Affiliation: University of Turin
Crivellaro S, Carrà G, Panuzzo C, Taulli R, Guerrasio A, Saglio G, et al
. The non-genomic loss of function of tumor suppressors: an essential role in the pathogenesis of chronic myeloid leukemia chronic phase. BMC Cancer. 2016;16:314 pubmed publisher
..In this review we will describe new insights on the role of FoxO, PP2A, p27, BLK, PTEN and other tumor suppressors in CML pathogenesis. Finally, we will describe strategies to promote tumor suppressors reactivation in CML. ..
Morotti A, Rocca S, Carrà G, Saglio G, Brancaccio M. Modeling myeloproliferative neoplasms: From mutations to mouse models and back again. Blood Rev. 2017;31:139-150 pubmed publisher
..This review focuses on MPN mouse models specifically developed to assess the pathogenetic roles of gene mutations found in human patients, as well as murine MPN-like phenotypes identified in genetically modified mice. ..
Carrà G, Crivellaro S, Taulli R, Guerrasio A, Saglio G, Morotti A. Mechanisms of p53 Functional De-Regulation: Role of the I?B-?/p53 Complex. Int J Mol Sci. 2016;17: pubmed
..Here, we review the mechanisms of p53 functional inactivation, with a particular emphasis on the interaction between p53 and I?B-?, the NFKBIA gene product. ..