Research Topics
Genomes and Genes | E MontiSummaryAffiliation: University of Brescia Country: Italy Publications
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Detail Information
Publications
Recent development in mammalian sialidase molecular biologyEugenio Monti
Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
Neurochem Res 27:649-63. 2002..Overall, the availability of the cDNA species encoding mammalian sialidases is an important step leading toward a comprehensive picture of the relationships between the structure and biological function of these enzymes...
Gallus gallus NEU3 sialidase as model to study protein evolution mechanism based on rapid evolving loopsEdoardo Giacopuzzi
Department of Biomedical Sciences and Biotechnology, Unit of Biology and Genetics, University of Brescia, Viale Europa 11, Brescia 25123, Italy
BMC Biochem 12:45. 2011..These features prompted us to extend our studies on this protein family in birds, to get insights on the evolution of this class of glycohydrolases...- Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene familyE Monti
Department of Biomedical Science and Biotechnology, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Genomics 83:445-53. 2004..Immunofluorescence staining and Western blot analysis demonstrated the association of NEU4 with the inner cell membranes... - Identification and expression of NEU3, a novel human sialidase associated to the plasma membraneE Monti
Telethon Institute of Genetics and Medicine TIGEM, San Raffaele Biomedical Science Park, Via Olgettina 58, 20132 Milan, Italy and Department of Biomedical Science and Biotechnology, University of Brescia, Via Valsabbina 19, 25123 Brescia, Italy
Biochem J 349:343-51. 2000..8. Immunofluorescence staining of the transfected COS7 cells demonstrated the protein's localization in the plasma membrane... - Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organizationM Manzoni
Sezione di Biologia e Genetica, Dipartimento di Scienze Biomediche e Biotecnologie, Viale Europa 11, 25123 Brescia, Italy
FEBS Lett 567:219-24. 2004..Among the mutants, only F408del induces a redistribution of the late endocytic compartment. These findings suggest that the overexpression of the mucolipin cation channel influences the dynamic equilibrium of late endocytic compartments... - Molecular cloning and biochemical characterization of sialidases from zebrafish (Danio rerio)Marta Manzoni
Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Biochem J 408:395-406. 2007..Overall, the redundancy of sialidases together with their expression profile and their activity exerted on gangliosides of living cells indicate the biological relevance of this class of enzymes in zebrafish... - Sialidase NEU3 is a peripheral membrane protein localized on the cell surface and in endosomal structuresGabriele Zanchetti
Department of Biomedical Sciences and Biotechnology, School of Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
Biochem J 408:211-9. 2007..Overall, these results provide important information about the biology of NEU3, the most studied member of the mammalian sialidase family... - The plasma membrane-associated sialidase MmNEU3 modifies the ganglioside pattern of adjacent cells supporting its involvement in cell-to-cell interactionsNadia Papini
Department of Medical Chemistry, Center of Excellence on Neurodegenerative Diseases, School of Medicine, University of Milan, 20090 Segrate, Italy
J Biol Chem 279:16989-95. 2004..These results indicate that the plasma membrane-associated sialidase MmNEU3 is able to hydrolyze ganglioside substrates in intact living cells at a neutral pH, mainly through cell-to-cell interactions... - Over-expression of mammalian sialidase NEU3 reduces Newcastle disease virus entry and propagation in COS7 cellsLuigi Anastasia
Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, Milan, Italy
Biochim Biophys Acta 1780:504-12. 2008..Evidence was also provided for the preferential association of NDV-HN at 4 degrees C to detergent resistant microdomains (DRMs) of COS7 cells plasma membranes... - Expression of sialidase Neu2 in leukemic K562 cells induces apoptosis by impairing Bcr-Abl/Src kinases signalingCristina Tringali
Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, LITA via Fratelli Cervi 93, Segrate, Milan, Italy
J Biol Chem 282:14364-72. 2007..In fact, three cytosolic glycoproteins, in the range 45-66 kDa, showed a 50-70% decrease of their sialic acid content upon Neu2 expression, supporting their possible role as modulators of the Bcr-Abl complex... - Modification of sialidase levels and sialoglycoconjugate pattern during erythroid and erytroleukemic cell differentiationCristina Tringali
Department of Medical Chemistry, Biochemistry and Biotechnology, Faculty of Exercise Science, University of Milan, LITA Segrate, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
Glycoconj J 24:67-79. 2007..Overall, these results point out the great differences in sialoglycoconjugate and sialidase patterns exhibited by normal and tumour cells... - Gangliosides play an important role in the organization of CD82-enriched microdomainsElena Odintsova
Cancer Research U K Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
Biochem J 400:315-25. 2006..Furthermore, these results demonstrate that the association between different tetraspanins in TERM is controlled by distinct mechanisms and identify Neu3 as a first physiological regulator of the integrity of these microdomains... - Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside moleculesCristina Tringali
Department of Medical Chemistry, Biochemistry, and Biotechnology, University of Milan, Medical Faculty, Laboratorio Interdisciplinare Tecnologie Avanzate L I T A Segrate, Via Fratelli Cervi 93, 20090 Segrate, Milan, Italy
J Biol Chem 279:3169-79. 2004..The last ability might be relevant in sialidase interactions with gangliosides under physiological conditions... - Cellular expression and alternative splicing of SLC25A23, a member of the mitochondrial Ca2+-dependent solute carrier gene familyMaria Teresa Bassi
Istituto Scientifico Eugenio Medea La Nostra Famiglia, Via Don Luigi Monza, 20 22040 Bosisio Parini LC, Italy
Gene 345:173-82. 2005..We believe that our study will contribute to a better knowledge of this family of mitochondrial carriers... - Crystal structure of the human cytosolic sialidase Neu2. Evidence for the dynamic nature of substrate recognitionLeonard M G Chavas
Structural Biology Research Center, Photon Factory, Institute of Materials Structure Science, High Energy Accelerator Research Organization, Tsukuba, Ibaraki 305 0801, Japan
J Biol Chem 280:469-75. 2005.... - Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscleLuigi Anastasia
Department of Medical Chemistry, Biochemistry and Biotechnology, University of Milan, L.I.T.A. via F.lli Cervi 93, 20090 Segrate, Milan, Italy
Cell Death Differ 13:2042-51. 2006..Moreover, this is the first study to demonstrate that plasticity changes arise in primary mouse and human cells following reversine exposure...