D Modiano

Summary

Affiliation: University of Rome La Sapienza
Country: Italy

Publications

  1. pmc Distribution of human CYP2C8*2 allele in three different African populations
    Giacomo M Paganotti
    Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Malar J 11:125. 2012
  2. pmc Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso
    Guillaume S Sanou
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    BMC Res Notes 5:76. 2012
  3. pmc Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical Africa
    Cinzia Rizzo
    Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Malar J 10:206. 2011
  4. pmc Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
    V D Mangano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 9:122-9. 2008
  5. ncbi request reprint The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes
    D Modiano
    Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
    Trans R Soc Trop Med Hyg 95:149-52. 2001
  6. ncbi request reprint Haemoglobin C protects against clinical Plasmodium falciparum malaria
    D Modiano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, University of Rome La Sapienza, 00185, Rome, Italy
    Nature 414:305-8. 2001
  7. ncbi request reprint Genetic epidemiology of susceptibility to malaria: not only academic exercises
    F Verra
    Malaria Epidemiology Group, Department of Public Health Sciences, University of Rome La Sapienza, Italy
    Parassitologia 50:147-50. 2008
  8. ncbi request reprint Haemoglobin C and S in natural selection against Plasmodium falciparum malaria: a plethora or a single shared adaptive mechanism?
    F Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Parassitologia 49:209-13. 2007
  9. pmc Differential structuring of human populations for homologous X and Y microsatellite loci
    R Scozzari
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Am J Hum Genet 61:719-33. 1997
  10. ncbi request reprint Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
    G Luoni
    Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 2:411-4. 2001

Collaborators

Detail Information

Publications22

  1. pmc Distribution of human CYP2C8*2 allele in three different African populations
    Giacomo M Paganotti
    Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Malar J 11:125. 2012
    ..CYP2C8 enzyme is involved in the metabolism of the anti-malarials amodiaquine and chloroquine. The presence of the CYP2C8*2 defective allele has been recently associated to higher rate of chloroquine-resistant malaria parasites...
  2. pmc Haematological parameters, natural regulatory CD4 + CD25 + FOXP3+ T cells and γδ T cells among two sympatric ethnic groups having different susceptibility to malaria in Burkina Faso
    Guillaume S Sanou
    Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou, Burkina Faso
    BMC Res Notes 5:76. 2012
    ..abstract:..
  3. pmc Wide cross-reactivity between Anopheles gambiae and Anopheles funestus SG6 salivary proteins supports exploitation of gSG6 as a marker of human exposure to major malaria vectors in tropical Africa
    Cinzia Rizzo
    Department of Public Health and Infectious Diseases, Sapienza University, P le Aldo Moro 5, 00185 Rome, Italy
    Malar J 10:206. 2011
    ..gambiae species complex whereas the A. funestus homologue, fSG6, is more divergent (80% identity with gSG6). The aim of this study was to evaluate cross-reactivity of human sera to gSG6 and fSG6...
  4. pmc Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection
    V D Mangano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 9:122-9. 2008
    ..02). These findings provide the first evidence of the involvement in malaria susceptibility of a specific locus within the 5q31 region, previously shown to be linked with P. falciparum infection levels...
  5. ncbi request reprint The lower susceptibility to Plasmodium falciparum malaria of Fulani of Burkina Faso (west Africa) is associated with low frequencies of classic malaria-resistance genes
    D Modiano
    Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
    Trans R Soc Trop Med Hyg 95:149-52. 2001
    ....
  6. ncbi request reprint Haemoglobin C protects against clinical Plasmodium falciparum malaria
    D Modiano
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, WHO Collaborating Centre for Malaria Epidemiology and Control, University of Rome La Sapienza, 00185, Rome, Italy
    Nature 414:305-8. 2001
    ....
  7. ncbi request reprint Genetic epidemiology of susceptibility to malaria: not only academic exercises
    F Verra
    Malaria Epidemiology Group, Department of Public Health Sciences, University of Rome La Sapienza, Italy
    Parassitologia 50:147-50. 2008
    ....
  8. ncbi request reprint Haemoglobin C and S in natural selection against Plasmodium falciparum malaria: a plethora or a single shared adaptive mechanism?
    F Verra
    Dipartimento di Scienze di Sanità Pubblica, Sezione di Parassitologia, Universita degli Studi di Roma La Sapienza, Roma, Italy
    Parassitologia 49:209-13. 2007
    ..Thus, these findings suggest that both HbC and HbS affect the early development of naturally acquired immunity against malaria. We reviewed the hypothesized mechanisms so far proposed in light of these recent results...
  9. pmc Differential structuring of human populations for homologous X and Y microsatellite loci
    R Scozzari
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, Rome, Italy
    Am J Hum Genet 61:719-33. 1997
    ..Possible factors involved in this differential structuring for homologous X and Y microsatellite polymorphisms are discussed...
  10. ncbi request reprint Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa
    G Luoni
    Fondazione Pasteur Cenci Bolognetti, Universita di Roma La Sapienza, Rome, Italy
    Genes Immun 2:411-4. 2001
    ..These data highlight the possibility of combining inter- and intra-ethnic comparisons to characterize critical determinants of malarial immunity in a natural setting...
  11. ncbi request reprint Different response to Plasmodium falciparum in west African sympatric ethnic groups: possible implications for malaria control strategies
    D Modiano
    Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
    Parassitologia 41:193-7. 1999
    ..These differences should be considered in the development of anti-malaria vaccines and in the evaluation and application of malaria control strategies...
  12. doi request reprint Genetics of susceptibility to Plasmodium falciparum: from classical malaria resistance genes towards genome-wide association studies
    F Verra
    Department of Public Health, University of Rome La Sapienza, Rome, Italy
    Parasite Immunol 31:234-53. 2009
    ..Thus, we anticipate substantial advances in the interpretation and validation of the effects of genetic variation on malaria susceptibility, and thereby on molecular mechanisms of protective immune responses and pathogenesis...
  13. pmc Combined use of biallelic and microsatellite Y-chromosome polymorphisms to infer affinities among African populations
    R Scozzari
    Dipartimento di Genetica e Biologia Molecolare, Universita La Sapienza, 00185, Rome, Italy
    Am J Hum Genet 65:829-46. 1999
    ..Despite some correspondence between language affiliation and genetic similarity, geographic proximity seems to be a better predictor of genetic affinity...
  14. ncbi request reprint Severe malaria in Burkina Faso: urban and rural environment
    D Modiano
    Dipartimento di Biologia Molecolare, Cellulare e Animale, Universita di Camerino, Italy
    Parassitologia 41:251-4. 1999
    ..4 vs 14.8%, p < 0.000). Our data, in line with previous results obtained comparing rural areas characterized by different inoculation rates, show that the epidemiological context influences the clinical presentation of SM...
  15. ncbi request reprint HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations
    D Modiano
    Istituto di Parassitologia, W H O Collaborating Centre for Malaria Epidemiology, Universita di Roma La Sapienza, Rome, Italy
    Tissue Antigens 57:128-37. 2001
    ..555). Our study does not suggest the involvement of HLA I in the higher resistance to malaria of Fulani, and confirms a low, if any, Caucasoid component in their gene pool...
  16. ncbi request reprint Control of epidemic malaria on the highlands of Madagascar
    M Albonico
    Ministry of Foreign Affairs, Rome, Italy
    Parassitologia 41:373-6. 1999
    ..4% of these infections were imported cases from coastal endemic areas. The efficiency of the system in monitoring the trend of malaria morbidity and in the rapid detection and response to malaria epidemics is still being evaluated...
  17. ncbi request reprint Genetic complexity and gametocyte production of Plasmodium falciparum in Fulani and Mossi communities in Burkina Faso
    G M Paganotti
    Institute of Infection and Immunology Research, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JT, UK
    Parasitology 132:607-14. 2006
    ..Multiple-clone infections with more than 1 gametocyte genotype were equally prevalent among Fulani and Mossi. These differences can most probably be attributed to genetic differences in malaria susceptibility in the 2 ethnic groups...
  18. ncbi request reprint Distinct interethnic differences in immunoglobulin G class/subclass and immunoglobulin M antibody responses to malaria antigens but not in immunoglobulin G responses to nonmalarial antigens in sympatric tribes living in West Africa
    A Bolad
    Department of Immunology, Wenner Gren Institute, Stockholm University, S 10691 Stockholm, Sweden
    Scand J Immunol 61:380-6. 2005
    ..In conclusion, our results show that the Fulani in two different countries show higher levels of anti-malarial antibodies than sympatric tribes, and this appears not to be a reflection of a general hyper-reactivity in the Fulani...
  19. ncbi request reprint [Epidemiology of malaria in a village of Sudanese savannah in Mali (Bancoumana). Anti-TRAP and anti-CS humoral immunity response]
    A Dolo
    Département d épidémiologie des affections parasitaires, Faculte de Medecine, de pharmacie et d odonto stomalogie, BP 1805, Bamako, Mali
    Bull Soc Pathol Exot 96:287-90. 2003
    ..These findings suggest no clear evidence of the protective role of anti-TRAP antibodies in uncomplicated malaria, possibly due to the limited persistence of these antibodies under natural situations...
  20. ncbi request reprint Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic marker
    V Giambra
    Dipartamento Biologia E Calef, Universita di Roma Tor Vergata, Viale della Ricerca Scientifica, 00133 Rome, Italy
    Ann Hum Genet 70:946-50. 2006
    ..Analysis of molecular variance of the allele frequencies indicates that the HS1,2-A polymorphism can be considered as a reliable anthropogenetic marker...
  21. ncbi request reprint Validity of Lot Quality Assurance Sampling to optimize falciparum malaria surveys in low-transmission areas
    L Rabarijaona
    Pasteur Institute of Madagascar, University of Rome, Italy
    Trans R Soc Trop Med Hyg 95:267-9. 2001
    ..LQAS is an effective tool for rapid assessment of falciparum malaria prevalence when monitoring malaria transmission...
  22. ncbi request reprint [Epidemiology of malaria in a village of Sudanese savannah area in Mali (Bancoumana). 2. Entomo-parasitological and clinical study ]
    A Dolo
    Dép d épidémiologie des affections parasitaires, Faculte de Medecine, de pharmacie et d odonto stomalogie, BP 1805, Bamako, Mali
    Bull Soc Pathol Exot 96:308-12. 2003
    ..This reduction of parasitologic index between 1993 and 1994 may be related to an increase of anti-malarial drug use in the population. Our results show that malaria is hyperendemic in the village of Bancoumana...