Research Topics
| A MohnSummaryAffiliation: University of Chieti Country: Italy Publications
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Detail Information
Publications
Treating diabetic retinopathy by tackling growth factor pathwaysFrancesco Chiarelli
Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
Curr Opin Investig Drugs 6:395-409. 2005..As the effects of GFs become better understood, pharmacological manipulation of GF synthesis and action will be useful in the early stages of vascular change with the potential to prevent diabetes-related visual loss...
Obese related effects of inflammatory markers and insulin resistance on increased carotid intima media thickness in pre-pubertal childrenCosimo Giannini
Department of Paediatrics, University of Chieti, Via dei Vestini 5, I 66100 Chieti, Italy
Atherosclerosis 197:448-56. 2008..In conclusion, early changes in glucose metabolism and an alteration of oxidant-antioxidant status may be present in obese pre-pubertal children; this could lead to increase IMT and early cardiovascular disease...
Serum levels of receptors for advanced glycation end products in normal-weight and obese children born small and large for gestational ageValentina Chiavaroli
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Care 35:1361-3. 2012....
Persistence of impaired pancreatic beta-cell function in children treated for acute lymphoblastic leukaemiaAngelika Mohn
Department of Paediatrics, University of Chieti, Via Dei Vestini 15, 66100, Chieti, Italy
Lancet 363:127-8. 2004..1, 7.2-153; p=0.02) were reduced in the children with impaired insulin response. Chemotherapy for acute lymphoblastic leukaemia is associated with beta-cell function damage, which persists even after therapy has been stopped...
A girl with persistent hyperferritinaemiaA Mohn
Department of Pediatrics, University of Chieti, Chieti, Italy
Lancet 365:1744. 2005
Increased oxidative stress in prepubertal children born small for gestational ageAngelika Mohn
Department of Pediatrics, University of Chieti, Via Dei Vestini 15, 66100 Chieti, Italy
J Clin Endocrinol Metab 92:1372-8. 2007..The development of insulin resistance (IR) seems to play a pivotal role; no data on the oxidant-antioxidant status are available in this risk group...
Increased oxidative stress in prepubertal severely obese children: effect of a dietary restriction-weight loss programAngelika Mohn
Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
J Clin Endocrinol Metab 90:2653-8. 2005..Altered oxidant-antioxidant status is already present in prepubertal severely obese children and is reversible with a dietary restriction-weight loss program, which should be highly encouraged and maintained over time in this age group...
Autosomal malignant osteopetrosis. From diagnosis to therapyA Mohn
Department of Paediatrics, University of Chieti, Chieti, Italy
Minerva Pediatr 56:115-8. 2004....
Influence of growth hormone therapy on pituitary and lumbar spine astrocytomas. A clinical observationAngelika Mohn
Department of Paediatrics, University of Chieti, Chieti, Italy
Horm Res 59:156-60. 2003..Substitution therapy with rGH requires further and longer studies before it can be recommended with absolute reassurance in children with subtotal resection of a pituitary astrocytoma...
Alterations in the oxidant-antioxidant status in prepubertal children with growth hormone deficiency: effect of growth hormone replacement therapyAngelika Mohn
Department of Paediatrics, University of Chieti, Italy
Clin Endocrinol (Oxf) 63:537-42. 2005..Furthermore, the effect of 12 months of conventional GH replacement (rGH) on oxidant-antioxidant status was evaluated in the GHD group only...
Hypophosphatasia in a child with widened anterior fontanelle: lessons learned from late diagnosis and incorrect treatmentAngelika Mohn
Department of Paediatrics, University Hospital of Chieti, Chieti, Italy
Acta Paediatr 100:e43-6. 2011..In fact, in rare bone-mineralizing disorders, this combined therapy might induce severe clinical complications...
An insulin-like growth factor-I receptor defect associated with short stature and impaired carbohydrate homeostasis in an Italian pedigreeA Mohn
Department of Pediatrics, University of Chieti, Chieti, Italy
Horm Res Paediatr 76:136-43. 2011..However, little is known about potential effects of mutations in the IGF1R on carbohydrate homeostasis...
Celiac disease in children and adolescents with type I diabetes: importance of hypoglycemiaA Mohn
Department of Paediatrics, University of Chieti, Italy
J Pediatr Gastroenterol Nutr 32:37-40. 2001..Symptomatic hypoglycemia is an unavoidable problem in the treatment of type I diabetes. Celiac disease is associated with malabsorption and may therefore represent an important risk factor...
Celiac disease--associated vertigo and nystagmusAngelika Mohn
Department of Paediatrics, University of Chieti, and General Paediatrician, Chieti, Italy
J Pediatr Gastroenterol Nutr 34:317-8. 2002
Euthyroid sick syndrome in children with Hodgkin diseaseA Mohn
Clinica Pediatrica, Universita di Chieti, Chieti, Italy
Pediatr Hematol Oncol 18:211-5. 2001..Thyroid function testing should be performed routinely at diagnosis and thereafter in children with Hodgkin disease to detect subtle abnormalities...
The effect of subclinical hypothyroidism on metabolic control in children and adolescents with Type 1 diabetes mellitusA Mohn
Department of Paediatrics, University of Chieti, Chieti, Italy
Diabet Med 19:70-3. 2002..A retrospective case control study was performed in order to explore the effect of subclinical hypothyroidism on metabolic control in Type 1 diabetes mellitus...
The potential role of insulin analogues in the treatment of children and adolescents with Type 1 diabetes mellitusA Mohn
Department of Paediatrics, University of Chieti, Italy
Diabetes Nutr Metab 14:349-57. 2001..Safety issues should also be carefully monitored when introducting analogues in long-term therapy...
Increased vascular endothelial growth factor serum concentrations may help to identify patients with onset of type 1 diabetes during childhood at risk for developing persistent microalbuminuriaF Santilli
Department of Medicine, Division of Pediatrics, University of Chieti, 66100 Chieti, Italy
J Clin Endocrinol Metab 86:3871-6. 2001..Persistently increased vascular endothelial growth factor serum levels may help to identify normotensive, normoalbuminuric patients with type 1 diabetes who are predisposed to develop persistent microalbuminuria later in life...
Increased carotid intima-media thickness in pre-pubertal children with constitutional leanness and severe obesity: the speculative role of insulin sensitivity, oxidant status, and chronic inflammationC Giannini
Departments of Pediatrics, Cardiology Clinical Pathology, University of Chieti, Via dei Vestini 5, I 66100 Chieti, Italy
Eur J Endocrinol 161:73-80. 2009....
Role of growth factors in the development of diabetic complicationsF Chiarelli
Department of Medicine, Division of Paediatrics, University of Chieti, Italy
Horm Res 53:53-67. 2000..Knowledge of the involvement of growth factors in diabetic microangiopathy opens the way to new therapeutic interventions aimed at blocking the deleterious actions of several growth factors...
Effects of high-dose vitamin E supplementation on oxidative stress and microalbuminuria in young adult patients with childhood onset type 1 diabetes mellitusC Giannini
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Metab Res Rev 23:539-46. 2007..The aim of this study was to evaluate the effects of high-dose vitamin E supplementation (1200 mg/day) on reducing both microalbuminuria (MA) and oxidative stress in patients with type 1 diabetes mellitus (T1DM) and persistent MA...
Physical exercise and diabetes during childhoodCosimo Giannini
Paediatrics Department, University of Chieti, Chieti, Italy
Acta Biomed 77:18-25. 2006..Thus, patients and health professionals have to know in details the physiological effect of physical exercise and its metabolic events in order sport to be healthy and enjoyable for all children, adolescents and young adults with T1DM...
Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuriaF Chiarelli
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Metab Res Rev 24:570-6. 2008..Soluble CD40 ligand (sCD40L) is supposed to be one of the most likely candidates for both retinopathy and nephropathy...
Macrovascular angiopathy in children and adolescents with type 1 diabetesCosimo Giannini
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Metab Res Rev 27:436-60. 2011..Furthermore, as vascular abnormalities begin as early as in childhood, potentially modifiable risk factors should be identified at an early stage of vascular disease development...
The importance of microalbuminuria as an indicator of incipient diabetic nephropathy: therapeutic implicationsF Chiarelli
Department of Paediatrics, University of Chieti, Italy
Ann Med 29:439-45. 1997..Screening programmes for microalbuminuria and early intervention can substantially modify the natural history of diabetic renal involvement and disease and possibly reduce the incidence of end-stage renal failure...
Macroangiopathy in adults and children with diabetes: risk factors (part 2)D Di Marzio
Department of Pediatrics, University of Chieti, Italy
Horm Metab Res 38:706-20. 2006....
Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implicationsA Verrotti
Department of Paediatrics, University of Chieti, Chieti, Italy
Obes Rev 12:e32-43. 2011....
Episodic spontaneous hypothermia potentially triggered by hyperinsulinemiaR Capanna
Department of Pediatrics, University of Chieti, Chieti, Italy
Horm Res 72:124-8. 2009..This case suggests hyperinsulinemia as a potential mechanism for episodic spontaneous hypothermia, probably mediated by an interaction between insulin and the serotoninergic system...
Screening for vascular complications in children and adolescents with type 1 diabetes mellitusF Chiarelli
Department of Pediatrics, University of Chieti, Italy
Horm Res 57:113-6. 2002..Early detection of diabetic microangiopathy and timely treatment of early signs of these complications have a pivotal role in prevention of blindness and end-stage renal failure in children and adolescents with diabetes...
Insulin resistance and oxidative stress in children born small and large for gestational ageValentina Chiavaroli
Department of Pediatrics, University of Chieti, Chieti, Italy
Pediatrics 124:695-702. 2009..Our aim was to evaluate the effect of BW and obesity on oxidative stress and IR in prepubertal SGA and LGA children compared with appropriate-for-gestational-age (AGA) children...
Serum angiogenin concentrations in young patients with diabetes mellitusF Chiarelli
Department of Medicine, Division of Pediatrics, University of Chieti, Italy
Eur J Clin Invest 32:110-4. 2002..Angiogenin serum levels were measured in a large group of type 1 diabetic young patients, looking at whether increased Angiogenin concentrations are associated with long-term glycemic control and microvascular complications...
The possible role of liver steatosis in defining metabolic syndrome in prepubertal childrenEbe D'Adamo
Department of Pediatrics, University of Chieti, Chieti, Italy
Metabolism 59:671-6. 2010..Therefore, screening for the MS should be performed in this age group; and hepatic steatosis should be considered as an additional diagnostic criterion...
Insulin sensitivity in prepubertal Caucasian normal weight childrenFabio G Masuccio
Department of Pediatrics, University of Chieti, Chieti, Italy
J Pediatr Endocrinol Metab 22:695-702. 2009..Determining whether or not a child is insulin resistant is becoming a matter of fundamental interest even in childhood, as the incidence of metabolic complications of insulin resistance is rising. Thus reference values are needed...
Survey on acute and chronic complications in children and adolescents with type 1 diabetes at Muhimbili National Hospital in Dar es Salaam, TanzaniaEdna S Majaliwa
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Care 30:2187-92. 2007..The purpose of this study was to assess glycemic control and complications of type 1 diabetes in children and adolescents in Tanzania...
Relationship between inflammatory markers, oxidant-antioxidant status and intima-media thickness in prepubertal children with juvenile idiopathic arthritisL Breda
Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100, Chieti, Italy
Clin Res Cardiol 102:63-71. 2013..To investigate the presence of possible early atherosclerotic changes in a group of prepubertal children with juvenile idiopathic arthritis (JIA) and to establish the potential beneficial effects of 1-year treatment...
Growth and puberty in children with HIV infectionE S Majaliwa
Department of Paediatrics, University of Chieti, 66100 Chieti, Italy
J Endocrinol Invest 32:85-90. 2009..Better understanding of the mechanisms leading to impairment of growth and puberty in children with perinatal HIV-1 infection might lead to appropriate treatment when required...
Levetiracetam monotherapy for childhood occipital epilepsy of gastautA Verrotti
Department of Paediatrics, University of Chieti, Chieti, Italy
Acta Neurol Scand 120:342-6. 2009..The aim of this open label pilot study was to evaluate the efficacy and tolerability of levetiracetam (LEV) as 'de novo' monotherapy in children and adolescents with late onset childhood occipital epilepsy-Gastaut type (COE-G)...
Type 2 diabetes mellitus in children and adolescentsM Marcovecchio
Department of Pediatrics, University of Chieti, Italy
J Endocrinol Invest 28:853-63. 2005..An appropriated intervention program must be started early, in order to prevent or retard the progression of the disease and associated comorbidities...
Kidney involvement and disease in patients with diabetesF Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
Panminerva Med 45:23-41. 2003....
New insights in diabetic autonomic neuropathy in children and adolescentsA Verrotti
Department of Paediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
Eur J Endocrinol 161:811-8. 2009..This article reviews recent developments in knowledge of epidemiology, pathogenesis, clinical symptoms, diagnosis, and therapy of DAN...
Angiopathy in children with diabetesF Chiarelli
Department of Paediatrics, University of Chieti, Chieti, Italy
Minerva Pediatr 54:187-201. 2002....
Circulating monocyte chemoattractant protein-1 and early development of nephropathy in type 1 diabetesFrancesco Chiarelli
Clinica Pediatrica, University of Chieti, Chieti, Italy Patologia Medica, University of Chieti, Chieti, Italy
Diabetes Care 25:1829-34. 2002..To investigate the possible role of hyperglycemia-dependent monocyte chemoattractant protein (MCP)-1 biosynthesis in the pathophysiology of early nephropathy in type 1 diabetes...
Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathyFrancesco Chiarelli
Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
Diabetes Care 28:1690-7. 2005..The objective of this study was to evaluate the effects of irbesartan, an angiotensin II receptor antagonist, on IAP in adolescents and young adults with type 1 diabetes and early signs of retinopathy and nephropathy...
Serum and urinary nitrites and nitrates and Doppler sonography in children with diabetesAlessandra Savino
Department of Pediatrics, University of Chieti, Chieti, Italy
Diabetes Care 29:2676-81. 2006....
Catamenial epilepsy: hormonal aspectsAlberto Verrotti
Department of Pediatrics, University of Chieti, Chieti, Italy
Gynecol Endocrinol 26:783-90. 2010..Also, variations in concentrations of antiepileptic drugs across the menstrual cycle may contribute to increased seizure susceptibility. A variety of approaches have been proposed for the treatment of catamenial epilepsy...
Bone and calcium metabolism and antiepileptic drugsAlberto Verrotti
Department of Pediatrics, University of Chieti, Italy
Clin Neurol Neurosurg 112:1-10. 2010..g., valproate) cannot be readily explained by vitamin D metabolism. In this article, the literature related to the effects of classic and new antiepileptic drugs on bone health and calcium metabolism is reviewed...
Growth, growth factors and diabetesFrancesco Chiarelli
Department of Pediatrics, University of Chieti, Italy
Eur J Endocrinol 151:U109-17. 2004....
Valproate-induced insulin resistance and obesity in childrenAlberto Verrotti
Department of Pediatrics, University of Chieti, Chieti, Italy
Horm Res 71:125-31. 2009..Among the side effects of VPA, weight gain is frequently reported, although the real incidence and magnitude of this problem is unknown. Its pathogenesis is most likely multifactorial, and is controversial...
Macroangiopathy in adults and children with diabetes: from molecular mechanisms to vascular damage (part 1)D Di Marzio
Department of Pediatrics, University of Chieti, Italy
Horm Metab Res 38:691-705. 2006..At the moment the best therapeutic strategy is to maintain metabolic control at a physiologic level and perform screening and early intervention for vascular complications...
Obesity-related renal injury in childhoodAlessandra Savino
Department of Pediatrics, University of Chieti, Chieti, Italy
Horm Res Paediatr 73:303-11. 2010..It is beyond the scope of this article to examine kidney disease as a component of syndromes that result in obesity in childhood...
Technology and the issue of cost/benefit in diabetesCosimo Giannini
Department of Pediatrics, University of Chieti, I 66100 Chieti, Italy
Diabetes Metab Res Rev 25:S34-44. 2009..Therefore, new technologically derived devices and therapeutic opportunity for diabetes should be rationally utilized in order to offer real advantages and reduce the relevant worldwide cost of diabetes...
Ambulatory blood pressure monitoring in obese children: role of insulin resistanceMaria L Marcovecchio
Department of Pediatrics, University of Chieti, Italy
J Hypertens 24:2431-6. 2006..This is of particular relevance because blood pressure tracks from childhood into adulthood and an already early-life high blood pressure is associated with an increased cardiovascular risk...
Role of ultrasonography in the diagnosis and follow-up of pediatric eosinophilic gastroenteritis: a case report and review of the literatureA Savino
Department of Pediatrics, University of Chieti, Chieti, Italy
Ultraschall Med 32:E57-62. 2011..Ultrasonography can also be easily used in the follow-up of these patients, and may obviate the frequent and potentially dangerous exposure to radiation...
Family history of premature cardiovascular disease as a sole and independent risk factor for increased carotid intima-media thicknessTommaso de Giorgis
Department of Pediatrics, University of Chieti, Chieti, Italy
J Hypertens 27:822-8. 2009....
Endothelial dysfunction in children with type 1 diabetes mellitusMariapina Pomilio
Clinica Pediatrica, University of Chieti, Italy
J Pediatr Endocrinol Metab 15:343-61. 2002..Complete understanding of the pathophysiology of endothelial dysfunction may lead to timely therapeutic intervention to prevent its development and to slow the progression of diabetic complications...
Role of physical exercise in children and adolescents with diabetes mellitusCosimo Giannini
Department of Pediatrics, University of Chieti, Italy
J Pediatr Endocrinol Metab 20:173-84. 2007..Appropriate education may allow a proper and correct approach to physical exercise...
Telomere length and obesityRaffaella Zannolli
Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
Acta Paediatr 97:952-4. 2008..To assess the telomere length in apparently healthy obese and normal-weight subjects...
Levetiracetam in absence epilepsyAlberto Verrotti
Department of Paediatrics, University of Chieti, Chieti, Italy
Dev Med Child Neurol 50:850-3. 2008..Prospective, large, long-term double-blind studies are needed to confirm these findings...
GNRH analog therapy in girls with early puberty is associated with the achievement of predicted final height but also with increased risk of polycystic ovary syndromeValentina Chiavaroli
Departments of Pediatrics Obstetrics and Gynecology University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
Eur J Endocrinol 163:55-62. 2010..Women with PCOS are at increased risk of cardiometabolic dysfunctions and infertility. Our aim was to assess GNRHa effectiveness on reaching adult stature and the risk of PCOS in girls with early puberty...
Is homeostasis model assessment better than the quantitative insulin-sensitivity check index and fasting glucose/insulin ratio?Angelika Mohn
Pediatrics 116:515; author reply 515-6. 2005
Insulin analoguesAngelika Mohn
N Engl J Med 352:1822-4; author reply 1822-4. 2005
Long-term follow-up of children treated for acute lymphoblastic leukemia and the recovery of beta-cell functionAngelika Mohn
Haematologica 91:1424-5. 2006..Our results show that although alterations of the glucose metabolism persists after stop-therapy they are reversible with time...
[Aspect of body image in physically disabled youth]Annette Boeger
, Fachbereich 2, , 45117 Essen
Prax Kinderpsychol Kinderpsychiatr 51:165-77. 2002..The results of the study underline the importance of body-associated psychotherapeutic intervention supplementing the many therapeutic measures of handicapped adolescence...
Validity of HOMA-IR as index of insulin resistance in obesityAngelika Mohn
J Pediatr 148:565-6; author reply 566. 2006
