Francesco Nicotra

Summary

Affiliation: University of Milano-Bicocca
Country: Italy

Publications

  1. doi request reprint Natural glycoconjugates with antitumor activity
    Barbara La Ferla
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126, Milano, Italy
    Nat Prod Rep 28:630-48. 2011
  2. doi request reprint Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Biococca, Piazza della Scienza 2, I 20126 Milano, Italy
    Future Med Chem 2:587-99. 2010
  3. doi request reprint Carbohydrate scaffolds in chemical genetic studies
    Francesco Nicotra
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy
    J Biotechnol 144:234-41. 2009
  4. doi request reprint Curcumin derivatives as new ligands of Aβ peptides
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, Milan, Italy
    J Biotechnol 156:317-24. 2010
  5. doi request reprint Targeting bacterial membranes: NMR spectroscopy characterization of substrate recognition and binding requirements of D-arabinose-5-phosphate isomerase
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126, Milan, Italy
    Chemistry 16:1897-902. 2010
  6. ncbi request reprint Dendron synthesis and carbohydrate immobilization on a biomaterial surface by a double-click reaction
    Davide Bini
    Department of Biotechnology and Biosciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Org Lett 16:1298-301. 2014
  7. doi request reprint Targeting bacterial membranes: identification of Pseudomonas aeruginosa D-arabinose-5P isomerase and NMR characterisation of its substrate recognition and binding properties
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Chembiochem 12:719-27. 2011
  8. doi request reprint cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands
    Cristina Airoldi
    Dept of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126, Milan, Italy
    Chem Commun (Camb) 47:10266-8. 2011
  9. doi request reprint Epoxide opening versus silica condensation during sol-gel hybrid biomaterial synthesis
    Luca Gabrielli
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Chemistry 19:7856-64. 2013
  10. doi request reprint The influence of plasma technology coupled to chemical grafting on the cell growth compliance of 3D hydroxyapatite scaffolds
    Laura Russo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    J Mater Sci Mater Med 23:2727-38. 2012

Collaborators

Detail Information

Publications34

  1. doi request reprint Natural glycoconjugates with antitumor activity
    Barbara La Ferla
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, I 20126, Milano, Italy
    Nat Prod Rep 28:630-48. 2011
    ..Taken together, all this information is useful for the design of new potential anti-tumor drugs...
  2. doi request reprint Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Biococca, Piazza della Scienza 2, I 20126 Milano, Italy
    Future Med Chem 2:587-99. 2010
    ..This mini-review will present examples of how to exploit carbohydrates mimics and scaffolds in drug research...
  3. doi request reprint Carbohydrate scaffolds in chemical genetic studies
    Francesco Nicotra
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza, 2, 20126 Milano, Italy
    J Biotechnol 144:234-41. 2009
    ..An example of solid phase combinatorial synthesis of a library of 37 compounds is reported...
  4. doi request reprint Curcumin derivatives as new ligands of Aβ peptides
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, Milan, Italy
    J Biotechnol 156:317-24. 2010
    ..All compounds retained Curcumin ability to bind Aβ peptide oligomers without inducing their aggregation. Moreover all Curcumin derivatives were able to stain very efficiently Aβ deposits...
  5. doi request reprint Targeting bacterial membranes: NMR spectroscopy characterization of substrate recognition and binding requirements of D-arabinose-5-phosphate isomerase
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126, Milan, Italy
    Chemistry 16:1897-902. 2010
    ..Due to the essential role of API enzymes in LPS biosynthesis and gram-negative bacteria survival, by exploiting these data, a new generation of potent antibacterial drugs could be developed...
  6. ncbi request reprint Dendron synthesis and carbohydrate immobilization on a biomaterial surface by a double-click reaction
    Davide Bini
    Department of Biotechnology and Biosciences, University of Milan Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Org Lett 16:1298-301. 2014
    ..XPS, FTIR, and ELLA assays confirmed the effectiveness of the collagen multivalent neoglycosylation. ..
  7. doi request reprint Targeting bacterial membranes: identification of Pseudomonas aeruginosa D-arabinose-5P isomerase and NMR characterisation of its substrate recognition and binding properties
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milan, Italy
    Chembiochem 12:719-27. 2011
    ..Our data provide important structural information for the rational design of new KdsD inhibitors as potential antibacterial drugs...
  8. doi request reprint cis-Glyco-fused benzopyran compounds as new amyloid-β peptide ligands
    Cristina Airoldi
    Dept of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126, Milan, Italy
    Chem Commun (Camb) 47:10266-8. 2011
    ..The conformational analysis of the compounds has also been carried out through molecular mechanics (MM) and molecular dynamics (MD) simulations...
  9. doi request reprint Epoxide opening versus silica condensation during sol-gel hybrid biomaterial synthesis
    Luca Gabrielli
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Chemistry 19:7856-64. 2013
    ....
  10. doi request reprint The influence of plasma technology coupled to chemical grafting on the cell growth compliance of 3D hydroxyapatite scaffolds
    Laura Russo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milan, Italy
    J Mater Sci Mater Med 23:2727-38. 2012
    ..In the present work, we investigated the influence of plasma surface modification coupled to chemical grafting on the cell growth compliance of HA 3D scaffolds...
  11. ncbi request reprint Inhibition of lipid a stimulated activation of human dendritic cells and macrophages by amino and hydroxylamino monosaccharides
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Milano, Italy
    Angew Chem Int Ed Engl 46:3308-12. 2007
  12. ncbi request reprint Bicyclic carbohydrate-derived scaffolds for combinatorial libraries
    Giovanni Cervi
    Dipartimento di Biotecnologie e Bioscienze, Universita degli Studi di Milano Bicocca, Piazza della Scienza 2, I 20126 Milano, Italy
    Bioorg Med Chem 14:3349-67. 2006
    ..The compounds synthesized on the solid phase were tested for their antiproliferative activity on tumor cell lines...
  13. ncbi request reprint Design, synthesis and biological evaluation of sugar-derived Ras inhibitors
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Chembiochem 6:1839-48. 2005
    ..All the synthetic compounds were active in inhibiting nucleotide exchange on p21 human Ras in vitro, and two of them selectively inhibited Ras-dependent cell growth in vivo...
  14. ncbi request reprint Arabinose 5-phosphate isomerase as a target for antibacterial design: Studies with substrate analogues and inhibitors
    Luca Gabrielli
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Bioorg Med Chem 22:2576-83. 2014
    ..We report here the first experimental evidence that KdsD may bind the furanose form of A5P, suggesting that catalysis of ring opening may be an important part of KdsD catalysis. ..
  15. ncbi request reprint Synthesis and biological evaluation of arabinose 5-phosphate mimics modified at position five
    Laura Cipolla
    Department of Biotechnology and Biosciences, Universita degli Studi Milano Bicocca, Piazza della Scienza 2, Milan, Italy
    Carbohydr Res 389:186-91. 2014
    ..The synthesised compounds were also characterised for their activity in vivo on P. aeruginosa and Escherichia coli strains. Unfortunately, none of the synthesised compounds was able neither to bind API nor to inhibit bacterial growth. ..
  16. ncbi request reprint Natural compounds against Alzheimer's disease: molecular recognition of Aβ1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Chem Asian J 8:596-602. 2013
    ..Finally, we demonstrated the possibility to exploit STD-NMR and trNOESY experiments to screen extracts from natural sources for the presence of Aβ peptide ligands...
  17. doi request reprint Functionalization of liposomes with ApoE-derived peptides at different density affects cellular uptake and drug transport across a blood-brain barrier model
    Francesca Re
    Department of Experimental Medicine, University of Milano Bicocca, Monza, Italy
    Nanomedicine 7:551-9. 2011
    ..01). Thus, these NLs appear particularly suitable for implementing further strategies for drug brain targeting...
  18. ncbi request reprint Synthesis and biological evaluation of novel lipid A antagonists
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126 Milan, Italy
    Bioorg Med Chem 14:190-9. 2006
    ..Both these molecules were active in inhibiting the inflammatory action of Escherichia coli lipid A on MT2 macrophages in a dose-dependent manner, while they were completely devoid of inflammatory activity...
  19. doi request reprint Sugar-decorated hydroxyapatite: an inorganic material bioactivated with carbohydrates
    Laura Russo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
    Carbohydr Res 346:1564-8. 2011
    ..The 'glycosylated' hydroxypatite was characterised by its ability to interact with glucose recognising lectins...
  20. ncbi request reprint Synthesis and biological evaluation of a small library of nojirimycin-derived bicyclic iminosugars
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
    Carbohydr Res 342:1813-30. 2007
    ....
  21. doi request reprint C-type natriuretic peptide: Structural studies, fragment synthesis, and preliminary biological evaluation in human osteosarcoma cell lines
    Nasrin Shaikh
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2 20126 Milano, Italy
    Biopolymers 94:213-9. 2010
    ....
  22. ncbi request reprint Chemoselective neoglycosylation
    Francesco Nicotra
    Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, Milan, Italy
    Adv Carbohydr Chem Biochem 61:353-98. 2007
  23. ncbi request reprint Carbohydrate-functionalized collagen matrices: design and characterization of a novel neoglycosylated biomaterial
    Laura Russo
    Department of Biotechnology and Biosciences, Universita degli Studi Milano Bicocca, Piazza della Scienza 2, Milan, Italy
    Carbohydr Res 389:12-7. 2014
    ..AFM analysis highlights that the chemical does not affect molecular assembly into fibrils. Moreover, ELLA biochemical assays show that the glycan moiety is efficiently exposed on the matrix surface for receptor recognition. ..
  24. pmc Neoglucosylated collagen matrices drive neuronal cells to differentiate
    Laura Russo
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, I 20126 Milano, Italy
    ACS Chem Neurosci 5:261-5. 2014
    ..Our work may offer to cell biologists new opportunities to study neuronal cell differentiation mechanisms in a cell environment closer to physiological conditions...
  25. doi request reprint Ultrasonic assisted Fischer glycosylation: generating diversity for glycochemistry
    Nasrin Shaikh
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126, Milano, Italy
    Mol Divers 15:341-5. 2011
    ..Remarkable acceleration of the glycosylation reactions (15 min-2 h compared to several hours) over reported procedures together with good yields were always observed...
  26. ncbi request reprint The Kdo biosynthetic pathway toward OM biogenesis as target in antibacterial drug design and development
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P za della Scienza 2, 20126 Milano, Italy
    Curr Drug Discov Technol 6:19-33. 2009
    ..Kdo is a monsaccharide essential for OM biogenesis, OM being an essential cellular structure shared by all Gram-negative bacteria. Hence, inhibitors of its biosynthesis can have a broad-spectrum antibacterial activity...
  27. doi request reprint Straightforward synthesis of novel Akt inhibitors based on a glucose scaffold
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Bicocca P za della Scienza 2, 20126 Milano, Italy
    Carbohydr Res 345:1291-8. 2010
    ..In addition, RNA interference experiments (siRNA) provide evidence of the ability of the compound to exert biological effects specifically through Akt signalling...
  28. ncbi request reprint Synthesis and conformational analysis of novel N(OCH3)-linked disaccharide analogues
    Francesco Peri
    Department of Biotechnology and Biosciences, University of Milano Bicocca, 20126 Milan, Italy
    Chemistry 10:1433-44. 2004
    ..It appears that N(OMe)-linked disaccharide analogues exhibit a slightly different conformational behavior to their parent natural disaccharides...
  29. ncbi request reprint General methods for iminosugar synthesis
    Laura Cipolla
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Italy
    Curr Top Med Chem 3:485-511. 2003
    ..Finally the synthesis of glycoconjugate-related iminosugars, where the "pseudoanomeric" centre is linked to amino acid or peptide residues, and iminosugar phosphonates and nucleosides have been reviewed...
  30. doi request reprint Thiol-ene mediated neoglycosylation of collagen patches: a preliminary study
    Laura Russo
    Department of Biotechnolgy and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126 Milano, Italy
    Langmuir 30:1336-42. 2014
    ..Preliminary biological evaluation in osteoarthritic models is reported. The proposed methodology can be extended to any thiolated surface for the development of smart biomaterials for innovative approaches in regenerative medicine. ..
  31. ncbi request reprint Design and characterization of a new class of inhibitors of ras activation
    Sonia Colombo
    Laboratory of Molecular Biology, Department of Biotechnology and Bioscience, University of Milano Bicocca, Piazza della Scienza 2, Milan 20126, Italy
    Ann N Y Acad Sci 1030:52-61. 2004
    ..In the long term we hope that the knowledge we derive from these compounds will help in the development of an alternative therapy targeting Ras for a specific inhibition of transformed cell proliferation...
  32. pmc Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors
    Davide Bini
    Department of Biotechnology and Biosciences, University of Milano Bicocca, Piazza della Scienza 2, 20126 Milano, Italy
    Beilstein J Org Chem 8:514-21. 2012
    ..Despite the fact that the activity was found in the micromolar range, these findings may help in elucidating the structural features of this class of enzymes of different origin, which are still scarcely characterised...
  33. doi request reprint Tetracycline prevents Aβ oligomer toxicity through an atypical supramolecular interaction
    Cristina Airoldi
    Department of Biotechnology and Biosciences, University of Milano Bicocca, P zza della Scienza 2, 20126, Milan, Italy
    Org Biomol Chem 9:463-72. 2011
    ..Our data shed light on a novel mechanism of anti-amyloidogenic activity displayed by tetracycline, governed by hydrophobic and charge multiparticle interactions...
  34. ncbi request reprint Novel Tn antigen-containing neoglycopeptides: synthesis and evaluation as anti tumor vaccines
    Laura Cipolla
    Department of Biotechnology and Biosciences, Universita degli Studi di Milano Bicocca, P za della Scienza 2, 20126, Milan, Italy
    Bioorg Med Chem 10:1639-46. 2002
    ..Neoglycopeptides 1--3 could be presented to and recognized by the T cell receptor; neoglycopeptide 3, bearing two B-epitopes, was presented to the TCR with higher efficiency, compared to neoglycopeptide 2, having only one B-epitope...