Massimo Negrini

Summary

Affiliation: University of Ferrara
Country: Italy

Publications

  1. ncbi request reprint MicroRNAs in human cancer: from research to therapy
    Massimo Negrini
    Dipartimento di Medicina Sperimentale e Diagnostica, Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy
    J Cell Sci 120:1833-40. 2007
  2. pmc miR-221 affects multiple cancer pathways by modulating the level of hundreds messenger RNAs
    Laura Lupini
    Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara Ferrara, Italy
    Front Genet 4:64. 2013
  3. ncbi request reprint microRNA involvement in hepatocellular carcinoma
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Anticancer Agents Med Chem 11:500-21. 2011
  4. doi request reprint MicroRNAs and cancer--new paradigms in molecular oncology
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, Interdepartment Center for Cancer Research, University of Ferrara, Ferrara 44100, Italy
    Curr Opin Cell Biol 21:470-9. 2009
  5. pmc Non-coding RNAs change their expression profile after Retinoid induced differentiation of the promyelocytic cell line NB4
    Annalisa Rossi
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S, Pansini 5, Napoli, Italy
    BMC Res Notes 3:24. 2010
  6. pmc MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
    Manuela Ferracin
    Dipartimento di Medicina Sperimentale e Diagnostica Università di Ferrara, Ferrara, Italy
    Mol Cancer 9:123. 2010
  7. ncbi request reprint miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression
    Manuela Ferracin
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Mol Cancer 12:130. 2013
  8. pmc mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
    Giovanni Lanza
    Department of Experimental and Diagnostic Medicine and Interdepartment Center for Cancer Research, University of Ferrara, Ferrara, Italy
    Mol Cancer 6:54. 2007
  9. pmc Anti-tumor activity of a miR-199-dependent oncolytic adenovirus
    Elisa Callegari
    Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Universita di Ferrara, Ferrara, Italy
    PLoS ONE 8:e73964. 2013
  10. pmc Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer
    Linda Ulazzi
    Dipartimento di Medicina Sperimentale e Diagnostica e Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Ferrara, Italy
    Mol Cancer 6:17. 2007

Detail Information

Publications38

  1. ncbi request reprint MicroRNAs in human cancer: from research to therapy
    Massimo Negrini
    Dipartimento di Medicina Sperimentale e Diagnostica, Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy
    J Cell Sci 120:1833-40. 2007
    ..Finally, miRNAs can be used as diagnostic markers, and their potential as therapeutic molecules has moved miRNAs from the area of basic research to the field of cancer biotechnology...
  2. pmc miR-221 affects multiple cancer pathways by modulating the level of hundreds messenger RNAs
    Laura Lupini
    Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Università di Ferrara Ferrara, Italy
    Front Genet 4:64. 2013
    ..The modulation of mRNA level of 602 genes confirms the ability of miR-221 to promote cancer by affecting multiple oncogenic pathways...
  3. ncbi request reprint microRNA involvement in hepatocellular carcinoma
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Anticancer Agents Med Chem 11:500-21. 2011
    ..In this context, the liver represents an organ of election to test therapeutic possibilities associated with miRNAs...
  4. doi request reprint MicroRNAs and cancer--new paradigms in molecular oncology
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, Interdepartment Center for Cancer Research, University of Ferrara, Ferrara 44100, Italy
    Curr Opin Cell Biol 21:470-9. 2009
    ..New diagnostic classifiers based on miRNAs will soon be available for medical practitioners and, even more importantly, miRNAs may become novel anti-cancer tools...
  5. pmc Non-coding RNAs change their expression profile after Retinoid induced differentiation of the promyelocytic cell line NB4
    Annalisa Rossi
    Department of Biochemistry and Medical Biotechnologies, University of Naples Federico II, Via S, Pansini 5, Napoli, Italy
    BMC Res Notes 3:24. 2010
    ....
  6. pmc MicroRNAs involvement in fludarabine refractory chronic lymphocytic leukemia
    Manuela Ferracin
    Dipartimento di Medicina Sperimentale e Diagnostica Università di Ferrara, Ferrara, Italy
    Mol Cancer 9:123. 2010
    ....
  7. ncbi request reprint miR-125b targets erythropoietin and its receptor and their expression correlates with metastatic potential and ERBB2/HER2 expression
    Manuela Ferracin
    Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara, Italy
    Mol Cancer 12:130. 2013
    ..Here, we investigated its targets in breast cancer cell lines after miRNA-mimic transfection. We examined the interactions of the validated targets with ERBB2 oncogene and the correlation of miR-125b expression with clinical variables...
  8. pmc mRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer
    Giovanni Lanza
    Department of Experimental and Diagnostic Medicine and Interdepartment Center for Cancer Research, University of Ferrara, Ferrara, Italy
    Mol Cancer 6:54. 2007
    ..Colorectal cancer develops through two main genetic instability pathways characterized by distinct pathologic features and clinical outcome...
  9. pmc Anti-tumor activity of a miR-199-dependent oncolytic adenovirus
    Elisa Callegari
    Dipartimento di Morfologia, Chirurgia e Medicina Sperimentale, Universita di Ferrara, Ferrara, Italy
    PLoS ONE 8:e73964. 2013
    ..In summary, we developed a novel oncolytic adenovirus, Ad-199T, which could demonstrate a therapeutic potential against liver cancer without causing significant hepatotoxicity. ..
  10. pmc Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer
    Linda Ulazzi
    Dipartimento di Medicina Sperimentale e Diagnostica e Centro Interdipartimentale per la Ricerca sul Cancro, Universita di Ferrara, Ferrara, Italy
    Mol Cancer 6:17. 2007
    ..Nidogens are highly conserved proteins of basement membranes. Two nidogen proteins, nidogen 1 and nidogen 2, are known in mammals...
  11. doi request reprint MINT31 methylation in gastric noninvasive neoplasia: potential role in the secondary prevention of gastric cancer
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Eur J Cancer Prev 21:442-8. 2012
    ..Hypermethylation of MINT31 predicted NIN persistence, as well as progression to higher grade or to GC, and might be used as a marker of GC risk...
  12. ncbi request reprint Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer
    Elena Miotto
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Cancer Res 64:8156-9. 2004
    ..Our results indicate that CDH4 may act as a tumor suppressor gene in human gastrointestinal tumors and can potentially be used as an early diagnostic marker for gastrointestinal tumorigenesis...
  13. ncbi request reprint BK virus, JC virus and Simian Virus 40 infection in humans, and association with human tumors
    Giuseppe Barbanti-Brodano
    University of Ferrara, Italy
    Adv Exp Med Biol 577:319-41. 2006
  14. doi request reprint Oncogenic role of miR-483-3p at the IGF2/483 locus
    Angelo Veronese
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Ferrara, Italy
    Cancer Res 70:3140-9. 2010
    ..Our results indicate that miR-483-3p could function as an antiapoptotic oncogene in various human cancers and reveal a new, potentially important target for anticancer therapy...
  15. pmc Reprogramming of miRNA networks in cancer and leukemia
    Stefano Volinia
    Data Mining for Analysis of Microarrays, Department of Morphology and Embryology, Universita degli Studi, Ferrara 44100, Italy
    Genome Res 20:589-99. 2010
    ..Finally, we experimentally validated the miRNA network with acute lymphocytic leukemia originated in Mir155 transgenic mice. Most of miRNAs deregulated in these transgenic mice were located close to hsa-miR-155 in the cancer network...
  16. ncbi request reprint Liver tumorigenicity promoted by microRNA-221 in a mouse transgenic model
    Elisa Callegari
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Ferrara, Italy
    Hepatology 56:1025-33. 2012
    ..To validate the tumor-promoting effect of miR-221, we showed that in vivo delivery of anti-miR-221 oligonucleotides leads to a significant reduction of the number and size of tumor nodules...
  17. ncbi request reprint Identification of differentially expressed microRNAs by microarray: a possible role for microRNA genes in pituitary adenomas
    Arianna Bottoni
    Department of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Ferrara, Italy
    J Cell Physiol 210:370-7. 2007
    ..Predictive miRNAs could be potentially useful diagnostic markers, improving the classification of pituitary adenomas...
  18. doi request reprint MicroRNA profiling for the identification of cancers with unknown primary tissue-of-origin
    Manuela Ferracin
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Ferrara, Italy
    J Pathol 225:43-53. 2011
    ....
  19. doi request reprint Micromarkers: miRNAs in cancer diagnosis and prognosis
    Manuela Ferracin
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Via Luigi Borsari 46, Ferrara, Italy
    Expert Rev Mol Diagn 10:297-308. 2010
    ..In addition, circulating miRNAs are expected to provide improved specificity and/or sensitivity over presently available markers...
  20. ncbi request reprint Simian virus 40 infection in humans and association with human diseases: results and hypotheses
    Giuseppe Barbanti-Brodano
    Department of Experimental and Diagnostic Medicine, Section of Microbiology, Center of Biotechnology, University of Ferrara, I 44100, Ferrara, Italy
    Virology 318:1-9. 2004
    ..Such a vaccine may represent in the future a useful immunoprophylactic and immunotherapeutic intervention against human tumors associated with SV40...
  21. pmc Genetic subclonal complexity and miR125a-5p down-regulation identify a subset of patients with inferior outcome in low-risk CLL patients
    Gian Matteo Rigolin
    Hematology Section, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale S Anna, Ferrara, Italy
    Oncotarget 5:140-9. 2014
    ....
  22. doi request reprint MicroRNA response to environmental mutagens in liver
    Bahaeldin K Elamin
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Ferrara, Italy
    Mutat Res 717:67-76. 2011
    ..This review will concentrate on the alterations in microRNA expression in response to environmental factors in relation to the risk of developing liver cancer...
  23. ncbi request reprint Modern treatment in chronic lymphocytic leukemia: impact on survival and efficacy in high-risk subgroups
    Antonio Cuneo
    Hematology Section, Department of Medical Sciences, University of Ferrara, University Hospital Arcispedale S Anna, Ferrara, Italy
    Cancer Med 3:555-64. 2014
    ....
  24. doi request reprint MicroRNAs: toward the clinic for breast cancer patients
    Manuela Ferracin
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Semin Oncol 38:764-75. 2011
    ..In this review, we describe current knowledge of the role of microRNAs in breast cancer...
  25. doi request reprint Chromosome aberrations detected by conventional karyotyping using novel mitogens in chronic lymphocytic leukemia with "normal" FISH: correlations with clinicobiologic parameters
    Gian Matteo Rigolin
    Section of Hematology, Azienda Ospedaliero Universitaria, Arcispedale S Anna, University of Ferrara, Italy
    Blood 119:2310-3. 2012
    ..In patients with chronic lymphocytic leukemia with normal FISH, karyotypic aberrations by conventional cytogenetics with novel mitogens identify a subset of cases with adverse prognostic features...
  26. doi request reprint MicroRNAs dysregulation in human malignant pleural mesothelioma
    Veronica Balatti
    Department of Morphology and Embryology, Section of Cellular Biology and Molecular Genetics, and Center of Biotechnology, University of Ferrara, Ferrara, Italy
    J Thorac Oncol 6:844-51. 2011
    ..Recent studies have shown the differential expression of mature miRNAs in several human cancers, suggesting their potential role as oncogenes or tumor suppressor genes...
  27. doi request reprint Altered miRNA expression in T regulatory cells in course of multiple sclerosis
    Giuseppe De Santis
    Section of Neurology, Department of Medical and Surgical Sciences of the Communication and Behaviour, University of Ferrara, Ferrara, Italy
    J Neuroimmunol 226:165-71. 2010
    ..Recently, microRNAs (miRNAs) have been involved in autoimmune disorders and their loss-of-function in immune cells was shown to facilitate systemic autoimmune disorders. Here, we analyzed the miRNA expression profile in Tregs from MS-RR...
  28. pmc Breast cancer metastasis: a microRNA story
    Massimo Negrini
    Department of Experimental and Diagnostic Medicine, Interdepartment Center for Cancer Research, University of Ferrara, Via Luigi Borsari, Ferrara 44100, Italy
    Breast Cancer Res 10:203. 2008
    ..The use of miRNAs as anticancer therapeutic agents is promising, and such fine molecular studies certainly help in bringing miRNAs closer to clinical practice...
  29. ncbi request reprint Multigene methylation analysis of gastrointestinal tumors: TPEF emerges as a frequent tumor-specific aberrantly methylated marker that can be detected in peripheral blood
    Silvia Sabbioni
    Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara, Italy
    Mol Diagn 7:201-7. 2003
    ....
  30. ncbi request reprint Clinical monoclonal B lymphocytosis versus Rai 0 chronic lymphocytic leukemia: A comparison of cellular, cytogenetic, molecular, and clinical features
    Fortunato Morabito
    Authors Affiliations Department of Onco Hematology, A O of Cosenza, Cosenza Department of Clinical Sciences and Community Health, University of Milano and Hematology 1 CTMO, Foundation IRCCS Ca Granda Ospedale Maggiore Policlinico, Milano SS Molecular Diagnostics, Scientific Direction, and Direzione Scientifica, IRCCS, San Martino IST, Genoa Department of Experimental and Diagnostic Medicine, University of Ferrara, Ferrara Division of Hematology, A O Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia Division of Hematology, University of Messina, Messina Department of Oncology and Hematology, Pugliese Ciaccio Hospital University of Magna Graecia and Cancer Center, Catanzaro Division of Hematology, Department of Biomedical Sciences, University of Catania and Ferrarotto Hospital, Catania and Division of Hematology, Department of Clinical and Experimental Medicine, Amedeo Avogadro University of Eastern Piedmont, Novara, Italy
    Clin Cancer Res 19:5890-900. 2013
    ....
  31. pmc Downregulation of the mitochondrial calcium uniporter by cancer-related miR-25
    Saverio Marchi
    Section of General Pathology, Department of Morphology, Surgery and Experimental Medicine, Interdisciplinary Center for the Study of Inflammation, Laboratory for Technologies of Advanced Therapies, University of Ferrara, 44121 Ferrara, Italy
    Curr Biol 23:58-63. 2013
    ....
  32. ncbi request reprint Oncogenic transformation by BK virus and association with human tumors
    Mauro Tognon
    Department of Morphology and Embryology, Section of Histology and Embryology, University of Ferrara, I 44100 Ferrara, Italy
    Oncogene 22:5192-200. 2003
    ..A 'hit and run' mechanism and secretion of paracrine growth factors by BKV Tag-positive cells, recruiting into proliferation neighboring and distant cells, are discussed as possible BKV pathogenic elements in human oncogenesis...
  33. pmc Genome wide identification of recessive cancer genes by combinatorial mutation analysis
    Stefano Volinia
    Data Mining for Analysis of Microarrays, Universita degli Studi, Ferrara, Italy
    PLoS ONE 3:e3380. 2008
    ..5% genes. The functions significantly affected by cancer mutations are exactly overlapping those of known cancer genes, with the critical exception for the absence of tyrosine kinases, as expected for a recessive gene-set...
  34. doi request reprint Clinicobiologic importance of cytogenetic lesions in chronic lymphocytic leukemia
    Francesco Cavazzini
    Section of Hematology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, Via Savonarola 9, Ferrara, Italy
    Expert Rev Hematol 2:305-14. 2009
    ..Evidence was provided that distinct treatment approaches may be effective in specific cytogenetic entities of CLL, making molecular cytogenetic investigations a necessary tool for a modern diagnostic work-up in CLL...
  35. ncbi request reprint Loss of methylation at chromosome 11p15.5 is common in human adult tumors
    Rosaria A M Scelfo
    Dipartimento di Medicina Sperimentale e Diagnostica, Universita di Ferrara, Via Luigi Borsari 46, 44100 Ferrara, Italy
    Oncogene 21:2564-72. 2002
    ..5 may result from the activation, by hypomethylation, of one or more negative regulatory elements...
  36. ncbi request reprint Cloning and characterization of the common fragile site FRA6F harboring a replicative senescence gene and frequently deleted in human tumors
    Cristina Morelli
    Department of Experimental and Diagnostic Medicine, Section of Microbiology and Center for Biotechnology, University of Ferrara, I 44100 Ferrara, Italy
    Oncogene 21:7266-76. 2002
    ..Moreover, a gene associated to hereditary schizophrenia maps within FRA6F. Therefore, FRA6F may represent a landmark for the identification and cloning of genes involved in senescence, leukemia, cancer and schizophrenia...
  37. ncbi request reprint Neoplastic circulating endothelial cells in multiple myeloma with 13q14 deletion
    Gian Matteo Rigolin
    Hematology Section, Department of Biomedical Sciences, University of Ferrara, Azienda Ospedaliero Universitaria Arcispedale S Anna, Corso Giovecca 203, 44100 Ferrara, Italy
    Blood 107:2531-5. 2006
    ....