Micaela Morelli

Summary

Affiliation: University of Cagliari
Country: Italy

Publications

  1. pmc A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease
    Micaela Morelli
    Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Parkinsons Dis 2012:489853. 2012
  2. pmc Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
    Mario Herrera-Marschitz
    Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, P O Box 70 000, Santiago 7, Chile
    Neurotox Res 19:603-27. 2011
  3. ncbi Methylxanthines and drug dependence: a focus on interactions with substances of abuse
    Micaela Morelli
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Handb Exp Pharmacol 200:483-507. 2011
  4. pmc Pathophysiological roles for purines: adenosine, caffeine and urate
    Micaela Morelli
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Prog Brain Res 183:183-208. 2010
  5. ncbi Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications
    Micaela Morelli
    University of Cagliari, Department of Toxicology, Via Ospedale 72, 09124 Cagliari, Italy
    Prog Neurobiol 83:293-309. 2007
  6. ncbi Adenosine A2A antagonists: potential preventive and palliative treatment for Parkinson's disease
    Micaela Morelli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Exp Neurol 184:20-3. 2003
  7. doi A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug
    Annalisa Pinna
    CNR Institute of Neuroscience Cagliari, 09124 Cagliari, Italy
    Neuropharmacology 58:613-23. 2010
  8. doi Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat
    Anna R Carta
    Department of Toxicology and Center of Excellence for Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    Synapse 62:524-33. 2008
  9. ncbi Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats
    Elisabetta Tronci
    Department of Toxicology, University of Cagliari, Italy
    Eur J Pharmacol 566:94-102. 2007
  10. doi Blockade of globus pallidus adenosine A(2A) receptors displays antiparkinsonian activity in 6-hydroxydopamine-lesioned rats treated with D(1) or D(2) dopamine receptor agonists
    Nicola Simola
    Department of Toxicology, University of Cagliari, 09124 Cagliari, Italy
    Synapse 62:345-51. 2008

Collaborators

Detail Information

Publications50

  1. pmc A(2A) Receptor Antagonism and Dyskinesia in Parkinson's Disease
    Micaela Morelli
    Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Parkinsons Dis 2012:489853. 2012
    ..Whether A(2A) antagonists might reduce the development of dyskinesia has not yet been tested clinically...
  2. pmc Perinatal asphyxia: current status and approaches towards neuroprotective strategies, with focus on sentinel proteins
    Mario Herrera-Marschitz
    Programme of Molecular and Clinical Pharmacology, ICBM, Medical Faculty, University of Chile, P O Box 70 000, Santiago 7, Chile
    Neurotox Res 19:603-27. 2011
    ..It is proposed that sentinel proteins can be used as markers for characterising long-term effects of perinatal asphyxia, and as targets for novel therapeutic development and innovative strategies for neonatal care...
  3. ncbi Methylxanthines and drug dependence: a focus on interactions with substances of abuse
    Micaela Morelli
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Handb Exp Pharmacol 200:483-507. 2011
    ....
  4. pmc Pathophysiological roles for purines: adenosine, caffeine and urate
    Micaela Morelli
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Prog Brain Res 183:183-208. 2010
    ....
  5. ncbi Role of adenosine A2A receptors in parkinsonian motor impairment and l-DOPA-induced motor complications
    Micaela Morelli
    University of Cagliari, Department of Toxicology, Via Ospedale 72, 09124 Cagliari, Italy
    Prog Neurobiol 83:293-309. 2007
    ..Finally, concluding remarks are made on post-mortem human brains and on the translation of adenosine A2A receptor antagonists in the treatment of PD...
  6. ncbi Adenosine A2A antagonists: potential preventive and palliative treatment for Parkinson's disease
    Micaela Morelli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Exp Neurol 184:20-3. 2003
  7. doi A new ethyladenine antagonist of adenosine A(2A) receptors: behavioral and biochemical characterization as an antiparkinsonian drug
    Annalisa Pinna
    CNR Institute of Neuroscience Cagliari, 09124 Cagliari, Italy
    Neuropharmacology 58:613-23. 2010
    ..The characterization of ANR 94 may represent a further therapeutic opportunity for the treatment of PD with this new class of drugs...
  8. doi Behavioral and biochemical correlates of the dyskinetic potential of dopaminergic agonists in the 6-OHDA lesioned rat
    Anna R Carta
    Department of Toxicology and Center of Excellence for Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    Synapse 62:524-33. 2008
    ..In contrast, increase of GAD67 mRNA in the GP was associated to both behavioral responses (SCT and AIMs), suggesting that neuroadaptive changes in this area were unrelated to the difference in dyskinetic potential of drugs...
  9. ncbi Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats
    Elisabetta Tronci
    Department of Toxicology, University of Cagliari, Italy
    Eur J Pharmacol 566:94-102. 2007
    ..Moreover, in agreement to other well characterized adenosine A2A receptor antagonists, ST1535 features antitremorigenic effects...
  10. doi Blockade of globus pallidus adenosine A(2A) receptors displays antiparkinsonian activity in 6-hydroxydopamine-lesioned rats treated with D(1) or D(2) dopamine receptor agonists
    Nicola Simola
    Department of Toxicology, University of Cagliari, 09124 Cagliari, Italy
    Synapse 62:345-51. 2008
    ....
  11. pmc Inactivation of neuronal forebrain A receptors protects dopaminergic neurons in a mouse model of Parkinson's disease
    Anna R Carta
    Department of Toxicology, University of Cagliari, Italy
    J Neurochem 111:1478-89. 2009
    ..With the symptomatic antiparkinsonian potential of several A(2A) receptor antagonists being pursued in clinical trials, this study adds to the rationale for broader clinical benefit and use of these drugs early in the treatment of PD...
  12. ncbi Adenosine A2A and dopamine receptor interactions in basal ganglia of dopamine denervated rats
    Anna R Carta
    Department of Toxicology and Center of Excellence for Neurobiology of Dependence, University of Cagliari, Italy
    Neurology 61:S39-43. 2003
    ..Moreover, the combination of SCH 58261 + L-dopa produces little or no change in the striatal, pallidal, and nigral expression of markers correlated with dopamine agonist dyskinetic potential...
  13. ncbi Dopamine and adenosine receptor interaction as basis for the treatment of Parkinson's disease
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    J Neurol Sci 248:48-52. 2006
    ..The prospective of providing additional antitremor benefits considerably enhances the therapeutic potential of A(2A) antagonists...
  14. ncbi Involvement of globus pallidus in the antiparkinsonian effects of adenosine A(2A) receptor antagonists
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    Exp Neurol 202:255-7. 2006
    ..4 +/- 16.3/1 h). These results suggest that A(2A) receptors located in the globus pallidus may be involved in the antiparkinsonian effects of A(2A) antagonists...
  15. doi Performance of movement in hemiparkinsonian rats influences the modifications induced by dopamine agonists in striatal efferent dynorphinergic neurons
    Lucia Frau
    Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Via Ospedale 72, 09124, Cagliari, Italy
    Exp Neurol 247:663-72. 2013
    ..Furthermore, these results may provide information on the first initial molecular events taking place in the complex processes that lead to dyskinetic movements in Parkinson's disease...
  16. doi Dyskinetic potential of dopamine agonists is associated with different striatonigral/striatopallidal zif-268 expression
    Anna R Carta
    Department of Toxicology, University of Cagliari, Cagliari, Italy Centre of Excellence for Studies on Neurobiology of Addiction, Cagliari, Italy
    Exp Neurol 224:395-402. 2010
    ....
  17. ncbi Subchronic intermittent caffeine administration to unilaterally 6-hydroxydopamine-lesioned rats sensitizes turning behaviour in response to dopamine D(1) but not D(2) receptor agonists
    Omar Cauli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Behav Pharmacol 16:621-6. 2005
    ..The results show that repeated intermittent caffeine exposure enhances the motor stimulant effects elicited by dopamine agonists by a preferential sensitization of dopamine D(1) receptors...
  18. ncbi Potentiation of amphetamine-mediated responses in caffeine-sensitized rats involves modifications in A2A receptors and zif-268 mRNAs in striatal neurons
    Elisabetta Tronci
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    J Neurochem 98:1078-89. 2006
    ..Results demonstrate that sensitization to caffeine and cross-sensitization to amphetamine are associated with post-synaptic neuroadaptive changes in selective neuronal populations of the striatum...
  19. doi Direct and indirect striatal efferent pathways are differentially influenced by low and high dyskinetic drugs: behavioural and biochemical evidence
    Anna R Carta
    Department of Toxicology, University of Cagliari, Via Ospedale 72, Cagliari, Italy
    Parkinsonism Relat Disord 14:S165-8. 2008
    ....
  20. ncbi How reliable is the behavioural evaluation of dyskinesia in animal models of Parkinson's disease?
    Anna R Carta
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari bCNR Institute for Neuroscience Section of Cagliari, Cagliari, Italy
    Behav Pharmacol 17:393-402. 2006
    ..Subsequently, the various models of dyskinesia are reviewed and conclusions are drawn as to how the environment in which experiments are performed can influence the behaviour observed...
  21. ncbi Blockade of adenosine A2A receptors antagonizes parkinsonian tremor in the rat tacrine model by an action on specific striatal regions
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124, Cagliari, Italy
    Exp Neurol 189:182-8. 2004
    ....
  22. doi Neuroprotective and anti-inflammatory effects of the adenosine A(2A) receptor antagonist ST1535 in a MPTP mouse model of Parkinson's disease
    Lucia Frau
    Department of Toxicology, University of Cagliari, Cagliari, Italy
    Synapse 65:181-8. 2011
    ..With its neuroprotective effect on dopaminergic neuron toxicity induced by MPTP and its antagonism on glial activation, ST1535 represents a new prospect for a disease-modifying drug...
  23. ncbi Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease
    Annalisa Pinna
    Section of Cagliari, CNR Institute of Neuroscience, Cagliari, Italy
    Synapse 61:606-14. 2007
    ....
  24. ncbi New adenosine A2A receptor antagonists: actions on Parkinson's disease models
    Annalisa Pinna
    CNR Institute for Neuroscience section Cagliari, Cagliari, Italy
    Eur J Pharmacol 512:157-64. 2005
    ..Taken together the results of this study indicate that some 8-substituted 9-ethyladenine derivatives ameliorate motor deficits in rat models of Parkinson's disease, suggesting a potential therapeutic role of these compounds...
  25. ncbi Subchronic caffeine exposure induces sensitization to caffeine and cross-sensitization to amphetamine ipsilateral turning behavior independent from dopamine release
    Omar Cauli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Cagliari, Italy
    Neuropsychopharmacology 28:1752-9. 2003
    ....
  26. doi Increase of dopamine D2(High) receptors in the striatum of rats sensitized to caffeine motor effects
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    Synapse 62:394-7. 2008
    ..This marked elevation in D2(High) receptors may account for the caffeine-induced behavioral dopamine supersensitivity and may help elucidate the interactions between caffeine and dopamine neurotransmission...
  27. ncbi Blockade of A2A receptors plus l-DOPA after nigrostriatal lesion results in GAD67 mRNA changes different from l-DOPA alone in the rat globus pallidus and substantia nigra reticulata
    Anna R Carta
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, 09124 Cagliari, Italy
    Exp Neurol 184:679-87. 2003
    ..In contrast, the lack of GAD67 mRNA changes in the GP and a less marked inhibition of SNr might correlate with the absence of dyskinetic potential observed after SCH58261 plus l-DOPA...
  28. doi Microglial and astroglial activation by 3,4-methylenedioxymethamphetamine (MDMA) in mice depends on S(+) enantiomer and is associated with an increase in body temperature and motility
    Lucia Frau
    Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Cagliari, Italy
    J Neurochem 124:69-78. 2013
    ....
  29. ncbi Sensitization to caffeine and cross-sensitization to amphetamine: influence of individual response to caffeine
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Via Ospedale, 09124 Cagliari, Italy
    Behav Brain Res 172:72-9. 2006
    ....
  30. ncbi The 6-hydroxydopamine model of Parkinson's disease
    Nicola Simola
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neurotox Res 11:151-67. 2007
    ..Thanks to studies performed in the 6-OHDA model, all these mechanisms have now been hypothesised to represent the site of pathological dysfunction at cellular level in Parkinson's disease...
  31. doi MPTP-induced dopamine neuron degeneration and glia activation is potentiated in MDMA-pretreated mice
    Giulia Costa
    Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Cagliari, Italy
    Mov Disord 28:1957-65. 2013
    ....
  32. doi Pharmacological characterization of 50-kHz ultrasonic vocalizations in rats: comparison of the effects of different psychoactive drugs and relevance in drug-induced reward
    Nicola Simola
    Department of Biomedical Sciences, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neuropharmacology 63:224-34. 2012
    ..These findings provide a better understanding of psychoactive properties of drugs with rewarding properties and usefulness of 50-kHz USVs in assessment of these properties...
  33. ncbi Modification of adenosine extracellular levels and adenosine A(2A) receptor mRNA by dopamine denervation
    Annalisa Pinna
    CNR Center for Neuropharmacology, University of Cagliari, Cagliari, Italy
    Eur J Pharmacol 446:75-82. 2002
    ....
  34. doi Caffeine enhances astroglia and microglia reactivity induced by 3,4-methylenedioxymethamphetamine ('ecstasy') in mouse brain
    Amit Khairnar
    Department of Toxicology, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Neurotox Res 17:435-9. 2010
    ..The abuse of MDMA is a growing worldwide problem; the results of this study suggest that combination of MDMA plus caffeine by increasing glial activation might have harmful health consequences...
  35. ncbi Synthesis of new 2-arylamino-6-trifluoromethylpyridine-3-carboxylic acid derivatives and investigation of their analgesic activity
    Maria T Cocco
    Dipartimento di Tossicologia, Universita degli Studi di Cagliari, Via Ospedale 72, Cagliari I 09124, Italy
    Bioorg Med Chem 12:4169-77. 2004
    ..When compared to aspirin, ibuprofen and flufenamic acid some of the new compounds exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect...
  36. doi Impulse control disorders and dopamine dysregulation syndrome associated with dopamine agonist therapy in Parkinson's disease
    Sandro Fenu
    Department of Toxicology, National Institute of Neuroscience and Centre of Excellence for Studies on the Neurobiology of Addiction, University of Cagliari, Cagliari, Italy
    Behav Pharmacol 20:363-79. 2009
    ..Finally, we focus on suggestions pointing to a role for dopamine D(3) receptors and sensitization phenomena as the main factors which may be the origin of these disorders...
  37. ncbi Acute perinatal asphyxia impairs non-spatial memory and alters motor coordination in adult male rats
    Nicola Simola
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Exp Brain Res 185:595-601. 2008
    ..The results of this study provide further insights into the long-term effects of perinatal asphyxia on neurobehavioural functions...
  38. ncbi Differential regulation of GAD67, enkephalin and dynorphin mRNAs by chronic-intermittent L-dopa and A2A receptor blockade plus L-dopa in dopamine-denervated rats
    Anna R Carta
    Department of Toxicology, University of Cagliari, 09124, Italy
    Synapse 44:166-74. 2002
    ....
  39. ncbi Subchronic caffeine administration sensitizes rats to the motor-activating effects of dopamine D(1) and D(2) receptor agonists
    Omar Cauli
    Department of Toxicology and Centre of Excellence for Neurobiology of Dependence, University of Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Psychopharmacology (Berl) 162:246-54. 2002
    ..In contrast, how caffeine influences the motor stimulant properties of selective D(1) and D(2) receptor agonists is still undefined...
  40. ncbi New therapies for the treatment of Parkinson's disease: adenosine A2A receptor antagonists
    Annalisa Pinna
    CNR Institute of Neuroscience Cagliari section, Italy
    Life Sci 77:3259-67. 2005
    ....
  41. doi Direct and long-lasting effects elicited by repeated drug administration on 50-kHz ultrasonic vocalizations are regulated differently: implications for the study of the affective properties of drugs of abuse
    Nicola Simola
    Department of Biomedical Sciences, Section of Neuropsychopharmacology, University of Cagliari, Cagliari, Italy
    Int J Neuropsychopharmacol 17:429-41. 2014
    ..This study demonstrates that the direct and long-lasting effects of drugs on 50-kHz USVs are regulated differently, providing a better understanding of the usefulness of these vocalizations in the study of psychoactive drugs...
  42. ncbi A critical evaluation of behavioral rodent models of motor impairment used for screening of antiparkinsonian activity: The case of adenosine A(2A) receptor antagonists
    Annalisa Pinna
    Institute of Neuroscience, National Research Council of Italy CNR, Cagliari, Italy
    Neurotox Res 25:392-401. 2014
    ..Therefore, on one hand, animal models of PD might have a limited validity; on the other hand, clinical trials should explore the efficacy of A(2A) receptor antagonists on a broader range of parkinsonian conditions...
  43. ncbi Synthesis of ibuprofen heterocyclic amides and investigation of their analgesic and toxicological properties
    Maria Teresa Cocco
    Dipartimento di Tossicologia, Universita degli Studi di Cagliari, Via Ospedale 72, 09124 Cagliari, Italy
    Eur J Med Chem 38:513-8. 2003
    ..When compared to parent ibuprofen some of the new amides exhibited a comparable or improved analgesic activity and a lower ulcerogenic effect...
  44. ncbi Expression of dyskinetic movements and turning behaviour in subchronic L-DOPA 6-hydroxydopamine-treated rats is influenced by the testing environment
    Annalisa Pinna
    CNR Institute of Neuroscience, Section of Cagliari, Italy
    Behav Brain Res 171:175-8. 2006
    ..In contrast, sensitisation in AIMs was obtained both in hemispherical bowls and cages. Results provide evidence that the choice of the environment used in evaluation of AIMs and turning behaviour is of crucial importance...
  45. ncbi Targeting adenosine A2A receptors in Parkinson's disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, MA 02129, USA
    Trends Neurosci 29:647-54. 2006
    ..Thus, we review here a prime example of translational neuroscience, through which antagonism of A2A receptors has now entered the arena of clinical trials with realistic prospects for advancing PD therapeutics...
  46. ncbi Adenosine A2A receptor antagonism increases striatal glutamate outflow in dopamine-denervated rats
    Claudia Corsi
    Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139, Florence, Italy
    Eur J Pharmacol 464:33-8. 2003
    ..These results may be relevant to our understanding of the mechanism of action of adenosine A(2A) receptor antagonists in Parkinson's disease...
  47. doi Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis
    Federico Da Settimo
    Dipartimento di Scienze Farmaceutiche and Dipartimento di Psichiatria, Neurobiologia, Farmacologia e Biotecnologie, Universita di Pisa, Via Bonanno 6, 56126 Pisa, Italy
    J Med Chem 51:5798-806. 2008
    ..The results of this study suggested that the novel N,N-disubstituted indol-3-ylglyoxylamides may represent a promising class of compounds potentially suited for the treatment of anxiety disorders...
  48. ncbi EEG modifications in the cortex and striatum after dopaminergic priming in the 6-hydroxydopamine rat model of Parkinson's disease
    Vasily V Vorobyov
    Institute of Cell Biophysics, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia
    Brain Res 972:177-85. 2003
    ..Development of priming might be related to the degree and cortical/striatal ratio of EEG power inhibition produced by dopamine agonists...
  49. ncbi Role of neuroactive steroid allopregnanolone in antipsychotic-like action of olanzapine in rodents
    Rajesh R Ugale
    University Department of Pharmaceutical Sciences, Nagpur University Campus, Nagpur, Maharashtra, India
    Neuropsychopharmacology 29:1597-609. 2004
    ..The present findings provide the first specific behavioral evidence in support of the hypothesis that neuroactive steroid ALLO- mediated GABAergic modulation is essential for the antipsychotic-like action of olanzapine...