Cinzia Nasuti

Summary

Affiliation: University of Camerino
Country: Italy

Publications

  1. doi request reprint Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
    Cinzia Nasuti
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy
    Toxicology 303:162-8. 2013
  2. doi request reprint Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Toxicology 251:45-50. 2008
  3. ncbi request reprint Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids
    Cinzia Nasuti
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino, 62032 Camerino MC, Italy
    Toxicology 229:194-205. 2007
  4. ncbi request reprint Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C
    Rosita Gabbianelli
    Dipartimento di Biologia MCA Biology, Universita di Camerino, Via Camerini 2, MC 62032, Italy
    Toxicology 203:17-26. 2004
  5. doi request reprint Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Italy
    J Appl Toxicol 29:317-22. 2009
  6. doi request reprint Early life permethrin insecticide treatment leads to heart damage in adult rats
    M S Dhivya Vadhana
    School of Advanced Studies, University of Camerino, Camerino, MC, Italy
    Exp Gerontol 46:731-8. 2011
  7. doi request reprint Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide
    Donatella Fedeli
    School of Pharmacy and School of Biosciences and Biotechnology, University of Camerino, Italy
    Biomarkers 17:604-9. 2012
  8. ncbi request reprint Different effects of Type I and Type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats
    Cinzia Nasuti
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino, 3, 62032, Camerino MC, Italy
    Toxicology 191:233-44. 2003
  9. doi request reprint Perturbation of rat heart plasma membrane fluidity due to metabolites of permethrin insecticide
    Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 11:226-34. 2011
  10. doi request reprint The impact of early life permethrin exposure on development of neurodegeneration in adulthood
    Manuel Carloni
    School of Pharmacy, University of Camerino, Italy
    Exp Gerontol 47:60-6. 2012

Collaborators

Detail Information

Publications22

  1. doi request reprint Effects of early life permethrin exposure on spatial working memory and on monoamine levels in different brain areas of pre-senescent rats
    Cinzia Nasuti
    School of Pharmacy, Pharmacology Unit, University of Camerino, Via Madonna delle Carceri, 62032 Camerino, MC, Italy
    Toxicology 303:162-8. 2013
    ..The concentration of the most representative marker for pyrethroid exposure (3-phenoxybenzoic acid) measured in the urine of rodents 12 h after the last treatment was 41.50 μg/L and it was completely eliminated after 96 h...
  2. doi request reprint Effect of permethrin plus antioxidants on locomotor activity and striatum in adolescent rats
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via Madonna delle Carceri, Camerino, Italy
    Toxicology 251:45-50. 2008
    ..In summary some differences between antioxidant treatments were observed at striatum level: Coenzyme Q(10)+Vitamin E maintains plasma membrane fluidity, while Vitamin E is more effective to preserve GSH level...
  3. ncbi request reprint Dopaminergic system modulation, behavioral changes, and oxidative stress after neonatal administration of pyrethroids
    Cinzia Nasuti
    Dipartimento di Medicina Sperimentale e Sanità Pubblica, Universita di Camerino, Via Scalzino, 62032 Camerino MC, Italy
    Toxicology 229:194-205. 2007
    ..Although the action of pyrethroids on various target cells is different, a preferential interaction with the extracellular side of plasma membrane proteins can be observed...
  4. ncbi request reprint Lymphocyte DNA damage in rats exposed to pyrethroids: effect of supplementation with Vitamins E and C
    Rosita Gabbianelli
    Dipartimento di Biologia MCA Biology, Universita di Camerino, Via Camerini 2, MC 62032, Italy
    Toxicology 203:17-26. 2004
    ..Moreover, treatment with Vitamins E and C maintained the activity of glutathione peroxidase, which was reduced in the presence of permethrin, and reduced the osmotic fragility, which had increased following permethrin treatment...
  5. doi request reprint Permethrin induces lymphocyte DNA lesions at both Endo III and Fpg sites and changes in monocyte respiratory burst in rats
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Italy
    J Appl Toxicol 29:317-22. 2009
    ..The reduced phagocyte respiratory burst induced by permethrin treatment and the type of DNA damage measured could represent new relevant aspects of pyrethroid toxicity which should be considered for human health...
  6. doi request reprint Early life permethrin insecticide treatment leads to heart damage in adult rats
    M S Dhivya Vadhana
    School of Advanced Studies, University of Camerino, Camerino, MC, Italy
    Exp Gerontol 46:731-8. 2011
    ....
  7. doi request reprint Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide
    Donatella Fedeli
    School of Pharmacy and School of Biosciences and Biotechnology, University of Camerino, Italy
    Biomarkers 17:604-9. 2012
    ..The results propose Nurr1, TNF-α, Rantes, GSH and plasma lipid peroxidation as peripheral biomarkers for monitoring the impact of early-life environmental exposure to xenobiotics in old age...
  8. ncbi request reprint Different effects of Type I and Type II pyrethroids on erythrocyte plasma membrane properties and enzymatic activity in rats
    Cinzia Nasuti
    Dipartimento di Scienze Farmacologiche e Medicina Sperimentale, Universita di Camerino, Via M Scalzino, 3, 62032, Camerino MC, Italy
    Toxicology 191:233-44. 2003
    ..Because of its hydrophilic character, CY limits oxidative damage in the erythrocyte cytosol at high doses...
  9. doi request reprint Perturbation of rat heart plasma membrane fluidity due to metabolites of permethrin insecticide
    Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 11:226-34. 2011
    ..Consequently, 3PBA induced the highest lipid peroxidation, while 3PBACID was the stronger inducer of protein damage...
  10. doi request reprint The impact of early life permethrin exposure on development of neurodegeneration in adulthood
    Manuel Carloni
    School of Pharmacy, University of Camerino, Italy
    Exp Gerontol 47:60-6. 2012
    ..The changes in biological markers found in our animal model could represent the basis to study neurodegenerative diseases whose development depends on individual gene signature and life style...
  11. doi request reprint Purine bases oxidation and repair following permethrin insecticide treatment in rat heart cells
    M S Dhivya Vadhana
    School of Advanced Studies, UNICAM, Camerino, Italy
    Cardiovasc Toxicol 10:199-207. 2010
    ..This work points to standardize conditions applicable to ex vivo cells following in vivo treatment in order to study the cardiotoxicity of insecticide...
  12. doi request reprint Effect of permethrin insecticide on rat polymorphonuclear neutrophils
    Rosita Gabbianelli
    Department of M C A Biology, University of Camerino, Via Gentile III da Varano, I 62032 Camerino MC, Italy
    Chem Biol Interact 182:245-52. 2009
    ..26 and 1.3 of total cells, respectively) and that the level of apoptotic cells is very low. In conclusion, immunotoxicity of permethrin measured in rats could prompt future studies on the consequences of chronic insecticide exposure...
  13. doi request reprint Early life permethrin exposure induces long-term brain changes in Nurr1, NF-kB and Nrf-2
    Manuel Carloni
    School of Pharmacy, University of Camerino, Italy
    Brain Res 1515:19-28. 2013
    ..Moreover the impairment of NF-kB and Nrf-2, important for the balance between pro- and anti-inflammatory systems, confirms that the neonatal permethrin treatment can influence genes involved with the onset of brain-ageing processes...
  14. ncbi request reprint Erythrocyte plasma membrane perturbations in rats fed a cholesterol-rich diet: effect of drinking sulphurous mineral water
    Cinzia Nasuti
    Dottorato di Ricerca in Invecchiamento e Nutrizione, Universita di Camerino, Camerino, Italy
    Ann Nutr Metab 49:9-15. 2005
    ..The purpose of the present study was to evaluate the ability of calcic and magnesic-sulphate-sulphurous spring mineral water (SMW) to reduce total and erythrocyte plasma membrane cholesterol in rats fed a cholesterol-rich diet...
  15. doi request reprint Novel imidazoline compounds as partial or full agonists of D2-like dopamine receptors inspired by I2-imidazoline binding sites ligand 2-BFI
    Gianfabio Giorgioni
    Scuola di Scienze del Farmaco e dei Prodotti della Salute, Universita degli Studi di Camerino, via Sant Agostino 1, 62032 Camerino, Italy
    Bioorg Med Chem 18:7085-91. 2010
    ....
  16. ncbi request reprint Lonidamine solid dispersions: in vitro and in vivo evaluation
    Giovanni Filippo Palmieri
    School of Pharmacy, University of Camerino, via S Agostino no 1, 62032 Camerino, MC, Italy
    Drug Dev Ind Pharm 28:1241-50. 2002
    ..Particularly, the AUC of the drug plasma levels was increased from 1.5 to 1.9-fold depending on the type of carrier...
  17. ncbi request reprint Alterations in rabbit aorta induced by types I and II pyrethroids
    Cinzia Nasuti
    Department of Experimental Medicine and Public Health, University of Camerino, Via M Scalzino 3, 62032 Camerino MC, Italy
    Environ Toxicol Pharmacol 23:250-3. 2007
    ..In conclusion, permethrin seems to induce more oxidative stress on the aorta wall than that cypermethrin does...
  18. ncbi request reprint Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors
    Piero Angeli
    Dipartimento di Scienze Chimiche, Universita di Camerino, MC, Italy
    Life Sci 70:1427-46. 2002
    ..Our results suggest that demox may interact with orthosteric and allosteric sites of atrial M2 muscarinic receptor...
  19. ncbi request reprint L-dopa- and dopamine-(R)-alpha-lipoic acid conjugates as multifunctional codrugs with antioxidant properties
    Antonio Di Stefano
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 49:1486-93. 2006
    ....
  20. ncbi request reprint Synthesis and study of L-dopa-glutathione codrugs as new anti-Parkinson agents with free radical scavenging properties
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 50:2506-15. 2007
    ....
  21. doi request reprint New L-dopa codrugs as potential antiparkinson agents
    Piera Sozio
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 341:412-7. 2008
    ..The results suggest that, though our codrugs are devoid of significant antioxidant activity, they are able to induce sustained delivery of DA in rat striatum and can improve LD and DA release in the brain...
  22. ncbi request reprint Cypermethrin-induced plasma membrane perturbation on erythrocytes from rats: reduction of fluidity in the hydrophobic core and in glutathione peroxidase activity
    Rosita Gabbianelli
    Dipartimento di Biologia M C A, Università di Camerino MC, Via M Scalzino, 3, 62032 Camerino MC, Italy
    Toxicology 175:91-101. 2002
    ..The results are discussed in terms of preferential localization of cypermethrin in the hydrophobic core of the membrane, where it increases lipid packing and consequently decreases membrane fluidity...