D Otranto


Affiliation: University of Bari
Country: Italy


  1. HodŽić A, Latrofa M, Annoscia G, Alić A, Beck R, Lia R, et al. The spread of zoonotic Thelazia callipaeda in the Balkan area. Parasit Vectors. 2014;7:352 pubmed publisher
    ..In addition, data regarding the spread of the infection in Europe over the last ten years suggests that an increasing pattern in the distribution of this disease in domestic and wild animals should be expected in the future. ..
  2. Otranto D, Testini G, Buonavoglia C, Parisi A, Brandonisio O, Circella E, et al. Experimental and field investigations on the role of birds as hosts of Leishmania infantum, with emphasis on the domestic chicken. Acta Trop. 2010;113:80-3 pubmed publisher
    ..infantum under experimental condition. The occurrence of anti-L. infantum antibodies in domestic gooses (A. anser) and in a pheasant (P. colchicus) points out their possible role in the epidemiology of visceral leishmaniasis. ..
  3. Otranto D, De Caprariis D, Lia R, Tarallo V, Lorusso V, Testini G, et al. Prevention of endemic canine vector-borne diseases using imidacloprid 10% and permethrin 50% in young dogs: a longitudinal field study. Vet Parasitol. 2010;172:323-32 pubmed publisher
    ..The results demonstrate that ImPer preventive treatment against arthropods protects autochthonous and naïve beagle dogs against CVBD-causing pathogens. ..
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    Otranto D, Traversa D. A review of dicrocoeliosis of ruminants including recent advances in the diagnosis and treatment. Vet Parasitol. 2002;107:317-35 pubmed
    ..The most important aspects of the aetiology, biological cycle, spread, epidemiology and pathogenesis of dicrocoeliosis are reviewed and the recent advances in the diagnosis and treatment are focused on. ..
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    Otranto D, Paradies P, Lia R, Latrofa M, Testini G, Cantacessi C, et al. Efficacy of a combination of 10% imidacloprid/50% permethrin for the prevention of leishmaniasis in kennelled dogs in an endemic area. Vet Parasitol. 2007;144:270-8 pubmed
    ..01). The results clearly show that a combination of imidacloprid 10% and permethrin 50%, by virtue of its repellent activity against sandflies, is effective under both application regimes in preventing CanL in the field in endemic areas. ..
  6. Otranto D, Latrofa M, Brianti E, Annoscia G, Parisi A, Dantas Torres F, et al. An assessment of genetic variability in the mitochondrial cytochrome c oxidase subunit 1 gene of Cercopithifilaria sp. (Spirurida, Onchocercidae) from dog and Rhipicephalus sanguineus populations. Mol Cell Probes. 2012;26:81-9 pubmed publisher
    ..The number of haplotypes identified here might be explained by complex ecology and transmission patterns as well as the high mutation rate of mitochondrial DNA and/or inbreeding associated with hosts and their vectors. ..
  7. Otranto D, Paradies P, De Caprariis D, Stanneck D, Testini G, Grimm F, et al. Toward diagnosing Leishmania infantum infection in asymptomatic dogs in an area where leishmaniasis is endemic. Clin Vaccine Immunol. 2009;16:337-43 pubmed publisher
    ..7% showing clinical signs related to CanL, while the remaining 87.3% were asymptomatic. A diagnostic scheme for assessment of the L. infantum infection status in asymptomatic dogs is suggested. ..
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    Otranto D, Zalla P, Testini G, Zanaj S. Cattle grub infestation by Hypoderma sp. in Albania and risks for European countries. Vet Parasitol. 2005;128:157-62 pubmed
    ..The hope is not only to reduce the parasitic intensity with obvious benefits for livestock production, but also to avoid the risk of spreading this parasitic disease to neighboring countries. ..
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    Otranto D, Tarsitano E, Traversa D, Giangaspero A, De Luca F, Puccini V. Differentiation among three species of bovine Thelazia (Nematoda: Thelaziidae) by polymerase chain reaction-restriction fragment length polymorphism of the first internal transcribed spacer ITS-1 (rDNA). Int J Parasitol. 2001;31:1693-8 pubmed
    ..This PCR-RFLP for the delineation of T. gulosa, T. rhodesi and T. skrjabini offers prospects as a molecular epidemiological tool to study parasite transmission patterns and prevalence. ..

More Information


  1. request reprint
    Otranto D, Lia R, Cantacessi C, Galli G, Paradies P, Mallia E, et al. Efficacy of a combination of imidacloprid 10%/permethrin 50% versus fipronil 10%/(S)-methoprene 12%, against ticks in naturally infected dogs. Vet Parasitol. 2005;130:293-304 pubmed
    ..t. (group A=98.43%, group B=77.56%). ..
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    Otranto D, Paradies P, Sasanelli M, Leone N, de Caprariis D, Chirico J, et al. Recombinant K39 dipstick immunochromatographic test: a new tool for the serodiagnosis of canine leishmaniasis. J Vet Diagn Invest. 2005;17:32-7 pubmed
    ..The rK39 dipstick proved to be a rapid, sensitive, and specific test that may be very useful in the field for large-scale screening and also in veterinary practice, requiring minimal equipment and operator expertise. ..
  3. Otranto D, Brianti E, Abramo F, Gaglio G, Napoli E, Latrofa M, et al. Cutaneous distribution and localization of Cercopithifilaria sp. microfilariae in dogs. Vet Parasitol. 2012;190:143-50 pubmed publisher
    ..3%) when compared to the microscopic examination (n=53; 34.9%) with five haplotypes sequenced. The results here presented suggested a close co-evolution of this filarioid with its vector. ..
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    Otranto D. The immunology of myiasis: parasite survival and host defense strategies. Trends Parasitol. 2001;17:176-82 pubmed
  5. Otranto D, Brianti E, Gaglio G, Dantas Torres F, Azzaro S, Giannetto S. Human ocular infection with Dirofilaria repens (Railliet and Henry, 1911) in an area endemic for canine dirofilariasis. Am J Trop Med Hyg. 2011;84:1002-4 pubmed publisher
    ..The relationship between the prevalence of D. repens in dogs and the occurrence of human cases of ocular dirofilariasis is discussed on the basis of a review of the historical literature. ..
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    Otranto D, Stevens J, Brianti E, Dorchies P. Human and livestock migrations: a history of bot fly biodiversity in the Mediterranean region. Trends Parasitol. 2006;22:209-13 pubmed
    ..The movement of animals and their associated parasites in this region can help to explain the evolution of parasitic biodiversity. ..
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    Otranto D, Milillo P, Capelli G, Colwell D. Species composition of Gasterophilus spp. (Diptera, Oestridae) causing equine gastric myiasis in southern Italy: parasite biodiversity and risks for extinction. Vet Parasitol. 2005;133:111-8 pubmed
    ..inermis, G. pecorum and G. haemorrhoidalis have been decreasing relative to G. intestinalis and G. nasalis which may suggest tendency toward the extinction of the three former species of Gasterophilus. ..
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    Otranto D, Lia R, Buono V, Traversa D, Giangaspero A. Biology of Thelazia callipaeda (Spirurida, Thelaziidae) eyeworms in naturally infected definitive hosts. Parasitology. 2004;129:627-33 pubmed
    ..This basic knowledge of the development of T. callipaeda will hopefully help future epidemiological studies to identify the intermediate hosts and define the likely risk for vectors in field conditions...
  9. Otranto D, Dantas Torres F, Tarallo V, Ramos R, Stanneck D, Baneth G, et al. Apparent tick paralysis by Rhipicephalus sanguineus (Acari: Ixodidae) in dogs. Vet Parasitol. 2012;188:325-9 pubmed publisher
    ..Other causes of neurological disease in dogs were excluded and the diagnosis of tick paralysis by R. sanguineus was confirmed (ex juvantibus) by early and complete recovery of 4 dogs following acaricidal treatment and tick removal...
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    Otranto D, Rehbein S, Weigl S, Cantacessi C, Parisi A, Lia R, et al. Morphological and molecular differentiation between Dicrocoelium dendriticum (Rudolphi, 1819) and Dicrocoelium chinensis (Sudarikov and Ryjikov, 1951) Tang and Tang, 1978 (Platyhelminthes: Digenea). Acta Trop. 2007;104:91-8 pubmed
    ..dendriticum and D. chinensis as two distinct digeneans infecting ruminants. The implications on the separate status of D. chinensis on the etiology, biology and diagnosis of dicrocoeliosis are discussed...
  11. Otranto D, Stevens J, Testini G, Cantacessi C, Maca J. Molecular characterization and phylogenesis of Steganinae (Diptera, Drosophilidae) inferred by the mitochondrial cytochrome c oxidase subunit 1. Med Vet Entomol. 2008;22:37-47 pubmed publisher
    ..The molecular data reported here represent the first molecular dataset based on cox1 of Steganinae flies and provide a base for further investigations into the evolutionary relationships among this little-studied subfamily...
  12. Otranto D, Diniz D, Dantas Torres F, Casiraghi M, de Almeida I, de Almeida L, et al. Human intraocular filariasis caused by Dirofilaria sp. nematode, Brazil. Emerg Infect Dis. 2011;17:863-6 pubmed publisher
    ..immitis infesting dogs in the same area. A zoonotic Dirofilaria species infesting wild mammals in Brazil and its implications are discussed...
  13. Otranto D, Testini G, Dantas Torres F, Latrofa M, Diniz P, de Caprariis D, et al. Diagnosis of canine vector-borne diseases in young dogs: a longitudinal study. J Clin Microbiol. 2010;48:3316-24 pubmed publisher
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    Otranto D, Lia R, Testini G, Milillo P, Shen J, Wang Z. Musca domestica is not a vector of Thelazia callipaeda in experimental or natural conditions. Med Vet Entomol. 2005;19:135-9 pubmed
    ..domestica collected from Group 3 were negative for T. callipaeda. The results clearly suggest that M. domestica is unlikely to act as a vector of T. callipaeda in southern Europe, in contrast with a single previous report...
  15. Otranto D, Dantas Torres F, Papadopoulos E, Petrić D, Ćupina A, Bain O. Tracking the vector of Onchocerca lupi in a rural area of Greece. Emerg Infect Dis. 2012;18:1196-200 pubmed publisher
    ..The scientific purposes of the expedition blended then with stories of humans, animals, and parasites in this rural area...
  16. request reprint
    Otranto D, Traversa D. Dicrocoeliosis of ruminants: a little known fluke disease. Trends Parasitol. 2003;19:12-5 pubmed
  17. request reprint
    Otranto D, Testini G, De Luca F, Hu M, Shamsi S, Gasser R. Analysis of genetic variability within Thelazia callipaeda (Nematoda: Thelazioidea) from Europe and Asia by sequencing and mutation scanning of the mitochondrial cytochrome c oxidase subunit 1 gene. Mol Cell Probes. 2005;19:306-13 pubmed
    ..The results for the SSCP analysis and sequencing were concordant, indicating that the mutation scanning approach provides a useful tool for investigating the population genetics and molecular ecology of T. callipaeda...
  18. Otranto D, Dantas Torres F, Weigl S, Latrofa M, Stanneck D, Decaprariis D, et al. Diagnosis of Hepatozoon canis in young dogs by cytology and PCR. Parasit Vectors. 2011;4:55 pubmed publisher
    ..Our study aimed to evaluate the best method to achieve a parasitological diagnosis of H. canis infection in a population of receptive young dogs, previously negative by cytology and exposed to tick infestation for one summer season...
  19. Otranto D, Eberhard M. Zoonotic helminths affecting the human eye. Parasit Vectors. 2011;4:41 pubmed publisher
    ..The biology and epidemiology of the most frequently reported HIE are discussed as well as clinical description of the diseases, diagnostic considerations and video clips on their presentation and surgical treatment...
  20. Otranto D, Sakru N, Testini G, Gürlü V, Yakar K, Lia R, et al. Case report: First evidence of human zoonotic infection by Onchocerca lupi (Spirurida, Onchocercidae). Am J Trop Med Hyg. 2011;84:55-8 pubmed publisher
    ..lupi should be considered in the differential diagnosis of other eye parasitic infections in humans. The role of dogs as natural hosts of O. lupi and the vectors of this zoonotic parasite need to be investigated...
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    Otranto D, Lia R, Cantacessi C, Testini G, Troccoli A, Shen J, et al. Nematode biology and larval development of Thelazia callipaeda (Spirurida, Thelaziidae) in the drosophilid intermediate host in Europe and China. Parasitology. 2005;131:847-55 pubmed
    ..callipaeda and discussed. Finally, the relationship between T. callipaeda and its fly vector is considered in light of disease prophylaxis and to model its dissemination into habitats and environments favourable to Phortica flies...
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    Otranto D, Ferroglio E, Lia R, Traversa D, Rossi L. Current status and epidemiological observation of Thelazia callipaeda (Spirurida, Thelaziidae) in dogs, cats and foxes in Italy: a "coincidence" or a parasitic disease of the Old Continent?. Vet Parasitol. 2003;116:315-25 pubmed
    ..callipaeda is also present in other European countries. Speculation as to the origins of this parasitic infestation in Europe and the biology of T. callipaeda and its vector/s is also discussed...
  23. request reprint
    Otranto D, Lia R, Traversa D, Giannetto S. Thelazia callipaeda (Spirurida, Thelaziidae) of carnivores and humans: morphological study by light and scanning electron microscopy. Parassitologia. 2003;45:125-33 pubmed
    ..The morphological characteristics useful for the identification of T. callipaeda are discussed...
  24. Otranto D, Paradies P, Testini G, Latrofa M, Weigl S, Cantacessi C, et al. Application of 10% imidacloprid/50% permethrin to prevent Ehrlichia canis exposure in dogs under natural conditions. Vet Parasitol. 2008;153:320-8 pubmed publisher
    ..canis at one or both follow-ups. ImPer, by virtue of its repellent and acaricidal activity against ticks, has been shown to be efficacious to prevent E. canis infection in treated dogs living under natural conditions in endemic areas...
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    Otranto D, Brianti E, Cantacessi C, Lia R, Maca J. The zoophilic fruitfly Phortica variegata: morphology, ecology and biological niche. Med Vet Entomol. 2006;20:358-64 pubmed
    ..The results reported here contribute basic knowledge on the ecology and geographical distribution of P. variegata flies, which will be fundamental to gaining a better understanding of their role as vectors of human and animal pathogens...
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    Otranto D, Paradies P, Testini G, Lia R, Giangaspero A, Traversa D, et al. First description of the endogenous life cycle of Hypoderma sinense affecting yaks and cattle in China. Med Vet Entomol. 2006;20:325-8 pubmed
    ..sinense will help to determine the timing of specific treatment programmes to guarantee the improvement of animal welfare and health, thus resulting in an increase in livestock production in China...
  27. request reprint
    Otranto D, Traversa D. Molecular characterization of the first internal transcribed spacer of ribosomal DNA of the most common species of eyeworms (Thelazioidea: Thelazia). J Parasitol. 2004;90:185-8 pubmed
    ..transmission patterns and prevalence in definitive and intermediate hosts...
  28. Otranto D, Dantas Torres F, Mallia E, DiGeronimo P, Brianti E, Testini G, et al. Thelazia callipaeda (Spirurida, Thelaziidae) in wild animals: report of new host species and ecological implications. Vet Parasitol. 2009;166:262-7 pubmed publisher
    ..The role the wild fauna plays in maintaining and spreading eyeworm infection in humans and domestic animals is also discussed...
  29. Otranto D, Dutto M. Human thelaziasis, Europe. Emerg Infect Dis. 2008;14:647-9 pubmed publisher
    ..Thelazia callipaeda eyeworm is a nematode transmitted by drosophilid flies to carnivores in Europe. It has also been reported in the Far East in humans. We report T. callipaeda infection in 4 human patients in Italy and France...
  30. Otranto D, Brianti E, Dantas Torres F, Weigl S, Latrofa M, Gaglio G, et al. Morphological and molecular data on the dermal microfilariae of a species of Cercopithifilaria from a dog in Sicily. Vet Parasitol. 2011;182:221-9 pubmed publisher
  31. Otranto D, Brianti E, Latrofa M, Annoscia G, Weigl S, Lia R, et al. On a Cercopithifilaria sp. transmitted by Rhipicephalus sanguineus: a neglected, but widespread filarioid of dogs. Parasit Vectors. 2012;5:1 pubmed publisher
    ..A large epidemiological survey was conducted by examining skin samples (n = 917) and ticks (n = 890) collected from dogs at different time points in Italy, central Spain and eastern Greece...
  32. Otranto D, Dantas Torres F, Cebeci Z, Yeniad B, Buyukbabani N, Boral O, et al. Human ocular filariasis: further evidence on the zoonotic role of Onchocerca lupi. Parasit Vectors. 2012;5:84 pubmed publisher
    ..lupi infesting human eyes in two patients from Turkey (case 1) and Tunisia (case 2). The importance of obtaining a correct sample collection and preparation of nematodes infesting human eyes is highlighted...
  33. request reprint
    Otranto D, Cantacessi C, Mallia E, Lia R. First report of Thelazia callipaeda (Spirurida, Thelaziidae) in wolves in Italy. J Wildl Dis. 2007;43:508-11 pubmed
    ..callipaeda was present. The competence of wolves as a definitive host for T. callipaeda is discussed in view of the relevance of wild fauna in maintaining and spreading eyeworm infection in humans and domestic animals...
  34. request reprint
    Otranto D, Cantacessi C, Testini G, Lia R. Phortica variegata as an intermediate host of Thelazia callipaeda under natural conditions: evidence for pathogen transmission by a male arthropod vector. Int J Parasitol. 2006;36:1167-73 pubmed
    ..The synchrony between the fly population dynamics and the biology of the nematode in the definitive host provides an interesting model for exploring the co-evolution of Thelazia spp. with their hosts...