Gian Maria Pacifici

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Pisa, Italy
    Int J Clin Pharmacol Ther 42:488-95. 2004
  2. ncbi Placental transfer of antibiotics administered to the mother: a review
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Pisa, Italy
    Int J Clin Pharmacol Ther 44:57-63. 2006
  3. doi Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure
    Gian Maria Pacifici
    Section of Pharmacology, Department of Translational Research and New Technologies in Medicine and Surgery, Medical School, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Paediatr Drugs 15:363-76. 2013
  4. pmc Clinical pharmacokinetics of vancomycin in the neonate: a review
    Gian Maria Pacifici
    University of Pisa, Medical School, Department of Neurosciences, Section of Pharmacology, Pisa IT
    Clinics (Sao Paulo) 67:831-7. 2012
  5. doi Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants
    Gian Maria Pacifici
    University of Pisa, Medical School, Department of Neurosciences, Italy
    Paediatr Drugs 14:233-46. 2012
  6. ncbi Transfer of antivirals across the human placenta
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, 56126 Pisa, Italy
    Early Hum Dev 81:647-54. 2005
  7. ncbi Pharmacokinetics of antivirals in neonate
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, I 56126 Pisa, Italy
    Early Hum Dev 81:773-80. 2005
  8. doi Clinical pharmacokinetics of penicillins in the neonate: a review of the literature
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, 56126, Pisa, Italy
    Eur J Clin Pharmacol 65:191-8. 2009
  9. doi Clinical pharmacokinetics of aminoglycosides in the neonate: a review
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, University of Pisa Medical School, Pisa, Italy
    Eur J Clin Pharmacol 65:419-27. 2009
  10. pmc Pharmacokinetics of cephalosporins in the neonate: a review
    Gian Maria Pacifici
    Section of Pharmacology, Department of Neurosciences, Medical School, University of Pisa, Pisa, Italy
    Clinics (Sao Paulo) 66:1267-74. 2011

Collaborators

  • H Mulla
  • M Vietri
  • A Pietrabissa
  • F Mosca
  • C De Santi
  • R Spisni
  • A M Rossi
  • F Vaglini
  • F Marchetti
  • V Maggini
  • R Barale
  • D Di Bello
  • E Fredianelli
  • R Cantini
  • A Rane
  • A Viani

Detail Information

Publications25

  1. ncbi Inhibition of human liver and duodenum sulfotransferases by drugs and dietary chemicals: a review of the literature
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Pisa, Italy
    Int J Clin Pharmacol Ther 42:488-95. 2004
    ..Under particular circumstances, human duodenum sulfotransferase is more resistant than liver sulfotransferase to the inhibition by mefenamic acid, salicylic acid and quercetin...
  2. ncbi Placental transfer of antibiotics administered to the mother: a review
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Pisa, Italy
    Int J Clin Pharmacol Ther 44:57-63. 2006
    ..A comparison of the drug concentration in maternal and fetal plasma gives an indication of the exposure of the fetus to the maternally administered antibiotics...
  3. doi Clinical pharmacology of indomethacin in preterm infants: implications in patent ductus arteriosus closure
    Gian Maria Pacifici
    Section of Pharmacology, Department of Translational Research and New Technologies in Medicine and Surgery, Medical School, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Paediatr Drugs 15:363-76. 2013
    ..A prolonged course of indomethacin appears to reduce the risk of severe intracranial hemorrhage and renal impairment in patients with PDA. In conclusion, indomethacin is a useful drug to treat PDA...
  4. pmc Clinical pharmacokinetics of vancomycin in the neonate: a review
    Gian Maria Pacifici
    University of Pisa, Medical School, Department of Neurosciences, Section of Pharmacology, Pisa IT
    Clinics (Sao Paulo) 67:831-7. 2012
    ..In addition to the prospective validation of available dosing guidelines, future studies should focus on the relevance of therapeutic drug monitoring and on the value of continuous vancomycin administration in neonates...
  5. doi Clinical pharmacology of the loop diuretics furosemide and bumetanide in neonates and infants
    Gian Maria Pacifici
    University of Pisa, Medical School, Department of Neurosciences, Italy
    Paediatr Drugs 14:233-46. 2012
    ..The maturation of the kidney governs the pharmacokinetics of furosemide and bumetanide in the infant. CL and t(½) are influenced by development, and this must be taken into consideration when planning a dosage regimen with these drugs...
  6. ncbi Transfer of antivirals across the human placenta
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, 56126 Pisa, Italy
    Early Hum Dev 81:647-54. 2005
    ..It is necessary to know which antivirals cross the placenta and reach the fetal circulation in pharmacologically significant concentrations in order to plan antiviral therapy...
  7. ncbi Pharmacokinetics of antivirals in neonate
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, I 56126 Pisa, Italy
    Early Hum Dev 81:773-80. 2005
    ..The antiviral therapy for newborn infants is a real necessity. Pharmacokinetics is an important contribution to therapy and no review has been published on the pharmacokinetics of antivirals in neonates up to now...
  8. doi Clinical pharmacokinetics of penicillins in the neonate: a review of the literature
    G M Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, 56126, Pisa, Italy
    Eur J Clin Pharmacol 65:191-8. 2009
    ..As such, the pharmacokinetics of penicillins need be studied in neonates in order to optimise therapy in this age class with these drugs...
  9. doi Clinical pharmacokinetics of aminoglycosides in the neonate: a review
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, University of Pisa Medical School, Pisa, Italy
    Eur J Clin Pharmacol 65:419-27. 2009
    ....
  10. pmc Pharmacokinetics of cephalosporins in the neonate: a review
    Gian Maria Pacifici
    Section of Pharmacology, Department of Neurosciences, Medical School, University of Pisa, Pisa, Italy
    Clinics (Sao Paulo) 66:1267-74. 2011
    ..Clearance and t1/2 are influenced by development, and this must be taken into consideration when planning a cephalosporin dosage regimen for the neonate...
  11. ncbi Sulfation of drugs and hormones in mid-gestation human fetus
    Gian Maria Pacifici
    Department of Neurosciences, Section of Pharmacology, Medical School, University of Pisa, Via Roma 55, 56126 Pisa, Italy
    Early Hum Dev 81:573-81. 2005
    ..Drugs and hormones are sulfated in human fetal tissues but a review on this topic has not yet been published...
  12. ncbi Sulfation of R(-)-apomorphine in the human liver and duodenum, and its inhibition by mefenamic acid, salicylic acid and quercetin
    M Vietri
    Department of Neurosciences, Section of Pharmacology, Via Roma 55, I 56126 Pisa, Italy
    Xenobiotica 32:587-94. 2002
    ..The non-steroidal anti-inflammatory drug mefenamic acid and the natural flavonoid quercetin inhibit the hepatic sulfation of apomorphine with an IC(50) in the order of nM...
  13. ncbi Differential inhibition of human liver and duodenum sulphotransferase activities by quercetin, a flavonoid present in vegetables, fruit and wine
    F Marchetti
    Department of Neurosciences, Section of Pharmacology, Medical School, Pisa, Italy
    Xenobiotica 31:841-7. 2001
    ..Such a difference may reflect the different composition of sulphotransferase forms in the liver and duodenum...
  14. ncbi Phenotype-genotype relationships of SULT1A1 in human liver and variations in the IC50 of the SULT1A1 inhibitor quercetin
    A M Rossi
    Department of Human and Environmental Sciences, Laboratory of Genetics and Environmental Mutagenesis, Medical School, Pisa, Italy
    Int J Clin Pharmacol Ther 42:561-7. 2004
    ..5 nM, respectively. There was a weak but significant correlation between the IC50 value and age of the liver donors (r = 0.283, p = 0.046). The observed variation did not correlate with the genotypes at the SULT1A1 and SULT1A2 loci...
  15. ncbi 7-OH-flavone is sulfated in the human liver and duodenum, whereas 5-OH-flavone and 3-OH-flavone are potent inhibitors of SULT1A1 activity and 7-OH-flavone sulfation rate
    M Vietri
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, I 56126 Pisa, Italy
    Xenobiotica 32:563-71. 2002
    ..4 microM (liver) and 213 +/- 47 microM (duodenum; p < 0.0001). 7. The position of the hydroxy group confers to the molecules of OH-flavones the quality of substrate or inhibitor of sulfotransferase...
  16. ncbi Inhibition of phenol sulfotransferase (SULT1A1) by quercetin in human adult and foetal livers
    C De Santi
    Department of Neurosciences, Section of Pharmacology, Medical School, University of Pisa, Via Roma 55, I 56126 Pisa, Italy
    Xenobiotica 32:363-8. 2002
    ..This suggests that quercetin may inhibit the sulfation rate of those drugs sulphated by SULT1A1. The inhibition of SULT1A1 is complex and not due solely to competition at the catalytic site of SULT1A1...
  17. ncbi Placental transfer and distribution of pinazepam and its metabolite N-desmethyldiazepam in the maternal and fetal rabbit: effect of the stage of gestation
    G M Pacifici
    Department of General Pathology, Medical School, University of Pisa, Italy
    Eur J Drug Metab Pharmacokinet 14:1-6. 1989
    ..In this tissue the concentrations of pinazepam were 5-10 times higher on the 27th rather than the 20th day of pregnancy. The stage of pregnancy influences the distribution pattern of pinazepam in rabbit fetuses and their mothers...
  18. ncbi Tissue distribution of drug-metabolizing enzymes in humans
    G M Pacifici
    Department of General Pathology, Medical School, University of Pisa, Italy
    Xenobiotica 18:849-56. 1988
    ..GST was the enzyme with the widest tissue distribution...
  19. ncbi Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver
    C De Santi
    Department of Neuroscience, Section of Pharmacology, Medical School, Cisanello Hospital at University of Pisa, Italy
    Int J Clin Pharmacol Ther 40:207-12. 2002
    ..In conclusion, quercetin and fisetin are methylated in human liver and their rates of methylation have a limited variation among subjects...
  20. ncbi Quercetin inhibits the sulfation of r(-)-apomorphine in human brain
    M Vietri
    Department of Neurosciences, Section of Pharmacology, Medical School, and University Hospital of Pisa, Italy
    Int J Clin Pharmacol Ther 41:30-5. 2003
    ..Quercetin is a potent inhibitor of apomorphine sulfation and may inhibit the sulfation of apomorphine in human brain in vivo...
  21. ncbi Curcumin is a potent inhibitor of phenol sulfotransferase (SULT1A1) in human liver and extrahepatic tissues
    M Vietri
    Department of Neurosciences, Section of Pharmacology, Medical School, Via Roma 55, I 56126 Pisa, Italy
    Xenobiotica 33:357-63. 2003
    ....
  22. ncbi Inhibition of mycophenolic acid glucuronidation by niflumic acid in human liver microsomes
    M Vietri
    Department of Neuroscience, Section of Pharmacology, Medical School, Via Roma 55, 56126 Pisa, Italy
    Eur J Clin Pharmacol 58:93-7. 2002
    ..The second aim was to study the inhibition type of niflumic acid (NA) for MPA glucuronidation in human liver. The third aim was to study the variability of the IC(50) value of NA for MPA glucuronidation in human liver...
  23. ncbi Quantitative contribution of endogenous compounds and hypoalbuminemia in reducing the binding of furosemide in the plasma of newborn infants
    A Viani
    Department of Biomedicine, University of Pisa Medical School, Italy
    Dev Pharmacol Ther 18:39-43. 1992
    ..The displacement of furosemide by salicylic acid, tolbutamide and azapropazone is 70% greater in newborn than in adult plasma. The greater displacing effect is largely due to hypoalbuminemia...