C Nervi

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. ncbi request reprint Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity
    C Nervi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Cancer Res 61:1247-9. 2001
  2. ncbi request reprint Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesis
    Clara Nervi
    Department of Histology and Medical Embryology University La Sapienza and San Raffaele Bio medical Park Foundation Rome, Italy
    Epigenetics 3:1-4. 2008
  3. ncbi request reprint Emerging role for microRNAs in acute promyelocytic leukemia
    C Nervi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Bio medical Park Foundation, Via di Castel Romano 100, 00128 Rome, Italy
    Curr Top Microbiol Immunol 313:73-84. 2007
  4. ncbi request reprint Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia
    F F Ferrara
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Cancer Res 61:2-7. 2001
  5. ncbi request reprint MicroRNAs and hematopoietic differentiation
    A Fatica
    Institute Pasteur Cenci Bolognetti, Department of Genetics and Molecular Biology and I B P M, University of Rome La Sapienza, Rome, Italy
    Cold Spring Harb Symp Quant Biol 71:205-10. 2006
  6. ncbi request reprint Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
    Francesco Fazi
    Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
    Cancer Cell 12:457-66. 2007
  7. ncbi request reprint Dielectric spectroscopy of blood cells suspensions: study on geometrical structure of biological cells
    Caterina Merla
    ICEmB, Rome Univ, Rome, Italy
    Conf Proc IEEE Eng Med Biol Soc 1:3194-7. 2006
  8. ncbi request reprint Dynamic and reversibility of heterochromatic gene silencing in human disease
    Giuseppe Zardo
    Department of Cellular Biotechnology, University of Rome La Sapienza, Italy
    Cell Res 15:679-90. 2005
  9. doi request reprint NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression
    Linda Marie Starnes
    Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy
    Blood 114:1753-63. 2009
  10. ncbi request reprint Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells
    Lidia De Felice
    Department of Cellular Biotechnology and Hematology, University of Rome La Sapienza, USA
    Cancer Res 65:1505-13. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicity
    C Nervi
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Cancer Res 61:1247-9. 2001
    ..Thus, TSA might represent a nontoxic and effective agent for the transcriptional therapy of neoplasia...
  2. ncbi request reprint Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesis
    Clara Nervi
    Department of Histology and Medical Embryology University La Sapienza and San Raffaele Bio medical Park Foundation Rome, Italy
    Epigenetics 3:1-4. 2008
    ..This finding indicates microRNAs as additional epigenetic targets for leukemogenesis and for therapeutic intervention in leukemias...
  3. ncbi request reprint Emerging role for microRNAs in acute promyelocytic leukemia
    C Nervi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Bio medical Park Foundation, Via di Castel Romano 100, 00128 Rome, Italy
    Curr Top Microbiol Immunol 313:73-84. 2007
    ....
  4. ncbi request reprint Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemia
    F F Ferrara
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Cancer Res 61:2-7. 2001
    ..These findings relate alteration of the RA pathway to myeloid leukemogenesis and underscore the potential of transcriptional/differentiation therapy in AML...
  5. ncbi request reprint MicroRNAs and hematopoietic differentiation
    A Fatica
    Institute Pasteur Cenci Bolognetti, Department of Genetics and Molecular Biology and I B P M, University of Rome La Sapienza, Rome, Italy
    Cold Spring Harb Symp Quant Biol 71:205-10. 2006
    ..An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished...
  6. ncbi request reprint Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein
    Francesco Fazi
    Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
    Cancer Cell 12:457-66. 2007
    ..Here, we identify an additional action for a leukemia fusion protein linking the epigenetic silencing of a microRNA locus to the differentiation block of leukemia...
  7. ncbi request reprint Dielectric spectroscopy of blood cells suspensions: study on geometrical structure of biological cells
    Caterina Merla
    ICEmB, Rome Univ, Rome, Italy
    Conf Proc IEEE Eng Med Biol Soc 1:3194-7. 2006
    ....
  8. ncbi request reprint Dynamic and reversibility of heterochromatic gene silencing in human disease
    Giuseppe Zardo
    Department of Cellular Biotechnology, University of Rome La Sapienza, Italy
    Cell Res 15:679-90. 2005
    ....
  9. doi request reprint NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression
    Linda Marie Starnes
    Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy
    Blood 114:1753-63. 2009
    ..Altogether, these results indicate that, in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage...
  10. ncbi request reprint Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cells
    Lidia De Felice
    Department of Cellular Biotechnology and Hematology, University of Rome La Sapienza, USA
    Cancer Res 65:1505-13. 2005
    ..These findings underscore the potentiality of novel epigenetic approaches to modify HSC fate in vitro...
  11. pmc Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathways
    Bianca Maria Scicchitano
    Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Roma, Italy
    Mol Biol Cell 16:3632-41. 2005
    ..Although MEF2-NFATc1 complexes appear to regulate the expression of an early muscle-specific gene product (myogenin), the activation of late muscle-specific gene expression (MCK) involves the formation of complexes including GATA2...
  12. ncbi request reprint Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia
    Giuseppe Cimino
    Department of Cellular Biotechnology and Hematology, University of Rome La Sapienza, Rome, Italy
    Cancer Res 66:8903-11. 2006
    ..Further studies are needed to evaluate whether VPA-ATRA treatment by reprogramming differentiation of the leukemic clone might improve the response to chemotherapy in leukemia patients...
  13. ncbi request reprint A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesis
    Francesco Fazi
    Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
    Cell 123:819-31. 2005
    ..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage...
  14. doi request reprint Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status
    Lorena Travaglini
    Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
    Int J Biochem Cell Biol 41:225-34. 2009
    ....
  15. doi request reprint MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
    Francesco Fazi
    Department of Histology and Medical Embryology, Sapienza University of Rome, Italy
    Cardiovasc Res 79:553-61. 2008
    ....
  16. ncbi request reprint AVP induces myogenesis through the transcriptional activation of the myocyte enhancer factor 2
    Bianca Maria Scicchitano
    Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Roma, Italy
    Mol Endocrinol 16:1407-16. 2002
    ..Together, these results show that AVP induces myogenic differentiation through the transcriptional activation of MEF2, a mechanism that is critical for myogenesis...
  17. pmc Targeting fusion protein/corepressor contact restores differentiation response in leukemia cells
    Serena Racanicchi
    Patologia Generale and Medicina Interna e Scienze Oncologiche, Dipartimento di Medicina Clinica e Sperimentale, Perugia University, Policlinico Monteluce, Perugia, Italy
    EMBO J 24:1232-42. 2005
    ..Our data indicate that fusion protein activity is permanently required to maintain the leukemia phenotype and show the route to developing a novel therapeutic approach for leukemia, based on its molecular pathogenesis...
  18. pmc Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemias
    Giuseppe Leone
    Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy
    Curr Med Chem 15:1274-87. 2008
    ..However, studies on leukemias have provided paradigmatic examples for the functional implications of the epigenetic alterations in cancer development and progression as well as their relevance for therapeutical targeting...
  19. ncbi request reprint Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor
    Luciano Di Croce
    Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
    Science 295:1079-82. 2002
    ..These results establish a mechanistic link between genetic and epigenetic changes during transformation and suggest that hypermethylation contributes to the early steps of carcinogenesis...
  20. pmc Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylases
    Simona Iezzi
    Laboratory of Muscle Biology, Muscle Gene Expression Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 99:7757-62. 2002
    ..These results represent the first evidence that DIs can enhance muscle differentiation and suggest the rationale for their use in manipulating adult and embryonic skeletal myogenesis...
  21. ncbi request reprint Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studies
    Maria C Petti
    Hematology Section, Regina Elena Cancer Institute, Department of Cellular Biotechnology, University La Sapienza, Rome, Italy
    Blood 100:1065-7. 2002
    ..Our findings indicate that the maturation block may be overcome and terminal differentiation obtained in this leukemia subset and support the view that sensitivity/refractoriness of this form to ATRA should be revisited...
  22. ncbi request reprint Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemia
    Francesco Fazi
    San Raffaele Bio medical Park Foundation, Rome, Italy
    Blood 109:4432-40. 2007
    ..Finally, RARbeta2 is commonly silenced by hypermethylation in primary AML blasts but not in normal hematopoietic precursors, thus suggesting a role for the epigenetic repression of the RA signaling pathway in myeloid leukemogenesis...
  23. ncbi request reprint Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cells
    Sylvie Côté
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and McGill University Department of Oncology and Medicine, Montreal, Quebec, Canada
    Blood 100:2586-96. 2002
    ..The variety of PML/RARalpha mutations arising in ATRA-resistant patients begins to explain how APL patients in relapse may differ in response to transcription therapy with HDAC inhibitors...
  24. ncbi request reprint Myc-binding-site recognition in the human genome is determined by chromatin context
    Ernesto Guccione
    Department of Experimental Oncology, European Institute of Oncology, IFOM IEO Campus, Milan 20139, Italy
    Nat Cell Biol 8:764-70. 2006
    ..These data imply that tethering of a transcription factor to restricted chromatin domains is rate-limiting for sequence-specific DNA binding in vivo...
  25. ncbi request reprint AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor
    Elena Puccetti
    Med Klinik III Abtl Hämatologie, Johann Wolfgang Goethe Universitat, 60590 Frankfurt, Germany
    Cancer Res 62:7050-8. 2002
    ....
  26. ncbi request reprint Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathway
    Alessandra Insinga
    Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
    Nat Med 11:71-6. 2005
    ..These results show that sensitivity to HDACIs in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway...
  27. ncbi request reprint Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571
    Tim Beissert
    Med Klinik III Abtl Hämatologie, Klinikum der J W Goethe Universität Frankfurt, Theodor Stern Kai 7, 60590 Frankfurt, Germany
    Blood 102:2985-93. 2003
    ..Our results indicate that targeting of the oligomerization interfaces of the X-ABL enhances the effects of STI571 in the treatment of leukemia caused by X-ABL...
  28. pmc MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marks
    Lluis Morey
    Centre de Regulacio Genomica, Universitat Pompeu Fabra, Barcelona, Spain
    Mol Cell Biol 28:5912-23. 2008
    ....
  29. ncbi request reprint Molecular signature of retinoic acid treatment in acute promyelocytic leukemia
    Natalia Meani
    Institute of Molecular Oncology of the Italian Foundation for Cancer Research, Via Adamello 16, 20139 Milan, Italy
    Oncogene 24:3358-68. 2005
    ....
  30. ncbi request reprint Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiation
    Rosamaria Mangiacasale
    CNR, Institute of Molecular Biology and Pathology, Rome, Italy
    Oncogene 22:2750-61. 2003
    ..The finding that an RT inhibitor can modulate cell proliferation and differentiation suggests that RT may represent a novel target in the development of therapeutical approaches to neoplasia...
  31. ncbi request reprint The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha
    Elena Puccetti
    Department of Hematology, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
    Cancer Res 65:6080-8. 2005
    ..Taken together, these data provide evidence that the dimerization capacity and the formation of a functionally charged pocket are indispensable for the PLZF/RARalpha-induced leukemogenesis...
  32. ncbi request reprint Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivo
    Francesco Fazi
    San Raffaele Bio medical Science Park of Rome, Rome, Italy
    Oncogene 24:1820-30. 2005
    ..These results extend the rationale for chromatin-targeted treatment in APL and RA-resistant leukemias...
  33. ncbi request reprint Expression of SMRTbeta promotes ligand-induced activation of mutated and wild-type retinoid receptors
    Sylvie Côté
    Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755, Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
    Blood 104:4226-35. 2004
    ....