Affiliation: University of Bologna
BonafÃ¨ F, Govoni M, Giordano E, Caldarera C, Guarnieri C, Muscari C. Hyaluronan and cardiac regeneration. J Biomed Sci. 2014;21:100 pubmed publisher
Muscari C, Gamberini C, Basile I, Bonafe F, Valgimigli S, Capitani O, et al
. Comparison between Culture Conditions Improving Growth and Differentiation of Blood and Bone Marrow Cells Committed to the Endothelial Cell Lineage. Biol Proced Online. 2010;12:9023 pubmed publisher
..BMMCs could better specialize for capillary formation in the presence of fibronectin and an elevated concentration of VEGF, whilst pig MSCs anyway showed a limited capability to differentiate into the endothelial cell lineage. ..
Muscari C, Bonafe F, Carboni M, Govoni M, Stanic I, Gamberini C, et al
. Difluoromethylornithine stimulates early cardiac commitment of mesenchymal stem cells in a model of mixed culture with cardiomyocytes. J Cell Biochem. 2008;103:1046-52 pubmed publisher
..These results suggest that polyamine depletion can represent a useful strategy to improve MSC differentiation into the cardiac lineage, especially in the presence of cardiomyocytes damaged by an ischemic environment. ..
Muscari C, Bonafe F, Fiumana E, Oranges C, Pinto V, Caldarera C, et al
. Comparison between stem cells harvested from wet and dry lipoaspirates. Connect Tissue Res. 2013;54:34-40 pubmed publisher
..In conclusion, WL yields about 40% fewer ASC than DL due to the combined effect of tissue dilution and the reduced frequency of ASC in the SVF. The main biological features of ASC are suitable for cell-based therapies. ..
BonafÃ¨ F, Guarnieri C, Muscari C. Cancer stem cells and mesenchymal stem cells in the hypoxic tumor niche: two different targets for one only drug. Med Hypotheses. 2015;84:227-30 pubmed publisher
..Corresponding experimental approaches to perform pre-clinical studies and verify this hypothesis are also addressed. ..
Muscari C, Bonafe F, Stanic I, Flamigni F, Stefanelli C, Farruggia G, et al
. Polyamine depletion reduces TNFalpha/MG132-induced apoptosis in bone marrow stromal cells. Stem Cells. 2005;23:983-91 pubmed
..Thus, polyamine depletion can be considered a useful tool for counteracting programmed cell death in BMSCs without involving the p53 proapoptotic protein. ..
Muscari C, Gamberini C, Carboni M, Basile I, Farruggia G, Bonafe F, et al
. Different expression of NOS isoforms in early endothelial progenitor cells derived from peripheral and cord blood. J Cell Biochem. 2007;102:992-1001 pubmed
Muscari C, Bonafe F, Martin Suarez S, Valgimigli S, Valente S, Fiumana E, et al
. Restored perfusion and reduced inflammation in the infarcted heart after grafting stem cells with a hyaluronan-based scaffold. J Cell Mol Med. 2013;17:518-30 pubmed publisher
..These beneficial effects are superior to those obtained after grafting only the scaffold or MSCs, suggesting that a synergic action was achieved using the cell-integrated polymer construct. ..