B Nico

Summary

Affiliation: University of Bari
Country: Italy

Publications

  1. doi request reprint Aquaporin-4 expression in primary human central nervous system lymphomas correlates with tumour cell proliferation and phenotypic heterogeneity of the vessel wall
    Beatrice Nico
    Department Basic Medical Sciences, Section of Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Eur J Cancer 48:772-81. 2012
  2. ncbi request reprint Morphofunctional aspects of the blood-brain barrier
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Curr Drug Metab 13:50-60. 2012
  3. pmc VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex
    Vincenzo Benagiano
    Dipartimento Scienze Mediche di Base, Sezione di Anatomia e Istologia, Università Bari, Italy
    BMC Neurosci 12:118. 2011
  4. ncbi request reprint Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Glia 42:235-51. 2003
  5. doi request reprint Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Lab Invest 90:1645-60. 2010
  6. doi request reprint Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy
    Beatrice Nico
    Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico I 70124 Bari, Italy
    Eur J Cancer 45:3315-25. 2009
  7. ncbi request reprint Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrier
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    J Cell Sci 114:1297-307. 2001
  8. ncbi request reprint Interferon beta-1a prevents the effects of lipopolysaccharide on embryonic brain microvessels
    B Nico
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Policlinico, Piazza G Cesare, 11, I 70124, Bari, Italy
    Brain Res Dev Brain Res 119:231-42. 2000
  9. ncbi request reprint HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Brain Pathol 17:399-406. 2007
  10. ncbi request reprint Aquaporin-4 expression during development of the cerebellum
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cerebellum 1:207-12. 2002

Detail Information

Publications125 found, 100 shown here

  1. doi request reprint Aquaporin-4 expression in primary human central nervous system lymphomas correlates with tumour cell proliferation and phenotypic heterogeneity of the vessel wall
    Beatrice Nico
    Department Basic Medical Sciences, Section of Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Eur J Cancer 48:772-81. 2012
    ....
  2. ncbi request reprint Morphofunctional aspects of the blood-brain barrier
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Bari, Italy
    Curr Drug Metab 13:50-60. 2012
    ..In most cases, these pathological conditions are associated with an increase in microvascular permeability, vasogenic edema, swollen atrocyte endfeet, and BBB disruption...
  3. pmc VAMP-2, SNAP-25A/B and syntaxin-1 in glutamatergic and GABAergic synapses of the rat cerebellar cortex
    Vincenzo Benagiano
    Dipartimento Scienze Mediche di Base, Sezione di Anatomia e Istologia, Università Bari, Italy
    BMC Neurosci 12:118. 2011
    ....
  4. ncbi request reprint Severe alterations of endothelial and glial cells in the blood-brain barrier of dystrophic mdx mice
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Glia 42:235-51. 2003
    ..The BBB alterations suggest that changes in vascular permeability are involved in the pathogenesis of the neurological dysfunction associated with DMD...
  5. doi request reprint Glial dystrophin-associated proteins, laminin and agrin, are downregulated in the brain of mdx mouse
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Lab Invest 90:1645-60. 2010
    ..These data indicate that in mdx brain the deficiency in dystrophin and dystrophin isoform (Dp71) is coupled with a reduction of DAP components, coupled with an altered anchoring to the basement membrane...
  6. doi request reprint Aquaporin-4 contributes to the resolution of peritumoural brain oedema in human glioblastoma multiforme after combined chemotherapy and radiotherapy
    Beatrice Nico
    Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico I 70124 Bari, Italy
    Eur J Cancer 45:3315-25. 2009
    ..These data indicate that in GBM chemotherapy and radiotherapy induce a down-regulation in AQP4 expression restoring its perivascular rearrangement suggesting its potential role in the resolution of brain oedema...
  7. ncbi request reprint Role of aquaporin-4 water channel in the development and integrity of the blood-brain barrier
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    J Cell Sci 114:1297-307. 2001
    ....
  8. ncbi request reprint Interferon beta-1a prevents the effects of lipopolysaccharide on embryonic brain microvessels
    B Nico
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Policlinico, Piazza G Cesare, 11, I 70124, Bari, Italy
    Brain Res Dev Brain Res 119:231-42. 2000
    ..These results indicate that the changes induced by LPS in the endothelial cells are prevented by IFNbeta-1a...
  9. ncbi request reprint HIF activation and VEGF overexpression are coupled with ZO-1 up-phosphorylation in the brain of dystrophic mdx mouse
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Brain Pathol 17:399-406. 2007
    ....
  10. ncbi request reprint Aquaporin-4 expression during development of the cerebellum
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cerebellum 1:207-12. 2002
    ..Overall, the data clearly indicate a close relationship between blood-brain barrier functioning and the control of water flux by astroglial cells and the crucial role played by AQP4 in this setting...
  11. doi request reprint Nerve growth factor and its receptors TrkA and p75 are upregulated in the brain of mdx dystrophic mouse
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
    Neuroscience 161:1057-66. 2009
    ....
  12. ncbi request reprint Increased matrix-metalloproteinase-2 and matrix-metalloproteinase-9 expression in the brain of dystrophic mdx mouse
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Neuroscience 140:835-48. 2006
    ..Overall, these data point to a specific pathogenetic role of matrix-metalloproteinase-2 and matrix-metalloproteinase-9 in neurological dysfunctions associated with Duchenne muscular dystrophy...
  13. ncbi request reprint Developmental expression of ZO-1 antigen in the mouse blood-brain barrier
    B Nico
    Institute of Human Anatomy, Histology and Embryology, University of Bari, Piazza G Cesare, 11, Policlinico, I 70124, Bari, Italy
    Brain Res Dev Brain Res 114:161-9. 1999
    ..The results indicate that the ZO-1 protein is a specific molecular marker in the developing brain endothelial tight junctions and that its expression takes place parallel to BBB morphofunctional maturation...
  14. ncbi request reprint Altered blood-brain barrier development in dystrophic MDX mice
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Neuroscience 125:921-35. 2004
    ..These results demonstrate that a reduction in dystrophin isoforms (Dp71) at glial endfeet leads to an altered development of the BBB, whose no-closure might contribute to the neurological dysfunctions associated with DMD...
  15. ncbi request reprint Human erythropoietin induces a pro-angiogenic phenotype in cultured endothelial cells and stimulates neovascularization in vivo
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, Department of Biomedical Sciences and Human Oncology, University of Bari School of Medicine, Bari, Italy
    Blood 93:2627-36. 1999
    ..Taken together, these data demonstrate the ability of Epo to interact directly with endothelial cells and to elicit an angiogenic response in vitro and in vivo and thus act as a bona fide direct angiogenic factor...
  16. ncbi request reprint Coordinate immunoreactivity to vascular endothelial growth factor receptor-2 and its ligand suggests a paracrine regulation during the development of the vascular system in the chick embryo bursa of Fabricius
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, I 70124 Bari, Italy
    Int J Mol Med 7:365-8. 2001
    ..These data support the view that VEGF acts as a paracrine stimulator of angiogenesis in the avian embryo and confirm the requirement of the endodermal layer for the normal formation of blood vessels by mesodermal cells...
  17. ncbi request reprint Clodronate inhibits angiogenesis in vitro and in vivo
    D Ribatti
    Department of Human Anatomy and Histology, Policlinico, I 70124 Bari, Italy
    Oncol Rep 19:1109-12. 2008
    ..Overall, these results suggest that antiangiogenesis by clodronate can be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer...
  18. ncbi request reprint Mast cells and their secretory granules are angiogenic in the chick embryo chorioallantoic membrane
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 31:602-8. 2001
    ..Many data suggest that the density of mast cells is highly correlated with the extent of both normal and pathological angiogenesis...
  19. ncbi request reprint Microvessel overexpression of aquaporin 1 parallels bone marrow angiogenesis in patients with active multiple myeloma
    A Vacca
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University School, Bari, Italy
    Br J Haematol 113:415-21. 2001
    ..It may, perhaps, favour angiogenesis in a positive loop and, hence, MM progression, and thus be applied for therapeutic vascular targeting...
  20. ncbi request reprint Cell-mediated delivery of fibroblast growth factor-2 and vascular endothelial growth factor onto the chick chorioallantoic membrane: endothelial fenestration and angiogenesis
    D Ribatti
    Department of Human Anatomy, University of Bari Medical School, Bari, Italy
    J Vasc Res 38:389-97. 2001
    ..The gelatin sponge/CAM assay may constitute a new model to study the mechanisms leading to endothelial fenestration in tumor growth...
  21. ncbi request reprint A possible role of tryptase in angiogenesis in the brain of mdx mouse, a model of Duchenne muscular dystrophy
    B Nico
    Department of Human Anatomy, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124, Bari, Italy
    Neuroscience 123:585-8. 2004
    ....
  22. ncbi request reprint In vivo absence of synergism between fibroblast growth factor-2 and vascular endothelial growth factor
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Hematother Stem Cell Res 10:905-12. 2001
    ..Thus, in an in vivo system, evaluation of synergistic action between two cytokines and discrimination of their specific activity are more difficult than in an in vitro assay...
  23. pmc Erythropoietin/erythropoietin-receptor system is involved in angiogenesis in human hepatocellular carcinoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 50:591-6. 2007
    ..To correlate microvascular density and erythropoietin (Epo)/Epo-receptor (EpoR) expression in endothelial and tumour cells with histopathological type in hepatocellular carcinoma (HCC)...
  24. pmc Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Br J Cancer 79:451-5. 1999
    ....
  25. ncbi request reprint Chorioallantoic membrane capillary bed: a useful target for studying angiogenesis and anti-angiogenesis in vivo
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, Bari, Italy
    Anat Rec 264:317-24. 2001
    ....
  26. pmc Erythropoietin/erythropoietin receptor system is involved in angiogenesis in human neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 50:636-41. 2007
    ..The aim of this study was to correlate microvascular density and Epo/Epo-receptor (EpoR) expression in endothelial and tumour cells to the clinical stage of NB...
  27. ncbi request reprint Angiogenesis and mast cell density with tryptase activity increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology University of Bari Medical School, Bari, Italy
    Int J Cancer 85:171-5. 2000
    ..These results suggest that angiogenesis in B-NHLs increases with their progression, and that MCs cooperate in its induction via the tryptase contained in their secretory granules...
  28. pmc Angiogenesis extent and macrophage density increase simultaneously with pathological progression in B-cell non-Hodgkin's lymphomas
    A Vacca
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Italy
    Br J Cancer 79:965-70. 1999
    ....
  29. ncbi request reprint Neovascularisation, expression of fibroblast growth factor-2, and mast cells with tryptase activity increase simultaneously with pathological progression in human malignant melanoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Eur J Cancer 39:666-74. 2003
    ..These results suggest that angiogenesis in human melanoma increases with tumour progression and that FGF-2 secreted by tumour cells and tryptase secreted by host MCs cooperate in its induction...
  30. ncbi request reprint In vivo inhibition of human hepatocellular carcinoma related angiogenesis by vinblastine and rapamycin
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histol Histopathol 22:285-9. 2007
    ..Sinergy on the part of these well-known drugs when used in combination as antiangiogenics at very low doses may be of significance in the designing of new ways of treating HCC...
  31. ncbi request reprint The role of aquaporin-4 in the blood-brain barrier development and integrity: studies in animal and cell culture models
    G P Nicchia
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Via Amendola 165 A, I 70126 Bari, Italy
    Neuroscience 129:935-45. 2004
    ..Finally, the role of the endothelial component on AQP4 cellular expression and distribution has been investigated using rat primary astrocytes and brain capillary endothelial cell co-cultures as an in vitro model of BBB...
  32. ncbi request reprint Localization of factor VIII-related antigen in the endothelium of the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    Histochem Cell Biol 112:447-50. 1999
    ..The application of this antibody may be useful for quantifying neovascularization in response to various angiogenic stimuli applied to the CAM...
  33. ncbi request reprint Inhibition of protein kinase C counteracts TNFalpha-induced intercellular adhesion molecule 1 expression and fluid phase endocytosis on brain microvascular endothelial cells
    G Defazio
    Department of Neurologic and Psychiatric Sciences, University of Bari, I 70124, Bari, Italy
    Brain Res 863:245-8. 2000
    ..5-10 nM) did not. These findings indicate that a PKC-dependent mechanism may affect TNFalpha signalling on different barrier properties of BMECs...
  34. pmc Temporal expression of the matrix metalloproteinase MMP-2 correlates with fibronectin immunoreactivity during the development of the vascular system in the chick embryo chorioallantoic membrane
    D Ribatti
    Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy
    J Anat 195:39-44. 1999
    ..These results indicate that MMP-2 activity and fibronectin expression are 2 strictly related components of angiogenesis occurring in vivo...
  35. ncbi request reprint Neridronate inhibits angiogenesis in vitro and in vivo
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare, 11, 70124 Bari, Italy
    Clin Rheumatol 26:1094-8. 2007
    ..Overall, these results suggest that anti-angiogenesis by neridronate could be used to treat a wide spectrum of angiogenesis-dependent diseases, including certain chronic inflammatory diseases and cancer...
  36. ncbi request reprint Erythropoietin as an angiogenic factor in gastric carcinoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 42:246-50. 2003
    ..In this study we correlated microvascular density and Epo receptor (Epo-R) expression in endothelial and tumour cells with histopathological type in gastric cancer...
  37. ncbi request reprint Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in the chick embryo area vasculosa
    B Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Histochem J 33:283-6. 2001
    ..In accord with other literature data, this suggests that vascular endothelial growth factor is required not only for proliferation, but also for the survival of endothelial cells...
  38. ncbi request reprint Vasculogenic mimicry by bone marrow macrophages in patients with multiple myeloma
    C Scavelli
    Department of Internal Medicine and Clinical Oncology, University of Bari Medical School, Bari, Italy
    Oncogene 27:663-74. 2008
    ..Macrophages may be a target for the MM antivascular treatment...
  39. ncbi request reprint Angiogenesis and mast cells in human breast cancer sentinel lymph nodes with and without micrometastases
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histopathology 51:837-42. 2007
    ..The aim was to correlate the extent of angiogenesis with the number of mast cells reactive with tryptase in biopsy specimens of sentinel lymph nodes with and without micrometastases obtained from patients with breast cancer...
  40. ncbi request reprint Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: in vitro and in vivo studies
    M A Frassanito
    Department of Biomedical Sciences and Human Oncology DIMO, General Pathology Section, Bari, Italy
    Leukemia 28:904-16. 2014
    ..In BM biopsies from patients and mice, nests of CAFs were found in close contact with MM cells, suggesting a supportive niche. Therefore, the targeting of CAFs in MM patients may be envisaged as a novel therapeutic strategy. ..
  41. ncbi request reprint The history of the angiogenic switch concept
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leukemia 21:44-52. 2007
    ....
  42. ncbi request reprint Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2
    D Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare 11, Policlinico, I 70124 Bari, Italy
    Int J Mol Med 8:265-8. 2001
    ..Our study confirms that leptin is angiogenic in vivo and suggests that, at least in the chick CAM, its activity is in part mediated by the activation of endogenous FGF-2...
  43. ncbi request reprint Postnatal vasculogenesis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, I 70124, Bari, Italy
    Mech Dev 100:157-63. 2001
    ..The potential biomedical applications of endothelial precursor cells and the new opportunities for the development of new forms of tumor-targeted treatments are discussed...
  44. ncbi request reprint Tissue distribution and membrane localization of aquaporin-9 water channel: evidence for sex-linked differences in liver
    G P Nicchia
    Dipartimento di Fisiologia Generale ed Ambientale, Bari, Italy
    J Histochem Cytochem 49:1547-56. 2001
    ..AQP9 expression in the osmosensitive region of the brain suggests a role in the mechanism of central osmoreception. All these findings show a unique tissue distribution of AQP9 compared to the other known aquaporins...
  45. ncbi request reprint First evaluation of the potential effectiveness in muscular dystrophy of a novel chimeric compound, BN 82270, acting as calpain-inhibitor and anti-oxidant
    Rosa Burdi
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Bari, Italy
    Neuromuscul Disord 16:237-48. 2006
    ..The drug/prodrug system may require posology adjustment to produce wider beneficial effects on all muscle types...
  46. doi request reprint Mast cells contribute to vasculogenic mimicry in multiple myeloma
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 17:19-22. 2008
    ....
  47. ncbi request reprint Desmin-positive pericytes in the chick embryo chorioallantoic membrane in response to fibroblast growth factor-2
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, I 70124 Bari, Italy
    Microvasc Res 68:13-9. 2004
    ....
  48. doi request reprint Four proteins governing overangiogenic endothelial cell phenotype in patients with multiple myeloma are plausible therapeutic targets
    S Berardi
    Department of Biomedical Sciences and Human Oncology, University of Bari Medical School, Bari, Italy
    Oncogene 31:2258-69. 2012
    ..These proteins were substantially impacted by anti-MM drugs, such as bortezomib, lenalidomide and panobinostat. Results suggest that these four proteins could be new targets for the antiangiogenic management of MM patients...
  49. doi request reprint Co-localization of tryptase and cathepsin-G in mast cells in cutaneous mastocytosis
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Cancer Lett 279:209-12. 2009
    ....
  50. ncbi request reprint Synergistic inhibition of human neuroblastoma-related angiogenesis by vinblastine and rapamycin
    Danilo Marimpietri
    Differentiation Therapy Unit Laboratory of Oncology, G Gaslini Childrens Hospital, Genoa 16148, and Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Oncogene 24:6785-95. 2005
    ..The observation that these well-known drugs display synergistic effects as antiangiogenics when administered frequently at very low dose may be of significance in the designing of new ways of treating NB...
  51. doi request reprint An alternative in vivo system for testing angiogenic potential of human neuroblastoma cells
    Domenica Mangieri
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Policlinico, Bari, Italy
    Cancer Lett 277:199-204. 2009
    ..This experimental model could be employed for further research on human tumor progression and anti-angiogenic molecules screening...
  52. ncbi request reprint Correlation of bone marrow angiogenesis and mast cells with tryptase activity in myelodysplastic syndromes
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Leukemia 16:1680-4. 2002
    ....
  53. doi request reprint Angiogenesis in asthma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Clin Exp Allergy 39:1815-21. 2009
    ..This review provides recent data showing the contribution of allergic inflammation in increased airway vascularity and potential therapeutical approaches in asthma treatment by acting on bronchial microvascular changes...
  54. ncbi request reprint Tumor vascularity and tryptase-positive mast cells correlate with a poor prognosis in melanoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Eur J Clin Invest 33:420-5. 2003
    ..Mast cell density (MCD) is highly correlated with the extent of both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumours...
  55. doi request reprint Angiogenic activity of multiple myeloma endothelial cells in vivo in the chick embryo chorioallantoic membrane assay is associated to a down-regulation in the expression of endogenous endostatin
    Domenica Mangieri
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 12:1023-8. 2008
    ..These data suggest that angiogenic switch in MM may involve loss of an endogenous angiogenesis inhibitor, such as endostatin...
  56. ncbi request reprint Vascular endothelial growth factor and vascular endothelial growth factor receptor-2 expression in mdx mouse brain
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Brain Res 953:12-6. 2002
    ..Our data suggest that increased vascularity in the brain of mdx mouse may be due, at least in part, to proliferation of endothelial cells in response to VEGF secreted by neuronal cells...
  57. ncbi request reprint Nerve growth factor as an angiogenic factor
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Microvasc Res 75:135-41. 2008
    ..This review summarizes the involvement of NGF in the regulation of angiogenesis in both normal and pathological conditions...
  58. ncbi request reprint Cross talk between haematopoiesis and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, 1 70124 Bari, Italy
    Adv Exp Med Biol 522:25-36. 2003
  59. doi request reprint Evaluation of potential synergistic action of a combined treatment with alpha-methyl-prednisolone and taurine on the mdx mouse model of Duchenne muscular dystrophy
    A Cozzoli
    Unit of Pharmacology, Department of Pharmaco Biology, Faculty of Pharmacy Department of Human Anatomy and Histology, Faculty of Medicine, University of Bari Metabolic Disease Unit, Paediatric Hospital Giovanni XXIII, Bari, Italy
    Neuropathol Appl Neurobiol 37:243-56. 2011
    ..This study is a preclinical evaluation of the effect of a combined treatment of α-methyl-prednisolone (PDN) with taurine, a safe aminoacid with positive effects on some pathology-related events...
  60. ncbi request reprint In situ hybridization and immunogold localization of vascular endothelial growth factor receptor-2 on the pericytes of the chick chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cytokine 17:262-5. 2002
    ....
  61. ncbi request reprint Evaluation of microvascular density in tumors: pro and contra
    Beatrice Nico
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Histol Histopathol 23:601-7. 2008
    ..There is such a wide range of antibodies and suppliers, antigen retrieval methods, designation of high and low vessel count groups, patient study groups and data interpretation, that it is exceedingly difficult to compare results...
  62. ncbi request reprint Docetaxel versus paclitaxel for antiangiogenesis
    Angelo Vacca
    Department of Biomedical Sciences and Human Oncology DIMO, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Hematother Stem Cell Res 11:103-18. 2002
    ..Their antiangiogenic activity could be applied to treat Kaposi's sarcoma and cancers...
  63. ncbi request reprint Angiogenesis and anti-angiogenesis in neuroblastoma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Eur J Cancer 38:750-7. 2002
    ..Accordingly, anti-angiogenic tumour therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block neuroblastoma progression are reviewed...
  64. pmc Angiogenesis in a human neuroblastoma xenograft model: mechanisms and inhibition by tumour-derived interferon-gamma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Br J Cancer 94:1845-52. 2006
    ..Once the dual origin of tumour vasculature is confirmed in NB patients, the xenograft model described here will prove useful in testing the efficacy of different antiangiogenic compounds...
  65. ncbi request reprint Endothelial progenitor cells in health and disease
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Histol Histopathol 20:1351-8. 2005
    ..Recent evidence, however, indicates that EPC contribute to vessel growth in the embryo and in ischemic, malignant or inflammed tissues in the adult, and can even be therapeutically used to stimulate vessel growth in ischemic tissues...
  66. ncbi request reprint In vitro modulation of adhesion molecules, adhesion phenomena, and fluid phase endocytosis on human umbilical vein endothelial cells and brain-derived microvascular endothelium by IFN-beta 1a
    G Defazio
    Istituto di Clinica Neurologica, , Policlinico, Bari, Italy
    J Interferon Cytokine Res 21:267-72. 2001
    ..In our study, 200 U/ml IFN-beta1a induced a reduction in adhesion of PBMC to HUVEC. The information reported herein may contribute to further elucidating some of the mechanisms of action of IFN-beta on vascular endothelium...
  67. ncbi request reprint Importance of the bone marrow microenvironment in inducing the angiogenic response in multiple myeloma
    D Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Oncogene 25:4257-66. 2006
    ..The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed...
  68. ncbi request reprint Synaptic contacts impaired by styrene-7,8-oxide toxicity
    P Corsi
    Dip di Farmacologia e Fisiologia Umana, Facolta di Medicina e Chirurgia, Universita degli Studi di Bari, 70124 Italy
    Toxicol Appl Pharmacol 224:49-59. 2007
    ..In addition, our data support the hypothesis developed by previous authors of reactive oxygen species (ROS) initiating events of SO cytotoxicity...
  69. ncbi request reprint Aquaporin-4 deficiency in skeletal muscle and brain of dystrophic mdx mice
    A Frigeri
    Dipartimento di Fisiologia Generale ed Ambientale, Universita degli Studi di Bari, I 70126 Bari, Italy
    FASEB J 15:90-98. 2001
    ....
  70. ncbi request reprint Vinblastine inhibits the angiogenic response induced by adrenomedullin in vitro and in vivo
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Oncogene 22:6458-61. 2003
    ..Nevertheless, the antiangiogenic activity of low-dose VBL deserves further investigation, alone or together with other antiangiogenic agents for the treatment of tumors characterized by enhanced angiogenesis...
  71. ncbi request reprint Fenretinide as an anti-angiogenic agent in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, 11 I 70124 Bari, Italy
    Cancer Lett 197:181-4. 2003
    ..This mini-review summarizes our literature and experimental data concerning the use of anti-angiogenic molecules, such as TNP-470 and fenretinide, in neuroblastoma treatment...
  72. ncbi request reprint Endothelial cells in the bone marrow of patients with multiple myeloma
    Angelo Vacca
    Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology, University of Bari Medical School, Policlinico Piazza Giulio Cesare, 11, I 70124 Bari, Italy
    Blood 102:3340-8. 2003
    ..In view of the heterogeneity of the antigenic phenotype of MMECs, a mixture (or a sequence) of antiangiogenic agents coupled with thalidomide would seem plausible for the biologic management of MM...
  73. ncbi request reprint Angiogenesis: basic and clinical aspects
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Ital J Anat Embryol 108:1-24. 2003
    ..Conversely, there are pathologic conditions in which preventing angiogenic processes could be useful in the treatment of a growing tumor or a chronic inflammatory process...
  74. ncbi request reprint Neovascularization and mast cells with tryptase activity increase simultaneously in human pterygium
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Cell Mol Med 11:585-9. 2007
    ..These results suggest that the characteristic neovascularization observed in pterygium may be sustained, at least in part, by MC angiogenic mediators, in particular tryptase...
  75. ncbi request reprint Tryptase- and leptin-positive mast cells correlate with vascular density in uterine leiomyomas
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Am J Obstet Gynecol 196:470.e1-7. 2007
    ..The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase and leptin in human leiomyomas...
  76. pmc Mast cells and angiogenesis in gastric carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Exp Pathol 91:350-6. 2010
    ..Understanding the mechanisms of gastric cancer angiogenesis provides a basis for a rational approach to the development of an antiangiogenic therapy in patients with this malignancy...
  77. doi request reprint Leptin-leptin receptor are involved in angiogenesis in human hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico, 70124 Bari, Italy
    Peptides 29:1596-602. 2008
    ..Taken together, these findings indicate that leptin/Ob-R correlate with angiogenesis and tumor progression in patients with HCC and that an anti-leptin antibody exerts an angiostatic activity in HCC...
  78. doi request reprint Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle
    Annamaria De Luca
    Unit of Pharmacology, Department of Pharmacobiology, Faculty of Pharmacy, University of Bari, Italy
    Neurobiol Dis 32:243-53. 2008
    ....
  79. ncbi request reprint Endothelial cell heterogeneity and organ specificity
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I 70124 Bari, Italy
    J Hematother Stem Cell Res 11:81-90. 2002
    ....
  80. ncbi request reprint Angiogenic activity of rat mast cells in the chick embryo chorioallantoic membrane is down-regulated by treatment with recombinant human alpha-2a interferon and partly mediated by fibroblast growth factor-2
    Domenico Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Haematologica 87:465-71. 2002
    ..We have previously demonstrated that isolated MC and their secretory granules, but not degranulated MC, induce an angiogenic response in the chick embryo chorioallantoic membrane (CAM) assay...
  81. ncbi request reprint Aquaporin-1 expression in the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piaza Giulio Cesare, 11 Policlinico, I 70124 Bari, Italy
    Anat Rec 268:85-9. 2002
    ....
  82. ncbi request reprint Cross-talk between hematopoiesis and angiogenesis signaling pathways
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Italy
    Curr Mol Med 2:537-43. 2002
    ....
  83. pmc Correlation between NGF/TrkA and microvascular density in human pterygium
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare 11, Bari, Italy
    Int J Exp Pathol 90:615-20. 2009
    ..Understanding the mechanism of angiogenesis in pterygium provides a basis for a rational approach to the development of anti-angiogenic therapy in patients affected by this disease...
  84. pmc Mast cells and macrophages in duodenal mucosa of mice overexpressing erythropoietin
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Anat 215:548-54. 2009
    ....
  85. ncbi request reprint In vivo angiogenic activity of neuroblastoma correlates with MYCN oncogene overexpression
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari, Policlinico, Bari, Italy
    Int J Cancer 102:351-4. 2002
    ....
  86. doi request reprint Morphological and molecular aspects of physiological vascular morphogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, 11, Policlinico 70124, Bari, Italy
    Angiogenesis 12:101-11. 2009
    ..This review article summarizes our knowledge concerning the principal factors involved in the regulation of vascular morphogenesis...
  87. ncbi request reprint The gelatin sponge-chorioallantoic membrane assay
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare 11, Policlinico, 70124 Bari, Italy
    Nat Protoc 1:85-91. 2006
    ..Nevertheless, the gelatin sponge-CAM assay is simple, inexpensive and suitable for large-scale screening...
  88. ncbi request reprint Angiogenic response induced by acellular brain scaffolds grafted onto the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Policlinico, Piazza Giulio Cesare 11, I 70124, Bari, Italy
    Brain Res 989:9-15. 2003
    ..In addition, the angiogenic response may depend, in part, also on the presence in the acellular matrix of transforming growth factor beta 1 (TGFbeta1)...
  89. ncbi request reprint Angiogenesis and anti-angiogenesis in hepatocellular carcinoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11 Policlinico, 70124 Bari, Italy
    Cancer Treat Rev 32:437-44. 2006
    ..Accordingly, anti-angiogenic tumor therapy has gained much interest in preclinical and clinical assessments. The recent applications of anti-angiogenic agents which interfere or block HCC progression are reviewed...
  90. pmc A multidisciplinary evaluation of the effectiveness of cyclosporine a in dystrophic mdx mice
    Annamaria De Luca
    Sezione di Farmacologia, Dipartimento Farmacobiologico, Facolta di Farmacia, Universita degli Studi di Bari, Via Orabona 4, Campus, 70125 Bari, Italy
    Am J Pathol 166:477-89. 2005
    ..The beneficial effect of CsA may involve different targets, reinforcing the usefulness of immunosuppressant drugs in muscular dystrophy...
  91. ncbi request reprint Development of the blood-brain barrier: a historical point of view
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G Cesare, Bari, Italy
    Anat Rec B New Anat 289:3-8. 2006
    ..This review article summarizes the historical background underlying our current knowledge of the cellular and molecular mechanisms involved in the development and maintenance of the BBB...
  92. ncbi request reprint Neovascularization and mast cells with tryptase activity increase simultaneously with pathologic progression in human endometrial cancer
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Am J Obstet Gynecol 193:1961-5. 2005
    ..The aim of this study was to correlate the extent of angiogenesis with the number of MC expressing tryptase in human endometrial adenocarcinoma...
  93. ncbi request reprint The role of adrenomedullin in angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Peptides 26:1670-5. 2005
    ..Finally, the role of AM as a potential target of antiangiogenic therapy is discussed...
  94. ncbi request reprint Hematopoietic cancer and angiogenesis
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Stem Cells Dev 13:484-95. 2004
    ....
  95. ncbi request reprint Angiogenesis in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Ann N Y Acad Sci 1028:133-42. 2004
    ..A major goal is the determination of whether inhibition of angiogenesis is a realistic way of inhibiting tumor cell dissemination and formation of metastasis in neuroblastoma...
  96. ncbi request reprint Microvascular density, vascular endothelial growth factor immunoreactivity in tumor cells, vessel diameter and intussusceptive microvascular growth in primary melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, 11 Piazza Giulio Cesare, Policlinico, I 70124 Bari, Italy
    Oncol Rep 14:81-4. 2005
    ....
  97. ncbi request reprint Thalidomide downregulates angiogenic genes in bone marrow endothelial cells of patients with active multiple myeloma
    Angelo Vacca
    Department of Internal Medicine and Clinical Oncology, Policlinico Piazza Giulio Cesare, University of Medical School Bari, Italy
    J Clin Oncol 23:5334-46. 2005
    ..To study the antiangiogenic effect of thalidomide...
  98. ncbi request reprint The structure of the vascular network of tumors
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Cancer Lett 248:18-23. 2007
    ..This review will focus on the factors influencing this heterogeneity...
  99. pmc In vivo time-course of the angiogenic response induced by multiple myeloma plasma cells in the chick embryo chorioallantoic membrane
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    J Anat 203:323-8. 2003
    ....
  100. ncbi request reprint Aquaporins in skeletal muscle: reassessment of the functional role of aquaporin-4
    Antonio Frigeri
    Department of General and Environmental Physiology and Centre of Excellence in Comparative Genomics CEGBA, University of Bari, Bari, Italy
    FASEB J 18:905-7. 2004
    ..These data imply an important role for aquaporins in skeletal muscle physiology as well as an involvement of AQP4 in the molecular alterations that occur in the muscle of DMD patients...
  101. pmc Erythropoietin is involved in angiogenesis in human primary melanoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy
    Int J Exp Pathol 91:495-9. 2010
    ..These findings suggest that Epo is secreted by tumour cells and it affects vascular endothelial cells via its receptor and promotes angiogenesis in a paracrine manner, playing an important role in melanoma angiogenesis...