G G Nussdorfer

Summary

Affiliation: University of Padova
Country: Italy

Publications

  1. ncbi Role of VIP, PACAP, and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:1443-67. 1998
  2. ncbi Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:949-68. 1998
  3. ncbi Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis
    G G Nussdorfer
    Department of Human Anatomy and Physiology Section of Anatomy, University of Padua, Via Gabelli 65, I 35121, Padua, Italy
    Peptides 21:309-24. 2000
  4. ncbi G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I 35121 Padova, Italy
    J Clin Endocrinol Metab 90:3466-71. 2005
  5. ncbi Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    J Clin Endocrinol Metab 86:4818-21. 2001
  6. ncbi Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex
    P Rebuffat
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 7:301-5. 2001
  7. ncbi Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth
    G P Rossi
    Departments of Clinical and Experimental Medicine, School of Medicine, University of Padua, 35121 Padua, Italy
    J Clin Endocrinol Metab 87:322-8. 2002
  8. ncbi Endothelin-1[1-31] acts as a selective ETA-receptor agonist in the rat adrenal cortex
    P Rebuffat
    Department of Human Anatomy and Physiology, Padua, Italy
    Histol Histopathol 16:535-40. 2001
  9. ncbi PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells
    G Mazzocchi
    Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
    Am J Physiol Endocrinol Metab 280:E209-13. 2001
  10. ncbi Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, University of Padua, Italy
    Horm Metab Res 32:265-8. 2000

Collaborators

  • G P Rossi
  • C Tortorella
  • A Semplicini
  • G Mazzocchi
  • L K Malendowicz
  • P Rebuffat
  • G Albertin
  • G Neri
  • A S Belloni
  • A Hochol
  • L Gottardo
  • M Trejter
  • R Spinazzi
  • W J Ginda
  • M Forneris
  • F Aragona
  • P G Andreis
  • C Macchi
  • M T Conconi
  • M Nowak
  • A Ziolkowska
  • R De Caro
  • N Jedrzejczak
  • M Majchrzak
  • A Markowska
  • M Rucinski
  • S Vigolo
  • P P Parnigotto
  • C Grandi
  • G Tamagno
  • E DeCarlo
  • G Bandoli
  • N Sicolo
  • D Guidolin
  • J B Warchol
  • M L Forneris
  • R Brelinska
  • M Piazza
  • D Fiore
  • S Blandamura
  • V Macchi
  • P Andreis
  • G Gottardo
  • C Robba
  • F Musajo
  • V Meneghelli
  • F G Musajo
  • M Boscaro

Detail Information

Publications48

  1. ncbi Role of VIP, PACAP, and related peptides in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:1443-67. 1998
    ..g., in the mediation of HPA axis responses to cold and inflammatory stresses) or may be somehow involved in the pathogenesis of Cushing disease or some case of hyperaldosteronism associated with secreting pheochromocytomas...
  2. ncbi Role of tachykinins in the regulation of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Anatomy, University of Padua, Italy
    Peptides 19:949-68. 1998
    ..g., physical or inflammatory stresses) or pathological conditions (e.g., ACTH-secreting pituitary tumors), when an excess of steroid-hormone production has to be counteracted...
  3. ncbi Secretin, glucagon, gastric inhibitory polypeptide, parathyroid hormone, and related peptides in the regulation of the hypothalamus- pituitary-adrenal axis
    G G Nussdorfer
    Department of Human Anatomy and Physiology Section of Anatomy, University of Padua, Via Gabelli 65, I 35121, Padua, Italy
    Peptides 21:309-24. 2000
    ..The involvement of growth hormone-releasing hormone and exendins in the functional regulation of the HPA axis has not yet been extensively investigated...
  4. ncbi G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I 35121 Padova, Italy
    J Clin Endocrinol Metab 90:3466-71. 2005
    ....
  5. ncbi Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    J Clin Endocrinol Metab 86:4818-21. 2001
    ..Collectively, these findings suggest that orexins stimulate catecholamine secretion from human pheochromocytomas, acting through OX2-R coupled to the PLC-PKC signaling pathway...
  6. ncbi Signaling pathways involved in the A and B receptor-mediated cortisol secretagogue effect of endothelins in the human adrenal cortex
    P Rebuffat
    Department of Human Anatomy and Physiology, Section of Anatomy, School of Medicine, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 7:301-5. 2001
    ....
  7. ncbi Endothelin-1[1-31]: a novel autocrine-paracrine regulator of human adrenal cortex secretion and growth
    G P Rossi
    Departments of Clinical and Experimental Medicine, School of Medicine, University of Padua, 35121 Padua, Italy
    J Clin Endocrinol Metab 87:322-8. 2002
    ....
  8. ncbi Endothelin-1[1-31] acts as a selective ETA-receptor agonist in the rat adrenal cortex
    P Rebuffat
    Department of Human Anatomy and Physiology, Padua, Italy
    Histol Histopathol 16:535-40. 2001
    ..Collectively, our findings provide strong evidence that ET-1[1-31] acts in the rat adrenal glands as a selective ETA-receptor agonist, mainly involved in the stimulation of ZG proliferative activity...
  9. ncbi PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells
    G Mazzocchi
    Section of Anatomy, Department of Human Anatomy and Physiology, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
    Am J Physiol Endocrinol Metab 280:E209-13. 2001
    ..It is concluded that PTH and PTH-RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA- and PLC/PKC-dependent signaling cascades...
  10. ncbi Glucagon inhibits ACTH-stimulated cortisol secretion from dispersed human adrenocortical cells by activating unidentified receptors negatively coupled with the adenylate cyclase cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, University of Padua, Italy
    Horm Metab Res 32:265-8. 2000
    ..Taken together, these findings suggest that glucagon, through the activation of unidentified receptors located on ZF/R cells, inhibits adenylate cyclase, thereby dampening glucocorticoid response to ACTH...
  11. ncbi Vasoactive intestinal peptide stimulates rat adrenal glucocorticoid secretion, through an ACTH receptor-dependent activation of the adenylate cyclase signaling pathway
    G Mazzocchi
    Department of Anatomy, University of Padua, Italy
    Horm Metab Res 30:241-3. 1998
    ..Collectively, these findings suggest that VIP stimulates glucocorticoid secretion of rat adrenals, through the aspecific activation of ACTH receptors coupled with the adenylate cyclase/PKA-dependent signaling pathway...
  12. pmc Stereological and functional investigations on isolated adrenocortical cells. III. Zona glomerulosa cells of chronically ACTH-treated rats
    P G Andreis
    Department of Anatomy, University of Padua, Italy
    J Anat 168:199-207. 1990
    ..In the light of these findings, the drop in the plasma level of aldosterone observed in rats after prolonged treatment with ACTH is assumed to be due to an enhanced metabolism of aldosterone, possibly at the hepatic level...
  13. ncbi Cerebellin stimulates the secretory activity of the rat adrenal gland: in vitro and in vivo studies
    G Albertin
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Padua, Italy
    Neuropeptides 34:7-11. 2000
    ....
  14. ncbi Preproorexin and orexin receptors are expressed in cortisol-secreting adrenocortical adenomas, and orexins stimulate in vitro cortisol secretion and growth of tumor cells
    R Spinazzi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I 35121 Padova, Italy
    J Clin Endocrinol Metab 90:3544-9. 2005
    ....
  15. ncbi Acute action of polypeptide YY (PYY) on rat adrenocortical cells: in vivo versus in vitro effects
    G Neri
    Department of Anatomy, University of Padua, Italy
    Neuropeptides 19:73-6. 1991
    ....
  16. ncbi Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    J Clin Endocrinol Metab 86:778-82. 2001
    ..Collectively, our findings suggest that orexins selectively stimulate glucocorticoid secretion from human adrenocortical cells, acting through OX1-R coupled with the adenylate cyclase-dependent signaling pathway...
  17. ncbi Adrenomedullin stimulates DNA synthesis of rat adrenal zona glomerulosa cells through activation of the mitogen-activated protein kinase-dependent cascade
    A Semplicini
    Department of Clinical and Experimental Medicine, University of Padua, Italy
    J Hypertens 19:599-602. 2001
    ..These results confirm the complex role played by this peptide in the regulation of zona glomerulosa cell physiology...
  18. ncbi Expression and function of adrenomedullin and its receptors in Conn's adenoma cells
    M Forneris
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    Int J Mol Med 8:675-9. 2001
    ....
  19. ncbi Effects of prolonged sodium restriction on the morphology and function of rat adrenocortical autotransplants
    A S Belloni
    Department of Anatomy, University of Padua, Italy
    Cell Tissue Res 265:35-41. 1991
    ..abstract truncated at 250 words)..
  20. ncbi Effects of neuropeptide-Y and substance-P on the secretory activity of dispersed zona-glomerulosa cells of rat adrenal gland
    G Neri
    Department of Anatomy, University of Padua, Italy
    Neuropeptides 17:121-5. 1990
    ..The possible physiological implications of these findings are discussed in light of previous studies suggesting a net adrenoglomerulotrophic effect of NPY and SP in vivo...
  21. ncbi Stimulation of endogenous nitric oxide production is involved in the inhibitory effect of adrenomedullin on aldosterone secretion in the rat
    P Rebuffat
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, 35121, Padua, Italy
    Peptides 22:923-6. 2001
    ....
  22. ncbi Cholecystokinin (CCK) stimulates aldosterone secretion from human adrenocortical cells via CCK2 receptors coupled to the adenylate cyclase/protein kinase A signaling cascade
    G Mazzocchi
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I 35121 Padua, Italy
    J Clin Endocrinol Metab 89:1277-84. 2004
    ....
  23. ncbi Proadrenomedullin N-terminal 20 peptide (PAMP) enhances proliferation of rat zona glomerulosa cells by activating MAPK cascade
    P Rebuffat
    Department of Human Anatomy and Physiology (Section of Anatomy, University of Padua, I-35121, Padua, Italy
    Peptides 22:1909-12. 2001
    ..Taken together, these data indicate that PAMP enhances proliferation of cultured rat ZG cells, through the TK-dependent activation of p42/p44 MAPK cascade...
  24. ncbi Human pheochromocytomas, but not adrenal medulla, express glucagon-receptor gene and possess an in vitro secretory response to glucagon
    G Albertin
    Department of Human Anatomy and Physiology, School of Medicine, University of Padua, I-35121, Padua, Italy
    Peptides 22:597-600. 2001
    ....
  25. ncbi Direct secretagogue effect of corticotropin-releasing factor on the rat adrenal cortex: the involvement of the zona medullaris
    P G Andreis
    Department of Anatomy, University of Padua, Italy
    Endocrinology 131:69-72. 1992
    ....
  26. ncbi Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 activity
    G Mazzocchi
    Department of Human Anatomy and Physiology, School of Medicine, University of Padua, Italy
    J Investig Med 49:191-4. 2001
    ..We advance the hypothesis that the elevated local concentration of steroid hormones that occur in adenomas down-regulates 11beta-HSD2 activity, thereby contributing to their abnormal steroidogenic function...
  27. ncbi Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axis
    G G Nussdorfer
    Department of Human Anatomy and Physiology, University of Padua, Italy
    Int Rev Cytol 206:249-84. 2001
    ....
  28. ncbi Endothelins stimulate aldosterone secretion from dispersed rat adrenal zona glomerulosa cells, acting through ETB receptors coupled with the phospholipase C-dependent signaling pathway
    P G Andreis
    Department of Human Anatomy and Physiology (Section of Anatomy, University of Padua, Via Gabelli 65, I-35121, Padua, Italy
    Peptides 22:117-22. 2001
    ....
  29. ncbi Effects of prolonged treatment with cyanoketone on the zona fasciculata of rat adrenal cortex. A combined morphometric and biochemical study
    C Robba
    Department of Anatomy, University of Padua, Italy
    Cell Tissue Res 250:599-605. 1987
    ....
  30. ncbi Proadrenomedullin-derived peptides as autocrine-paracrine regulators of cell growth
    A S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Italy
    Histol Histopathol 16:1263-74. 2001
    ..Both pADM-derived peptides are thought to be involved in embryogenesis, such a contention being based on the demonstration of high pADM-gene expression during the crucial phases of organ growth and differentiation...
  31. ncbi Calcitonin gene-related peptide (CGRP), acting via CGRP type 1 receptors, inhibits potassium-stimulated aldosterone secretion and enhances basal catecholamine secretion from rat adrenal gland
    C Tortorella
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I-35121 Padua, Italy
    Int J Mol Med 8:261-4. 2001
    ..The conclusion is drawn that CGRP, like ADM, inhibits agonist-stimulated aldosterone secretion and stimulates basal catecholamine release in the rat, exclusively acting via CGRP1 receptors...
  32. ncbi Thyrotropin-releasing hormone inhibits glucocorticoid secretion of rat adrenal cortex: in vivo and in vitro studies
    G Neri
    Department of Anatomy, University of Padua, Italy
    Endocrinology 133:511-4. 1993
    ..e. 11- and 18-hydroxylation) without affecting the earlier steps, including the rate-limiting one of this process...
  33. ncbi Reciprocal regulation of endothelin-1 and nitric oxide: relevance in the physiology and pathology of the cardiovascular system
    G P Rossi
    Department of Clinical and Experimental Medicine, University Hospital, University of Padua, Italy
    Int Rev Cytol 209:241-72. 2001
    ..Moreover, an imbalance between ET-1 and NO systems may underly the mechanisms involved in the pathogenesis of systemic and pulmonary hypertension and atherosclerosis...
  34. ncbi Expression of adrenomedullin and its receptors in the human adrenal cortex and aldosteronomas
    G Albertin
    Department of Human Anatomy and Physiology Section of Anatomy, School of Medicine, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    Int J Mol Med 8:423-6. 2001
    ..In conclusion, our investigation provides the first evidence that human adrenal cortex and aldosteronomas express the ADM system, that may play a role in the paracrine or autocrine control of their functions...
  35. ncbi Cerebellin enhances in vitro secretory activity of human adrenal gland
    G Mazzocchi
    Department of Human Anatomy, University of Padua, Italy
    J Clin Endocrinol Metab 84:632-5. 1999
    ....
  36. ncbi Two selective rat adrenomedullin (AM)-receptor antagonists: AM20-50 and AM24-50
    A S Belloni
    Department of Human Anatomy and Physiology, Section of Anatomy, University of Padua, Via Gabelli 65, I 35121 Padua, Italy
    Cell Mol Biol (Noisy-le-grand) 49:939-43. 2003
    ..Moreover, they provide the first evidence that rAMI-50 and its fragments should be used in the investigations carried out in the rat...
  37. ncbi Adrenocortical oncocytoma: case report and review of the literature
    C Macchi
    Department of Anatomy, University of Padua, Italy
    Tumori 84:403-7. 1998
    ..Although the classic histological approach clearly indicates the benign nature of the tumor, the immunocytochemical and ultrastructural features of oncocytes may suggest their potential for malignant behavior...
  38. ncbi Neuropeptide-Y family of peptides in the autocrine-paracrine regulation of adrenocortical function
    G G Nussdorfer
    Department of Anatomy, University of Padua, Padova, Italy
    Horm Metab Res 30:368-73. 1998
    ....
  39. ncbi Endothelins stimulate deoxyribonucleic acid synthesis and cell proliferation in rat adrenal zona glomerulosa, acting through an endothelin A receptor coupled with protein kinase C- and tyrosine kinase-dependent signaling pathways
    G Mazzocchi
    Department of Anatomy, University of Padua, Italy
    Endocrinology 138:2333-7. 1997
    ....
  40. ncbi Effects of some vanadyl coordination compounds on the in vitro insulin release from rat pancreatic islets
    M T Conconi
    Departments of Pharmaceutical Sciences, University of Padua, Padua, Italy
    Horm Metab Res 35:402-6. 2003
    ....
  41. ncbi Effects of orexins A and B on the secretory and proliferative activity of immature and regenerating rat adrenal glands
    L K Malendowicz
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Histol Histopathol 16:713-7. 2001
    ....
  42. ncbi Prolonged orexin administration stimulates steroid-hormone secretion, acting directly on the rat adrenal gland
    L K Malendowicz
    Department of Histology and Embryology, School of Medicine, PL-60781 Poznan, Poland
    Int J Mol Med 7:401-4. 2001
    ..Taken together, these findings indicate that orexins exert a marked direct chronic secretagogue action on adrenocortical cells, acting through both OX1R and OX2R...
  43. ncbi Prolonged cerebellin administration inhibits the growth, but enhances steroidogenic capacity of rat adrenal cortex
    A Hochol
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Endocr Res 27:11-7. 2001
    ..The conclusion is drawn that cerebellin chronic administration evokes a marked hypoplastic atrophy of rat adrenocortical cells, that is coupled with an enhanced ACTH-independent steroidogenic capacity of the remaining parenchymal cells...
  44. ncbi Cholecystokinin stimulates aldosterone secretion from dispersed rat zona glomerulosa cells, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase-dependent cascade
    L K Malendowicz
    Department of Histology and Embryology, School of Medicine, PL-60781 Poznan, Poland
    Endocrinology 142:4251-5. 2001
    ..In conclusion, our study provides evidence that cholecystokinin, acting through cholecystokinin receptors 1 and 2 coupled with the adenylate cyclase/PKA cascade, exerts a sizeable secretagogue action on rat zona glomerulosa cells...
  45. ncbi Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals
    W J Ginda
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Horm Metab Res 31:367-9. 1999
    ..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function...
  46. ncbi Effect of pentagastrin on steroid secretion and proliferative activity of regenerating rat adrenal cortex
    A Hochol
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Cytobios 106:119-24. 2001
    ..It is suggested that the activation of CCK2 receptors exerts a growth promoting action on the regenerating rat adrenal cortex...
  47. ncbi Studies on the involvement of endogenous neuropeptides in the control of thymocyte proliferation in the rat
    M Trejter
    Department of Histology and Embryology, School of Medicine, Poznan Poland
    Histol Histopathol 16:155-8. 2001
    ....
  48. ncbi Effects of bilateral splanchnic-nerve section and chemical sympathectomy on PACAP38 content in the rat adrenals
    W J Ginda
    Department of Histology and Embryology, School of Medicine, Poznan, Poland
    Horm Metab Res 31:483-5. 1999
    ..In contrast, chemical sympathectomy, obtained by administering newborn rats with 6-hydroxydopamine, was ineffective. Our findings support the view that splanchnic nerves play an important role in the control of rat adrenal function...