of the opening of the mitochondrial ATP-sensitive K(+) channels...
  45. doi Apelin-13 limits infarct size and improves cardiac postischemic mechanical recovery only if given after ischemia
    Raffaella Rastaldo
    Dipartimento di Scienze Cliniche e Biologiche, Facoltà di Medicina e Chirurgia S Luigi Gonzaga, Regione Gonzole 10, 10043 Orbassano TO Italy
    Am J Physiol Heart Circ Physiol 300:H2308-15. 2011
    ..Apelin-13 protects the heart only if given after ischemia. In this protection NO plays an important role. Apelin-13 efficiency as postconditioning mimetic cannot be explained by the increased APJ level...
  46. pmc Morphological characterization of GFP stably transfected adult mesenchymal bone marrow stem cells
    Stefania Raimondo
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, TO, Italy
    J Anat 208:3-12. 2006
    ..e. those derived from rat bone marrow transfected with green fluorescent protein. The results provide a basis for experimental studies of the differentiation of these cells in normal and pathological tissues...
  47. ncbi Nandrolone-pretreatment enhances cardiac beta(2)-adrenoceptor expression and reverses heart contractile down-regulation in the post-stress period of acute-stressed rats
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Ospedale S Luigi, Regione Gonzole, 10043 Orbassano, TO, Italy
    J Steroid Biochem Mol Biol 107:106-13. 2007
    ..This might represent a risk for cardiovascular incidents in anabolic steroid addicts under stressing conditions...
  48. ncbi Effect of differences in post-exercise lactate accumulation in athletes' haemodynamics
    Antonio Crisafulli
    Department of Science Applied to Biological Systems, Section of Human Physiology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Appl Physiol Nutr Metab 31:423-31. 2006
    ..Nevertheless, mechanisms controlling the cardiovascular apparatus successfully prevented a drop in blood pressure in spite of the cardiovascular stress...
  49. ncbi Muscle metaboreflex-induced increases in stroke volume
    Antonio Crisafulli
    Interdepartmental Centre of Technologies and Environments Related to Sport, University of Cagliari, Cagliari, Italy
    Med Sci Sports Exerc 35:221-8; discussion 229. 2003
    ..The aim of this study was to evaluate changes in central hemodynamics occurring during the metaboreflex activation...
  50. ncbi Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm
    David A Wink
    Tumor Biology Section, Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bldg 10, Rm B3 B69, Bethesda, MD 20892, USA
    Am J Physiol Heart Circ Physiol 285:H2264-76. 2003
    ..This article discusses the emerging aspects of HNO chemistry and attempts to provide a framework for the distinct effects of NO and HNO in vivo...
  51. ncbi Delayed preconditioning-mimetic actions of exercise or nitroglycerin do not affect haemodynamics and exercise performance in trained or sedentary individuals
    Antonio Crisafulli
    Department of Sciences Applied to Biological Systems, Section of Human Physiology, University of Cagliari, Cagliari, Italy
    J Sports Sci 25:1393-401. 2007
    ..Moreover, nitroglycerin pre-treatment does not ameliorate endothelial function...
  52. ncbi Modulation of cardiac contractility by muscle metaboreflex following efforts of different intensities in humans
    Antonio Crisafulli
    Dept of Science Applied to Biological Systems, University of Cagliari, 09124 Cagliari, Italy
    Am J Physiol Heart Circ Physiol 291:H3035-42. 2006
    ..Moreover, the cardiovascular response during metaboreflex is not merely achieved by vasoconstriction alone, but it appears that there is a complex interplay between peripheral vasoconstriction and heart contractility recruitment...
  53. ncbi Haemodynamic responses following intermittent supramaximal exercise in athletes
    Antonio Crisafulli
    Department of Sciences Applied to Biological Systems, Section of Human Physiology, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Exp Physiol 89:665-74. 2004
    ....
  54. ncbi Impaired central hemodynamic response and exaggerated vasoconstriction during muscle metaboreflex activation in heart failure patients
    Antonio Crisafulli
    Department of Science Applied to Biological Systems, University of Cagliari, Via Porcell 4, 09124 Cagliari, Italy
    Am J Physiol Heart Circ Physiol 292:H2988-96. 2007
    ..The incapacity to enhance cardiac performance and stroke volume is probably the primary cause of this cardiovascular alteration...
  55. ncbi Myocardial protection from ischemic preconditioning is not blocked by sub-chronic inhibition of carnitine palmitoyltransferase I
    Claudia Penna
    Dipartimento di Scienze Cliniche e Biologiche dell Università degli Studi di Torino, Orbassano TO, Italy
    Life Sci 77:2004-17. 2005
    ....
  56. ncbi Exercise-induced and nitroglycerin-induced myocardial preconditioning improves hemodynamics in patients with angina
    Antonio Crisafulli
    Centro Interdipartimentale per le Tecnologie e gli Ambienti Collegati allo Sport, University of Cagliari, 09100 Cagliari, Italy
    Am J Physiol Heart Circ Physiol 287:H235-42. 2004
    ..Furthermore, the mimicking of exercise-induced SWOP by PI-SWOP with transdermal nitroglycerin may represent an important clinical aspect...
  57. ncbi Post-infarct heart repair with granulocyte-colony stimulating factor: is it a utopian goal?
    Pasquale Pagliaro
    Cardiovasc Res 71:405-7. 2006
  58. ncbi In vitro and in vivo studies of F(0)F(1)ATP synthase regulation by inhibitor protein IF(1) in goat heart
    Francesca Di Pancrazio
    Department of Biomedical Sciences and Technologies and M A T I Center of Excellence, University of Udine, P le Kolbe 4, 33100 Udine, Italy
    Biochim Biophys Acta 1659:52-62. 2004
    ..In addition, both in vivo and in vitro, 1.3-1.4 mol of IF(1) was predicted to fully inactivate 1 mol of synthase, thus excluding the existence of significant numbers of non-inhibitory binding sites for IF(1) in the F(0) sector...