Research Topics
Genomes and Genes | G G NussdorferSummaryAffiliation: University of Padova Country: Italy Publications
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Publications
Role of VIP, PACAP, and related peptides in the regulation of the hypothalamo-pituitary-adrenal axisG G Nussdorfer
Department of Anatomy, University of Padua, Italy
Peptides 19:1443-67. 1998..g., in the mediation of HPA axis responses to cold and inflammatory stresses) or may be somehow involved in the pathogenesis of Cushing disease or some case of hyperaldosteronism associated with secreting pheochromocytomas...- Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axisG G Nussdorfer
Department of Anatomy, University of Padua, Italy
Peptides 19:949-68. 1998..g., physical or inflammatory stresses) or pathological conditions (e.g., ACTH-secreting pituitary tumors), when an excess of steroid-hormone production has to be counteracted... - Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axisG G Nussdorfer
Department of Human Anatomy and Physiology Section of Anatomy, University of Padua, Via Gabelli 65, I 35121, Padua, Italy
Peptides 21:309-24. 2000..The involvement of growth hormone-releasing hormone and exendins in the functional regulation of the HPA axis has not yet been extensively investigated... - G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascadesG Mazzocchi
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I 35121 Padova, Italy
J Clin Endocrinol Metab 90:3466-71. 2005.... - Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and BG Mazzocchi
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
J Clin Endocrinol Metab 86:4818-21. 2001..Collectively, these findings suggest that orexins stimulate catecholamine secretion from human pheochromocytomas, acting through OX2-R coupled to the PLC-PKC signaling pathway... - Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortexP Rebuffat
Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
Int J Mol Med 7:301-5. 2001.... - Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growthG P Rossi
Departments of Clinical and Experimental Medicine, School of Medicine, University of Padua, 35121 Padua, Italy
J Clin Endocrinol Metab 87:322-8. 2002.... - Endothelin-1[1-31] acts as a selective ETA-receptor agonist in the rat adrenal cortexP Rebuffat
Department of Human Anatomy and Physiology, Padua, Italy
Histol Histopathol 16:535-40. 2001..Collectively, our findings provide strong evidence that ET-1[1-31] acts in the rat adrenal glands as a selective ETA-receptor agonist, mainly involved in the stimulation of ZG proliferative activity... - PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cellsG Mazzocchi
Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
Am J Physiol Endocrinol Metab 280:E209-13. 2001..It is concluded that PTH and PTH-RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA- and PLC/PKC-dependent signaling cascades... - Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascadeG Mazzocchi
Department of Human Anatomy and Physiology, University of Padua, Italy
Horm Metab Res 32:265-8. 2000..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH... - Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathwayG Mazzocchi
Department of Anatomy, University of Padua, Italy
Horm Metab Res 30:241-3. 1998..Collectively, these findings suggest that VIP stimulates glucocorticoid secretion of rat adrenals, through the aspecific activation of ACTH receptors coupled with the adenylate cyclase/PKA-dependent signaling pathway... 
Stereological and functional investigations on isolated adrenocortical cells. III. Zona glomerulosa cells of chronically ACTH-treated ratsP G Andreis
Department of Anatomy, University of Padua, Italy
J Anat 168:199-207. 1990..In the light of these findings, the drop in the plasma level of aldosterone observed in rats after prolonged treatment with ACTH is assumed to be due to an enhanced metabolism of aldosterone, possibly at the hepatic level...- Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studiesG Albertin
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Padua, Italy
Neuropeptides 34:7-11. 2000.... - Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cellsR Spinazzi
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I 35121 Padova, Italy
J Clin Endocrinol Metab 90:3544-9. 2005.... - Acute action of polypeptide YY (PYY) on rat adrenocortical cells: in vivo versus in vitro effectsG Neri
Department of Anatomy, University of Padua, Italy
Neuropeptides 19:73-6. 1991.... - Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascadeG Mazzocchi
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
J Clin Endocrinol Metab 86:778-82. 2001..Collectively, our findings suggest that orexins selectively stimulate glucocorticoid secretion from human adrenocortical cells, acting through OX1-R coupled with the adenylate cyclase-dependent signaling pathway... - Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascadeA Semplicini
Department of Clinical and Experimental Medicine, University of Padua, Italy
J Hypertens 19:599-602. 2001..These results confirm the complex role played by this peptide in the regulation of zona glomerulosa cell physiology... - Expression and function of adrenomedullin and its receptors in Conn's adenoma cellsM Forneris
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
Int J Mol Med 8:675-9. 2001.... - Effects of prolonged sodium restriction on the morphology and function of rat adrenocortical autotransplantsA S Belloni
Department of Anatomy, University of Padua, Italy
Cell Tissue Res 265:35-41. 1991..abstract truncated at 250 words).. - Effects of neuropeptide-Y and substance-P on the secretory activity of dispersed zona-glomerulosa cells of rat adrenal glandG Neri
Department of Anatomy, University of Padua, Italy
Neuropeptides 17:121-5. 1990..The possible physiological implications of these findings are discussed in light of previous studies suggesting a net adrenoglomerulotrophic effect of NPY and SP in vivo... - Stimulation of endogenous nitric oxide production is involved in the inhibitory effect of adrenomedullin on aldosterone secretion in the ratP Rebuffat
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, 35121, Padua, Italy
Peptides 22:923-6. 2001.... - Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascadeG Mazzocchi
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
J Clin Endocrinol Metab 89:1277-84. 2004.... - Proadrenomedullin N-terminal 20 peptide (PAMP) enhances proliferation of rat zona glomerulosa cells by activating MAPK cascadeP Rebuffat
Department of Human Anatomy and Physiology (Section of Anatomy, University of Padua, I-35121, Padua, Italy
Peptides 22:1909-12. 2001..Taken together, these data indicate that PAMP enhances proliferation of cultured rat ZG cells, through the TK-dependent activation of p42/p44 MAPK cascade... - Human pheochromocytomas, but not adrenal medulla, express glucagon-receptor gene and possess an in vitro secretory response to glucagonG Albertin
Department of Human Anatomy and Physiology, School of Medicine, University of Padua, I-35121, Padua, Italy
Peptides 22:597-600. 2001.... - Direct secretagogue effect of corticotropin-releasing factor on the rat adrenal cortex: the involvement of the zona medullarisP G Andreis
Department of Anatomy, University of Padua, Italy
Endocrinology 131:69-72. 1992.... - Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 activityG Mazzocchi
Department of Human Anatomy and Physiology, School of Medicine, University of Padua, Italy
J Investig Med 49:191-4. 2001..We advance the hypothesis that the elevated local concentration of steroid hormones that occur in adenomas down-regulates 11beta-HSD2 activity, thereby contributing to their abnormal steroidogenic function... - Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axisG G Nussdorfer
Department of Human Anatomy and Physiology, University of Padua, Italy
Int Rev Cytol 206:249-84. 2001.... - Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting through ETB receptors coupled with the phospholipase C-dependent signaling pathwayP G Andreis
Department of Human Anatomy and Physiology (Section of Anatomy, University of Padua, Via Gabelli 65, I-35121, Padua, Italy
Peptides 22:117-22. 2001.... - Effects of prolonged treatment with cyanoketone on the zona fasciculata of rat adrenal cortex. A combined morphometric and biochemical studyC Robba
Department of Anatomy, University of Padua, Italy
Cell Tissue Res 250:599-605. 1987.... - Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growthA S Belloni
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Italy
Histol Histopathol 16:1263-74. 2001..Both pADM-derived peptides are thought to be involved in embryogenesis, such a contention being based on the demonstration of high pADM-gene expression during the crucial phases of organ growth and differentiation... - Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal glandC Tortorella
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
Int J Mol Med 8:261-4. 2001..The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors... - Thyrotropin-releasing hormone inhibits glucocorticoid secretion of rat adrenal cortex: in vivo and in vitro studiesG Neri
Department of Anatomy, University of Padua, Italy
Endocrinology 133:511-4. 1993..e. 11- and 18-hydroxylation) without affecting the earlier steps, including the rate-limiting one of this process... - Reciprocal regulation of endothelin-1 and nitric oxide: relevance in the physiology and pathology of the cardiovascular systemG P Rossi
Department of Clinical and Experimental Medicine, University Hospital, University of Padua, Italy
Int Rev Cytol 209:241-72. 2001..Moreover, an imbalance between ET-1 and NO systems may underly the mechanisms involved in the pathogenesis of systemic and pulmonary hypertension and atherosclerosis... - Expression of adrenomedullin and its receptors in the human adrenal cortex and aldosteronomasG Albertin
Department of Human Anatomy and Physiology Section of Anatomy, School of Medicine, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
Int J Mol Med 8:423-6. 2001..In conclusion, our investigation provides the first evidence that human adrenal cortex and aldosteronomas express the ADM system, that may play a role in the paracrine or autocrine control of their functions... - Cerebellin enhances in vitro secretory activity of human adrenal glandG Mazzocchi
Department of Human Anatomy, University of Padua, Italy
J Clin Endocrinol Metab 84:632-5. 1999.... - Two selective rat adrenomedullin (AM)-receptor antagonists: AM20-50 and AM24-50A S Belloni
Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
Cell Mol Biol (Noisy-le-grand) 49:939-43. 2003..Moreover, they provide the first evidence that rAMI-50 and its fragments should be used in the investigations carried out in the rat... - Adrenocortical oncocytoma: case report and review of the literatureC Macchi
Department of Anatomy, University of Padua, Italy
Tumori 84:403-7. 1998..Although the classic histological approach clearly indicates the benign nature of the tumor, the immunocytochemical and ultrastructural features of oncocytes may suggest their potential for malignant behavior... - Neuropeptide-Y family of peptides in the autocrine-paracrine regulation of adrenocortical functionG G Nussdorfer
Department of Anatomy, University of Padua, Padova, Italy
Horm Metab Res 30:368-73. 1998.... - Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathwaysG Mazzocchi
Department of Anatomy, University of Padua, Italy
Endocrinology 138:2333-7. 1997.... - Effects of some vanadyl coordination compounds on the in vitro insulin release from rat pancreatic isletsM T Conconi
Departments of Pharmaceutical Sciences, University of Padua, Padua, Italy
Horm Metab Res 35:402-6. 2003.... - Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glandsL K Malendowicz
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Histol Histopathol 16:713-7. 2001.... - Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal glandL K Malendowicz
Department of Histology and Embryology, School of Medicine, PL-60781 Poznan, Poland
Int J Mol Med 7:401-4. 2001..Taken together, these findings indicate that orexins exert a marked direct chronic secretagogue action on adrenocortical cells, acting through both OX1R and OX2R... - Prolonged cerebellin administration inhibits the growth, but enhances steroidogenic capacity of rat adrenal cortexA Hochol
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Endocr Res 27:11-7. 2001..The conclusion is drawn that cerebellin chronic administration evokes a marked hypoplastic atrophy of rat adrenocortical cells, that is coupled with an enhanced ACTH-independent steroidogenic capacity of the remaining parenchymal cells... - Cholecystokinin stimulates aldosterone secretion from dispersed rat zona glomerulosa cells, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase-dependent cascadeL K Malendowicz
Department of Histology and Embryology, School of Medicine, PL-60781 Poznan, Poland
Endocrinology 142:4251-5. 2001..In conclusion, our study provides evidence that cholecystokinin, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase/PKA cascade, exerts a sizeable secretagogue action on rat zona glomerulosa cells... - Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenalsW J Ginda
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Horm Metab Res 31:367-9. 1999..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function... - Effect of pentagastrin on steroid secretion and proliferative activity of regenerating rat adrenal cortexA Hochol
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Cytobios 106:119-24. 2001..It is suggested that the activation of CCK2 receptors exerts a growth promoting action on the regenerating rat adrenal cortex... - Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the ratM Trejter
Department of Histology and Embryology, School of Medicine, Poznan Poland
Histol Histopathol 16:155-8. 2001.... - Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenalsW J Ginda
Department of Histology and Embryology, School of Medicine, Poznan, Poland
Horm Metab Res 31:483-5. 1999..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function...