Research Topics
Genomes and GenesSpecies | P MocarelliSummaryAffiliation: University of Milano-Bicocca Country: Italy Publications
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Detail Information
Publications
Genome-wide screening of copy number alterations and LOH events in renal cell carcinomas and integration with gene expression profileIngrid Cifola
Dept of Biomedical Sciences and Technologies and CISI, University of Milan, Milan, Italy
Mol Cancer 7:6. 2008....- Perinatal exposure to low doses of dioxin can permanently impair human semen qualityPaolo Mocarelli
University Department of Laboratory Medicine, Hospital of Desio, Monza Brianza, Italy
Environ Health Perspect 119:713-8. 2011..In recent decades, young men in some industrialized areas have reportedly experienced a decrease in semen quality... 
Paternal concentrations of dioxin and sex ratio of offspringP Mocarelli
Department of Laboratory Medicine, University Milano Bicocca, Hospital of Desio, Desio Milano, Italy
Lancet 355:1858-63. 2000..We have continued the study to determine whether the parents' sex and/or age at exposure affected the sex ratio of their children...- Dioxin exposure, from infancy through puberty, produces endocrine disruption and affects human semen qualityPaolo Mocarelli
University Department of Laboratory Medicine, Hospital of Desio, Milano, Italy
Environ Health Perspect 116:70-7. 2008..In 1976 an accident exposed residents in Seveso, Italy, to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)... - Heat shock proteins in human cancerC Sarto
University Department of Clinical Pathology, Desio Hospital, Desio Milan, Italy
Electrophoresis 21:1218-26. 2000..In this review, we mainly describe the relationship of hsp expression with human cancer, and discuss what is known about their post-translational modifications according to malignancies... - Time trends of major coronary risk factors in a northern Italian population (1986-1994). How remarkable are socioeconomic differences in an industrialized low CHD incidence country?M Ferrario
Research Centre for Chronic Degenerative Diseases and Department of Internal Medicine and Prevention and Health Biotechnology, University of Milan Bicocca, Milan, Italy
Int J Epidemiol 30:285-97. 2001..The goals are to estimate time trends (1986-1994) of major coronary risk factors in an industrialized low CHD incidence population and to assess education class (EC) differences in risk factor prevalence and in time trends... - Contribution of proteomics to the molecular analysis of renal cell carcinoma with an emphasis on manganese superoxide dismutaseC Sarto
University Department of Laboratory Medicine, University Milano Bicocca, Hospital of Desio, Desio Milano, Italy
Proteomics 1:1288-94. 2001..The expression of this protein has been evaluated in numerous human tumour types including RCC, and post-translational modifications are being investigated... - Serum dioxin concentrations and breast cancer risk in the Seveso Women's Health StudyMarcella Warner
School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 110:625-8. 2002..Individual serum TCDD is significantly related with breast cancer incidence among women in the SWHS cohort. Continued follow-up of the cohort will help shed light on the possible role of TCDD in the pathogenesis of breast cancer... - CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, ItalyMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Blvd, EPS, Bethesda, MD 20892 7236, USA
Toxicology 207:191-202. 2005..Genetic variation in cytochrome P450 induction may identify subjects with variable responsiveness to TCDD and potentially increased risk of disease... - Expanding the proteome two-dimensional gel electrophoresis reference map of human renal cortex by peptide mass fingerprintingFulvio Magni
Department of Experimental, Environmental Medicine and Medical Biotechnologies, University of Milano Bicocca, Monza, Italy
Proteomics 5:816-25. 2005..This more comprehensive view of the proteome of the human renal cortex could be of invaluable help to the differential proteomic display of urological diseases... - Characterization of heat shock protein 27 phosphorylation sites in renal cell carcinomaLucia Tremolada
Department of Experimental, Environmental Medicine and Medical Biotechnologies, University of Milano-Bicocca, Monza, Italy
Proteomics 5:788-95. 2005..Knowledge of the diversity and modulation of HSP27 phosphorylation protein species might represent useful markers involved in the differentiation of RCC... - Serum dioxin concentrations and age at menopauseBrenda Eskenazi
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
Environ Health Perspect 113:858-62. 2005..04). These results suggest a nonmonotonic dose-related association with increasing risk of earlier menopause up to about 100 ppt TCDD, but not above... - Primary cell cultures arising from normal kidney and renal cell carcinoma retain the proteomic profile of corresponding tissuesRoberto A Perego
Department of Experimental, Environmental Medicine and Medical Biotechnologies, Milano Bicocca University, Monza, Italy
J Proteome Res 4:1503-10. 2005.... - Serum dioxin concentrations and quality of ovarian function in women of SevesoMarcella Warner
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
Environ Health Perspect 115:336-40. 2007..On 10 July 1976, an explosion exposed residents of Seveso, Italy, to the highest levels of TCDD in a population. Twenty years later, we initiated the Seveso Women's Health Study to study reproductive health... - Serum dioxin concentrations and risk of uterine leiomyoma in the Seveso Women's Health StudyBrenda Eskenazi
Department of Epidemiology, School of Public Health, University of California, Berkeley, CA 94720 7380, USA
Am J Epidemiol 166:79-87. 2007..0 parts per trillion. This finding suggests that TCDD may have antiestrogenic effects in the uterine myometrium, in contrast to apparently estrogenic effects previously found in the breast of Seveso Women's Health Study women... 
AQP1 expression analysis in human diseases: implications for proteomic characterizationFulvio Magni
Department of Experimental Medicine, Faculty of Medicine, Via Cadore 48, 20052 Monza, Italy
Expert Rev Proteomics 5:29-43. 2008..Moreover, the relevance of AQP1 in human diseases is also explained. Its role in human tumors and, in particular, those of the kidney (e.g., clear cell renal carcinoma) is discussed...- Concentration and microsatellite status of plasma DNA for monitoring patients with renal carcinomaRoberto A Perego
Department of Experimental Medicine, School of Medicine, University of Milano Bicocca, Via Cadore 48, 20052 Monza MI, Italy
Eur J Cancer 44:1039-47. 2008..9%) at follow-up, and in 1 case preceded the recurrence of disease. Plasma DNA concentration combined with microsatellite LOH in plasma DNA may predict disease recurrence in RCC patients... - Dioxin-Like TEQ of women from the Seveso, Italy area by ID-HRGC/HRMS and CALUXMarcella Warner
School of Public Health, University of California at Berkeley, 94720, USA
J Expo Anal Environ Epidemiol 15:310-8. 2005..04, P=0.82). More validation of the CALUX bioassay with larger sample volume is needed before application as an exposure measure in large-scale epidemiologic studies of health effects of dioxin-like compounds... - Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch HandJoel E Michalek
Air Force Research Laboratory, Brooks Air Force Base, San Antonio, Texas 78235 5250, USA
J Expo Anal Environ Epidemiol 12:44-53. 2002..27 years followed by a slower rate after 3 years is consistent with the expected pattern in a two-compartment open model, with a distribution phase of rapid elimination followed by a slower elimination phase... - Serum dioxin concentrations and endometriosis: a cohort study in Seveso, ItalyBrenda Eskenazi
Center for Children s Environmental Health, School of Public Health, University of California at Berkeley, Berkeley, California 94720, USA
Environ Health Perspect 110:629-34. 2002..Unavoidable disease misclassification in a population-based study may have led to an underestimate of the true risk of endometriosis... - Serum dioxin concentrations and menstrual cycle characteristicsBrenda Eskenazi
School of Public Health, University of California at Berkeley, Berkeley, CA 94720 7360, USA
Am J Epidemiol 156:383-92. 2002..16 days, 95% CI: -0.08, 0.41). These results are consistent with effects of TCDD on ovarian function noted in some animal species and with greater sensitivity to TCDD during development... - Renal cell carcinoma: handling and treatmentCecilia Sarto
University Department of Laboratory Medicine Desio Hospital, Desio, Milan, Italy
Proteomics 2:1627-9. 2002..The mechanical dissection and cell separation by magnetic beads coated with anti-Ber and EP4 antibodies to minimize the contamination of nonepithelial cells are described... - Immunologic effects of dioxin: new results from Seveso and comparison with other studiesAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland 20892, USA
Environ Health Perspect 110:1169-73. 2002..The possible long-term immunologic effects of TCDD exhibited by the participants of the present study, coupled with the increased incidence of lymphatic tumors in the area of the accident, warrant further investigation... - TCDD-mediated alterations in the AhR-dependent pathway in Seveso, Italy, 20 years after the accidentMaria Teresa Landi
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD 20892 7236, USA
Carcinogenesis 24:673-80. 2003.... - Maternal serum dioxin levels and birth outcomes in women of Seveso, ItalyBrenda Eskenazi
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7360, USA
Environ Health Perspect 111:947-53. 2003..It remains possible that the effects of TCDD on birth outcomes are yet to be observed, because the most heavily exposed women in Seveso were the youngest and the least likely to have yet had a pregnancy... - Developmental dental aberrations after the dioxin accident in SevesoSatu Alaluusua
Department of Pedodontics and Orthodontics, Institute of Dentistry, University of Helsinki, Helsinki, Finland
Environ Health Perspect 112:1313-8. 2004..The results support our hypothesis that dioxins can interfere with human organogenesis... - Relationship of serum TCDD concentrations and age at exposure of female residents of Seveso, ItalyBrenda Eskenazi
School of Public Health, University of California at Berkeley, 2150 Shattuck Avenue, Berkeley, CA 94720 7380, USA
Environ Health Perspect 112:22-7. 2004..As a consequence, previous SWHS studies that considered only TCDD exposure may have underestimated health effects due to total TEQ concentrations... - Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohortLesa L Aylward
Exponent, Inc, 1800 Diagonal Road, Suite 355, Alexandria, VA 22314, USA
J Expo Anal Environ Epidemiol 15:51-65. 2005.... - Aryl-hydrocarbon receptor-dependent pathway and toxic effects of TCDD in humans: a population-based study in Seveso, ItalyAndrea Baccarelli
Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892 7236, USA
Toxicol Lett 149:287-93. 2004..Markers within the AhR pathway were correlated with one another. Our findings suggest the presence of long-term effects in the subjects exposed to TCDD after the Seveso accident... - Expression of heat shock protein 27 in human renal cell carcinomaCecilia Sarto
University Department of Laboratory Medicine, University Milano Bicocca, Hospital of Desio, Desio, Italy
Proteomics 4:2252-60. 2004.... - Serum dioxin concentrations and age at menarcheMarcella Warner
School of Public Health, University of California at Berkeley, Berkeley, California 94720 7380, USA
Environ Health Perspect 112:1289-92. 2004..Given that animal evidence suggests in utero exposure has the most significant effect on onset of puberty, continued follow-up of the offspring of the SWHS cohort is important... - Proteomic knowledge of human aquaporinsFulvio Magni
Department of Experimental, Environmental Medicine and Medical Biotechnologies, University of Milano-Bicocca, Monza, Italy
Proteomics 6:5637-49. 2006..Moreover, the clinical importance of the best studied aquaporin (AQP1) in human diseases is also provided... - Proteome profile of human urine with two-dimensional liquid phase fractionationMonica Soldi
University Department of Laboratory Medicine, Hospital of Desio-University of Milano-Bicocca, Desio, Italy
Proteomics 5:2641-7. 2005..In addition, this system also allows to separate particularly proteins with 40-9 kDa molecular weight... - Prognostic significance of the long pentraxin PTX3 in acute myocardial infarctionRoberto Latini
Mario Negri Institute for Pharmacological Research, Milan, Italy
Circulation 110:2349-54. 2004..The aim of this study was to assess the prognostic value of PTX3 in MI compared with the best-known and clinically relevant biological markers... - Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso childrenBrent D Kerger
Health Science Resource Integration, Tallahassee, Florida, USA
Environ Health Perspect 114:1596-602. 2006..Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents...