Research Topics
Species | C NerviSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Detail Information
Publications
Inhibition of histone deacetylase activity by trichostatin A modulates gene expression during mouse embryogenesis without apparent toxicityC Nervi
Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
Cancer Res 61:1247-9. 2001..Thus, TSA might represent a nontoxic and effective agent for the transcriptional therapy of neoplasia...- Oncoproteins, heterochromatin silencing and microRNAs: a new link for leukemogenesisClara Nervi
Department of Histology and Medical Embryology University La Sapienza and San Raffaele Bio medical Park Foundation Rome, Italy
Epigenetics 3:1-4. 2008..This finding indicates microRNAs as additional epigenetic targets for leukemogenesis and for therapeutic intervention in leukemias... - Emerging role for microRNAs in acute promyelocytic leukemiaC Nervi
Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Bio medical Park Foundation, Via di Castel Romano 100, 00128 Rome, Italy
Curr Top Microbiol Immunol 313:73-84. 2007.... - Histone deacetylase-targeted treatment restores retinoic acid signaling and differentiation in acute myeloid leukemiaF F Ferrara
Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
Cancer Res 61:2-7. 2001..These findings relate alteration of the RA pathway to myeloid leukemogenesis and underscore the potential of transcriptional/differentiation therapy in AML... - MicroRNAs and hematopoietic differentiationA Fatica
Institute Pasteur Cenci-Bolognetti, Department of Genetics and Molecular Biology and I.B.P.M, University of Rome La Sapienza, Rome, Italy
Cold Spring Harb Symp Quant Biol 71:205-10. 2006..An interesting interplay between miRNAs and lineage-specific transcriptional factors has been found, and this can help us to understand how terminal differentiation is accomplished... - Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoproteinFrancesco Fazi
Department of Histology and Medical Embryology, University La Sapienza, Rome, 00161, Italy
Cancer Cell 12:457-66. 2007..Here, we identify an additional action for a leukemia fusion protein linking the epigenetic silencing of a microRNA locus to the differentiation block of leukemia... - Dielectric spectroscopy of blood cells suspensions: study on geometrical structure of biological cellsCaterina Merla
ICEmB, Rome Univ, Rome, Italy
Conf Proc IEEE Eng Med Biol Soc 1:3194-7. 2006.... - Dynamic and reversibility of heterochromatic gene silencing in human diseaseGiuseppe Zardo
Department of Cellular Biotechnology, University of Rome La Sapienza, Italy
Cell Res 15:679-90. 2005.... 
NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expressionLinda Marie Starnes
Department of Histology and Medical Embryology, University La Sapienza, Rome, Italy
Blood 114:1753-63. 2009..Altogether, these results indicate that, in early hematopoiesis, the NFI-A expression level acts as a novel factor channeling HPCs into either the E or G lineage...- Histone deacetylase inhibitor valproic acid enhances the cytokine-induced expansion of human hematopoietic stem cellsLidia De Felice
Department of Cellular Biotechnology and Hematology, University of Rome La Sapienza, USA
Cancer Res 65:1505-13. 2005..These findings underscore the potentiality of novel epigenetic approaches to modify HSC fate in vitro... 
Vasopressin-dependent myogenic cell differentiation is mediated by both Ca2+/calmodulin-dependent kinase and calcineurin pathwaysBianca Maria Scicchitano
Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Roma, Italy
Mol Biol Cell 16:3632-41. 2005..Although MEF2-NFATc1 complexes appear to regulate the expression of an early muscle-specific gene product (myogenin), the activation of late muscle-specific gene expression (MCK) involves the formation of complexes including GATA2...- Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemiaGiuseppe Cimino
Department of Cellular Biotechnology and Hematology, University of Rome La Sapienza, Rome, Italy
Cancer Res 66:8903-11. 2006..Further studies are needed to evaluate whether VPA-ATRA treatment by reprogramming differentiation of the leukemic clone might improve the response to chemotherapy in leukemia patients... - A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPalpha regulates human granulopoiesisFrancesco Fazi
Department of Histology and Medical Embryology, University of Rome La Sapienza and San Raffaele Biomedical Science Park of Rome, Via di Castel Romano 100, 00128, Rome, Italy
Cell 123:819-31. 2005..Altogether, our data indicate that miR-223 plays a crucial role during granulopoiesis and point to the NFI-A repression as an important molecular pathway mediating gene reprogramming in this cell lineage... - Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor statusLorena Travaglini
Department of Histology and Medical Embryology, University of Rome La Sapienza, Italy
Int J Biochem Cell Biol 41:225-34. 2009.... - MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determinationFrancesco Fazi
Department of Histology and Medical Embryology, Sapienza University of Rome, Italy
Cardiovasc Res 79:553-61. 2008.... - AVP induces myogenesis through the transcriptional activation of the myocyte enhancer factor 2Bianca Maria Scicchitano
Department of Histology and Medical Embryology, University of Rome La Sapienza, 00161 Roma, Italy
Mol Endocrinol 16:1407-16. 2002..Together, these results show that AVP induces myogenic differentiation through the transcriptional activation of MEF2, a mechanism that is critical for myogenesis... - Targeting fusion protein/corepressor contact restores differentiation response in leukemia cellsSerena Racanicchi
Patologia Generale and Medicina Interna e Scienze Oncologiche, Dipartimento di Medicina Clinica e Sperimentale, Perugia University, Policlinico Monteluce, Perugia, Italy
EMBO J 24:1232-42. 2005..Our data indicate that fusion protein activity is permanently required to maintain the leukemia phenotype and show the route to developing a novel therapeutic approach for leukemia, based on its molecular pathogenesis... - Epigenetic treatment of myelodysplastic syndromes and acute myeloid leukemiasGiuseppe Leone
Istituto di Ematologia, Universita Cattolica del Sacro Cuore, Rome, Italy
Curr Med Chem 15:1274-87. 2008..However, studies on leukemias have provided paradigmatic examples for the functional implications of the epigenetic alterations in cancer development and progression as well as their relevance for therapeutical targeting... - Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factorLuciano Di Croce
Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Science 295:1079-82. 2002..These results establish a mechanistic link between genetic and epigenetic changes during transformation and suggest that hypermethylation contributes to the early steps of carcinogenesis... - Stage-specific modulation of skeletal myogenesis by inhibitors of nuclear deacetylasesSimona Iezzi
Laboratory of Muscle Biology, Muscle Gene Expression Group, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Proc Natl Acad Sci U S A 99:7757-62. 2002..These results represent the first evidence that DIs can enhance muscle differentiation and suggest the rationale for their use in manipulating adult and embryonic skeletal myogenesis... - Complete remission through blast cell differentiation in PLZF/RARalpha-positive acute promyelocytic leukemia: in vitro and in vivo studiesMaria C Petti
Hematology Section, Regina Elena Cancer Institute, Department of Cellular Biotechnology, University La Sapienza, Rome, Italy
Blood 100:1065-7. 2002..Our findings indicate that the maturation block may be overcome and terminal differentiation obtained in this leukemia subset and support the view that sensitivity/refractoriness of this form to ATRA should be revisited... - Heterochromatic gene repression of the retinoic acid pathway in acute myeloid leukemiaFrancesco Fazi
San Raffaele Bio medical Park Foundation, Rome, Italy
Blood 109:4432-40. 2007..Finally, RARbeta2 is commonly silenced by hypermethylation in primary AML blasts but not in normal hematopoietic precursors, thus suggesting a role for the epigenetic repression of the RA signaling pathway in myeloid leukemogenesis... - Response to histone deacetylase inhibition of novel PML/RARalpha mutants detected in retinoic acid-resistant APL cellsSylvie Côté
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital and McGill University Department of Oncology and Medicine, Montreal, Quebec, Canada
Blood 100:2586-96. 2002..The variety of PML/RARalpha mutations arising in ATRA-resistant patients begins to explain how APL patients in relapse may differ in response to transcription therapy with HDAC inhibitors... - Myc-binding-site recognition in the human genome is determined by chromatin contextErnesto Guccione
Department of Experimental Oncology, European Institute of Oncology, IFOM-IEO Campus, Milan 20139, Italy
Nat Cell Biol 8:764-70. 2006..These data imply that tethering of a transcription factor to restricted chromatin domains is rate-limiting for sequence-specific DNA binding in vivo... - AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptorElena Puccetti
Med Klinik III Abtl Hämatologie, Johann Wolfgang Goethe Universitat, 60590 Frankfurt, Germany
Cancer Res 62:7050-8. 2002.... - Inhibitors of histone deacetylases induce tumor-selective apoptosis through activation of the death receptor pathwayAlessandra Insinga
Department of Experimental Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy
Nat Med 11:71-6. 2005..These results show that sensitivity to HDACIs in leukemias is a property of the fully transformed phenotype and depends on activation of a specific death pathway... - Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571Tim Beissert
, , Theodor Stern Kai 7, 60590 Frankfurt, Germany
Blood 102:2985-93. 2003..Our results indicate that targeting of the oligomerization interfaces of the X-ABL enhances the effects of STI571 in the treatment of leukemia caused by X-ABL... - MBD3, a component of the NuRD complex, facilitates chromatin alteration and deposition of epigenetic marksLluis Morey
Centre de Regulacio Genomica, Universitat Pompeu Fabra, Barcelona, Spain
Mol Cell Biol 28:5912-23. 2008.... - Molecular signature of retinoic acid treatment in acute promyelocytic leukemiaNatalia Meani
Institute of Molecular Oncology of the Italian Foundation for Cancer Research, Via Adamello 16, 20139 Milan, Italy
Oncogene 24:3358-68. 2005.... - Exposure of normal and transformed cells to nevirapine, a reverse transcriptase inhibitor, reduces cell growth and promotes differentiationRosamaria Mangiacasale
CNR, Institute of Molecular Biology and Pathology, Rome, Italy
Oncogene 22:2750-61. 2003..The finding that an RT inhibitor can modulate cell proliferation and differentiation suggests that RT may represent a novel target in the development of therapeutical approaches to neoplasia... - The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalphaElena Puccetti
Department of Hematology, Johann Wolfgang Goethe Universitat, Frankfurt, Germany
Cancer Res 65:6080-8. 2005..Taken together, these data provide evidence that the dimerization capacity and the formation of a functionally charged pocket are indispensable for the PLZF/RARalpha-induced leukemogenesis... - Retinoic acid targets DNA-methyltransferases and histone deacetylases during APL blast differentiation in vitro and in vivoFrancesco Fazi
San Raffaele Bio medical Science Park of Rome, Rome, Italy
Oncogene 24:1820-30. 2005..These results extend the rationale for chromatin-targeted treatment in APL and RA-resistant leukemias... - Expression of SMRTbeta promotes ligand-induced activation of mutated and wild-type retinoid receptorsSylvie Côté
Lady Davis Institute for Medical Research, Sir Mortimer B Davis Jewish General Hospital, 3755, Chemin de la Cote Ste Catherine, Montreal, Quebec, Canada H3T 1E2
Blood 104:4226-35. 2004....