Lorenzo Montanaro

Summary

Affiliation: University of Bologna
Country: Italy

Publications

  1. ncbi Increased mortality rate and not impaired ribosomal biogenesis is responsible for proliferative defect in dyskeratosis congenita cell lines
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Bologna, Italy
    J Invest Dermatol 118:193-8. 2002
  2. pmc Enhanced telomere shortening in transformed lymphoblasts from patients with X linked dyskeratosis
    L Montanaro
    Universita degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Clin Pathol 56:583-6. 2003
  3. ncbi Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
  4. doi Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
  5. ncbi Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008
  6. doi Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
  7. ncbi DKC1 gene mutations in human sporadic cancer
    Marianna Penzo
    Department of Experimental Pathology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Histol Histopathol 28:365-72. 2013
  8. doi Ribosome biogenesis and control of cell proliferation: p53 is not alone
    Giulio Donati
    Department of Experimental Pathology, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    Cancer Res 72:1602-7. 2012
  9. doi What the nucleolus says to a tumour pathologist
    Massimo Derenzini
    Dipartimento di Scienze Cliniche Radiologiche e Istocitopatologiche, Universita di Bologna, Bologna, Italy
    Histopathology 54:753-62. 2009
  10. ncbi Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    J Pathol 222:345-9. 2010

Collaborators

Detail Information

Publications23

  1. ncbi Increased mortality rate and not impaired ribosomal biogenesis is responsible for proliferative defect in dyskeratosis congenita cell lines
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita degli Studi di Bologna, Bologna, Italy
    J Invest Dermatol 118:193-8. 2002
    ....
  2. pmc Enhanced telomere shortening in transformed lymphoblasts from patients with X linked dyskeratosis
    L Montanaro
    Universita degli Studi di Bologna, Dipartimento di Patologia Sperimentale, Via S Giacomo 14, 40126 Bologna, Italy
    J Clin Pathol 56:583-6. 2003
    ..This report aimed to verify whether this is caused by a defect in telomerase function...
  3. ncbi Novel dyskerin-mediated mechanism of p53 inactivation through defective mRNA translation
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126 Bologna, Italy
    Cancer Res 70:4767-77. 2010
    ..Our findings suggest that a dyskerin-mediated mechanism of p53 inactivation may occur in a subset of human tumors...
  4. doi Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure
    Massimo Derenzini
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    Clin Cancer Res 14:2199-209. 2008
    ....
  5. ncbi Relationship between dyskerin expression and telomerase activity in human breast cancer
    Lorenzo Montanaro
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Bologna, Italy
    Cell Oncol 30:483-90. 2008
    ..This should be taken into consideration when utilizing TERT expression as a surrogate indicator of telomerase activity in tumour pathology...
  6. doi Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation
    Giulio Donati
    Dipartimento di Patologia Sperimentale, Universita di Bologna, 40126 Bologna, Italy
    J Cell Sci 124:3017-28. 2011
    ....
  7. ncbi DKC1 gene mutations in human sporadic cancer
    Marianna Penzo
    Department of Experimental Pathology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    Histol Histopathol 28:365-72. 2013
    ..The present study aims to determine whether mutations of the DKC1 gene may also be present in frequent human sporadic cancers (breast, colon and lung cancers), thus potentially contributing to the neoplastic phenotype...
  8. doi Ribosome biogenesis and control of cell proliferation: p53 is not alone
    Giulio Donati
    Department of Experimental Pathology, Alma Mater Studiorum, Universita di Bologna, Bologna, Italy
    Cancer Res 72:1602-7. 2012
    ....
  9. doi What the nucleolus says to a tumour pathologist
    Massimo Derenzini
    Dipartimento di Scienze Cliniche Radiologiche e Istocitopatologiche, Universita di Bologna, Bologna, Italy
    Histopathology 54:753-62. 2009
    ..Indeed, a series of studies carried out on numerous human tumours has shown that nucleolar hypertrophy (prominent nucleolus) was an independent predictive and prognostic parameter of a fatal clinical outcome...
  10. ncbi Dyskerin and cancer: more than telomerase. The defect in mRNA translation helps in explaining how a proliferative defect leads to cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, Alma Mater Studiorum Universita di Bologna, Bologna, Italy
    J Pathol 222:345-9. 2010
    ..In addition, the current evidence pointing to a role played by dyskerin in tumours in the general population is also discussed...
  11. pmc Nucleolus, ribosomes, and cancer
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Bologna, Italy
    Am J Pathol 173:301-10. 2008
    ....
  12. ncbi Key role of the achievement of an appropriate ribosomal RNA complement for G1-S phase transition in H4-II-E-C3 rat hepatoma cells
    Massimo Derenzini
    Dipartimento di Patologia Sperimentale, Sezione di Patologia Clinica, Universita di Bologna, Bologna, Italia
    J Cell Physiol 202:483-91. 2005
    ..Our results indicated that the achievement of an appropriate amount of rRNA allows G1/S phase transition, probably by modulating the expression of cyclin E mRNA...
  13. ncbi Location of rRNA transcription to the nucleolar components: disappearance of the fibrillar centers in nucleoli of regenerating rat hepatocytes
    Lorenzo Montanaro
    Department of Experimental Pathology, University of Bologna, Via S Giacomo 14, 40126 Bologna, Italy
    Cell Struct Funct 36:49-56. 2011
    ....
  14. ncbi Nucleolar size and activity are related to pRb and p53 status in human breast cancer
    Davide Trere
    Department of Experimental Pathology, Unit of Clinical Pathology, University of Bologna, Bologna, Italy
    J Histochem Cytochem 52:1601-7. 2004
    ....
  15. ncbi The p53-mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein
    Massimo Derenzini
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy
    J Pathol 219:373-82. 2009
    ....
  16. ncbi Healthy early preantral follicle can be obtained in a culture of frozen-thawed human ovarian tissue of 32 weeks
    Raffaella Fabbri
    Human Reproduction Medicine Unit, S Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
    Ultrastruct Pathol 31:257-62. 2007
    ..The synergy in action of NAC and FSH plays an important role in follicle growth of ovarian tissue cultures. For the first time a well-preserved preantral follicle was found in a culture of frozen-thawed human ovarian tissue...
  17. ncbi Targeted inhibition of NMYC by peptide nucleic acid in N-myc amplified human neuroblastoma cells: cell-cycle inhibition with induction of neuronal cell differentiation and apoptosis
    Andrea Pession
    Department of Pediatrics, University of Bologna, S Orsola Hospital, I 40138 Bologna, Italy
    Int J Oncol 24:265-72. 2004
    ..Selectivity of the PNA was demonstrated by altering three point mutations. These findings should encourage development of a PNA-based tumor-specific agent for neuroblastoma (or other neoplasms) with N-myc overexpression...
  18. ncbi Evaluation of thymidylate synthase protein expression by Western blotting and immunohistochemistry on human colon carcinoma xenografts in nude mice
    Massimo Derenzini
    Department of Experimental Pathology, University of Bologna, Italy
    J Histochem Cytochem 50:1633-40. 2002
    ....
  19. pmc The nucleolar size is associated to the methylation status of ribosomal DNA in breast carcinomas
    Maria Giulia Bacalini
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
    BMC Cancer 14:361. 2014
    ..In this study we analyzed the methylation profiles of the rDNA promoter and of the 5' regions of 18S and 28S in breast cancer...
  20. doi 5'-Untranslated region of heat shock protein 70 mRNA drives translation under hypertonic conditions
    Laura Rocchi
    Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy
    Biochem Biophys Res Commun 431:321-5. 2013
    ..The described mechanism may also play a role in the control of translation of other messengers encoding for proteins involved in the adaptation to hypertonicity...
  21. ncbi Inhibition of human dyskerin as a new approach to target ribosome biogenesis
    Laura Rocchi
    Department of Experimental, Diagnostic and Specialty Medicine, Alma Mater Studiorum, University of Bologna, Bologna, Italy Surgical Pathology Unit, University Hospital of Parma, Parma, Italy
    PLoS ONE 9:e101971. 2014
    ..Therefore, the presented results, obtained through the usage of computational tools and experimental validation, indicate an alternative therapeutic strategy to target ribosome biogenesis pathway. ..
  22. doi Carnitine-acyltransferase system inhibition, cancer cell death, and prevention of myc-induced lymphomagenesis
    Annalisa Pacilli
    Dipartimento di Patologia Sperimentale, Universita di Bologna, Via San Giacomo 14, 40126, Bologna, Italy
    J Natl Cancer Inst 105:489-98. 2013
    ..We investigated the therapeutic potential of ST1326, an inhibitor of carnitine-palmitoyl transferase 1A (CPT1A), the rate-limiting enzyme for fatty acid (FA) import into mitochondria...
  23. ncbi Initiation of mRNA translation in oncogenesis: the role of eIF4E
    Lorenzo Montanaro
    Cancer Biology and Genetics Program, Department of Pathology, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New, York 10021, USA
    Cell Cycle 3:1387-9. 2004
    ....