Giuseppe Opocher

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. doi request reprint Functional consequences of succinate dehydrogenase mutations
    Giuseppe Opocher
    Familial Cancer Clinic, Veneto Institute of Oncology, Istituto di Recovero e Cura a Carattere Scientifico, Department of Medical and Surgical Sciences, University of Padova, Via Gattamelata 64, Padua, Italy
    Endocr Pract 17:64-71. 2011
  2. pmc RET codon 609 mutations: a contribution for better clinical managing
    Caterina Mian
    Department of Medicine, University of Padova, Padova, Italy
    Clinics (Sao Paulo) 67:33-6. 2012
  3. ncbi request reprint Clinical and genetic aspects of phaeochromocytoma
    Giuseppe Opocher
    Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Horm Res 59:56-61. 2003
  4. ncbi request reprint Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1
    Giuseppe Opocher
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35128 Padova, Italy
    Fam Cancer 4:13-6. 2005
  5. ncbi request reprint Fine analysis of the short arm of chromosome 1 in sporadic and familial pheochromocytoma
    G Opocher
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Clin Endocrinol (Oxf) 59:707-15. 2003
  6. doi request reprint Characterization of the largest kindred with MEN2A due to a Cys609Ser RET mutation
    Caterina Mian
    Endocrinology Unit, University of Padua, Padua, Italy
    Fam Cancer 8:379-82. 2009
  7. doi request reprint The endemic paraganglioma syndrome type 1: origin, spread, and clinical expression
    Francesca Schiavi
    Department of Medicine, University of Padova, Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology, Instituto di Ricovero e Cura a Carattere Scientifico, Via Gattamelata 64, 35128 Padova, Italy
    J Clin Endocrinol Metab 97:E637-41. 2012
  8. doi request reprint Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification
    Caterina Mian
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale n 105, 35128 Padova, Italy
    Eur J Endocrinol 164:971-6. 2011
  9. doi request reprint Factors influencing the rising rates of adrenal surgery: analysis of a 25-year experience
    Antonio Toniato
    Surgical Pathology Medical and Surgical Sciences, University of Padua, Padua, Italy
    Surg Endosc 23:503-7. 2009
  10. doi request reprint Is genetic screening indicated in apparently sporadic pheochromocytomas and paragangliomas?
    Maurizio Iacobone
    Endocrine Surgery Unit, University of Padua, Padua, Italy
    Surgery 150:1194-201. 2011

Detail Information

Publications46

  1. doi request reprint Functional consequences of succinate dehydrogenase mutations
    Giuseppe Opocher
    Familial Cancer Clinic, Veneto Institute of Oncology, Istituto di Recovero e Cura a Carattere Scientifico, Department of Medical and Surgical Sciences, University of Padova, Via Gattamelata 64, Padua, Italy
    Endocr Pract 17:64-71. 2011
    ..To explore the genotype-phenotype correlation among the different forms of hereditary paraganglioma...
  2. pmc RET codon 609 mutations: a contribution for better clinical managing
    Caterina Mian
    Department of Medicine, University of Padova, Padova, Italy
    Clinics (Sao Paulo) 67:33-6. 2012
    ....
  3. ncbi request reprint Clinical and genetic aspects of phaeochromocytoma
    Giuseppe Opocher
    Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Horm Res 59:56-61. 2003
    ..Molecular evidence suggests that other genes such as SDHD or SDHB may control its development; the possibility of other putative phaeochromocytoma genes is currently being investigated...
  4. ncbi request reprint Pheochromocytoma in von Hippel-Lindau disease and neurofibromatosis type 1
    Giuseppe Opocher
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale 105, 35128 Padova, Italy
    Fam Cancer 4:13-6. 2005
    ..Whether there is a common pathway among these different genes is still a matter of debate...
  5. ncbi request reprint Fine analysis of the short arm of chromosome 1 in sporadic and familial pheochromocytoma
    G Opocher
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    Clin Endocrinol (Oxf) 59:707-15. 2003
    ..Recent studies provided evidence that a new tumour suppressor gene, mapping on the short arm of chromosome 1, could be involved in early tumourigenesis of pheochromocytoma...
  6. doi request reprint Characterization of the largest kindred with MEN2A due to a Cys609Ser RET mutation
    Caterina Mian
    Endocrinology Unit, University of Padua, Padua, Italy
    Fam Cancer 8:379-82. 2009
    ..In conclusion, at variance from what already known, in this large kindred the Cys609Ser RET mutation predispose to a scarcely aggressive, highly penetrant MTC and a low penetrance of pheochromocytoma and primary hyperparathyroidism...
  7. doi request reprint The endemic paraganglioma syndrome type 1: origin, spread, and clinical expression
    Francesca Schiavi
    Department of Medicine, University of Padova, Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology, Instituto di Ricovero e Cura a Carattere Scientifico, Via Gattamelata 64, 35128 Padova, Italy
    J Clin Endocrinol Metab 97:E637-41. 2012
    ..Anecdotal evidence suggests a high incidence in Trentino, Italy, of head and neck paragangliomas (HNPGL), a rare autosomal dominant disease called paraganglioma type 1 syndrome and caused by germ-line mutations of the SDHD gene...
  8. doi request reprint Combined RET and Ki-67 assessment in sporadic medullary thyroid carcinoma: a useful tool for patient risk stratification
    Caterina Mian
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padova, Via Ospedale n 105, 35128 Padova, Italy
    Eur J Endocrinol 164:971-6. 2011
    ..In sporadic forms, stage at diagnosis is the most important negative prognostic factor. The aim of this study was to evaluate the prognostic impact of molecular and immunohistochemical markers in sporadic MTC...
  9. doi request reprint Factors influencing the rising rates of adrenal surgery: analysis of a 25-year experience
    Antonio Toniato
    Surgical Pathology Medical and Surgical Sciences, University of Padua, Padua, Italy
    Surg Endosc 23:503-7. 2009
    ..There is still debate on the transperitoneal versus the retroperitoneal approach, the advantages and drawbacks of which are discussed here...
  10. doi request reprint Is genetic screening indicated in apparently sporadic pheochromocytomas and paragangliomas?
    Maurizio Iacobone
    Endocrine Surgery Unit, University of Padua, Padua, Italy
    Surgery 150:1194-201. 2011
    ..This study aimed to assess the effective rate of germline mutations causing Pheo and Paraganglioma (PGL), and the role of systematic genetic screening...
  11. ncbi request reprint Familial nonsyndromic pheochromocytoma
    Giuseppe Opocher
    Endocrinology Unit, Department of Medical and Surgical Sciences, University Hospital of Padova, Padova, Italy
    Ann N Y Acad Sci 1073:149-55. 2006
    ....
  12. pmc MicroRNA profiles in familial and sporadic medullary thyroid carcinoma: preliminary relationships with RET status and outcome
    Caterina Mian
    Endocrinology Unit, Department of Medicine, University of Padua, Via Aristide Gabelli 61, Padua, Italy
    Thyroid 22:890-6. 2012
    ..The aim of this study was to test the hypothesis that different miRNA profiles are related to RET status and prognosis in patients with hereditary MTC (hMTC) and sporadic MTC (sMTC)...
  13. ncbi request reprint Is the laparoscopic adrenalectomy for pheochromocytoma the best treatment?
    Antonio Toniato
    Institute of Surgical Pathology, Department of Medical and Surgical Sciences, University of Padua School of Medicine, Italy
    Surgery 141:723-7. 2007
    ....
  14. ncbi request reprint Molecular characteristics in papillary thyroid cancers (PTCs) with no 131I uptake
    Caterina Mian
    Endocrinology Unit, Department of Medical and Surgical Sciences, University of Padua, Italy
    Clin Endocrinol (Oxf) 68:108-16. 2008
    ..Papillary thyroid cancers (PTCs) with no iodine uptake have an aggressive behaviour and a poor prognosis. The aim of our study was to characterize, at molecular level, a subset of PTC with no 131 iodine ((131)I) uptake...
  15. doi request reprint Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study
    Antonio Toniato
    Surgical Pathology Clinic, Department of Medical and Surgical Sciences, University of Padua School of Medicine, Padova, Italy
    Ann Surg 249:388-91. 2009
    ....
  16. ncbi request reprint The M235T polymorphism of the angiotensinogen gene in women with polycystic ovary syndrome
    Elisa Zulian
    Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Fertil Steril 84:1520-1. 2005
    ....
  17. ncbi request reprint Predictors and prevalence of paraganglioma syndrome associated with mutations of the SDHC gene
    Francesca Schiavi
    Department of Endocrinology, University of Padova, Padova, Italy
    JAMA 294:2057-63. 2005
    ..In contrast with those with germline mutations of the SDHB and SDHD genes, clinical and genetic data on patients with mutations of SDHC are scarce...
  18. doi request reprint Genetics of pheochromocytomas and paragangliomas
    Giuseppe Opocher
    Veneto Institute of Oncology, Padova, Italy
    Best Pract Res Clin Endocrinol Metab 24:943-56. 2010
    ..A mechanism conducing to a defective apoptosis is the common pathways of those genes. Finally, there is also good evidence of the role of other genes, not yet completely identified...
  19. ncbi request reprint Laparoscopic adrenalectomy for pheochromocytoma: is it really more difficult?
    Antonio Toniato
    Institute of Surgical Pathology, Department of Medical and Surgical Sciences, University of Padua, Via Giustiniani 2, Padua, 35128, Italy
    Surg Endosc 21:1323-6. 2007
    ..Laparoscopic adrenalectomy (LA) has become the gold standard technique for almost all the adrenal masses, but several Authors still debate about LA in pheochromocytoma...
  20. doi request reprint Within-patient reproducibility of the aldosterone: renin ratio in primary aldosteronism
    Gian Paolo Rossi
    DMCS Internal Medicine 4, University Hospital, Via Giustiniani 2, 35126 Padova, Italy
    Hypertension 55:83-9. 2010
    ..Hence, contrary to previously claimed poor reproducibility of the ARR, these data support its use for the screening of primary aldosteronism...
  21. ncbi request reprint Paraganglioma syndrome: SDHB, SDHC, and SDHD mutations in head and neck paragangliomas
    Francesca Schiavi
    Unità di Endocrinologia, Dipartimento Scienze Mediche e Chirurgiche, Universita di Padova, Italy
    Ann N Y Acad Sci 1073:190-7. 2006
    ..SDHB, SDHC, and SDHD molecular screening is important in all HNPs, with or without primary indicators of paraganglioma syndrome, to orient mutation-driven clinical screening for additional HNPs and pheochromocytoma...
  22. doi request reprint Prevalence of AIP mutations in a large series of sporadic Italian acromegalic patients and evaluation of CDKN1B status in acromegalic patients with multiple endocrine neoplasia
    G Occhi
    Endocrinology Division, Department of Medical and Surgical Sciences, Via Ospedale, 105, 35128 Padova, Italy
    Eur J Endocrinol 163:369-76. 2010
    ..Somatotropinomas are present in most AIP mutated FIPA kindreds, as well as in two-thirds of MEN4 patients who carry pituitary tumors...
  23. ncbi request reprint Retinal abnormalities associated with a mutation of the nucleotide 683 in von Hippel-Lindau disease
    S Piermarocchi
    Institute of Ophthalmology, University of Padua, Italy
    Graefes Arch Clin Exp Ophthalmol 238:615-20. 2000
    ..von Hippel-Lindau disease (VHL) is a hereditary cancer syndrome in which affected individuals are at risk of developing tumors in multiple organs, including eyes, cerebellum, spinal cord, kidneys, inner ear, adrenal glands and pancreas...
  24. ncbi request reprint A meta-iodobenzylguanidine scintigraphic scoring system increases accuracy in the diagnostic management of pheochromocytoma
    D Cecchin
    Nuclear Medicine Service, Department of Diagnostic Medical Sciences, School of Medicine, University of Padua, Via Ospedale 105, 35128 Padua, Italy
    Endocr Relat Cancer 13:525-33. 2006
    ..3% respectively. Normal adrenal tissue uptake was correctly discriminated from pheochromocytomas in 18 out of 20 patients, with adrenal uptake equal to the liver (grade 2), using the proposed cut-off level...
  25. ncbi request reprint Somatic mosaicism in von Hippel-Lindau Disease
    A Murgia
    Department of Pediatrics, University of Padua, Italy
    Hum Mutat 15:114. 2000
    ..Hum Mutat 15:114, 2000...
  26. ncbi request reprint Unilateral adrenal tumor, erectile dysfunction and infertility in a patient with 21-hydroxylase deficiency: effects of glucocorticoid treatment and surgery
    C Scaroni
    Department of Endocrinology, University of Padova, Padova, Italy
    Exp Clin Endocrinol Diabetes 111:41-3. 2003
    ..Impotence during treatment is probably due to a decrease of excessive adrenal androgens while testicular androgen production is still suppressed...
  27. doi request reprint Role of the genetic study in the management of carotid body tumor in paraganglioma syndrome
    M Antonello
    Department of Cardiac, Thoracic and Vascular Sciences, Section of Vascular and Endovascular Surgery, University of Padua, Italy
    Eur J Vasc Endovasc Surg 36:517-9. 2008
    ..During a 3-years follow-up the thoracic paraganglioma as expected, didn't increase. Genetic analysis of succinate dehydrogenase, should be performed in the management of CBT...
  28. ncbi request reprint Does dynamic testing have a place in the modern assessment of endocrine hypertension?
    F Mantero
    Division of Endocrinology, Department of Medical and Surgical Sciences, University of Padua, Padua, Italy
    J Endocrinol Invest 26:92-8. 2003
    ..Endocrine hypertension comprises a spectrum of diseases (Table 1)...
  29. ncbi request reprint Molecular diagnosis of inherited diseases
    A Murgia
    Department of Pediatrics, University of Padua, Italy
    Clin Chim Acta 280:73-80. 1999
    ....
  30. ncbi request reprint Angiotensin II receptors in cortical and medullary adrenal tumors
    G Opocher
    Institute of Semeiotica Medica, University of Padua, Italy
    J Clin Endocrinol Metab 82:865-9. 1997
    ..Further investigation of the expression and functional characterization of Ang II receptors is required to better clarify their possible role in adrenal tumorigenesis...
  31. doi request reprint Long-term prognosis of patients with pediatric pheochromocytoma
    Birke Bausch
    2nd Department of Medicine, University of Freiburg, Freiburg, Germany Department of Surgery, University Hospital Schleswig Holstein, Campus Luebeck, Luebeck, Germany Department of Medicine, Familial Cancer Clinic and Oncoendocrinology, University of Padova, Padova, Italy Center for Endocrinological Investigations CEDIE, Hospital de Niños R Gutiérrez, Buenos Aires, Argentina Department of Surgery, Center of Minimally Invasive Surgery, Kliniken Essen Mitte, Essen, Germany Department of Hypertension, Institute of Cardiology, Warsaw, Poland Department of Endocrinology, University of Lorraine, Nancy, France Division of Pediatric Surgery, Department of Pediatrics, University Hospital of Padova, Padova, Italy Pediatric Oncology, Division of Hematology and Oncology, Department of Pediatrics, University Hospital of Padova, Padova, Italy Department of Endocrinology, University Medical Center, University of Duisburg and Essen, Essen, Germany Department of Pediatrics, Hospital Great Ormond Street, London, Sixth Hospital of Shanghai Jiaotong University
    Endocr Relat Cancer 21:17-25. 2014
    ..Based on these data, gene-adjusted, specific surveillance guidelines can help effective preventive medicine. ..
  32. pmc A novel mutation in the upstream open reading frame of the CDKN1B gene causes a MEN4 phenotype
    Gianluca Occhi
    Department of Medicine, Endocrinology Unit, University of Padova, Padova, Italy
    PLoS Genet 9:e1003350. 2013
    ..This study adds the CDKN1B gene to the short list of genes for which mutations that either create, delete, or severely modify their regulatory uORFs have been associated with human diseases...
  33. ncbi request reprint Molecular analysis of two uncharacterized sequence variants of the VHL gene
    Maddalena Martella
    Department of Pediatrics, University of Padova, Via Giustiniani 3, 35128 Padua, Italy
    J Hum Genet 51:964-8. 2006
    ..mRNA analysis will be required to ultimately resolve this issue...
  34. ncbi request reprint Genetics of adrenal tumors
    G Opocher
    Familial Cancer Clinic, Veneto Institute of Oncology, Padua, Italy
    Minerva Endocrinol 34:107-21. 2009
    ....
  35. ncbi request reprint Genetics and biology of pheochromocytoma
    M Mannelli
    Department of Clinical Pathophysiology, Endocrinology Unit, University of Florence, Florence, Italy
    Exp Clin Endocrinol Diabetes 115:160-5. 2007
    ..The clinical picture and the biological characteristics of the tumor may suggest the priority of the genes to be tested first...
  36. doi request reprint 18F-DOPA PET/CT in the evaluation of hereditary SDH-deficiency paraganglioma-pheochromocytoma syndromes
    Maria Cristina Marzola
    From the Department of Nuclear Medicine, PET CT Centre, Medical Physics Unit, Santa Maria della Misericordia Hospital, Rovigo, Italy Department of Medicine DIMED, University of Padova, Padova, Italy Familial Cancer Clinic and Oncoendocrinology, Veneto Institute of Oncology, IRCCS, Milan, Italy and Department of Radiology, University of Southern California, Los Angeles, CA
    Clin Nucl Med 39:e53-8. 2014
    ....
  37. ncbi request reprint Difficulties in the mutation analysis of plasminogen gene: a study in two patients with ligneous conjunctivitis
    Maria Teresa Sartori
    Second Chair of Internal Medicine, Department of Medical and Surgical Sciences, University of Padua Medical School, Italy
    Clin Appl Thromb Hemost 12:77-84. 2006
    ..In conclusion, these data confirm the difficulty of plasminogen genetic analysis and may help researchers to better identify the true plasminogen gene mutations causing molecular defects...
  38. ncbi request reprint Neurosurgical treatment of von Hippel-Lindau-associated hemangioblastomas: benefits, risks and outcome
    G Pavesi
    Neurosurgical Operative Unit, Padova Hospital, Padua, Italy
    J Neurosurg Sci 52:29-36. 2008
    ....
  39. ncbi request reprint Atrial natriuretic peptide infusion in primary aldosteronism. Renal, hemodynamic and hormonal effects
    S Rocco
    Institute of Semeiotica Medica, University of Padua, Italy
    Am J Hypertens 3:668-73. 1990
    ..These data confirm the potent natriuretic effect of ANP infusion and the lack of correlation between ANP induced natriuresis and the effect of ANP on aldosterone in patients with primary aldosteronism...
  40. ncbi request reprint Phaeochromocytoma, new genes and screening strategies
    Anne Paule Gimenez-Roqueplo
    Department of Genetics, Hopital Europeen Georges Pompidou, Assistance Publique Hopitaux de Paris, France
    Clin Endocrinol (Oxf) 65:699-705. 2006
    ..The ENS@T Phaeochromocytoma Working Group recommends the genetic testing of all patients with PH and FPGL and suggests a practice algorithm for the management of their exploration...
  41. ncbi request reprint Genetic and clinical investigation of pheochromocytoma: a 22-year experience, from Freiburg, Germany to international effort
    Birke Bausch
    Department of Nephrology, Albert Ludwigs University, Freiburg, Germany
    Ann N Y Acad Sci 1073:122-37. 2006
    ..We differentiated distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations. Finally, we identified predictors and prevalence of paraganglioma syndromes associated with mutations of the SDHC gene...
  42. ncbi request reprint Germline NF1 mutational spectra and loss-of-heterozygosity analyses in patients with pheochromocytoma and neurofibromatosis type 1
    Birke Bausch
    Department of Neurology, University Medical Center Freiburg, Germany
    J Clin Endocrinol Metab 92:2784-92. 2007
    ..Because of the low prevalence of pheochromocytoma in NF1, we ascertained subjects by pheochromocytoma that also had NF1 in the hope of describing the germline NF1 mutational spectra of NF1-related pheochromocytoma...
  43. ncbi request reprint Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations
    Hartmut P H Neumann
    Department of Nephrology and Hypertension, Albert Ludwigs University, Freiburg, Germany
    JAMA 292:943-51. 2004
    ..In both syndromes, pheochromocytomas as well as head and neck paragangliomas occur; however, details for individual risks and other clinical characteristics are unknown...
  44. ncbi request reprint Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma
    Massimo Terzolo
    Dipartimento di Scienze Cliniche e Biologiche, Medicina Interna I, Universita di Torino, Turin, Orbassano, Italy
    Eur J Endocrinol 153:307-15. 2005
    ..In the present study, we have determined the prevalence of alterations of the hypothalamic-pituitary-adrenal axis in such patients and examined whether any correlation between endocrine data and the clinical phenotype exists...
  45. ncbi request reprint Low frequency of VHL gene mutations in young individuals with polycythemia and high serum erythropoietin
    Maria Luigia Randi
    Haematologica 90:689-91. 2005
    ..The man's unaffected mother and sister carry the same mutation. No other VHL genomic or expression alterations were found. In one other patient different genetic conditions were found...
  46. ncbi request reprint Genetic polymorphism of the renin-angiotensin-aldosterone system and arterial hypertension in the Italian population: the GENIPER Project
    Maurizio Castellano
    Dipartimento di Scienze Mediche e Chirurgiche, University of Brescia, c o 2Medicina, Spedali Civili, 25100 Brescia, Italy
    J Hypertens 21:1853-60. 2003
    ..To detect the association of single polymorphisms of the renin-angiotensin-aldosterone system (RAAS), or different combinations thereof, with hypertension...