Francesco Novelli

Summary

Affiliation: University of Turin
Country: Italy

Publications

  1. pmc Three are better than one: plasminogen receptors as cancer theranostic targets
    Patrizia Ceruti
    Center for Experimental Research and Medical Studies CERMS, Azienda Ospedaliera Città della Salute e della Scienza, Via Cherasco 15, Turin, 10126, Italy
    Exp Hematol Oncol 2:12. 2013
  2. ncbi request reprint The role of IL-12, IL-23 and IFN-gamma in immunity to viruses
    Francesco Novelli
    Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, Rene Descartes University of Paris, INSERM U550, 156 rue de Vaugirard, 75015 Paris, France
    Cytokine Growth Factor Rev 15:367-77. 2004
  3. doi request reprint Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer
    Barbara Tomaino
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 10:105-12. 2011
  4. doi request reprint Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling
    Gabriella Regis
    Molecular Biotechnology Center, University of Turin, Via Nizza 52, 10126 Turin, Italy
    Semin Cell Dev Biol 19:351-9. 2008
  5. ncbi request reprint IFN-gamma inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis
    Virginia De Rose
    Respiratory Disease Division, Department of Clinical and Biological Sciences, University of Turin, Italy
    J Leukoc Biol 76:423-32. 2004
  6. doi request reprint α-Enolase: a promising therapeutic and diagnostic tumor target
    Michela Capello
    Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    FEBS J 278:1064-74. 2011
  7. doi request reprint Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer
    Paola Cappello
    Center for Experimental Research and Medical Studies, Città della Salute e della Scienza di Torino, Italy
    Gastroenterology 144:1098-106. 2013
  8. ncbi request reprint IFN-gamma regulates Fas ligand expression in human CD4+ T lymphocytes and controls their anti-mycobacterial cytotoxic functions
    Daniela Boselli
    Department of Medicine and Experimental Oncology, University of Turin, and Center for Experimental Research and Medical Studies, S Giovanni Battista Hospital, Turin, Italy
    Eur J Immunol 37:2196-204. 2007
  9. pmc Investigation of the ovarian and prostate cancer peptidome for candidate early detection markers using a novel nanoparticle biomarker capture technology
    Claudia Fredolini
    Department of Urology, S Giovanni Bosco Hospital, Turin, Italy
    AAPS J 12:504-18. 2010
  10. ncbi request reprint Autoantibody signature in human ductal pancreatic adenocarcinoma
    Barbara Tomaino
    Center for Experimental Research and Medical Studies and University of Turin, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 6:4025-31. 2007

Collaborators

Detail Information

Publications22

  1. pmc Three are better than one: plasminogen receptors as cancer theranostic targets
    Patrizia Ceruti
    Center for Experimental Research and Medical Studies CERMS, Azienda Ospedaliera Città della Salute e della Scienza, Via Cherasco 15, Turin, 10126, Italy
    Exp Hematol Oncol 2:12. 2013
    ..This analysis emphasizes the possibility of delineating new personalized therapeutic strategies to counteract tumor growth and metastasis by targeting plasminogen receptors, as well as their potential application as cancer predictors...
  2. ncbi request reprint The role of IL-12, IL-23 and IFN-gamma in immunity to viruses
    Francesco Novelli
    Laboratory of Human Genetics of Infectious Diseases, Necker Medical School, Rene Descartes University of Paris, INSERM U550, 156 rue de Vaugirard, 75015 Paris, France
    Cytokine Growth Factor Rev 15:367-77. 2004
    ....
  3. doi request reprint Circulating autoantibodies to phosphorylated α-enolase are a hallmark of pancreatic cancer
    Barbara Tomaino
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 10:105-12. 2011
    ..In conclusion, our results demonstrate that ENOA phosphorylation is associated with PDAC and induces specific autoantibody production in PDAC patients that may have diagnostic value...
  4. doi request reprint Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling
    Gabriella Regis
    Molecular Biotechnology Center, University of Turin, Via Nizza 52, 10126 Turin, Italy
    Semin Cell Dev Biol 19:351-9. 2008
    ....
  5. ncbi request reprint IFN-gamma inhibits the proliferation of allergen-activated T lymphocytes from atopic, asthmatic patients by inducing Fas/FasL-mediated apoptosis
    Virginia De Rose
    Respiratory Disease Division, Department of Clinical and Biological Sciences, University of Turin, Italy
    J Leukoc Biol 76:423-32. 2004
    ..The defect in IFN-gamma production involved in the allergic, immune response may therefore be responsible for a decrease in apoptosis of allergen-activated T lymphocytes in the airways of atopic, asthmatic patients...
  6. doi request reprint α-Enolase: a promising therapeutic and diagnostic tumor target
    Michela Capello
    Department of Medicine and Experimental Oncology, Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, University of Turin, Turin, Italy
    FEBS J 278:1064-74. 2011
    ..In our opinion, this information can pave the way for effective new therapeutic and diagnostic strategies to counteract the growth of the most aggressive human disease...
  7. doi request reprint Vaccination with ENO1 DNA prolongs survival of genetically engineered mice with pancreatic cancer
    Paola Cappello
    Center for Experimental Research and Medical Studies, Città della Salute e della Scienza di Torino, Italy
    Gastroenterology 144:1098-106. 2013
    ..We investigated whether an ENO1 DNA vaccine elicits antitumor immune responses and prolongs survival of mice that spontaneously develop autochthonous, lethal pancreatic carcinomas...
  8. ncbi request reprint IFN-gamma regulates Fas ligand expression in human CD4+ T lymphocytes and controls their anti-mycobacterial cytotoxic functions
    Daniela Boselli
    Department of Medicine and Experimental Oncology, University of Turin, and Center for Experimental Research and Medical Studies, S Giovanni Battista Hospital, Turin, Italy
    Eur J Immunol 37:2196-204. 2007
    ..Conversely, defective FasL expression on IFN-gammaR1DN CD4+ T cells impairs their cytotoxic functions and highlights a novel role for IFN-gamma signaling in the control of mycobacterial infection in humans...
  9. pmc Investigation of the ovarian and prostate cancer peptidome for candidate early detection markers using a novel nanoparticle biomarker capture technology
    Claudia Fredolini
    Department of Urology, S Giovanni Bosco Hospital, Turin, Italy
    AAPS J 12:504-18. 2010
    ..Differentially abundant candidate peptidome biomarkers that appear to be specific for early-stage ovarian and prostate cancer have been identified and reveal the potential utility for this new methodology...
  10. ncbi request reprint Autoantibody signature in human ductal pancreatic adenocarcinoma
    Barbara Tomaino
    Center for Experimental Research and Medical Studies and University of Turin, San Giovanni Battista Hospital, Turin, Italy
    J Proteome Res 6:4025-31. 2007
    ..The results of further studies of these serological-defined antigens could be of diagnostic and therapeutic significance in PDAC...
  11. doi request reprint T-helper 17 cells expand in multiple sclerosis and are inhibited by interferon-beta
    Luca Durelli
    Department of Clinical and Biological Sciences, Division of Neurology, San Luigi Gonzaga School of Medicine, Orbassano Torino, Turin, Italy
    Ann Neurol 65:499-509. 2009
    ..We characterized the Th1/Th17 cell populations in peripheral blood (PB), their interferon (IFN) receptor expression sensitivity to IFN-beta in MS patients...
  12. ncbi request reprint Requirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells
    Giuliana Losana
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    Eur J Immunol 32:693-700. 2002
    ....
  13. ncbi request reprint Iron regulates T-lymphocyte sensitivity to the IFN-gamma/STAT1 signaling pathway in vitro and in vivo
    Gabriella Regis
    Laboratory of Tumor Immunology, CeRMS, San Giovanni Battista Hospital Molinette, Via Santena 5, I 10126 Turin, Italy
    Blood 105:3214-21. 2005
    ..These data provide valuable insights for novel therapeutic approaches aimed at reinstating the IFN-gamma/STAT1 apoptotic signaling pathway in autoreactive or neoplastic T cells by means of iron chelation...
  14. ncbi request reprint Retroviral-mediated gene transfer restores IL-12 and IL-23 signaling pathways in T cells from IL-12 receptor beta1-deficient patients
    Marita Bosticardo
    Disorders of Immunity Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, 49 Convent Drive, Building 49, Room 3A20, MSC 4442, Bethesda, MD 20892 4442, USA
    Mol Ther 9:895-901. 2004
    ..These results indicate that the biological defects of T cells from patients carrying IL-12Rbeta1 deficiency can be corrected by gene transfer and form the basis for further development of gene therapy for this disease...
  15. ncbi request reprint IGF-1 down-regulates IFN-gamma R2 chain surface expression and desensitizes IFN-gamma/STAT-1 signaling in human T lymphocytes
    Paola Bernabei
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, and Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    Blood 102:2933-9. 2003
    ..These data indicate that IGF-1 plays a critical role in the desensitization of IFN-gamma/STAT-1 signaling in T lymphocytes by delivering a signal for IFN-gamma R2 internalization...
  16. ncbi request reprint In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth
    Laura Conti
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Turin, Italy
    Blood 109:2496-504. 2007
    ..These data indicate that the inhibition of IGF-1 signaling combined with IFN-gamma administration could be a promising approach to suppress the growth of neoplastic T cells resistant to each treatment on its own...
  17. ncbi request reprint Death receptor ligands in tumors
    Paola Cappello
    Department of Clinical and Biological Sciences, University of Turin, Italy
    J Immunother 25:1-15. 2002
    ....
  18. ncbi request reprint IFN-gamma and IL-12 differentially regulate CC-chemokine secretion and CCR5 expression in human T lymphocytes
    Giuliana Losana
    Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy
    J Leukoc Biol 72:735-42. 2002
    ....
  19. pmc A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency
    Gilles Courtois
    Unité de Biologie Moléculaire de l Expression Génique, Centre National de la Recherche Scientifique URA 2582, Institut Pasteur, Paris, France
    J Clin Invest 112:1108-15. 2003
    ..Our report highlights both the diversity of genotypes associated with EDA-ID and the diversity of immunologic phenotypes associated with mutations in different components of the NF-kappaB signaling pathway...
  20. ncbi request reprint CCL16/LEC powerfully triggers effector and antigen-presenting functions of macrophages and enhances T cell cytotoxicity
    Paola Cappello
    Department of Clinical and Bilogical Sciences, University of Turin, Orbassano, Italy
    J Leukoc Biol 75:135-42. 2004
    ..These data reveal a new function for CCL16 in the immune-response scenario. CCL16 significantly enhances the effector and the antigen-presenting function of macrophages and augments T cell lytic activity...
  21. ncbi request reprint IFNgammaR2 trafficking tunes IFNgamma-STAT1 signaling in T lymphocytes
    Gabriella Regis
    Center for Experimental Research and Medical Studies CERMS, San Giovanni Battista Hospital, Via Santena 5, I 10126 Turin, Italy
    Trends Immunol 27:96-101. 2006
    ....
  22. ncbi request reprint CC-chemokine ligand 16 induces a novel maturation program in human immature monocyte-derived dendritic cells
    Paola Cappello
    Center for Experimental Research and Medical Studies, San Giovanni Battista Hospital, Turin, Italy
    J Immunol 177:6143-51. 2006
    ..Our findings indicate that induction of MoDC maturation is an important property of CCL16 and suggest that chemokines may not only organize the migration of MoDCs, but also directly regulate their ability to prime T cell responses...