E Nisoli

Summary

Affiliation: University of Milan
Country: Italy

Publications

  1. ncbi request reprint Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus
    Antonio Giordano
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Ancona, Italy
    FEBS Lett 514:135-40. 2002
  2. doi request reprint Amino acids and mitochondrial biogenesis
    Enzo Nisoli
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, University of Milan, Milan, Italy
    Am J Cardiol 101:22E-25E. 2008
  3. ncbi request reprint Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
  4. ncbi request reprint Mitochondrial biogenesis as a cellular signaling framework
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157, Milan, Italy
    Biochem Pharmacol 67:1-15. 2004
  5. ncbi request reprint A benefit-risk assessment of sibutramine in the management of obesity
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, University of Milan, LITA Vialba, Luigi Sacco Hospital, Milan, Italy
    Drug Saf 26:1027-48. 2003
  6. ncbi request reprint Emerging aspects of pharmacotherapy for obesity and metabolic syndrome
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, L Sacco Hospital, University of Milan, LITA Vialba, Via G B Grassi 74, 20157 Milan, Italy
    Pharmacol Res 50:453-69. 2004
  7. ncbi request reprint Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
    Science 299:896-9. 2003
  8. ncbi request reprint New pharmacological tools for obesity
    E Nisoli
    Center for Study and Research on Obesity, University of Milan, Department of Preclinical Sciences, L Sacco Hospital, Milan, Italy
    J Endocrinol Invest 25:905-14. 2002
  9. ncbi request reprint Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
    J Pathol 198:378-87. 2002
  10. ncbi request reprint An assessment of the safety and efficacy of sibutramine, an anti-obesity drug with a novel mechanism of action
    E Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, School of Medicine, University of Milan, LITA Vialba, L Sacco Hospital, Via G B Grassi, 74, Milan 20157, Italy
    Obes Rev 1:127-39. 2000

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Evidence for a functional nitric oxide synthase system in brown adipocyte nucleus
    Antonio Giordano
    Institute of Normal Human Morphology, Faculty of Medicine, University of Ancona, Ancona, Italy
    FEBS Lett 514:135-40. 2002
    ..These data suggest the existence of a noradrenaline-modulated functional NOS system in the nucleus of brown adipocytes...
  2. doi request reprint Amino acids and mitochondrial biogenesis
    Enzo Nisoli
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, University of Milan, Milan, Italy
    Am J Cardiol 101:22E-25E. 2008
    ..Here, we suggest that some types of nutrients, including specific mixtures of amino acids, may improve mitochondrial biogenesis and energy production in energy-defective conditions by increasing endothelial NO synthase expression...
  3. ncbi request reprint Calorie restriction promotes mitochondrial biogenesis by inducing the expression of eNOS
    Enzo Nisoli
    Integrated Laboratories Network, Department of Preclinical Sciences, Luigi Sacco Hospital, Milan University, 20157 Milan, Italy
    Science 310:314-7. 2005
    ..These effects were strongly attenuated in eNOS null-mutant mice. Thus, nitric oxide plays a fundamental role in the processes induced by calorie restriction and may be involved in the extension of life span in mammals...
  4. ncbi request reprint Mitochondrial biogenesis as a cellular signaling framework
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157, Milan, Italy
    Biochem Pharmacol 67:1-15. 2004
    ..Some of these are now being elucidated. Generation of nitric oxide (NO) appears to be a novel player in this scenario, possibly acting as a unifying molecular switch to trigger the whole mitochondriogenic process...
  5. ncbi request reprint A benefit-risk assessment of sibutramine in the management of obesity
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, University of Milan, LITA Vialba, Luigi Sacco Hospital, Milan, Italy
    Drug Saf 26:1027-48. 2003
    ..The assessment of the benefit-risk profile of sibutramine remained positive, although the product must be kept under regular review...
  6. ncbi request reprint Emerging aspects of pharmacotherapy for obesity and metabolic syndrome
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, L Sacco Hospital, University of Milan, LITA Vialba, Via G B Grassi 74, 20157 Milan, Italy
    Pharmacol Res 50:453-69. 2004
    ..Here we review some among the most promising avenues in these two fields of drug therapy of obesity and, consequently, of metabolic syndrome...
  7. ncbi request reprint Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, Luigi Sacco Hospital, University of Milan, Milan 20157, Italy
    Science 299:896-9. 2003
    ..Thus, a nitric oxide-cGMP-dependent pathway controls mitochondrial biogenesis and body energy balance...
  8. ncbi request reprint New pharmacological tools for obesity
    E Nisoli
    Center for Study and Research on Obesity, University of Milan, Department of Preclinical Sciences, L Sacco Hospital, Milan, Italy
    J Endocrinol Invest 25:905-14. 2002
    ..In the present review we concentrate on the first of these strategies, by underlining the new pharmacological tools which are presently studied...
  9. ncbi request reprint Multiple symmetric lipomatosis may be the consequence of defective noradrenergic modulation of proliferation and differentiation of brown fat cells
    Enzo Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, Italy
    J Pathol 198:378-87. 2002
    ..The study did not find any association between beta(3)-adrenoceptor gene polymorphism and noradrenergic signalling defects in MSL subjects with or without mitochondrial DNA mutations...
  10. ncbi request reprint An assessment of the safety and efficacy of sibutramine, an anti-obesity drug with a novel mechanism of action
    E Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, School of Medicine, University of Milan, LITA Vialba, L Sacco Hospital, Via G B Grassi, 74, Milan 20157, Italy
    Obes Rev 1:127-39. 2000
    ..Finally, sibutramine does not have the potential for abuse that is characteristic of amphetamine and it is indistinguishable from placebo in abuse potential studies...
  11. ncbi request reprint Protective effects of noradrenaline against tumor necrosis factor-alpha-induced apoptosis in cultured rat brown adipocytes: role of nitric oxide-induced heat shock protein 70 expression
    E Nisoli
    Center for Study and Research on Obesity, Department of Preclinical Sciences, LITA Vialba, L Sacco Hospital, Milan University, Milan, Italy
    Int J Obes Relat Metab Disord 25:1421-30. 2001
    ..To elucidate the effects and molecular mechanism(s) by means of which noradrenaline (NA) protects against the tumor necrosis factor (TNF)-alpha-induced apoptosis of brown adipocytes...
  12. ncbi request reprint Defective mitochondrial biogenesis: a hallmark of the high cardiovascular risk in the metabolic syndrome?
    Enzo Nisoli
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Circ Res 100:795-806. 2007
    ..Here we summarize some recent findings and propose a hypothesis for the high cardiovascular risk linked to the metabolic syndrome...
  13. ncbi request reprint Nitric oxide and mitochondrial biogenesis
    Enzo Nisoli
    Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Via Vanvitelli 32, 20129 Milan, Italy
    J Cell Sci 119:2855-62. 2006
    ..NO-induced mitochondrial biogenesis seems to be linked to proliferation and differentiation of normal and tumor cells, as well as in aging...
  14. ncbi request reprint Can endogenous gaseous messengers control mitochondrial biogenesis in mammalian cells?
    Enzo Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, LITA Vialba, Luigi Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    Prostaglandins Other Lipid Mediat 73:9-27. 2004
    ..Some of these are now being elucidated. Generation of nitric oxide (NO) appears to be a novel player in this scenario, possibly acting as a unifying molecular switch to trigger the whole process of the mitochondrial biogenesis...
  15. ncbi request reprint Induction of fatty acid translocase/CD36, peroxisome proliferator-activated receptor-gamma2, leptin, uncoupling proteins 2 and 3, and tumor necrosis factor-alpha gene expression in human subcutaneous fat by lipid infusion
    E Nisoli
    Department of Preclinical Sciences, Center for Study and Research on Obesity, L Sacco Hospital, Univeristy of Milan, Italy
    Diabetes 49:319-24. 2000
    ....
  16. ncbi request reprint Nerve growth factor, beta3-adrenoceptor and uncoupling protein 1 expression in rat brown fat during postnatal development
    E Nisoli
    Centre for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, LITA Vialba, Ospedale L Sacco, School of Medicine, University of Milan, Milano, Italy
    Neurosci Lett 246:5-8. 1998
    ..Relatively low levels of NGF were present in the brown fat of aged rats. Taken together, these results suggest that NGF may be responsible for regulating sympathetic innervation during the perinatal and adult periods...
  17. pmc Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity
    E Nisoli
    Center for Study and Research on Obesity, LITA Vialba, L Sacco Hospital, University of Milan, Via G B Grassi 74, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 97:8033-8. 2000
    ..These results indicate that TNF-alpha plays an important role in multiple aspects of brown adipose tissue biology and mediates the abnormalities that occur at this site in obesity...
  18. ncbi request reprint D2 dopamine receptor (DRD2) gene Taq1A polymorphism and the eating-related psychological traits in eating disorders (anorexia nervosa and bulimia) and obesity
    E Nisoli
    Center for the Study and Research on Obesity, Department of Preclinical Sciences, Ospedale Sacco, University of Milan, Milan, Italy
    Eat Weight Disord 12:91-6. 2007
    ..For this reason, the aim of this study was to evaluate if the presence of A1 allele, in eating disorders and obesity, is associated with some particular psycho-pathological characteristics...
  19. ncbi request reprint Efficacy and tolerability of moclobemide in bulimia nervosa: a placebo-controlled trial
    M O Carruba
    Center for Study and Research on Obesity, Department of Preclinical Sciences, L Sacco Hospital, University of Milan, Italy
    Int Clin Psychopharmacol 16:27-32. 2001
    ....
  20. pmc TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents
    Alessandra Valerio
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy
    J Clin Invest 116:2791-8. 2006
    ..Our findings demonstrate that TNF-alpha impairs mitochondrial biogenesis and function in different tissues of obese rodents by downregulating eNOS expression and suggest a novel pathophysiological process that sustains obesity...
  21. pmc Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes
    Laura Tedesco
    Integrated Laboratories Network, Center for Study and Research on Obesity, Department of Pharmacology, Chemotherapy and Medical Toxicology, School of Medicine, Milan University, Milan, Italy
    Diabetes 57:2028-36. 2008
    ..This study was undertaken to test whether CB1 receptor blockade increases the espression of eNOS and mitochondrial biogenesis in white adipocytes...
  22. ncbi request reprint Nitric oxide and mitochondrial biogenesis: a key to long-term regulation of cellular metabolism
    Emilio Clementi
    E Medea Scientific Institute, 23842 Bosisio Parini, Italy
    Comp Biochem Physiol A Mol Integr Physiol 142:102-10. 2005
    ..This may explain why dysregulation of the NO signalling pathway is often associated with the pathogenesis of metabolic disorders...
  23. pmc The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
    Daniela Cota
    Clinical Neuroendocrinology Group, Max Planck Institute of Psychiatry, Munich, Germany
    J Clin Invest 112:423-31. 2003
    ....
  24. pmc Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals
    Enzo Nisoli
    Department of Preclinical Sciences, Laboratorio Interdisciplinare Technologie Avanzate LITA Vialba, University of Milan, 20157 Milan, Italy
    Proc Natl Acad Sci U S A 101:16507-12. 2004
    ..We conclude that NO/cGMP stimulates mitochondrial biogenesis, both in vitro and in vivo, and that this stimulation is associated with increased mitochondrial function, resulting in enhanced formation of ATP...
  25. doi request reprint Morphometric changes induced by amino acid supplementation in skeletal and cardiac muscles of old mice
    Giovanni Corsetti
    Division of Human Anatomy, Department of Biomedical Sciences and Biotechnology, University of Brescia, Brescia, Italy
    Am J Cardiol 101:26E-34E. 2008
    ..These findings indicate that AAm restored muscular morphologic parameters and probably improved the mechanical performance of these organs...
  26. ncbi request reprint Role of insulin and free fatty acids in the regulation of ob gene expression and plasma leptin in normal rats
    Claudio Pagano
    Endocrine Metabolic Library, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy
    Obes Res 12:2062-9. 2004
    ..In this study, we evaluated whether leptin secretion induced by FFA is due directly to an increased FFA availability or whether it is mediated by insulin levels...
  27. ncbi request reprint Regional-dependent increase of sympathetic innervation in rat white adipose tissue during prolonged fasting
    Antonio Giordano
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto, 10 A, 60020 Ancona, Italy
    J Histochem Cytochem 53:679-87. 2005
    ....
  28. ncbi request reprint A critical reflection on the definition of metabolic syndrome
    Giovanni Federspil
    Clinica Medica 3, Department of Medical and Surgical Sciences, Padua University, Italy
    Pharmacol Res 53:449-56. 2006
    ..In the present review we analyze in detail the epistemological issues regarding definition and the methodological approaches to definition of the metabolic syndrome...
  29. pmc Really different knockout strains in movement?
    Enzo Nisoli
    J Physiol 586:913; author reply 915-6. 2008
  30. ncbi request reprint The hydrolipidic ratio in age-related maturation of adipose tissues
    Isabella Cavallini
    Section of Anatomy and Histology, Department of Morphological and Biomedical Sciences, Medical Faculty, University of Verona, Strada Le Grazie 8, 37134 Verona, Italy
    Biomed Pharmacother 60:139-43. 2006
    ..This increase was relatively low in iBAT (40%) and high in the e/r/pWAT (204-273%). The work expand the knowledge about the physiological significance of the HLR by 1H-spectroscopy...
  31. doi request reprint Leptin-dependent STAT3 phosphorylation in postnatal mouse hypothalamus
    Andrea Frontini
    Institute of Normal Human Morphology, Marche Polytechnic University, Via Tronto 10 A, 60020 Ancona, Italy
    Brain Res 1215:105-15. 2008
    ..These cells did not express mature or immature neuronal or glial markers. Their ultrastructural appearance, though suggestive of differentiating cells, was not conclusive for a specific phenotype...
  32. ncbi request reprint Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta
    Alessandra Valerio
    Center for Study and Research on Obesity, School of Medicine, University of Milan, 20129 Milan, Italy
    J Biol Chem 281:12950-8. 2006
    ..We concluded that the leptin-mediated regulation of growth cone morphogenesis in cortical neurons relies on upstream regulators of GSK3beta activity...
  33. pmc Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
    Manrico Morroni
    Institute of Anatomy, School of Medicine, University of Ancona, Via Tronto 10 A, 60020 Ancona, Italy
    Proc Natl Acad Sci U S A 101:16801-6. 2004
    ..We conclude that reversible adipocyte-to-epithelium and epithelium-to-adipocyte transdifferentiation occurs in the mammary gland of adult mice during pregnancy and lactation...