Luca M Neri

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms
    L M Neri
    Section of Human Anatomy, University of Ferrara, Ferrara, Italy
    Biochem Biophys Res Commun 259:314-20. 1999
  2. ncbi Erythropoietin-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of phosphatidylinositol 3-kinase and intranuclear generation of phosphatidylinositol (3,4,5) trisphosphate
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Cell Signal 14:21-9. 2002
  3. ncbi Protein kinase C isoforms and lipid second messengers: a critical nuclear partnership?
    L M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Histol Histopathol 17:1311-6. 2002
  4. ncbi The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Biochim Biophys Acta 1584:73-80. 2002
  5. ncbi The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Universita di Ferrara, Ferrara, Italy
    Mol Cancer Res 1:234-46. 2003
  6. pmc Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana Normale, Universita di Ferrara, 44100 Ferrara, Italy
    Mol Biol Cell 13:947-64. 2002
  7. ncbi Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin
    Paola Borgatti
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Ferrara, Italy
    J Cell Physiol 196:79-88. 2003
  8. pmc The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
    Carolina Simioni
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Oncotarget 4:1496-506. 2013
  9. ncbi Mitogenic effects of Brazilian arthropod venom on isolated islet beta cells: in vitro morphologic ultrastructural and functional studies
    Giovanni Luca
    Department of Internal Medicine, University of Perugia, Italy
    J Investig Med 51:79-85. 2003
  10. ncbi Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice
    Giovanni Luca
    Department of Internal Medicine Di M I, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Via E dal Pozzo, Perugia 06126, Italy
    Cell Transplant 14:249-61. 2005

Collaborators

  • Alberto M Martelli
  • Alfonso Bellacosa
  • Silvano Capitani
  • Giovanni Luca
  • Carolina Simioni
  • Mario Calvitti
  • Ennio Becchetti
  • Giuseppe Basta
  • Riccardo Calafiore
  • Paolo Brunetti
  • Tiziano Baroni
  • Paola Borgatti
  • Rengul Cetin-Atalay
  • James A McCubrey
  • Alice Cani
  • Claudio Nastruzzi
  • Geovana Novaes
  • Mari Cleide Sogayar
  • Maria Lucia Correa-Giannella
  • Evanguedes Kalapothakis
  • Giovanna Tabellini
  • Sylva Stuchi Maria Engler
  • Carmine Fanelli
  • Freddy Goldberg Eliaschewitz

Detail Information

Publications10

  1. ncbi Monocytic differentiation of HL-60 cells is characterized by the nuclear translocation of phosphatidylinositol 3-kinase and of definite phosphatidylinositol-specific phospholipase C isoforms
    L M Neri
    Section of Human Anatomy, University of Ferrara, Ferrara, Italy
    Biochem Biophys Res Commun 259:314-20. 1999
    ..Furthermore, PKC xi nuclear translocation appears to be related to PI 3-K activity...
  2. ncbi Erythropoietin-induced erythroid differentiation of K562 cells is accompanied by the nuclear translocation of phosphatidylinositol 3-kinase and intranuclear generation of phosphatidylinositol (3,4,5) trisphosphate
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Cell Signal 14:21-9. 2002
    ..These findings strongly suggest that an important step in the signaling pathways that mediate EPO-induced erythroid differentiation may be represented by the intranuclear translocation of an active PtdIns 3-K...
  3. ncbi Protein kinase C isoforms and lipid second messengers: a critical nuclear partnership?
    L M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Histol Histopathol 17:1311-6. 2002
    ..In this article, we review the current knowledge about lipid second messengers that are involved in regulating the translocation and/or the activity of different protein kinase C isoforms identified at the nuclear level...
  4. ncbi The nuclear phosphoinositide 3-kinase/AKT pathway: a new second messenger system
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Via Fossato di Mortara 66, 44100 Ferrara, Italy
    Biochim Biophys Acta 1584:73-80. 2002
    ..In this review, we shall summarize the most updated findings about these molecules in relationship with the nuclear compartment and provide an overview of the possible mechanisms by which they regulate important cell functions...
  5. ncbi The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Universita di Ferrara, Ferrara, Italy
    Mol Cancer Res 1:234-46. 2003
    ..Our findings suggest that an up-regulation of the PI3K/AKT1 pathway might be one of the survival mechanisms responsible for the onset of resistance to chemotherapeutic and differentiating therapy in patients with acute leukemia...
  6. pmc Proliferating or differentiating stimuli act on different lipid-dependent signaling pathways in nuclei of human leukemia cells
    Luca M Neri
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana Normale, Universita di Ferrara, 44100 Ferrara, Italy
    Mol Biol Cell 13:947-64. 2002
    ..Our results assume a particular significance in light of the proposed use of pharmacological inhibitors of PKC-dependent biochemical pathways for the therapy of cancer disease...
  7. ncbi Threonine 308 phosphorylated form of Akt translocates to the nucleus of PC12 cells under nerve growth factor stimulation and associates with the nuclear matrix protein nucleolin
    Paola Borgatti
    Dipartimento di Morfologia ed Embriologia, Sezione di Anatomia Umana, Universita di Ferrara, Ferrara, Italy
    J Cell Physiol 196:79-88. 2003
    ....
  8. pmc The AKT inhibitor MK-2206 is cytotoxic in hepatocarcinoma cells displaying hyperphosphorylated AKT-1 and synergizes with conventional chemotherapy
    Carolina Simioni
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Oncotarget 4:1496-506. 2013
    ..Our findings suggest that the use of Akt inhibitors, either alone or in combination with doxorubicin, may be considered as an attractive therapeutic regimen for the treatment of HCC. ..
  9. ncbi Mitogenic effects of Brazilian arthropod venom on isolated islet beta cells: in vitro morphologic ultrastructural and functional studies
    Giovanni Luca
    Department of Internal Medicine, University of Perugia, Italy
    J Investig Med 51:79-85. 2003
    ..The venom was previously known to induce nesidioblastosis-like effects with chronic hypoglycemia and pancreatitis in animal models...
  10. ncbi Accelerated functional maturation of isolated neonatal porcine cell clusters: in vitro and in vivo results in NOD mice
    Giovanni Luca
    Department of Internal Medicine Di M I, Section of Internal Medicine and Endocrine and Metabolic Sciences, University of Perugia, Via E dal Pozzo, Perugia 06126, Italy
    Cell Transplant 14:249-61. 2005
    ..Graft of microencapsulated neonatal porcine islets, precultured in Sertoli cells, has been proven successful in correcting hyperglycemia in stringent animal model of spontaneous diabetes...