Adriano Mollica

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. doi request reprint Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies
    Adriano Mollica
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Bioorg Med Chem 23:5311-8. 2015
  2. ncbi request reprint New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Protein Pept Lett 22:696-711. 2015
  3. doi request reprint DPP-4 inhibitors: a patent review (2012 - 2014)
    Roberto Costante
    Università di Chieti Pescara G d Annunzio, Dipartimento di Farmacia, Via dei Vestini 31, 66100, Chieti, Italy 08713554476 08713554476
    Expert Opin Ther Pat 25:209-36. 2015
  4. doi request reprint Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines
    Adriano Mollica
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy Electronic address
    Fitoterapia 98:91-7. 2014
  5. doi request reprint Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation
    Adriano Mollica
    Dipartimento di Farmacia, Università degli Studi G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Eur J Med Chem 68:167-77. 2013
  6. ncbi request reprint Strategies for developing tuberculosis vaccines: emerging approaches
    Adriano Mollica
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Curr Drug Targets 14:938-51. 2013
  7. doi request reprint Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    J Pept Sci 19:233-9. 2013
  8. doi request reprint The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 55:3027-35. 2012
  9. doi request reprint cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 55:8477-82. 2012
  10. ncbi request reprint (Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM
    Adriano Mollica
    Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Chieti Pescara G D Annunzio, Chieti, Italy
    Protein Pept Lett 19:1245-9. 2012

Collaborators

Detail Information

Publications33

  1. doi request reprint Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies
    Adriano Mollica
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Bioorg Med Chem 23:5311-8. 2015
    ....
  2. ncbi request reprint New Insight on the Synthesis of Neurotoxins Domoic Acid and Kainic Acid
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Protein Pept Lett 22:696-711. 2015
    ..We focused our attention on domoic acid and kainic acid and we report here a concise and up to date review on their stereoselective and asymmetric syntheses. ..
  3. doi request reprint DPP-4 inhibitors: a patent review (2012 - 2014)
    Roberto Costante
    Università di Chieti Pescara G d Annunzio, Dipartimento di Farmacia, Via dei Vestini 31, 66100, Chieti, Italy 08713554476 08713554476
    Expert Opin Ther Pat 25:209-36. 2015
    ..Therefore, DPP-4 inhibitors are considered as one of the well-established therapies available for type 2 diabetes mellitus...
  4. doi request reprint Synthesis and anti-cancer activity of naturally occurring 2,5-diketopiperazines
    Adriano Mollica
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti Scalo CH, Italy Electronic address
    Fitoterapia 98:91-7. 2014
    ..A comparative study with the non-geranylated saturated derivative of (11) revealed the importance of the presence of the geranyloxy side chain and the exocyclic 2,5-DPK double bond moiety for the observed activity...
  5. doi request reprint Hybrid peptides endomorphin-2/DAMGO: design, synthesis and biological evaluation
    Adriano Mollica
    Dipartimento di Farmacia, Università degli Studi G d Annunzio di Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Eur J Med Chem 68:167-77. 2013
    ..Double N-methylation on both Phe residues and C-terminal ethanolamide led to analogue 6e, which possesses a good in vitro μ affinity (Kiμ=34 nM), combined with a remarkable in vivo antinociceptive activity...
  6. ncbi request reprint Strategies for developing tuberculosis vaccines: emerging approaches
    Adriano Mollica
    Department of Pharmacy, University G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Curr Drug Targets 14:938-51. 2013
    ..There is a greater need therefore to develop adjuvant/carrier systems to increase the immunogenicity of these newer vaccine candidates. ..
  7. doi request reprint Antinociceptive profile of potent opioid peptide AM94, a fluorinated analogue of biphalin with non-hydrazine linker
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    J Pept Sci 19:233-9. 2013
    ..Conformational properties of biphalin and AM94 were also investigated by variable-temperature (1)H NMR and energy minimization...
  8. doi request reprint The cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 55:3027-35. 2012
    ..4% at 1 μM; for linear tetrapeptide acid 13: K(i)(μ) = 2000 nM; GPI (IC(50)) = 0% at 1 μM; for linear tetrapeptide amide 15: K(i)(μ) = 310 nM; GPI (IC(50)) = 894 nM)...
  9. doi request reprint cis-4-amino-L-proline residue as a scaffold for the synthesis of cyclic and linear endomorphin-2 analogues: part 2
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 55:8477-82. 2012
    ..g., 9a, k(i)(μ) = 63 nm, gpi (ic(50)) = 480 nm; 9b, k(i)(μ) = 38 nm, gpi (ic(50)) = 330 nm...
  10. ncbi request reprint (Acyloxy)alkoxy moiety as amino acids protecting group for the synthesis of (R,R)-2,7 diaminosuberic acid via RCM
    Adriano Mollica
    Faculty of Pharmacy, Department of Pharmaceutical Sciences, University of Chieti Pescara G D Annunzio, Chieti, Italy
    Protein Pept Lett 19:1245-9. 2012
    ....
  11. ncbi request reprint Role of formyl peptide receptors (FPR) in abnormal inflammation responses involved in neurodegenerative diseases
    Adriano Mollica
    University G d Annunzio of Chieti Pescara, Faculty of Pharmacy Dipartimento di Scienze del Farmaco, Via dei Vestini, 31, 66100 Chieti, Italy
    Antiinflamm Antiallergy Agents Med Chem 11:20-36. 2012
    ..Recent results demonstrate that targeting of inflammatory glia cytokine pathways, can suppress Aβ-induced neuroinflammation in vivo, resulting in the attenuation of neuronal damage...
  12. doi request reprint Synthesis and bioactivity of secondary metabolites from marine sponges containing dibrominated indolic systems
    Adriano Mollica
    Via dei Vestini 31, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University G d Annunzio of Chieti Pescara, Chieti 66100, Italy
    Molecules 17:6083-99. 2012
    ....
  13. doi request reprint Synthesis and biological evaluation of new active For-Met-Leu-Phe-OMe analogues containing para-substituted Phe residues
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Pept Sci 18:418-26. 2012
    ..The influence of the different substitution at the position 4 on the aromatic ring of phenylalanine is discussed...
  14. ncbi request reprint Delivery methods of camptothecin and its hydrosoluble analogue irinotecan for treatment of colorectal cancer
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Curr Drug Deliv 9:122-31. 2012
    ..The aim of this work is to review the state of the art of camptothecin and its derivative irinotecan's delivery methods...
  15. doi request reprint New potent biphalin analogues containing p-fluoro-L-phenylalanine at the 4,4' positions and non-hydrazine linkers
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, Chieti, Italy
    Amino Acids 40:1503-11. 2011
    ..Binding values are: Kμ(i)=0.51 nM and Kδ(i)=12.8 nM for compound 9, Kμ(i)=0.09 nM and Kδ(i)=0.11 nM for analogue 10...
  16. ncbi request reprint N-(tert)-butyloxycarbonyl)-beta,beta-cyclopentyl-cysteine (acetamidomethyl)-methyl ester for synthesis of novel peptidomimetic derivatives
    Adriano Mollica
    Dipartimento di Scienze del Farmaco, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Protein Pept Lett 17:925-9. 2010
    ....
  17. pmc Synthesis of stable and potent delta/mu opioid peptides: analogues of H-Tyr-c[D-Cys-Gly-Phe-D-Cys]-OH by ring-closing metathesis
    Adriano Mollica
    Universita degli Studi G D Annunzio, Via dei Vestini 31, I 66013 Chieti, Italy
    J Med Chem 50:3138-42. 2007
    ..All the cyclic products containing a olefinic bond are slightly selective but highly active and potent for the delta and mu opioid receptors. Activity toward the kappa opioid receptors was absent or very low...
  18. pmc Biological active analogues of the opioid peptide biphalin: mixed α/β(3)-peptides
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    J Med Chem 56:3419-23. 2013
    ..The derivative 1 containing hβ(3) Phe in place of Phe showed good μ- and δ-receptor affinities (Ki(δ) = 0.72 nM; Ki(μ) = 1.1 nM) and antinociceptive activity in vivo together with an increased enzymatic stability in human plasma...
  19. doi request reprint CNS delivery of L-dopa by a new hybrid glutathione-methionine peptidomimetic prodrug
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Amino Acids 42:261-9. 2012
    ..These results are of significance for prospective therapeutic application of prodrug 1 in pathological events associated with free radical damage and decreasing DA concentration in the brain...
  20. ncbi request reprint Structure-activity relationships of biphalin analogs and their biological evaluation on opioid receptors
    Federica Feliciani
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    Mini Rev Med Chem 13:11-33. 2013
    ....
  21. doi request reprint Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Via dei Vestini 31, 66100, Chieti, Italy
    Chem Biol Drug Des 86:156-62. 2015
    ..Antinociceptive activity evaluated in vitro and in vivo revealed differential affinity for CaV 2.2 and opioid receptors and no significant synergistic activity. ..
  22. doi request reprint Recent application of analytical methods to phase I and phase II drugs development: a review
    Marcello Locatelli
    Dipartimento di Scienze del Farmaco, Università degli Studi G d Annunzio Chieti Pescara, Via dei Vestini 31, 66100, Chieti, Italy
    Biomed Chromatogr 26:283-300. 2012
    ..The aim of this review is to report the processes required for the validation of drug efficacy with reference to the description of 'classic' and modern techniques used...
  23. doi request reprint A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms
    Simone Carradori
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Bioorg Med Chem 24:1095-105. 2016
    ..A computational approach has been carried out to further rationalize the biological data and to characterize the binding mode of some of these inhibitors. ..
  24. doi request reprint New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies
    Simone Carradori
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy Electronic address
    Bioorg Med Chem 23:2975-81. 2015
    ....
  25. pmc Conformationally constrained histidines in the design of peptidomimetics: strategies for the χ-space control
    Azzurra Stefanucci
    Department of Pharmaceutical Sciences, University of Chieti Pescara G D Annunzio, Via dei Vestini 31, 66100 Chieti, Italy
    Int J Mol Sci 12:2853-90. 2011
    ..Examples of the use of the described analogues to replace native histidine in bioactive peptides are also given...
  26. doi request reprint Orexigenic effects of endomorphin-2 (EM-2) related to decreased CRH gene expression and increased dopamine and norepinephrine activity in the hypothalamus
    Luigi Brunetti
    Department of Pharmacy, G D Annunzio University, Via dei Vestini 31, 66013 Chieti, Italy Electronic address
    Peptides 48:83-8. 2013
    ..We can conclude that the orexigenic effect of μ-opioid receptor activation by EM-2 could be related to both inhibition of CRH and stimulation of dopamine and norepinephrine levels, in the hypothalamus...
  27. pmc Recent advances in the treatment of neurodegenerative diseases based on GSH delivery systems
    Ivana Cacciatore
    Department of Drug Sciences, Faculty of Pharmacy, G D Annunzio University, Chieti, Italy
    Oxid Med Cell Longev 2012:240146. 2012
    ..Here, we discuss the beneficial properties of these approaches and their potential implications for the future treatment of patients suffering from neurodegenerative diseases, and more specifically from PD and AD...
  28. doi request reprint Ibuprofen and glutathione conjugate as a potential therapeutic agent for treating Alzheimer's disease
    Francesco Pinnen
    Dipartimento di Scienze del Farmaco, Universita G D Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 344:139-48. 2011
    ..c.v.) infusion of Aβ(1-40) in rats, and thus that codrug 1 could prove useful as a tool for controlling AD induced cerebral amyloid deposits and behavioral deterioration...
  29. doi request reprint Cyclotides: a natural combinatorial peptide library or a bioactive sequence player?
    Adriano Mollica
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    J Enzyme Inhib Med Chem 30:575-80. 2015
    ..For these reasons, cyclotides probably represent today a step further in the development of new tools in drug design. ..
  30. doi request reprint Potent biphalin analogs with µ/δ mixed opioid activity: in vivo and in vitro biological evaluation
    Roberto Costante
    Dipartimento di Farmacia, Università di Chieti Pescara G d Annunzio, Chieti, Italy
    Arch Pharm (Weinheim) 347:305-12. 2014
    ....
  31. doi request reprint The analgesic activity of biphalin and its analog AM 94 in rats
    Sheila Leone
    Department of Drug Sciences, G D Annunzio University, Via dei Vestini 31, 66013 Chieti, Italy
    Eur J Pharmacol 685:70-3. 2012
    ..Our data suggest that AM 94 could be regarded as a novel pharmacologically active opioid compound for eliciting potent and sustained analgesia after central and peripheral administration...
  32. doi request reprint Prodrug approach for increasing cellular glutathione levels
    Ivana Cacciatore
    Department of Drug Sciences, School of Pharmacy, G D Annunzio University, Via dei Vestini 31, 66100 Chieti, Italy
    Molecules 15:1242-64. 2010
    ..This review discusses different strategies for increasing GSH levels by supplying reversible bioconjugates able to cross the cellular membrane more easily than GSH and to provide a source of thiols for GSH synthesis...
  33. doi request reprint Nitric oxide donors and selective carbonic anhydrase inhibitors: a dual pharmacological approach for the treatment of glaucoma, cancer and osteoporosis
    Simone Carradori
    Department of Pharmacy, G D Annunzio University of Chieti Pescara, Via dei Vestini 31, 66100 Chieti, Italy
    Molecules 20:5667-79. 2015
    ..According to the encouraging results they could be proposed for the treatment of angle-open glaucoma, cancer regression and osteoporosis, in which both NO and CA activities are involved. ..