F Pacini

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: a consensus report
    Furio Pacini
    University of Siena, Siena, Italy
    Eur J Endocrinol 153:651-9. 2005
  2. doi request reprint The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels
    Giuseppe Martini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Internal Medicine, University of Siena, Siena, Italy
    Thyroid 18:455-60. 2008
  3. doi request reprint Lack of association between urinary iodine excretion and successful thyroid ablation in thyroid cancer patients
    Hernan P Tala Jury
    University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 95:230-7. 2010
  4. ncbi request reprint New insight in the follow-up strategies of differentiated thyroid cancer
    F Pacini
    Section of Endocrinology and Metabolism, University of Siena, Siena, Italy
    J Endocrinol Invest 35:36-9. 2012
  5. pmc Effects of Acute Recombinant Human TSH on Serum Ghrelin Levels
    Cristina Ciuoli
    Section of Endocrinology, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena Siena, Italy
    Front Endocrinol (Lausanne) 2:94. 2011
  6. doi request reprint Management of differentiated thyroid cancer of the follicular epithelium
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy
    Ann Med 44:651-5. 2012
  7. doi request reprint Expression of the ring ligase PRAJA2 in thyroid cancer
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology, and Metabolism and Biochemistry, Policlinico Santa Maria alle Scotte, Viale Bracci 1, University of Siena, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:4253-9. 2012
  8. doi request reprint Thyroid microcarcinoma
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Best Pract Res Clin Endocrinol Metab 26:421-9. 2012
  9. doi request reprint Thyroid microcarcinoma
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Best Pract Res Clin Endocrinol Metab 26:381-9. 2012
  10. doi request reprint Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism, and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:E1327-31. 2012

Detail Information

Publications78

  1. ncbi request reprint Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: a consensus report
    Furio Pacini
    University of Siena, Siena, Italy
    Eur J Endocrinol 153:651-9. 2005
    ..To determine, based on published literature and expert clinical experience, current indications for the post-surgical administration of a large radioiodine activity in patients with differentiated thyroid cancer...
  2. doi request reprint The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels
    Giuseppe Martini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Internal Medicine, University of Siena, Siena, Italy
    Thyroid 18:455-60. 2008
    ....
  3. doi request reprint Lack of association between urinary iodine excretion and successful thyroid ablation in thyroid cancer patients
    Hernan P Tala Jury
    University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 95:230-7. 2010
    ..Low-iodine diet is prescribed before (131)I administration in patients with differentiated thyroid cancer, although no study has properly quantified its clinical benefit...
  4. ncbi request reprint New insight in the follow-up strategies of differentiated thyroid cancer
    F Pacini
    Section of Endocrinology and Metabolism, University of Siena, Siena, Italy
    J Endocrinol Invest 35:36-9. 2012
    ....
  5. pmc Effects of Acute Recombinant Human TSH on Serum Ghrelin Levels
    Cristina Ciuoli
    Section of Endocrinology, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena Siena, Italy
    Front Endocrinol (Lausanne) 2:94. 2011
    ..01) and returned to pre-treatment levels at 96 h. Conclusion: Our study demonstrates that acute exogenous TSH administration has a suppressive effect on ghrelin secretion independent from changes in thyroid status...
  6. doi request reprint Management of differentiated thyroid cancer of the follicular epithelium
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy
    Ann Med 44:651-5. 2012
    ..In view of this change in the presentation of the disease, the objective of thyroid cancer management should be aimed at achieving complete cure using the less aggressive diagnostic and therapeutic procedures...
  7. doi request reprint Expression of the ring ligase PRAJA2 in thyroid cancer
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology, and Metabolism and Biochemistry, Policlinico Santa Maria alle Scotte, Viale Bracci 1, University of Siena, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:4253-9. 2012
    ..Differentiated thyroid cancer expresses a functional TSH receptor, and its growth and progression are positively regulated by TSH and cAMP signaling...
  8. doi request reprint Thyroid microcarcinoma
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Best Pract Res Clin Endocrinol Metab 26:421-9. 2012
    ....
  9. doi request reprint Thyroid microcarcinoma
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Best Pract Res Clin Endocrinol Metab 26:381-9. 2012
    ....
  10. doi request reprint Telomere abnormalities and chromosome fragility in patients affected by familial papillary thyroid cancer
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism, and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 97:E1327-31. 2012
    ..Studies carried out in our unit have demonstrated that familial papillary thyroid cancer (fPTC) patients display an imbalance, at the germinal level, in telomere-telomerase complex...
  11. doi request reprint Approach to and treatment of differentiated thyroid carcinoma
    Furio Pacini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, VialeBracci 1, 53100 Siena, Italy
    Med Clin North Am 96:369-83. 2012
    ..This review addresses the multiple steps of current management, based on previous assumptions...
  12. doi request reprint Medullary thyroid carcinoma
    F Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Siena, Italy
    Clin Oncol (R Coll Radiol) 22:475-85. 2010
    ..Carriers of the RET gene are candidates for prophylactic thyroidectomy at different ages depending on the risk associated with the specific RET mutations...
  13. pmc Lack of germline A339V mutation in thyroid transcription factor-1 (TITF-1/NKX2.1) gene in familial papillary thyroid cancer
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Siena, Italy
    Thyroid Res 3:4. 2010
    ..We concluded that the A339V mutation in thyroid transcription factor-1 (TITF-1/NKX2.1) is not correlated with the familial form of PTC, even when the tumor was in the context of multinodular goiter...
  14. ncbi request reprint Targeted therapy in radioiodine refractory thyroid cancer
    F Pacini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Siena, Italy
    Q J Nucl Med Mol Imaging 53:520-5. 2009
    ..This review will summarize the most relevant achievements in the field and will discuss the limit and perspective of the new compounds...
  15. doi request reprint Diagnostic and therapeutic use of recombinant human TSH (rhTSH) in differentiated thyroid cancer
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Italy
    Best Pract Res Clin Endocrinol Metab 22:1009-21. 2008
    ..This review will focus on the clinical application of rhTSH in the management of DTC, highlighting current indications and future perspectives...
  16. ncbi request reprint European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
    Furio Pacini
    Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Eur J Endocrinol 154:787-803. 2006
  17. doi request reprint Telomerase and the endocrine system
    Furio Pacini
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Siena 53100, Italy
    Nat Rev Endocrinol 7:420-30. 2011
    ..A number of studies have demonstrated unequivocally that reactivation of telomerase in the presence of short telomeres is one of the most common features of human cancers, including those of the endocrine system...
  18. doi request reprint Telomere length in neoplastic and nonneoplastic tissues of patients with familial and sporadic papillary thyroid cancer
    Marco Capezzone
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 96:E1852-6. 2011
    ..Recently, we have reported that patients with the familial form of papillary thyroid cancer (FPTC) have short telomeres in blood leucocytes...
  19. ncbi request reprint Management of thyroid nodules: a clinicopathological, evidence-based approach
    Furio Pacini
    Section of Endocrinology and Metabolism, University of Siena, Siena, Italy
    Eur J Nucl Med Mol Imaging 31:1443-9. 2004
    ..This review aims to offer a practical approach to the management of nodular thyroid disorders, considering the way in which the pathophysiology of the disease provides clues to the correct clinical diagnosis and therapy...
  20. ncbi request reprint Radioiodine treatment of metastatic differentiated thyroid cancer in patients on L-thyroxine, using recombinant human TSH
    F Lippi
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Endocrinol 144:5-11. 2001
    ....
  21. doi request reprint The use of ultrasensitive thyroglobulin assays reduces but does not abolish the need for TSH stimulation in patients with differentiated thyroid carcinoma
    M G Castagna
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 34:e219-23. 2011
    ..Our study indicates that the combination of neck ultrasound and basal ultrasensitive Tg allows to identify all patients free of disease and can decrease the need for rhTSH stimulation in nearly 80% of the patients...
  22. ncbi request reprint Outcome of differentiated thyroid cancer with detectable serum Tg and negative diagnostic (131)I whole body scan: comparison of patients treated with high (131)I activities versus untreated patients
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 86:4092-7. 2001
    ..If positive in the lung, (131)I treatment should be continued up to total remission; surgical treatment should be preferred in patients with node metastases, and no treatment should be used in those with thyroid bed uptake or no uptake...
  23. ncbi request reprint Recombinant human thyrotropin-stimulated serum thyroglobulin combined with neck ultrasonography has the highest sensitivity in monitoring differentiated thyroid carcinoma
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 88:3668-73. 2003
    ....
  24. ncbi request reprint Limited value of repeat recombinant human thyrotropin (rhTSH)-stimulated thyroglobulin testing in differentiated thyroid carcinoma patients with previous negative rhTSH-stimulated thyroglobulin and undetectable basal serum thyroglobulin levels
    M G Castagna
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 93:76-81. 2008
    ..One year after initial treatment, low-risk differentiated thyroid cancer (DTC) patients undergo recombinant human (rh)TSH-stimulated serum thyroglobulin (Tg) (rhTSH-Tg) and neck ultrasound (US)...
  25. ncbi request reprint Effectiveness of radioiodine (131-I) as definitive therapy in patients with autoimmune and non-autoimmune hyperthyroidism
    B Tarantini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 29:594-8. 2006
    ..No influence was found between outcome and clinical parameters at the moment of 131-I therapy. In conclusion, our results indicate that RAI therapy is highly effective and safe for the control of hyperthyroidism...
  26. ncbi request reprint Radioiodine ablation of thyroid remnants after preparation with recombinant human thyrotropin in differentiated thyroid carcinoma: results of an international, randomized, controlled study
    F Pacini
    Section of Endocrinology, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 91:926-32. 2006
    ..Quality of life was determined at the time of randomization and ablation. After the administration of the 131-I dose, the rate of radiation clearance from blood, thyroid remnant, and whole body was measured...
  27. doi request reprint Differentiated thyroid cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up
    F Pacini
    Department of Internal Medicine, University of Siena, Siena, Italy
    Ann Oncol 19:ii99-101. 2008
  28. doi request reprint Familial non-medullary thyroid carcinoma displays the features of clinical anticipation suggestive of a distinct biological entity
    M Capezzone
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    Endocr Relat Cancer 15:1075-81. 2008
    ..04) when compared with the first generation. In conclusion, FNMTC displays the features of clinical 'anticipation' with the second generation acquiring the disease at an earlier age and having more advanced disease at presentation...
  29. ncbi request reprint Serum ghrelin levels in growth hormone-sufficient and growth hormone-deficient patients during growth hormone-releasing hormone plus arginine test
    B Tarantini
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Via Bracci, 53100 Siena, Italy
    J Endocrinol Invest 32:335-7. 2009
    ..We evaluated the circulating ghrelin levels in GH-deficient (GHD) and in GH-sufficient (GHS) patients during GHRH plus arginine test...
  30. ncbi request reprint A comparison of 1850 (50 mCi) and 3700 MBq (100 mCi) 131-iodine administered doses for recombinant thyrotropin-stimulated postoperative thyroid remnant ablation in differentiated thyroid cancer
    Tania Pilli
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Nuclear Medicine, University of Siena, 53100 Sienna, Italy
    J Clin Endocrinol Metab 92:3542-6. 2007
    ..We investigated whether 1850 MBq (131)I had a similar successful rate to 3700 MBq in patients prepared with rhTSH...
  31. ncbi request reprint Presurgical serum thyroglobulin has no prognostic value in papillary thyroid cancer
    Elisa Guarino
    Department of Internal Medicine, Endocrinology and Metabolism, Section of Endocrinology and Metabolism, University of Siena, Italy
    Thyroid 15:1041-5. 2005
    ..In conclusion, this study failed to show any prognostic value of presurgical serum thyroglobulin determination that consequently should not be measured...
  32. ncbi request reprint Diagnostic 131-iodine whole-body scan may be avoided in thyroid cancer patients who have undetectable stimulated serum Tg levels after initial treatment
    F Pacini
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:1499-501. 2002
    ..These patients may be monitored with clinical examination, neck ultrasound, and serum Tg measurements on L-T(4)...
  33. ncbi request reprint L-thyroxine requirement in patients with autoimmune hypothyroidism and parietal cell antibodies
    Serenella Checchi
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, 53100 Siena, Italy
    J Clin Endocrinol Metab 93:465-9. 2008
    ..Hypothyroid patients on l-T(4) therapy may require replacement doses exceeding the theoretical needs to normalize serum TSH due to low patient compliance, drugs interference, and malabsorption...
  34. doi request reprint Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology
    Silvia Cantara
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology, and Metabolism and Biochemistry, University of Siena, Policlinico Santa Maria alle Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 95:1365-9. 2010
    ..0%). Conclusions: Our findings demonstrate that molecular analysis of cytological specimens is feasible and that its results in combination with cytology improves the diagnostic performance of traditional cytology...
  35. ncbi request reprint Cyclic Cushing's disease with paradoxical response to dexamethasone
    S Checchi
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism, and Biochemistry, University of Siena, Siena, Italy
    J Endocrinol Invest 28:741-5. 2005
    ..In such patients, the pituitary-adrenal axis should be tested possibly during the acute phase of their disease or using the dexamethasone suppression test during asymptomatic intervals...
  36. pmc Ultrasound examination using contrast agent and elastosonography in the evaluation of single thyroid nodules: Preliminary results
    F S Ferrari
    Diagnostica per Immagini, Performance srl, Siena, Italy
    J Ultrasound 11:47-54. 2008
    ..To evaluate the usefulness of ultrasound (US) using contrast agent and elastosonography in the characterization of thyroid nodules...
  37. ncbi request reprint Role of percutaneous ethanol injection in management of nodular lesions of the thyroid gland
    Furio Pacini
    University of Siena, Siena, Italy
    J Nucl Med 44:211-2. 2003
  38. ncbi request reprint Multinodular goiter of unusual shape and location
    Lucia Brilli
    Department of Internal Medicine, Endocrine Metabolic Sciences and Biochemistry, Section of Endocrinology, University of Siena, Siena, Italy
    Thyroid 17:693-4. 2007
  39. ncbi request reprint Guidelines for diagnosis and therapy of MEN type 1 and type 2
    M L Brandi
    Department of Internal Medicine, University of Florence, 50139 Florence, Italy
    J Clin Endocrinol Metab 86:5658-71. 2001
    ....
  40. doi request reprint Targeted therapy in refractory thyroid cancer: current achievements and limitations
    Lucia Brilli
    Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, Section of Endocrinology and Metabolism, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    Future Oncol 7:657-68. 2011
    ..The aim of this article is to describe the benefits and limitations of innovative drugs that are currently under investigation in patients with refractory thyroid cancer...
  41. ncbi request reprint Serum ghrelin as a marker of atrophic body gastritis in patients with parietal cell antibodies
    Serenella Checchi
    Section of Endocrinology and Metabolism, Department of Internal Medicine, Endocrinology and Metabolism and Biochemistry, University of Siena, Viale Bracci 1, 53100 Siena, Italy
    J Clin Endocrinol Metab 92:4346-51. 2007
    ..We studied the diagnostic use of the measurement of serum ghrelin compared with other markers of gastric damage in predicting the presence of ABG in patients with autoimmune gastritis...
  42. doi request reprint Short telomeres, telomerase reverse transcriptase gene amplification, and increased telomerase activity in the blood of familial papillary thyroid cancer patients
    Marco Capezzone
    Department of Internal Medicine, University of Siena, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy
    J Clin Endocrinol Metab 93:3950-7. 2008
    ..Differentiated papillary thyroid cancer is mostly sporadic, but the recurrence of the familial form has been reported. Short or dysfunctional telomeres have been associated with familial benign diseases and familial breast cancer...
  43. ncbi request reprint Disappearance of humoral thyroid autoimmunity after complete removal of thyroid antigens
    Luca Chiovato
    Universita di Pisa, Pisa, Italy
    Ann Intern Med 139:346-51. 2003
    ..The development of antibodies to thyroid peroxidase, thyroglobulin, and thyroid-stimulating hormone (TSH) receptor is a main feature of autoimmune thyroid diseases...
  44. ncbi request reprint Thyroid cancer in children and adolescents
    Furio Pacini
    J Endocrinol Invest 25:572-3. 2002
  45. pmc Expanding indications for recombinant human TSH in thyroid cancer
    Bryan R Haugen
    Thyroid 18:687-94. 2008
  46. ncbi request reprint Ablation of thyroid residues with 30 mCi (131)I: a comparison in thyroid cancer patients prepared with recombinant human TSH or thyroid hormone withdrawal
    Furio Pacini
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4063-8. 2002
    ....
  47. ncbi request reprint Cytotoxic effects of carboplatinum and epirubicin in the setting of an elevated serum thyrotropin for advanced poorly differentiated thyroid cancer
    Ferruccio Santini
    Department of Endocrinology, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 87:4160-5. 2002
    ..In conclusion, the response rate of poorly differentiated thyroid cancer to chemotherapy observed in this study was favorable and promising. TSH stimulation may have contributed to these results...
  48. ncbi request reprint Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective
    Martin Schlumberger
    Institut Gustave Roussy, Villejuif, France
    Eur J Endocrinol 150:105-12. 2004
    ..We sought to develop an improved protocol for the follow-up of low-risk patients with DTC based on the findings of recent studies...
  49. ncbi request reprint Low specificity of blood thyroglobulin messenger ribonucleic acid assay prevents its use in the follow-up of differentiated thyroid cancer patients
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:33-9. 2004
    ..On the contrary, serum Tg measurement is a very sensitive and specific thyroid tumor marker, and we recommend that the follow-up of patients affected by DTC must be performed using serum Tg rather than blood Tg mRNA measurement...
  50. ncbi request reprint The effect of short-term treatment with recombinant human thyroid-stimulating hormones on leydig cell function in men
    Joaquin Lado-Abeal
    Department of Medicine, The University of Chicago Medical Center, Chicago, Illinois 60637, USA
    Thyroid 13:649-52. 2003
    ..In conclusion, short-term elevations in serum TSH levels in the range reported in hypothyroid boys with precocious puberty did not increase serum testosterone levels in adult men...
  51. ncbi request reprint Follow-up of differentiated thyroid cancer
    Furio Pacini
    Department of Endocrinology, University of Pisa, Ospedale Cisanello, Via Paradisa 2, 56124 Pisa, Italy
    Eur J Nucl Med Mol Imaging 29:S492-6. 2002
    ..Using this strategy, most patients will achieve definitive cure and will have a normal quality of life...
  52. ncbi request reprint Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal
    Heribert Hänscheid
    Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg, D 97080 Wurzburg, Germany
    J Nucl Med 47:648-54. 2006
    ..7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented...
  53. ncbi request reprint Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice
    Martin Schlumberger
    service de Medicine Nucleaire, Institut Gustave Roussy, 94805 Villejuif, France
    Eur J Endocrinol 151:539-48. 2004
    ..We also offer expanded and additional comments on various issues in the management of DTC...
  54. ncbi request reprint A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal
    Pamela R Schroeder
    Johns Hopkins Medical Institutions, Division of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:878-84. 2006
    ..Levothyroxine (L-T4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests' sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without L-T4 withdrawal...
  55. ncbi request reprint rhTSH-aided radioiodine ablation and treatment of differentiated thyroid carcinoma: a comprehensive review
    Markus Luster
    Department of Nuclear Medicine, University of Wurzburg, Josef Schneider Str 2, 97080 Wurzburg, Germany
    Endocr Relat Cancer 12:49-64. 2005
    ....
  56. ncbi request reprint Influence of human body composition on serum peak thyrotropin (TSH) after recombinant human TSH administration in patients with differentiated thyroid carcinoma
    Maria Grazia Castagna
    Department of Endocrinology and Metabolism, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 90:4047-50. 2005
    ..Furthermore, to verify whether the serum peak TSH influenced the efficacy of radioiodine ((131)I), we compared the rate of thyroid remnant ablation according to the patients' BMI...
  57. ncbi request reprint How the availability of recombinant human TSH has changed the management of patients who have thyroid cancer
    Martin Schlumberger
    University Paris Sud, Paris, France
    Nat Clin Pract Endocrinol Metab 3:641-50. 2007
    ....
  58. ncbi request reprint RET/PTC3 rearrangement and thyroid differentiation gene analysis in a struma ovarii fortuitously revealed by elevated serum thyroglobulin concentration
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    Thyroid 15:1355-61. 2005
    ....
  59. ncbi request reprint Minimally invasive video-assisted thyroidectomy for papillary carcinoma: a prospective study of its completeness
    Paolo Miccoli
    Department of Surgery, University of Pisa, S Chiara Hospital, Via Roma 67, 56100 Pisa, Italy
    Surgery 132:1070-3; discussion 1073-4. 2002
    ..Some are concerned about this procedure in patients with thyroid cancer. This prospective study aimed to demonstrate that near-total thyroidectomy can be performed by MIVAT with similar results compared with open thyroidectomy...
  60. ncbi request reprint All-trans-retinoic acid treatment inhibits the growth of retinoic acid receptor beta messenger ribonucleic acid expressing thyroid cancer cell lines but does not reinduce the expression of thyroid-specific genes
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    J Clin Endocrinol Metab 90:2403-11. 2005
    ..The finding of a basal and RA-induced RARbeta mRNA expression only in cell lines responding to all-trans-RA suggests that the growth inhibition might be mediated by RARbeta...
  61. ncbi request reprint Medullary and papillary tumors are frequently associated in the same thyroid gland without evidence of reciprocal influence in their biologic behavior
    Rosa Paula Biscolla
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    Thyroid 14:946-52. 2004
    ..Moreover, although we cannot completely exclude a shared pathogenic event as the cause of both MTC and PTC, the molecular analysis of RET gene alterations did not show any common mutation...
  62. ncbi request reprint Establishment of a non-tumorigenic papillary thyroid cell line (FB-2) carrying the RET/PTC1 rearrangement
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa, Italy
    Int J Cancer 97:608-14. 2002
    ..Moreover, FB-2 cells produced high levels of interleukin (IL)-6 and IL-8...
  63. pmc Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma
    Fulvio Basolo
    Dipartimento di Oncologia, Universita degli Studi di Pisa, Pisa Fondazione Senatore Pascale, Naples, Italy
    Am J Pathol 160:247-54. 2002
    ..In conclusion, we postulate that the correlation between the RET/PTC rearrangement type and the aggressiveness of human PTC is related to the efficiency with which the oncogene subtype delivers mitogenic signals to thyroid cells...
  64. ncbi request reprint Treatment with drugs able to reduce iodine efflux significantly increases the intracellular retention time in thyroid cancer cells stably transfected with sodium iodide symporter complementary deoxyribonucleic acid
    Rossella Elisei
    Department of Endocrinology and Metabolism, Via Paradisa 2, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 91:2389-95. 2006
    ..One of the major limits of gene therapy with sodium iodide symporter (NIS), which enables cells to be subjected to radioiodine therapy, is that NIS-transfected cells rapidly release the intracellular iodine...
  65. doi request reprint Thyroid autoantibodies and thyroid function in subjects exposed to Chernobyl fallout during childhood: evidence for a transient radiation-induced elevation of serum thyroid antibodies without an increase in thyroid autoimmune disease
    Laura Agate
    Department of Endocrinology, University of Pisa, Via Paradisa 2, Pisa, Italy
    J Clin Endocrinol Metab 93:2729-36. 2008
    ..An increase in the prevalence of thyroid autoantibodies (ATAs) was reported 6-8 yr after the Chernobyl accident in radiation-exposed children and adolescents...
  66. ncbi request reprint Why do we need guidelines for differentiated thyroid cancer?
    Furio Pacini
    Thyroid 16:103-4. 2006
  67. doi request reprint BRAFV600E mutation, but not RET/PTC rearrangements, is correlated with a lower expression of both thyroperoxidase and sodium iodide symporter genes in papillary thyroid cancer
    Cristina Romei
    Departments of Endocrinology and Metabolism Oncology Surgery, University of Pisa, 56100 Pisa, Italy
    Endocr Relat Cancer 15:511-20. 2008
    ....
  68. ncbi request reprint Where do we stand with targeted therapy of refractory thyroid cancer?--Utility of RECIST criteria
    Furio Pacini
    Thyroid 18:279-80. 2008
  69. ncbi request reprint Prognostic significance of somatic RET oncogene mutations in sporadic medullary thyroid cancer: a 10-year follow-up study
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:682-7. 2008
    ..The aim of this study was to verify the prognostic value of somatic RET mutations in a large series of MTCs with a long follow up...
  70. ncbi request reprint Clinical features and therapeutic implication of papillary thyroid microcarcinoma
    Kalliopi Pazaitou-Panayiotou
    Department of Endocrinology Endocrine Oncology, Theaghenion Cancer Hospital, 2 Al Simeonidi Street, Thessaloniki, Greece
    Thyroid 17:1085-92. 2007
    ..Distant metastases are extremely rare, but have been reported. Although deaths related to PTM are almost unknown, PTM raises therapeutic implications. This review addresses the issue of definition, treatment, and follow-up of PTM...
  71. ncbi request reprint Biology and clinical application of the NIS gene
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, Italy
    Tumori 89:523-8. 2003
    ..This has demonstrated the feasibility of the in vitro technique but also raised the problem of the absence of the iodide organification machinery in non-thyroidal cells, which, at the moment, represents the major limit of this strategy...
  72. ncbi request reprint RET genetic screening in patients with medullary thyroid cancer and their relatives: experience with 807 individuals at one center
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:4725-9. 2007
    ....
  73. ncbi request reprint Impact of routine measurement of serum calcitonin on the diagnosis and outcome of medullary thyroid cancer: experience in 10,864 patients with nodular thyroid disorders
    Rossella Elisei
    Department of Endocrinology and Metabolism, University of Pisa, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:163-8. 2004
    ..On this basis, routine measurement of basal serum CT levels should be considered an integral part of the diagnostic evaluation of thyroid nodules...
  74. ncbi request reprint BRAF(V599E) mutation is the leading genetic event in adult sporadic papillary thyroid carcinomas
    Efisio Puxeddu
    Dipartimento di Medicina Interna, Universita di Perugia, Perugia
    J Clin Endocrinol Metab 89:2414-20. 2004
    ....
  75. ncbi request reprint Galectin-3 and oncofetal-fibronectin expression in thyroid neoplasia as assessed by reverse transcription-polymerase chain reaction and immunochemistry in cytologic and pathologic specimens
    Riccardo Giannini
    Department of Oncology, University of Pisa, Pisa, Italy
    Thyroid 13:765-70. 2003
    ....
  76. ncbi request reprint RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population
    Rossella Elisei
    Department of Endocrinology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy
    J Clin Endocrinol Metab 89:3579-84. 2004
    ..A putative role of the G691S polymorphism as genetic modifier in the normal subjects remains to be established...
  77. ncbi request reprint Simian virus 40-like sequences from early and late regions in human thyroid tumors of different histotypes
    Agnese Vivaldi
    Department of Endocrinology and Metabolism, Section of Endocrinology, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:892-9. 2003
    ..The presence of the SV40 footprint in PBMC implies that blood cells are vectors of the virus in other tissues of the host...