Affiliation: University of Rome Tor Vergata
Monteleone I, Marafini I, Zorzi F, Di Fusco D, Dinallo V, Rizzo A, et al
. Smad7 Knockdown Restores Aryl Hydrocarbon Receptor-mediated Protective Signals in the Gut. J Crohns Colitis. 2016;10:670-7 pubmed publisher
..The inverse correlation between Smad7 and AhR expression helps to propagate inflammatory signals in the gut. ..
Monteleone I, Marafini I, Dinallo V, Di Fusco D, Troncone E, Zorzi F, et al
. Sodium chloride-enriched Diet Enhanced Inflammatory Cytokine Production and Exacerbated Experimental Colitis in Mice. J Crohns Colitis. 2017;11:237-245 pubmed publisher
..Our data indicated that exposure of intestinal mononuclear cells to a high-NaCl diet enhanced effector cytokine production and contributed to the exacerbation of experimental colitis in mice. ..
Monteleone I, Rizzo A, Sarra M, Sica G, Sileri P, Biancone L, et al
. Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract. Gastroenterology. 2011;141:237-48, 248.e1 pubmed publisher
..AhR is down-regulated in intestinal tissue of patients with IBD; AhR signaling, via IL-22, inhibits inflammation and colitis in the gastrointestinal tract of mice. AhR-related compounds might be developed to treat patients with IBDs. ..