Research Topics
Species | D ModianoSummaryAffiliation: University of Rome La Sapienza Country: Italy Publications
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Detail Information
Publications
Distribution of human CYP2C8*2 allele in three different African populationsGiacomo M Paganotti
Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
Malar J 11:125. 2012..CYP2C8 enzyme is involved in the metabolism of the anti-malarials amodiaquine and chloroquine. The presence of the CYP2C8*2 defective allele has been recently associated to higher rate of chloroquine-resistant malaria parasites...- Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina FasoGuillaume S Sanou
Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
BMC Res Notes 5:76. 2012..abstract:.. - Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical AfricaCinzia Rizzo
Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
Malar J 10:206. 2011..gambiae species complex whereas the A. funestus homologue, fSG6, is more divergent (80% identity with gSG6). The aim of this study was to evaluate cross-reactivity of human sera to gSG6 and fSG6... - Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infectionV D Mangano
Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita di Roma La Sapienza, Rome, Italy
Genes Immun 9:122-9. 2008..02). These findings provide the first evidence of the involvement in malaria susceptibility of a specific locus within the 5q31 region, previously shown to be linked with P. falciparum infection levels... 
The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genesD Modiano
Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
Trans R Soc Trop Med Hyg 95:149-52. 2001....- Haemoglobin C protects against clinical Plasmodium falciparum malariaD Modiano
Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, University of Rome La Sapienza, 00185, Rome, Italy
Nature 414:305-8. 2001.... - Genetic epidemiology of susceptibility to malaria: not only academic exercisesF Verra
Malaria Epidemiology Group, Department of Public Health Sciences, University of Rome La Sapienza, Italy
Parassitologia 50:147-50. 2008.... - Haemoglobin C and S in natural selection against Plasmodium falciparum malaria: a plethora or a single shared adaptive mechanism?F Verra
Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita degli Studi di Roma La Sapienza, Roma, Italy
Parassitologia 49:209-13. 2007..Thus, these findings suggest that both HbC and HbS affect the early development of naturally acquired immunity against malaria. We reviewed the hypothesized mechanisms so far proposed in light of these recent results... - Differential structuring of human populations for homologous X and Y microsatellite lociR Scozzari
Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
Am J Hum Genet 61:719-33. 1997..Possible factors involved in this differential structuring for homologous X and Y microsatellite polymorphisms are discussed... - Antimalarial antibody levels and IL4 polymorphism in the Fulani of West AfricaG Luoni
Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
Genes Immun 2:411-4. 2001..These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting... - Different response to Plasmodium falciparum in west African sympatric ethnic groups: possible implications for malaria control strategiesD Modiano
Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
Parassitologia 41:193-7. 1999..These differences should be considered in the development of anti-malaria vaccines and in the evaluation and application of malaria control strategies... 
Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studiesF Verra
Department of Public Health, University of Rome La Sapienza, Rome, Italy
Parasite Immunol 31:234-53. 2009..Thus, we anticipate substantial advances in the interpretation and validation of the effects of genetic variation on malaria susceptibility, and thereby on molecular mechanisms of protective immune responses and pathogenesis...- Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populationsR Scozzari
Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185, Rome, Italy
Am J Hum Genet 65:829-46. 1999..Despite some correspondence between language affiliation and genetic similarity, geographic proximity seems to be a better predictor of genetic affinity... - Severe malaria in Burkina Faso: urban and rural environmentD Modiano
Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
Parassitologia 41:251-4. 1999..4 vs 14.8%, p < 0.000). Our data, in line with previous results obtained comparing rural areas characterized by different inoculation rates, show that the epidemiological context influences the clinical presentation of SM... - HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populationsD Modiano
Istituto di Parassitologia, W H O Collaborating Centre for Malaria Epidemiology, Universita di Roma La Sapienza, Rome, Italy
Tissue Antigens 57:128-37. 2001..555). Our study does not suggest the involvement of HLA I in the higher resistance to malaria of Fulani, and confirms a low, if any, Caucasoid component in their gene pool... - Control of epidemic malaria on the highlands of MadagascarM Albonico
Ministry of Foreign Affairs, Rome, Italy
Parassitologia 41:373-6. 1999..4% of these infections were imported cases from coastal endemic areas. The efficiency of the system in monitoring the trend of malaria morbidity and in the rapid detection and response to malaria epidemics is still being evaluated... - Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina FasoG M Paganotti
Institute of Infection and Immunology Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
Parasitology 132:607-14. 2006..Multiple-clone infections with more than 1 gametocyte genotype were equally prevalent among Fulani and Mossi. These differences can most probably be attributed to genetic differences in malaria susceptibility in the 2 ethnic groups... - Distinct interethnic differences in immunoglobulin G class/subclass and immunoglobulin M antibody responses to malaria antigens but not in immunoglobulin G responses to nonmalarial antigens in sympatric tribes living in West AfricaA Bolad
Department of Immunology, Wenner-Gren Institute, Stockholm University, S-10691 Stockholm, Sweden
Scand J Immunol 61:380-6. 2005..In conclusion, our results show that the Fulani in two different countries show higher levels of anti-malarial antibodies than sympatric tribes, and this appears not to be a reflection of a general hyper-reactivity in the Fulani... - [Epidemiology of malaria in a village of Sudanese savannah in Mali (Bancoumana). Anti-TRAP and anti-CS humoral immunity response]A Dolo
Département d épidémiologie des affections parasitaires, Faculte de Medecine, de pharmacie et d odonto stomalogie, BP 1805, Bamako, Mali
Bull Soc Pathol Exot 96:287-90. 2003..These findings suggest no clear evidence of the protective role of anti-TRAP antibodies in uncomplicated malaria, possibly due to the limited persistence of these antibodies under natural situations... - Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic markerV Giambra
Dipartamento Biologia E Calef, Universita di Roma Tor Vergata, Viale della Ricerca Scientifica, 00133 Rome, Italy
Ann Hum Genet 70:946-50. 2006..Analysis of molecular variance of the allele frequencies indicates that the HS1,2-A polymorphism can be considered as a reliable anthropogenetic marker... - Validity of Lot Quality Assurance Sampling to optimize falciparum malaria surveys in low-transmission areasL Rabarijaona
Pasteur Institute of Madagascar, University of Rome, Italy
Trans R Soc Trop Med Hyg 95:267-9. 2001..LQAS is an effective tool for rapid assessment of falciparum malaria prevalence when monitoring malaria transmission... - [Epidemiology of malaria in a village of Sudanese savannah area in Mali (Bancoumana). 2. Entomo-parasitological and clinical study ]A Dolo
Dép d épidémiologie des affections parasitaires, Faculte de Medecine, de pharmacie et d odonto stomalogie, BP 1805, Bamako, Mali
Bull Soc Pathol Exot 96:308-12. 2003..This reduction of parasitologic index between 1993 and 1994 may be related to an increase of anti-malarial drug use in the population. Our results show that malaria is hyperendemic in the village of Bancoumana...