Simonetta Oliaro Bosso
Affiliation: University of Turin
Bruni N, Della Pepa C, Oliaro Bosso S, Pessione E, Gastaldi D, Dosio F. Cannabinoid Delivery Systems for Pain and Inflammation Treatment. Molecules. 2018;23: pubmed publisher
..Likely future directions are also considered and reported. ..
Pippione A, Carnovale I, Bonanni D, Sini M, Goyal P, Marini E, et al
. Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid. Eur J Med Chem. 2018;150:930-945 pubmed publisher
..Structure determination of AKR1C3 co-crystallized with one representative compound from each of the two series clearly identified both compounds in the androstenedione binding site, hence supporting the biochemical data. ..
Ferrante T, Barge A, Taramino S, Oliaro Bosso S, Balliano G. 4-Methylzymosterone and Other Intermediates of Sterol Biosynthesis from Yeast Mutants Engineered in the ERG27 Gene Encoding 3-Ketosteroid Reductase. Lipids. 2016;51:1103-13 pubmed publisher
Pippione A, Giraudo A, Bonanni D, Carnovale I, Marini E, Cena C, et al
. Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach. Eur J Med Chem. 2017;139:936-946 pubmed publisher
..This compound was also shown to diminish testosterone production in the AKR1C3-expressing 22RV1 prostate cancer cell line while synergistic effect was observed when 8 was administered in combination with abiraterone or enzalutamide. ..