Domenico Motola

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. doi request reprint Possible occurrence of paraesthesia in patients taking norethisterone: an analysis on the WHO Global Individual Case Reports database (VigiBase)
    Elena Buccellato
    University of Bologna, Department of Medical and Surgical Sciences, Unit of Pharmacology, Via Irnerio 48 Postal Code 40126, Bologna, Italy 39 051 2091779 39 051 48862
    Expert Opin Drug Saf 12:615-9. 2013
  2. ncbi request reprint Ticlopidine safety profile: a case/non-case study on the basis of the spontaneous ADRs reporting in Italy
    Domenico Motola
    Clinical Pharmacology Unit, Department of Medicine and Public Health, University of Verona, Italy
    Curr Drug Saf 7:99-105. 2012
  3. doi request reprint Cardiovascular, ocular and bone adverse reactions associated with thiazolidinediones: a disproportionality analysis of the US FDA adverse event reporting system database
    Domenico Motola
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 35:315-23. 2012
  4. ncbi request reprint Influence of regulatory measures on the rate of spontaneous adverse drug reaction reporting in Italy
    Domenico Motola
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 31:609-16. 2008
  5. doi request reprint Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, and Ahterosclerosis and Metabolic Diseases Study Centre, G Descovich, Department of Clinical Medicine and Applied Biotechnology D Campanacci, S Orsola Malpighi University Hospital, Bologna, Italy
    Eur J Clin Pharmacol 64:425-32. 2008
  6. pmc Adherence to chronic cardiovascular therapies: persistence over the years and dose coverage
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 63:346-55. 2007
  7. ncbi request reprint Hepatic adverse drug reactions: a case/non-case study in Italy
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Eur J Clin Pharmacol 63:73-9. 2007
  8. ncbi request reprint Initial treatment of hypertension and adherence to therapy in general practice in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Eur J Clin Pharmacol 61:603-9. 2005
  9. ncbi request reprint Fluvastatin and hepatic reactions: a signal from spontaneous reporting in Italy
    Anita Conforti
    Clinical Pharmacology Unit, Reference Centre for Education and Communication, WHO Programme for International Drug Monitoring, University of Verona, Verona, Italy
    Drug Saf 29:1163-72. 2006
  10. pmc An update on the first decade of the European centralized procedure: how many innovative drugs?
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 62:610-6. 2006

Collaborators

Detail Information

Publications27

  1. doi request reprint Possible occurrence of paraesthesia in patients taking norethisterone: an analysis on the WHO Global Individual Case Reports database (VigiBase)
    Elena Buccellato
    University of Bologna, Department of Medical and Surgical Sciences, Unit of Pharmacology, Via Irnerio 48 Postal Code 40126, Bologna, Italy 39 051 2091779 39 051 48862
    Expert Opin Drug Saf 12:615-9. 2013
    ..Since paraesthesia can be caused by several drugs, clinicians should consider that it may be also caused by norethisterone. ..
  2. ncbi request reprint Ticlopidine safety profile: a case/non-case study on the basis of the spontaneous ADRs reporting in Italy
    Domenico Motola
    Clinical Pharmacology Unit, Department of Medicine and Public Health, University of Verona, Italy
    Curr Drug Saf 7:99-105. 2012
    ..Its most important adverse drug reactions (ADRs) involve haematological system. Our aim was to evaluate the safety profile of ticlopidine in the real life, on the basis of spontaneous ADR reporting...
  3. doi request reprint Cardiovascular, ocular and bone adverse reactions associated with thiazolidinediones: a disproportionality analysis of the US FDA adverse event reporting system database
    Domenico Motola
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 35:315-23. 2012
    ..The risk of myocardial infarction, macular oedema and bone fractures associated with thiazolidinediones (TZDs) has been extensively investigated...
  4. ncbi request reprint Influence of regulatory measures on the rate of spontaneous adverse drug reaction reporting in Italy
    Domenico Motola
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 31:609-16. 2008
    ..However, excessive reporting induced by external events may also impair signal detection by increasing the noise level...
  5. doi request reprint Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, and Ahterosclerosis and Metabolic Diseases Study Centre, G Descovich, Department of Clinical Medicine and Applied Biotechnology D Campanacci, S Orsola Malpighi University Hospital, Bologna, Italy
    Eur J Clin Pharmacol 64:425-32. 2008
    ..To evaluate the pattern of use of statins in the Emilia Romagna Region, with a focus on the therapeutic regimens and the patient's risk profile as predictors of adherence to therapy...
  6. pmc Adherence to chronic cardiovascular therapies: persistence over the years and dose coverage
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 63:346-55. 2007
    ..To evaluate adherence to chronic cardiovascular drug treatments, in terms of long-term persistence and dose coverage...
  7. ncbi request reprint Hepatic adverse drug reactions: a case/non-case study in Italy
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Eur J Clin Pharmacol 63:73-9. 2007
    ..To assess the extent of drug-induced liver injuries in Italy we compared the number of cases of hepatic ADRs with reports of all other drug-related reactions present in the same database...
  8. ncbi request reprint Initial treatment of hypertension and adherence to therapy in general practice in Italy
    Elisabetta Poluzzi
    Department of Pharmacology, and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Eur J Clin Pharmacol 61:603-9. 2005
    ..The approach to the pharmacological treatment of hypertension is guided by international recommendations and adherence to treatment is known to result in effective prevention of cardiovascular risk...
  9. ncbi request reprint Fluvastatin and hepatic reactions: a signal from spontaneous reporting in Italy
    Anita Conforti
    Clinical Pharmacology Unit, Reference Centre for Education and Communication, WHO Programme for International Drug Monitoring, University of Verona, Verona, Italy
    Drug Saf 29:1163-72. 2006
    ..It is still unclear whether serious hepatic reactions are dose related and more frequent than the expected rate in the general population...
  10. pmc An update on the first decade of the European centralized procedure: how many innovative drugs?
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 62:610-6. 2006
    ..nonbiotechnological agents in the first decade of European Medicines Agency activity, also studying a possible time trend...
  11. doi request reprint A 3 year survey on the use of antibacterial agents in five Italian hospitals
    Alberto Vaccheri
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    J Antimicrob Chemother 61:953-8. 2008
    ..We investigated the pattern of antibiotic consumption in 2002-04 in a sample of Italian hospitals, and compared this with antibiotic consumption data in primary healthcare in the Emilia-Romagna region...
  12. doi request reprint Pattern of triptan use and cardiovascular coprescription: a pharmacoepidemiological study in Italy
    Chiara Biagi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Eur J Clin Pharmacol 67:1283-9. 2011
    ..We evaluated the incidence, prevalence, and patterns of triptan use with a special focus on patients who also received cardiovascular drugs, considered as a deviation from appropriate triptan use...
  13. doi request reprint Safety profile of the fluoroquinolones: analysis of adverse drug reactions in relation to prescription data using four regional pharmacovigilance databases in Italy
    Francesco Lapi
    Department of Pharmacology, University of Florence, Tuscan Regional Centre of Pharmacovigilance, Florence, Italy
    Drug Saf 33:789-99. 2010
    ..The aim of this study was to reassess the safety profiles of fluoroquinolones using the database of the Italian Interregional Group of Pharmacovigilance (IGP) and the administrative data of fluoroquinolone prescriptions...
  14. ncbi request reprint Drug-induced anaphylaxis : case/non-case study based on an italian pharmacovigilance database
    Roberto Leone
    Clinical Pharmacology Unit, Reference Centre for Education and Communication within the WHO Programme for International Drug Monitoring, University of Verona, Verona, Italy
    Drug Saf 28:547-56. 2005
    ..To identify the number of cases of anaphylaxis reported in association with different classes of drugs and compare it with other reports contained in the same database...
  15. ncbi request reprint Gastro-intestinal problems and concomitant medication in NSAID users: additional findings from a questionnaire-based survey in Italy
    Maria Chiara Silvani
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Eur J Clin Pharmacol 62:235-41. 2006
    ..In a previous questionnaire-based survey, we found extensive use of nonsteroidal anti-inflammatory drugs (NSAIDs) in subjects with risk factors for serious gastrointestinal complications...
  16. doi request reprint Cardiovascular events in statin recipients: impact of adherence to treatment in a 3-year record linkage study
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126, Bologna, Italy
    Eur J Clin Pharmacol 67:407-14. 2011
    ..This study aimed to evaluate the occurrence of cardiovascular events in Italian statin recipients, focussing on the relationship between degree of adherence to therapy and occurrence of events in a 3-year follow-up...
  17. doi request reprint Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Drug Saf 33:303-14. 2010
    ..In this context, the US FDA Adverse Event Reporting System (AERS) is an important source of information, which can be applied to the analysis of TdP liability of marketed drugs...
  18. doi request reprint Identifying adverse drug reactions associated with drug-drug interactions: data mining of a spontaneous reporting database in Italy
    Roberto Leone
    Clinical Pharmacology Unit, Reference Centre for Education and Communication within the WHO Programme for International Drug Monitoring, University of Verona, Verona, Italy
    Drug Saf 33:667-75. 2010
    ..A spontaneous reporting database could be a valuable resource for detection of ADRs associated with DDIs; however, data in the literature are limited...
  19. doi request reprint Stronger association of drug-induced progressive multifocal leukoencephalopathy (PML) with biological immunomodulating agents
    Carlo Piccinni
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Eur J Clin Pharmacol 66:199-206. 2010
    ..The aim of the present study was to collect and compare cases of drug-induced PML in order to contribute to the debate about the role of the underlying diseases and/or drug immunosuppression in PML occurrence...
  20. pmc Assessing the association of pioglitazone use and bladder cancer through drug adverse event reporting
    Carlo Piccinni
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Diabetes Care 34:1369-71. 2011
    ..To analyze the association between pioglitazone use and bladder cancer through a spontaneous adverse event reporting system for medications...
  21. doi request reprint Underreporting in pharmacovigilance: an intervention for Italian GPs (Emilia-Romagna region)
    Chiara Biagi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, Postal Code 40126, Bologna, Italy
    Eur J Clin Pharmacol 69:237-44. 2013
    ..Underreporting is a major limitation of spontaneous reporting systems for suspected adverse drug reactions (ADRs). Several interventions to increase the ADR reporting rate have been proposed, but their efficacy remains poorly investigated...
  22. ncbi request reprint Pattern of NSAID use in the Italian general population: a questionnaire-based survey
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Via Irnerio 48, 40126 Bologna, BO, Italy
    Eur J Clin Pharmacol 60:731-8. 2004
    ..A detailed knowledge of the pattern of use of NSAIDs may help doctors in advising their patients about appropriateness and safety of use...
  23. pmc Dronedarone-associated acute renal failure: evidence coming from the Italian spontaneous ADR reporting database
    Chiara Biagi
    Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy Pharmacovigilance Regional Centre of Emilia Romagna, Bologna, Italy
    Br J Clin Pharmacol 75:1351-5. 2013
    ..To describe cases of acute renal failure (ARF) and of renal failure (RF) from dronedarone retrieved in the general population during post-marketing surveillance through the Italian spontaneous ADR reporting database...
  24. ncbi request reprint Prescriptions of antidepressants in primary care in Italy: pattern of use after admission of selective serotonin reuptake inhibitors for reimbursement
    Elisabetta Poluzzi
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna BO, Italy
    Eur J Clin Pharmacol 59:825-31. 2004
    ..Italy is reported to have a relatively low consumption of antidepressants. This is probably due to the fact that until 2000 antidepressants were reimbursed with some restrictions...
  25. doi request reprint Statin-associated gynecomastia: evidence coming from the Italian spontaneous ADR reporting database and literature
    Giuseppe Roberto
    Department of Pharmacology, University of Bologna, Via Irnerio 48, Bologna, Italy
    Eur J Clin Pharmacol 68:1007-11. 2012
    ..The aim of this study was to add to the body of evidence on statin-induced gynecomastia based on data retrieved from the Italian spontaneous adverse drug reaction (ADR) reporting database...
  26. ncbi request reprint Adverse drug reactions related to the use of fluoroquinolone antimicrobials: an analysis of spontaneous reports and fluoroquinolone consumption data from three italian regions
    Roberto Leone
    Clinical Pharmacology Unit, WHO Reference Centre for Education and Communication in International Drug Monitoring, University of Verona, Italy
    Drug Saf 26:109-20. 2003
    ..To analyse and compare with one another and with other antibacterial drugs the adverse drug reactions (ADRs) of the different fluoroquinolones currently used in Italy, spontaneously reported from doctors in three northern Italian regions...
  27. pmc Therapeutic innovation in the European Union: analysis of the drugs approved by the EMEA between 1995 and 2003
    Domenico Motola
    Department of Pharmacology and Interuniversity Research Centre for Pharmacoepidemiology, University of Bologna, Bologna, Italy
    Br J Clin Pharmacol 59:475-8. 2005
    ..Most (80%) of the EMEA-approved therapeutic agents were for serious diseases. The remaining ones were for risk factors (7%) or nonserious diseases (13%)...