Giuseppe Murdaca

Summary

Affiliation: University of Genoa
Country: Italy

Publications

  1. ncbi request reprint Autoimmune intrahepatic cholangiopathy associated with antiphospholipid antibody syndrome
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genova, Genova, Italy
    Eur J Gastroenterol Hepatol 19:910-2. 2007
  2. ncbi request reprint Efficacy and safety of etanercept in chronic immune-mediated disease
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 010 353 7924 39 010 555 6950
    Expert Opin Drug Saf 13:649-61. 2014
  3. doi request reprint Current therapies for the treatment of systemic sclerosis-related pulmonary arterial hypertension: efficacy and safety
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 0103537924 39 0105556950
    Expert Opin Drug Saf 13:295-305. 2014
  4. doi request reprint Influenza and pneumococcal vaccinations of patients with systemic lupus erythematosus: current views upon safety and immunogenicity
    Giuseppe Murdaca
    Department of Internal Medicine, Clinical Immunology Unit, University of Genova, Genova, Italy Electronic address
    Autoimmun Rev 13:75-84. 2014
  5. ncbi request reprint Use of leflunomide plus TNF-α inhibitors in rheumatoid arthritis
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 0103537924 39 0105556950
    Expert Opin Drug Saf 12:801-4. 2013
  6. doi request reprint Free radicals and endothelial dysfunction: potential positive effects of TNF-α inhibitors
    Giuseppe Murdaca
    Department of Internal Medicine, Clinical Immunology Unit, University of Genova, Italy
    Redox Rep 18:95-9. 2013
  7. doi request reprint Selective TNF-α inhibitor-induced injection site reactions
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy
    Expert Opin Drug Saf 12:187-93. 2013
  8. doi request reprint Determination of lymphotoxin-alpha levels in patients with psoriatic arthritis undergoing etanercept treatment
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Interferon Cytokine Res 32:277-9. 2012
  9. doi request reprint Endothelial dysfunction in rheumatic autoimmune diseases
    Giuseppe Murdaca
    Department of Internal Medicine, Viale Benedetto XV, N 6, University of Genoa, 16132 Genoa, Italy
    Atherosclerosis 224:309-17. 2012
  10. doi request reprint Current views on diagnostic approach and treatment of lymphedema
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genova, Italy
    Am J Med 125:134-40. 2012

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Autoimmune intrahepatic cholangiopathy associated with antiphospholipid antibody syndrome
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genova, Genova, Italy
    Eur J Gastroenterol Hepatol 19:910-2. 2007
    ..To our knowledge, this is the first description of a patient with an association of intrahepatic cholangiopathy and aPL, thus suggesting that autoimmune liver disease might associate with aPL syndrome...
  2. ncbi request reprint Efficacy and safety of etanercept in chronic immune-mediated disease
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 010 353 7924 39 010 555 6950
    Expert Opin Drug Saf 13:649-61. 2014
    ..Etanercept is a fusion protein that acts as a 'decoy receptor' for TNF-α...
  3. doi request reprint Current therapies for the treatment of systemic sclerosis-related pulmonary arterial hypertension: efficacy and safety
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 0103537924 39 0105556950
    Expert Opin Drug Saf 13:295-305. 2014
    ..Patients with limited SSc typically develop pulmonary arterial hypertension (PAH). TNF-α, VEGF, platelet-derived growth factor and endothelin-1 play a key role in the development of PAH...
  4. doi request reprint Influenza and pneumococcal vaccinations of patients with systemic lupus erythematosus: current views upon safety and immunogenicity
    Giuseppe Murdaca
    Department of Internal Medicine, Clinical Immunology Unit, University of Genova, Genova, Italy Electronic address
    Autoimmun Rev 13:75-84. 2014
    ....
  5. ncbi request reprint Use of leflunomide plus TNF-α inhibitors in rheumatoid arthritis
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy 39 0103537924 39 0105556950
    Expert Opin Drug Saf 12:801-4. 2013
    ....
  6. doi request reprint Free radicals and endothelial dysfunction: potential positive effects of TNF-α inhibitors
    Giuseppe Murdaca
    Department of Internal Medicine, Clinical Immunology Unit, University of Genova, Italy
    Redox Rep 18:95-9. 2013
    ..However, TNF-α also plays a key role in endothelial dysfunction and, thus, in the development and progression of atherosclerosis. What, then, is the potential therapeutic role of TNF-α inhibitors?..
  7. doi request reprint Selective TNF-α inhibitor-induced injection site reactions
    Giuseppe Murdaca
    University of Genova, Department of Internal Medicine, Clinical Immunology Unit, Viale Benedetto XV, N 6, 16132 Genova, Italy
    Expert Opin Drug Saf 12:187-93. 2013
    ..TNF-α blockers have demonstrated efficacy in large, randomized controlled clinical trials either as monotherapy or in combination with other anti-inflammatory or disease-modifying anti-rheumatic drugs...
  8. doi request reprint Determination of lymphotoxin-alpha levels in patients with psoriatic arthritis undergoing etanercept treatment
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    J Interferon Cytokine Res 32:277-9. 2012
    ..Further studies are required to better define the role of LT-α and LT-α blockade by etanercept in PsA patients...
  9. doi request reprint Endothelial dysfunction in rheumatic autoimmune diseases
    Giuseppe Murdaca
    Department of Internal Medicine, Viale Benedetto XV, N 6, University of Genoa, 16132 Genoa, Italy
    Atherosclerosis 224:309-17. 2012
    ....
  10. doi request reprint Current views on diagnostic approach and treatment of lymphedema
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genova, Italy
    Am J Med 125:134-40. 2012
    ..In this review, we report an update upon the diagnostic approach and the medical and surgical therapy for both primary and secondary lymphedema...
  11. doi request reprint Anti-tumor necrosis factor-α treatment with infliximab for disseminated granuloma annulare
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Am J Clin Dermatol 11:437-9. 2010
    ..We suggest that infliximab may be proposed as an additional therapeutic option in the treatment of recalcitrant forms of disseminated GA...
  12. doi request reprint The role of Th17 lymphocytes in the autoimmune and chronic inflammatory diseases
    Giuseppe Murdaca
    Department of Internal Medicine, DIMI, University of Genoa, Viale Benedetto XV, N 6, 16132 Genoa, Italy
    Intern Emerg Med 6:487-95. 2011
    ..In this review we will focus on recent information regarding IL-17 and its relevance in autoimmune and chronic inflammatory diseases...
  13. ncbi request reprint Anti-TNF-alpha inhibitors: a new therapeutic approach for inflammatory immune-mediated diseases: an update upon efficacy and adverse events
    G Murdaca
    Department of Internal Medicine, University of Genova, Genova, Italy
    Int J Immunopathol Pharmacol 22:557-65. 2009
    ..Nevertheless, some differences may exist among the three agents. In this paper, we will briefly review the indications for the use of the three TNF-alpha inhibitors, the pre-treatment considerations and the reported adverse events...
  14. doi request reprint Adalimumab for the treatment of immune-mediated diseases: an update on old and recent indications
    G Murdaca
    Department of Internal Medicine, University of Genoa, Italy
    Drugs Today (Barc) 47:277-88. 2011
    ....
  15. doi request reprint Soluble human leukocyte antigen-G serum levels in patients with acquired immune deficiency syndrome affected by different disease-defining conditions before and after antiretroviral treatment
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Hum Immunol 72:712-6. 2011
    ....
  16. ncbi request reprint Update upon efficacy and safety of TNF-α inhibitors
    Giuseppe Murdaca
    University of Genoa, Department of Internal Medicine, Viale Benedetto XV, N 6, 16132 Genova, Italy 390103537924 390105556950
    Expert Opin Drug Saf 11:1-5. 2012
    ..This editorial discusses the recent indications of TNF-α inhibitors, the pretreatment considerations, the reported adverse events and, finally, the recommendations for its use in pregnancy...
  17. ncbi request reprint Behavior of serum human major histocompatibility complex class I antigen levels in human immunodeficiency virus-infected patients during antiretroviral therapy: correlation with clinical outcome
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Hum Immunol 68:894-900. 2007
    ..These results suggest that the measurement of sHLA-I antigens serum level might represent a useful surrogate marker to monitor HIV-positive patients undergoing HAART treatment...
  18. ncbi request reprint A case of transposition of the great arteries in a female infant of a HIV-1-infected woman. Potential teratogenic effects of antiretroviral drugs
    Giuseppe Murdaca
    Intern Emerg Med 1:86-8. 2006
  19. doi request reprint Behavior of non-classical soluble HLA class G antigens in human immunodeficiency virus 1-infected patients before and after HAART: comparison with classical soluble HLA-A, -B, -C antigens and potential role in immune-reconstitution
    Giuseppe Murdaca
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Clin Immunol 133:238-44. 2009
    ....
  20. doi request reprint Sublingual immunotherapy reduces soluble HLA-G and HLA-A,-B,-C serum levels in patients with allergic rhinitis
    Giorgio Ciprandi
    DIMI, University of Genoa, Genoa, Italy
    Int Immunopharmacol 9:253-7. 2009
    ..Therefore, the clinical implication of this study is that these soluble molecules might be interpreted as biomarker of response to SLIT...
  21. ncbi request reprint The impaired NK cell cytolytic function in viremic HIV-1 infection is associated with a reduced surface expression of natural cytotoxicity receptors (NKp46, NKp30 and NKp44)
    Andrea De Maria
    Dipartimento di Medicina Interna, University of Genoa, Genoa, Italy
    Eur J Immunol 33:2410-8. 2003
    ....
  22. doi request reprint Soluble serum HLA-G and HLA-A, -B, -C molecules in patients with seasonal allergic rhinitis exposed to pollens
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Italy
    Int Immunopharmacol 9:1058-62. 2009
    ..To date, however, no study has investigated there in AR patients during the pollen season...
  23. doi request reprint Soluble HLA-G molecule in patients with perennial allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Genoa, Italy
    Int Arch Allergy Immunol 150:278-81. 2009
    ..Allergic rhinitis (AR) is characterized by T helper 2 polarized immune response. The soluble HLA-G (sHLA-G) molecule has an immunomodulatory activity. However, so far, no study has investigated this activity in perennial AR (PAR)...
  24. doi request reprint Vdelta1 T lymphocytes producing IFN-gamma and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans
    Daniela Fenoglio
    Centre of Excellence for Biological Sciences, University of Genoa, Genoa, Italy
    Blood 113:6611-8. 2009
    ....
  25. ncbi request reprint Regulation of gammadelta T cell survival by soluble HLA-I: involvement of CD8 and activating killer Ig-like receptors
    Alessandro Poggi
    Laboratory of Experimental Oncology D, National Institute for Cancer Research, Genoa, Italy
    Eur J Immunol 35:2670-8. 2005
    ..These findings suggest that sHLA-I can regulate gammadelta T cell survival and that activating KIR may amplify antigen-specific Vdelta2 T cell responses...
  26. doi request reprint Adipokines and sublingual immunotherapy: preliminary report
    Giorgio Ciprandi
    Department of Internal Medicine, University of Genoa, Italy
    Hum Immunol 70:73-8. 2009
    ..In conclusion, the results of this preliminary study show that a single preseasonal SLIT course does not induce significant modifications in serum adipokines levels but induces only a slight increase...
  27. doi request reprint Traditional and non traditional risk factors in accelerated atherosclerosis in systemic lupus erythematosus: role of vascular endothelial growth factor (VEGATS Study)
    Barbara Maria Colombo
    Department of Internal Medicine, University of Genoa, Italy
    Autoimmun Rev 8:309-15. 2009
    ..To evaluate the role of vascular endothelial growth factor (VEGF) in accelerated atherosclerosis in patients with Systemic Lupus Erythematosus (SLE)...
  28. doi request reprint Serum vascular endothelial growth factor in allergic rhinitis and systemic lupus erythematosus
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino, University of Genoa, Genoa, Italy
    Hum Immunol 69:510-2. 2008
    ..The relevance of this phenomenon is further apparent, as it is also observed in patients with inactive disease...
  29. pmc Decay of human immunodeficiency virus type 1 unintegrated DNA containing two long terminal repeats in infected individuals after 3 to 8 years of sustained control of viremia
    Jennifer L McDermott
    Section of Microbiology, School of Medicine, University of Genova, Largo Rosanna Benzi, 10, 16132 Genova EC, Italy
    J Clin Microbiol 43:5272-4. 2005
    ..Although total HIV DNA was detected in 60 2 LTR DNA-negative samples, the absence of 2 LTR DNA in 90% of patients following 7 to 8 years of highly active antiretroviral therapy suggests suppression of cryptic viral replication...
  30. ncbi request reprint Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat
    Alessandro Poggi
    Laboratory of Immunology, National Institute fo Cancer Research, Largo R Benzi 10, I 16132, Genoa, Italy
    Blood 103:2205-13. 2004
    ....
  31. ncbi request reprint Intima-media thickness: a marker of accelerated atherosclerosis in women with systemic lupus erythematosus
    Barbara Maria Colombo
    Department of Internal Medicine, University of Genova, Genova, Italy
    Ann N Y Acad Sci 1108:121-6. 2007
    ..Moreover, the evaluation of the Framingham Point Score suggests that SLE is an additional risk factor for cardiovascular disease...
  32. ncbi request reprint Emerging biologic drugs for the treatment of rheumatoid arthritis
    Francesco Puppo
    Department of Internal Medicine Di M I, University of Genoa, Viale Benedetto XV, n 6 16132 Genova, Italy
    Autoimmun Rev 4:537-41. 2005
    ..Moreover, promising results have been obtained in animal models utilizing suppressors of cytokine signaling (SOCS) and dominant-negative TNF variants to inactivate TNF signaling...
  33. ncbi request reprint Potential use of TNF-α inhibitors in systemic sclerosis
    Giuseppe Murdaca
    Department of Internal Medicine, Clinical Immunology Unit, University of Genova, Viale Benedetto XV, N 6, 16132 Genova, Italy
    Immunotherapy 6:283-9. 2014
    ..Randomized controlled trials with TNF-α inhibitors in patients with SSc are needed to confirm the potential role of these agents in the treatment of SSc. ..
  34. doi request reprint A multi-peptide, dual-adjuvant telomerase vaccine (GX301) is highly immunogenic in patients with prostate and renal cancer
    Daniela Fenoglio
    Centre of Excellence for Biomedical Research, University of Genoa, Viale Benedetto XV n 7, 16132 Genoa, Italy
    Cancer Immunol Immunother 62:1041-52. 2013
    ..GX301 is a vaccine constituted by four telomerase peptides and two adjuvants, Montanide ISA-51 and Imiquimod...
  35. doi request reprint Emerging biological drugs: a new therapeutic approach for Systemic Lupus Erythematosus. An update upon efficacy and adverse events
    Giuseppe Murdaca
    Department of Internal Medicine Di M I, University of Genova, Genoa, Italy
    Autoimmun Rev 11:56-60. 2011
    ..In this review we will focus on biological drugs whose potential efficacy has been evaluated in open-label and randomized clinical trials...
  36. doi request reprint Two year sublingual immunotherapy affects serum leptin
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa, Genoa, Italy
    Int Immunopharmacol 9:1244-6. 2009
    ..It has been demonstrated that serum leptin is elevated in females with allergic rhinitis. Recently, it has been reported that one course of sublingual immunotherapy (SLIT) does not affect serum leptin levels...
  37. doi request reprint Lymphatic microsurgery to treat lymphedema: techniques and indications for better results
    Francesco Boccardo
    Unit of Lymphatic Surgery, Department of Surgery, IRCCS S Martino University Hospital IST, Genoa, Italy
    Ann Plast Surg 71:191-5. 2013
    ....
  38. doi request reprint Serum adiponectin levels in patients with pollen-induced allergic rhinitis
    Giorgio Ciprandi
    Department of Internal Medicine, Azienda Ospedaliera Universitaria San Martino University of Genoa Genoa, Italy
    Int Immunopharmacol 8:945-9. 2008
    ..Several studies have outlined a possible relationship between an increased body mass index and respiratory allergic diseases, such as asthma and rhinitis...
  39. ncbi request reprint Immunogenicity of erythropoietin and other growth factors
    Francesco Indiveri
    Department of Internal Medicine, Division of Internal Medicine and Clinical Immunology, University of Genoa, Italy
    Rev Clin Exp Hematol . 2002
    ..In this review, the literature concerning the molecular structure and the genetic profile of EPO as well as the relationship between neutralizing EPO antibodies and NI-PRCA have been analyzed...
  40. ncbi request reprint Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients
    Paola Costa
    Dipartimento di Medicina Interna, University of Genova, Genoa, Italy
    AIDS 17:257-60. 2003
    ..The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients...
  41. ncbi request reprint Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients
    Manuela Fogli
    Dipartimanto di Medicina Interna, Universita degli Studi di Genova, Largo B Benzi 10, I 16132 Genoa, Italy
    Eur J Immunol 34:2313-21. 2004
    ..These results suggest a consistent continuous involvement of the innate immune response in the failure to control viral replication...
  42. doi request reprint Antiretroviral genotypic resistance in plasma RNA and whole blood DNA in HIV-1 infected patients failing HAART
    Annalisa Saracino
    Clinic of Infectious Diseases, University of Foggia, Foggia, Italy
    J Med Virol 80:1695-706. 2008
    ..Therefore, in some cases DNA plus RNA genotyping might assist in choosing more accurately subsequent antiretroviral regimens...
  43. doi request reprint Body mass index in Th1 and Th2 diseases
    Barbara Maria Colombo
    Immunol Lett 117:119-20. 2008
    ..Several studies have outlined a relationship between increased body mass index (BMI) and respiratory allergic diseases. This study provides evidence of a significant different BMI between Th2-mediated disorders and Th1-mediated ones...