Cinzia Nasuti

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. ncbi Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
    Nasuti Cinzia
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy Electronic address
    Toxicology 303:162-8. 2013
  2. ncbi Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Toxicology 251:45-50. 2008
  3. ncbi Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids
    Cinzia Nasuti
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino, 62032 Camerino MC, Italy
    Toxicology 229:194-205. 2007
  4. ncbi Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C
    Rosita Gabbianelli
    Dipartimento di Biologia MCA Biology, Universita di Camerino, Via Camerini 2, MC 62032, Italy
    Toxicology 203:17-26. 2004
  5. ncbi Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Italy
    J Appl Toxicol 29:317-22. 2009
  6. ncbi Different effects of Type I and Type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats
    Cinzia Nasuti
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino, 3, 62032, Camerino MC, Italy
    Toxicology 191:233-44. 2003
  7. ncbi Early life permethrin insecticide treatment leads to heart damage in adult rats
    M S Dhivya Vadhana
    School of Advanced Studies, University of Camerino, Camerino, MC, Italy
    Exp Gerontol 46:731-8. 2011
  8. ncbi Perturbation of rat heart plasma membrane fluidity due to metabolites of permethrin insecticide
    Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 11:226-34. 2011
  9. ncbi The impact of early life permethrin exposure on development of neurodegeneration in adulthood
    Manuel Carloni
    School of Pharmacy, University of Camerino, Italy
    Exp Gerontol 47:60-6. 2012
  10. ncbi Purine bases oxidation and repair following permethrin insecticide treatment in rat heart cells
    M S Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 10:199-207. 2010

Collaborators

Detail Information

Publications21

  1. ncbi Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
    Nasuti Cinzia
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy Electronic address
    Toxicology 303:162-8. 2013
    ..The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12h after the last treatment was 41.50μg/L and it was completely eliminated after 96h...
  2. ncbi Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Toxicology 251:45-50. 2008
    ..In summary some differences between antioxidant treatments were observed at striatum level: Coenzyme Q(10)+Vitamin E maintains plasma membrane fluidity, while Vitamin E is more effective to preserve GSH level...
  3. ncbi Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids
    Cinzia Nasuti
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino, 62032 Camerino MC, Italy
    Toxicology 229:194-205. 2007
    ..Although the action of pyrethroids on various target cells is different, a preferential interaction with the extracellular side of plasma membrane proteins can be observed...
  4. ncbi Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C
    Rosita Gabbianelli
    Dipartimento di Biologia MCA Biology, Universita di Camerino, Via Camerini 2, MC 62032, Italy
    Toxicology 203:17-26. 2004
    ..Moreover, treatment with Vitamins E and C maintained the activity of glutathione peroxidase, which was reduced in the presence of permethrin, and reduced the osmotic fragility, which had increased following permethrin treatment...
  5. ncbi Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Italy
    J Appl Toxicol 29:317-22. 2009
    ..The reduced phagocyte respiratory burst induced by permethrin treatment and the type of DNA damage measured could represent new relevant aspects of pyrethroid toxicity which should be considered for human health...
  6. ncbi Different effects of Type I and Type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats
    Cinzia Nasuti
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino, 3, 62032, Camerino MC, Italy
    Toxicology 191:233-44. 2003
    ..Because of its hydrophilic character, CY limits oxidative damage in the erythrocyte cytosol at high doses...
  7. ncbi Early life permethrin insecticide treatment leads to heart damage in adult rats
    M S Dhivya Vadhana
    School of Advanced Studies, University of Camerino, Camerino, MC, Italy
    Exp Gerontol 46:731-8. 2011
    ....
  8. ncbi Perturbation of rat heart plasma membrane fluidity due to metabolites of permethrin insecticide
    Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 11:226-34. 2011
    ..Consequently, 3PBA induced the highest lipid peroxidation, while 3PBACID was the stronger inducer of protein damage...
  9. ncbi The impact of early life permethrin exposure on development of neurodegeneration in adulthood
    Manuel Carloni
    School of Pharmacy, University of Camerino, Italy
    Exp Gerontol 47:60-6. 2012
    ..The changes in biological markers found in our animal model could represent the basis to study neurodegenerative diseases whose development depends on individual gene signature and life style...
  10. ncbi Purine bases oxidation and repair following permethrin insecticide treatment in rat heart cells
    M S Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 10:199-207. 2010
    ..This work points to standardize conditions applicable to ex vivo cells following in vivo treatment in order to study the cardiotoxicity of insecticide...
  11. ncbi Effect of permethrin insecticide on rat polymorphonuclear neutrophils
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Via Gentile III da Varano, I 62032 Camerino MC, Italy
    Chem Biol Interact 182:245-52. 2009
    ..26 and 1.3 of total cells, respectively) and that the level of apoptotic cells is very low. In conclusion, immunotoxicity of permethrin measured in rats could prompt future studies on the consequences of chronic insecticide exposure...
  12. ncbi Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide
    Donatella Fedeli
    School of Pharmacy and School of Biosciences and Biotechnology, University of Camerino, Italy
    Biomarkers 17:604-9. 2012
    ..The results propose Nurr1, TNF-α, Rantes, GSH and plasma lipid peroxidation as peripheral biomarkers for monitoring the impact of early-life environmental exposure to xenobiotics in old age...
  13. ncbi Erythrocyte plasma membrane perturbations in rats fed a cholesterol-rich diet: effect of drinking sulphurous mineral water
    Cinzia Nasuti
    Dottorato di Ricerca in Invecchiamento e Nutrizione, , Camerino, Italy
    Ann Nutr Metab 49:9-15. 2005
    ..CONCLUSION: Hydropinic treatment with SMW is of interest from the biomedical point of view, because it could represent an alternative approach in interventions aimed at ameliorating biological injury deriving from hypercholesterolaemia...
  14. ncbi Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI
    Gianfabio Giorgioni
    Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universita degli Studi di Camerino, via Sant Agostino 1, 62032 Camerino, Italy
    Bioorg Med Chem 18:7085-91. 2010
    ....
  15. ncbi Lonidamine solid dispersions: in vitro and in vivo evaluation
    Giovanni Filippo Palmieri
    School of Pharmacy, University of Camerino, via S Agostino no 1, 62032 Camerino, MC, Italy
    Drug Dev Ind Pharm 28:1241-50. 2002
    ..Particularly, the AUC of the drug plasma levels was increased from 1.5 to 1.9-fold depending on the type of carrier...
  16. ncbi Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors
    Piero Angeli
    Dipartimento di Scienze Chimiche, Universita di Camerino, MC, Italy
    Life Sci 70:1427-46. 2002
    ..Our results suggest that demox may interact with orthosteric and allosteric sites of atrial M2 muscarinic receptor...
  17. ncbi Alterations in rabbit aorta induced by types I and II pyrethroids
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via M Scalzino 3, 62032 Camerino MC, Italy
    Environ Toxicol Pharmacol 23:250-3. 2007
    ..In conclusion, permethrin seems to induce more oxidative stress on the aorta wall than that cypermethrin does...
  18. ncbi L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties
    Antonio Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 49:1486-93. 2006
    ....
  19. ncbi Synthesis and study of L-dopa-glutathione codrugs as new anti-Parkinson agents with free radical scavenging properties
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 50:2506-15. 2007
    ....
  20. ncbi New L-dopa codrugs as potential antiparkinson agents
    Piera Sozio
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 341:412-7. 2008
    ..The results suggest that, though our codrugs are devoid of significant antioxidant activity, they are able to induce sustained delivery of DA in rat striatum and can improve LD and DA release in the brain...
  21. ncbi Cypermethrin-induced plasma membrane perturbation on erythrocytes from rats: reduction of fluidity in the hydrophobic core and in glutathione peroxidase activity
    Rosita Gabbianelli
    Dipartimento di Biologia M.C.A, , Via M. Scalzino, 3, 62032 Camerino (MC, Italy
    Toxicology 175:91-101. 2002
    ..The results are discussed in terms of preferential localization of cypermethrin in the hydrophobic core of the membrane, where it increases lipid packing and consequently decreases membrane fluidity...