Fausta Omodeo-Salè

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. pmc Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme
    F Omodeo-Sale
    Dipartimento di Scienze Molecolari Applicate ai Biosistemi DISMAB, Facolta di Farmacia, Universita di Milano, Milan, Italy
    Am J Physiol Cell Physiol 299:C148-54. 2010
  2. pmc Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes
    Fausta Omodeo-Salè
    Dipartimento di Scienze Molecolari Applicate ai Biosistemi DISMAB, Facolta di Farmacia, Universita degli Studi di Milano, Milan, Italy
    Antimicrob Agents Chemother 53:4339-44. 2009
  3. ncbi request reprint Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX
    Fausta Omodeo-Salè
    Institute of General Physiology and Biochemistry G Esposito, University of Milan, Via Trentacoste 2, 20134 Milan, Italy
    Biochem Pharmacol 74:1383-9. 2007
  4. ncbi request reprint Regulation of human erythrocyte glyceraldehyde-3-phosphate dehydrogenase by ferriprotoporphyrin IX
    Fausta Omodeo Salè
    Institute of General Physiology and Biochemistry G Esposito, Facolta di Farmacia, University of Milan, Milan, Italy
    FEBS Lett 579:5095-9. 2005
  5. ncbi request reprint Major artifacts encountered in studying biological samples containing ferric protoporphyrin IX
    Fausta Omodeo Salè
    Department of Pharmacy, Institute of General Physiology and Biochemistry G Esposito, University of Milan, Milan 20134, Italy
    Anal Biochem 339:257-61. 2005
  6. ncbi request reprint Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products
    Fausta Omodeo-Salè
    Institute of General Physiology and Biochemistry G Esposito, University of Milan, Milan, Italy
    Eur J Haematol 74:324-32. 2005
  7. ncbi request reprint Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum
    Fausta Omodeo-Salè
    Istituto di Fisiologia Generale e Chimica Biologica Giovanni Esposito, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy
    Blood 102:705-11. 2003
  8. pmc The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1
    Nicoletta Basilico
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy
    J Biomed Biotechnol 2010:854927. 2010
  9. doi request reprint Two complementary fluorimetric assays for the determination of aminoquinoline binding and uptake by human erythrocytes in vitro
    Nicoletta Basilico
    Institute of General Physiology and Biochemistry G Esposito, Department of Public Health Microbiology Virology, Faculty of Pharmacy, University of Milan, Milan, Italy
    Anal Biochem 385:371-3. 2009
  10. doi request reprint Hypoxia modulates the effect of dihydroartemisinin on endothelial cells
    S D'Alessandro
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita di Milano, Via Pascal 36, Milan, Italy
    Biochem Pharmacol 82:476-84. 2011

Collaborators

Detail Information

Publications14

  1. pmc Dysregulation of L-arginine metabolism and bioavailability associated to free plasma heme
    F Omodeo-Sale
    Dipartimento di Scienze Molecolari Applicate ai Biosistemi DISMAB, Facolta di Farmacia, Universita di Milano, Milan, Italy
    Am J Physiol Cell Physiol 299:C148-54. 2010
    ..We conclude that L-Arg transport across RBC membrane is impaired and arginase-mediated L-Arg consumption enhanced by free heme. This could contribute to reduced NO production in severe malaria...
  2. pmc Novel antimalarial aminoquinolines: heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes
    Fausta Omodeo-Salè
    Dipartimento di Scienze Molecolari Applicate ai Biosistemi DISMAB, Facolta di Farmacia, Universita degli Studi di Milano, Milan, Italy
    Antimicrob Agents Chemother 53:4339-44. 2009
    ....
  3. ncbi request reprint Modulation of glyceraldehyde 3 phosphate dehydrogenase activity and tyr-phosphorylation of Band 3 in human erythrocytes treated with ferriprotoporphyrin IX
    Fausta Omodeo-Salè
    Institute of General Physiology and Biochemistry G Esposito, University of Milan, Via Trentacoste 2, 20134 Milan, Italy
    Biochem Pharmacol 74:1383-9. 2007
    ....
  4. ncbi request reprint Regulation of human erythrocyte glyceraldehyde-3-phosphate dehydrogenase by ferriprotoporphyrin IX
    Fausta Omodeo Salè
    Institute of General Physiology and Biochemistry G Esposito, Facolta di Farmacia, University of Milan, Milan, Italy
    FEBS Lett 579:5095-9. 2005
    ..Second, G3PD binding to the membrane is modified and the enzyme is activated through displacement into the cytosol and/or release from its binding site...
  5. ncbi request reprint Major artifacts encountered in studying biological samples containing ferric protoporphyrin IX
    Fausta Omodeo Salè
    Department of Pharmacy, Institute of General Physiology and Biochemistry G Esposito, University of Milan, Milan 20134, Italy
    Anal Biochem 339:257-61. 2005
    ..Third, in the presence of thiol compounds such as N-acetyl cysteine, FP is degraded to products that interfere with the thiobarbituric acid assay, one of the most widely used methods to measure the extent of lipoperoxidation...
  6. ncbi request reprint Destabilisation and subsequent lysis of human erythrocytes induced by Plasmodium falciparum haem products
    Fausta Omodeo-Salè
    Institute of General Physiology and Biochemistry G Esposito, University of Milan, Milan, Italy
    Eur J Haematol 74:324-32. 2005
    ..These changes could contribute to the reduced red cell deformability associated with severe malaria...
  7. ncbi request reprint Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum
    Fausta Omodeo-Salè
    Istituto di Fisiologia Generale e Chimica Biologica Giovanni Esposito, Facolta di Farmacia, Via Trentacoste 2, 20134 Milano, Italy
    Blood 102:705-11. 2003
    ..In summary, we demonstrated that membrane damage leading to accelerated senescence of both infected and uninfected erythrocytes will likely contribute to malaria anemia...
  8. pmc The lipid moiety of haemozoin (Malaria Pigment) and P. falciparum parasitised red blood cells bind synthetic and native endothelin-1
    Nicoletta Basilico
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita degli Studi di Milano, Via Pascal 36, 20133 Milan, Italy
    J Biomed Biotechnol 2010:854927. 2010
    ..The results indicate that ET-1 binds to the lipids moiety of HZ and membranes of infected RBCs. These findings may help understanding the consequences of parasite sequestration in severe malaria...
  9. doi request reprint Two complementary fluorimetric assays for the determination of aminoquinoline binding and uptake by human erythrocytes in vitro
    Nicoletta Basilico
    Institute of General Physiology and Biochemistry G Esposito, Department of Public Health Microbiology Virology, Faculty of Pharmacy, University of Milan, Milan, Italy
    Anal Biochem 385:371-3. 2009
    ..Drug uptake is dose dependent and related to the number of erythrocytes. These assays could be useful when studying the cell interaction of quinoline-type compounds not available in the radioactive form...
  10. doi request reprint Hypoxia modulates the effect of dihydroartemisinin on endothelial cells
    S D'Alessandro
    Dipartimento di Sanità Pubblica Microbiologia Virologia, Universita di Milano, Via Pascal 36, Milan, Italy
    Biochem Pharmacol 82:476-84. 2011
    ..This should be considered when studying both the effects of artemisinin derivatives as antimalarials and the potential therapeutic applications of these drugs as anti-tumor agents...
  11. ncbi request reprint Ultrastructural characteristics, biological activity and pharmacological relevance of synthetic malaria pigment (beta-haematin)
    D Taramelli
    Istituto di Microbiologia, Universita di Milano, Via Pascal 36, 20133 Milano, Italy
    Parassitologia 43:45-9. 2001
    ..This was confirmed by the observation that thiol-reducing agents (NAC, cystein) were able to inhibit BH formation and were toxic to parasites in vitro...
  12. ncbi request reprint Macrophage populations of different origins have distinct susceptibilities to lipid peroxidation induced by beta-haematin (malaria pigment)
    F Omodeo-Sale
    Istituto di Fisiologia Generale e Chimica Biologica, Universita di Milano, Milan, Italy
    FEBS Lett 433:215-8. 1998
    ..These findings offer a new interpretation for the contentious immunomodulatory effects of beta-haematin reported for phagocytes of different origins...
  13. pmc Chronic deficiency of nitric oxide affects hypoxia inducible factor-1α (HIF-1α) stability and migration in human endothelial cells
    Maria Grazia Cattaneo
    Department of Pharmacology, School of Medicine, Universita degli Studi di Milano, Milano, Italy
    PLoS ONE 6:e29680. 2011
    ..Here, the behavioural and molecular consequences deriving from NO deficiency in human umbilical vein endothelial cells (HUVECs) were investigated...
  14. ncbi request reprint Old and new targets for innovative antimalarial compounds: the different strategies of the Italian Malaria Network
    N Basilico
    Dipartimento Salute Pubblica Microbiologia Virologia, Universita di Milano, Italy
    Parassitologia 50:133-6. 2008
    ....