Clelia Miracco

Summary

Affiliation: University of Siena
Country: Italy

Publications

  1. ncbi request reprint In situ detection of telomeres by fluorescence in situ hybridization and telomerase activity in glioblastoma multiforme: correlation with p53 status, EGFR, c-myc, MIB1, and Topoisomerase IIalpha protein expression
    Clelia Miracco
    Dipartimento di Patologia Umana e Oncologia, Sezione di Anatomia Patologica, Policlinico Le Scotte, I 53100 Siena, Italy
    Int J Oncol 23:1529-35. 2003
  2. pmc Possible implication of local immune response in Darier's disease: an immunohistochemical characterization of lesional inflammatory infiltrate
    Clelia Miracco
    Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte 6, 53100 Siena, Italy
    Mediators Inflamm 2010:350304. 2010
  3. ncbi request reprint Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines
    Clelia Miracco
    Istituto di Anatomia e Istologia Patologica, Policlinico Le Scotte, Viale Bracci 6, I 53100 Siena, Italy
    Int J Oncol 23:213-20. 2003
  4. ncbi request reprint Lipomatous mixed tumour of the skin: a histological, immunohistochemical and ultrastructural study
    C Miracco
    Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy
    Br J Dermatol 146:899-903. 2002
  5. ncbi request reprint Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Br J Dermatol 146:399-408. 2002
  6. ncbi request reprint Benign lymphoepithelial lesion associated with squamous cell carcinoma of the skin: an immunohistochemical and molecular genetic study
    Clelia Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
    J Cutan Pathol 29:33-7. 2002
  7. ncbi request reprint Utility of tumour-infiltrating CD25+FOXP3+ regulatory T cell evaluation in predicting local recurrence in vertical growth phase cutaneous melanoma
    Clelia Miracco
    Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, Siena 53100, Italy
    Oncol Rep 18:1115-22. 2007
  8. ncbi request reprint Telomerase activity, Ki-67, cyclin D1 and A expression, and apoptosis in solitary fibrous tumors: additional features of a predictable course?
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Pathol Res Pract 197:475-81. 2001
  9. ncbi request reprint Cyclin D1, B and A expression and cell turnover in psoriatic skin lesions before and after cyclosporin treatment
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy
    Br J Dermatol 143:950-6. 2000
  10. ncbi request reprint Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    J Cutan Pathol 27:419-22. 2000

Detail Information

Publications76

  1. ncbi request reprint In situ detection of telomeres by fluorescence in situ hybridization and telomerase activity in glioblastoma multiforme: correlation with p53 status, EGFR, c-myc, MIB1, and Topoisomerase IIalpha protein expression
    Clelia Miracco
    Dipartimento di Patologia Umana e Oncologia, Sezione di Anatomia Patologica, Policlinico Le Scotte, I 53100 Siena, Italy
    Int J Oncol 23:1529-35. 2003
    ..05). Tumors overexpressing EGFR had a significantly shorter lifetime (p=0.0001). TeNo seems to be inversely correlated to tumor proliferation and lifetime in glioblastoma multiforme...
  2. pmc Possible implication of local immune response in Darier's disease: an immunohistochemical characterization of lesional inflammatory infiltrate
    Clelia Miracco
    Section of Pathological Anatomy, Department of Human Pathology and Oncology, University of Siena, Policlinico Santa Maria alle Scotte, Via delle Scotte 6, 53100 Siena, Italy
    Mediators Inflamm 2010:350304. 2010
    ....
  3. ncbi request reprint Evaluation of MDR1, LRP, MRP, and topoisomerase IIalpha gene mRNA transcripts before and after interferon-alpha, and correlation with the mRNA expression level of the telomerase subunits hTERT and TEP1 in five unselected human melanoma cell lines
    Clelia Miracco
    Istituto di Anatomia e Istologia Patologica, Policlinico Le Scotte, Viale Bracci 6, I 53100 Siena, Italy
    Int J Oncol 23:213-20. 2003
    ..IFN-alpha modulates differently MDR gene transcripts in human melanoma cell lines. Positive correlation between TEP1 and LRP also seems to identify them as common targets of IFN-alpha effects...
  4. ncbi request reprint Lipomatous mixed tumour of the skin: a histological, immunohistochemical and ultrastructural study
    C Miracco
    Institute of Pathological Anatomy and Histology, Policlinico Le Scotte, University of Siena, Viale Bracci 6, 53100 Siena, Italy
    Br J Dermatol 146:899-903. 2002
    ..Owing to this peculiarity, some authors have defined it as 'lipomatous pleomorphic adenoma'. We are not aware of previously reported similar lesions in the skin...
  5. ncbi request reprint Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Br J Dermatol 146:399-408. 2002
    ....
  6. ncbi request reprint Benign lymphoepithelial lesion associated with squamous cell carcinoma of the skin: an immunohistochemical and molecular genetic study
    Clelia Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Siena, Italy
    J Cutan Pathol 29:33-7. 2002
    ..Skin lesions similar to LEL have been described in lymphomas, and are caused by neoplastic lymphocytes which infiltrate adnexal structures. To date, BLEL have not widely been recognized in the skin...
  7. ncbi request reprint Utility of tumour-infiltrating CD25+FOXP3+ regulatory T cell evaluation in predicting local recurrence in vertical growth phase cutaneous melanoma
    Clelia Miracco
    Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, Siena 53100, Italy
    Oncol Rep 18:1115-22. 2007
    ..The analysis of a larger series of patients and correlation with other clinical parameters, such as distant metastases and/or patient survival, are mandatory for validating its use as a prognostic indicator...
  8. ncbi request reprint Telomerase activity, Ki-67, cyclin D1 and A expression, and apoptosis in solitary fibrous tumors: additional features of a predictable course?
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Pathol Res Pract 197:475-81. 2001
    ..We suggest that TA, Ki-67, cyclin expression, and AI be evaluated in SFTs as possible adjunctive pathological criteria of behavior...
  9. ncbi request reprint Cyclin D1, B and A expression and cell turnover in psoriatic skin lesions before and after cyclosporin treatment
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Via delle Scotte 6, 53100 Siena, Italy
    Br J Dermatol 143:950-6. 2000
    ..It is known that the cell cycle and cell proliferation are regulated by the sequential activation of cyclin-dependent kinase/cyclin complexes...
  10. ncbi request reprint Unusual second malignancies following radiation therapy: subcutaneous pleomorphic rhabdomyosarcoma and cutaneous melanoma. Two case reports
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    J Cutan Pathol 27:419-22. 2000
    ....
  11. ncbi request reprint Protein and mRNA expression of autophagy gene Beclin 1 in human brain tumours
    Clelia Miracco
    Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, I 53100 Siena, Italy
    Int J Oncol 30:429-36. 2007
    ..Further studies are needed to highlight Beclin 1 function in tumour suppression and/or in tumour survival through autophagy and other related programmed cell death processes in brain tumours...
  12. ncbi request reprint Macrophage migration inhibitory factor protein and mRNA expression in cutaneous melanocytic tumours
    Clelia Miracco
    Sezione di Anatomia Patologica, Dipartimento di Patologia Umana e Oncologia, Universita di Siena, 53100 Siena, Italy
    Int J Oncol 28:345-52. 2006
    ....
  13. doi request reprint Beclin 1 and LC3 autophagic gene expression in cutaneous melanocytic lesions
    Clelia Miracco
    Department of Human Pathology and Oncology, University of Siena, 53100 Siena, Italy
    Hum Pathol 41:503-12. 2010
    ..Our results, therefore, indicate that beclin 1 and LC3 II autophagic gene expression is altered also in melanocytic neoplasms...
  14. ncbi request reprint The prognostic role of Beclin 1 protein expression in high-grade gliomas
    Luigi Pirtoli
    Department of Human Pathology and Oncology, Section of Radiological Sciences, University of Siena, Italy
    Autophagy 5:930-6. 2009
    ..037). Furthermore, among patients showing a MGMT methylated gene, survival was significantly higher in cases with a higher BPCE score. BPCE score might be added to pathological evaluation of HGG for prognostic purposes...
  15. doi request reprint Objective follow-up of atypical melanocytic skin lesions: a retrospective study
    Pietro Rubegni
    Department of Clinical Medicine and Immunological Science, Policlinico Le Scotte, Siena, Italy
    Arch Dermatol Res 302:551-60. 2010
    ....
  16. doi request reprint Nucleolin protein expression in cutaneous melanocytic lesions
    Vasileios Mourmouras
    Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, Siena, Italy
    J Cutan Pathol 36:637-46. 2009
    ..There are only few studies on its tissue expression in human cancer and none in melanoma. We aimed at exploring this protein and its prognostic impact in cutaneous melanocytic lesions...
  17. doi request reprint Long-term survival and immunological parameters in metastatic melanoma patients who responded to ipilimumab 10 mg/kg within an expanded access programme
    Anna Maria Di Giacomo
    Division of Medical Oncology and Immunotherapy, Department of Oncology, Istituto Toscano Tumori, University Hospital of Siena, Strada delle Scotte 14, 53100 Siena, Italy
    Cancer Immunol Immunother 62:1021-8. 2013
    ..We provide preliminary data describing the correlation between immunological parameters and response/survival among patients with advanced melanoma who received ipilimumab 10 mg/kg in an expanded access programme...
  18. ncbi request reprint Hypohidrotic ectodermal dysplasia and intrathoracic neuroblastoma
    Sabrina Buoni
    Department of Pediatrics, Section of Pediatric Neurology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Pediatr Dermatol 24:267-71. 2007
    ..Although this new association could be a chance occurrence, its description may alert physicians to look for similar combinations and report these, as it may lead to better syndrome delineation, and patient care...
  19. doi request reprint New neurocutaneous syndrome with defect in cell trafficking and melanosome pathway: the future challenge
    Raffaella Zannolli
    Department of Pediatrics, Section of Pediatrics Neurology and Pediatrics Neuropsychiatric Unit, Azienda Ospedaliera Universitaria Senese, Policlinico Le Scotte, University of Siena, Viale Bracci, I 53100 Siena, Italy
    Brain Dev 30:461-8. 2008
    ..Case study of a CNS impairment lacking in presumptive cause; case presents with a clinical phenotype encompassing multiple differently expressed and combined symptoms, as well as a subtle skin defect...
  20. doi request reprint A single centre melanoma thickness trend (1985-2009) in relation to skin areas accessible and non-accessible to self-inspection
    Pietro Rubegni
    Department of Clinical Medicine and Immunological Sciences, Dermatology Section, University Hospital of Siena, Italy
    Australas J Dermatol 53:32-6. 2012
    ..The objective was to determine historical changes in thickness, melanoma proportions and anatomical site of presentation over a 25-year period in our Department...
  21. doi request reprint Inducible nitric oxide synthase expression in melanoma: implications in lymphangiogenesis
    Daniela Massi
    Department of Human Pathology and Oncology, University of Florence, Florence, Italy
    Mod Pathol 22:21-30. 2009
    ..Mechanistic studies are needed to address the possibility that inducible nitric oxide synthase controls lymphangiogenesis, dissemination and lymphatic borne metastases...
  22. ncbi request reprint Subcutaneous panniculitis lymphoma: erythema nodosum-like
    Massimiliano Risulo
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy
    Clin Lymphoma Myeloma 7:239-41. 2006
    ....
  23. doi request reprint Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases
    Anna Maria Di Giacomo
    Division of Medical Oncology and Immunotherapy, Istituto Toscano Tumori, University Hospital of Siena, Siena, Italy
    Cancer Immunol Immunother 58:1297-306. 2009
    ..Moreover, because the patterns of response to ipilimumab differ from chemotherapy, we need to understand how and when patients may respond to treatment so that appropriate clinical decisions can be made...
  24. doi request reprint Efficacy of cyclosporine A treatment in relapsing febrile lobular panniculitis associated with small vessel vasculitis
    Luca Cantarini
    Unit of Rheumatology, Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Policlinico Le Scotte, University of Siena, Viale Bracci 1, 53100, Siena, Italy
    Rheumatol Int 30:797-9. 2010
    ..The association with small vessel vasculitis has been rarely reported. We report here an unusual case of WCD associated with small vessels vasculitis also describing the efficacy of Cyclosporin A treatment...
  25. doi request reprint Ipilimumab experience in heavily pretreated patients with melanoma in an expanded access program at the University Hospital of Siena (Italy)
    Anna Maria Di Giacomo
    Medical Oncology and Immunotherapy, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 53100, Siena, Italy
    Cancer Immunol Immunother 60:467-77. 2011
    ..To evaluate the feasibility of ipilimumab treatment for metastatic melanoma outside the boundaries of clinical trials, in a setting similar to that of daily practice...
  26. doi request reprint Ipilimumab in pretreated patients with metastatic uveal melanoma: safety and clinical efficacy
    Riccardo Danielli
    Medical Oncology and Immunotherapy Unit, University Hospital of Siena, Istituto Toscano Tumori, Strada delle Scotte, 53100 Siena, Italy
    Cancer Immunol Immunother 61:41-8. 2012
    ..The results indicate UM is a potential indication for ipilimumab treatment that should be further investigated in clinical trials...
  27. doi request reprint Neuroradiological follow-up of the growth of papillary tumor of the pineal region: a case report
    Alfonso Cerase
    Unit of Neuroimaging and Neurointervention, Azienda Ospedaliera Universitaria Senese, Santa Maria alle Scotte General Hospital, Siena, Italy
    J Neurooncol 95:433-5. 2009
    ..854 x 10(-3) mm(2)/s. Treatment included surgery followed by irradiation. Three-month MRI follow-up did not show disease relapse...
  28. ncbi request reprint Focal cortical dysplasia type 1b as a cause of severe epilepsy with multiple independent spike foci
    Sabrina Buoni
    Department of Pediatrics, Section of Pediatric Neurology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Brain Dev 30:53-8. 2008
    ..1) Hidden FCD type 1b could represent a missing diagnosis in patients with SE-MISF in the absence of other causes for their seizures. (2) Complete callosotomy can be efficacious in patients with SE-MISF with hidden FCD type 1b...
  29. doi request reprint Pediatric sinonasal neuroendocrine carcinoma after treatment of retinoblastoma
    Alessandro Franchi
    Department of Human Pathology and Oncology, University of Florence, 50134 Florence, Italy
    Hum Pathol 40:750-5. 2009
    ..These tumors represent a peculiar subset of undifferentiated sinonasal neoplasms with extremely aggressive clinical behavior...
  30. ncbi request reprint Automated diagnosis of pigmented skin lesions
    Pietro Rubegni
    Department of Dermatology, University of Siena, Siena, Italy
    Int J Cancer 101:576-80. 2002
    ..In conclusion, the good diagnostic performance and high speed in reading and analyzing lesions (real time) of our method constitute an important step in the direction of automated diagnosis of pigmented skin lesions...
  31. doi request reprint Myelodysplasia presenting as thoracic spinal epidural extramedullary hematopoiesis: a rare treatable cause of spinal cord myelopathy
    Lucia Monti
    Unit NINT Neuroimaging and Neurointervention, Department of Neurological and Sensorial Sciences, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Viale Mario Bracci 16, 53100 Siena, Italy
    Skeletal Radiol 41:611-4. 2012
    ..Surgical spinal cord decompression resulted in complete clinical remission...
  32. ncbi request reprint Three-dimensional conformal radiotherapy, temozolomide chemotherapy, and high-dose fractionated stereotactic boost in a protocol-driven, postoperative treatment schedule for high-grade gliomas
    Luigi Pirtoli
    Section of Radiological Sciences, Department of Human Pathology and Oncology, University of Siena, Siena, Italy
    Tumori 95:329-37. 2009
    ..The survival results of a protocol-driven, postoperative treatment schedule are reported here to contribute to the discussion on this issue...
  33. ncbi request reprint Cutaneous metastases from adenocarcinoma of the rete testis
    Pietro Rubegni
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy
    J Cutan Pathol 33:181-4. 2006
    ..We discuss the differential diagnosis to this rare entity, which include metastatic adenocarcinoma, serous tumor of the testis, and mesothelioma of the tunica vaginalis...
  34. ncbi request reprint A nodule on a boy's back
    Giovambattista De Aloe
    University of Siena, Siena, Italy
    Arch Dermatol 143:417-22. 2007
  35. doi request reprint Use of donor bone marrow mesenchymal stem cells for treatment of skin allograft rejection in a preclinical rat model
    Paolo Sbano
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Siena, Italy
    Arch Dermatol Res 300:115-24. 2008
    ..Results of our study in a rat tissue transplantation model demonstrated a possible immunogenic role for donor (allogeneic) MSC, confirming the need of adequate preclinical experimentation before clinical use...
  36. ncbi request reprint Kabuki syndrome with trichrome vitiligo, ectodermal defect and hypogammaglobulinemia A and G
    Raffaella Zannolli
    Department of Pediatrics, Section of Neurology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Brain Dev 29:373-6. 2007
    ..Our report may provide important clues for understanding the pathogenesis of the KS...
  37. doi request reprint Telomere length and obesity
    Raffaella Zannolli
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Acta Paediatr 97:952-4. 2008
    ..To assess the telomere length in apparently healthy obese and normal-weight subjects...
  38. ncbi request reprint Development of a mouse model for the study of Toscana virus pathogenesis
    Maria Grazia Cusi
    Department of Molecular Biology, Virology Section, University of Siena, Policlinico Le Scotte, V le Bracci, Building V, 53100 Siena, Italy
    Virology 333:66-73. 2005
    ..c.- and i.c.-treated mice suggests their possible involvement in the diffusion of the infection. This animal model may be helpful for the development of prophylactic measures against TOSV infections...
  39. ncbi request reprint Primary cutaneous aspergillosis in an immunocompetent patient
    Clara Romano
    Institute of Dermatological Sciences, University of Siena, Siena, Italy
    Mycoses 46:56-9. 2003
    ..Diagnosis was based on histological and mycological examination. Systemic involvement was not found. Surgical excision led to clinical and mycological recovery, confirmed at follow-up 18 months later...
  40. ncbi request reprint An unusual case of tinea capitis due to Trichophyton soudanense
    Clara Romano
    Istituto di Scienze Dermatologiche, Universita degli Studi di Firenze, Italy
    Mycoses 46:64-6. 2003
    ..Diagnosis was based on culture. Genome study by single primer PCR fingerprinting was also performed. A younger sister, aged 10 months, was the healthy carrier of the mycete...
  41. ncbi request reprint Immunohistochemical study of subcutaneous phaeohyphomycoses
    C Romano
    Institute of Dermatological Sciences, Siena University, Italy
    Mycoses 45:368-72. 2002
    ..In four cases, intra-epidermal CD1a+ cell number was slightly lower than in control skin. CD68+ cells were not found in the epidermis...
  42. ncbi request reprint Different patterns of cell proliferation and death and oncogene expression in cutaneous malignant melanoma
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    J Cutan Pathol 25:244-51. 1998
    ..Bc12, c-myc, and p53 were not equally expressed nor equally related to tumor cell turnover in all CMs, suggesting their different influence on the various types and stages, and the role of other factors in CM growth control...
  43. doi request reprint A case of primary localized cutaneous infection due to Fusarium oxysporum
    C Romano
    Department of Clinical Medicine and Immunological Science, University of Siena, Siena, Italy
    Mycopathologia 170:39-46. 2010
    ..125). The patient had normal immune status and was successfully treated with surgical excision. Recovery was confirmed at follow-up 8 months later...
  44. ncbi request reprint 18q-syndrome and ectodermal dysplasia syndrome: description of a child and his family
    R Zannolli
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Am J Med Genet A 116:192-9. 2003
    ..Most of these abnormalities were not explained by the 18q- deletion. The family pedigree suggested the presence of a subtle involvement of ectodermal and/or mesodermal structures. Karyotypes of the other family members were normal...
  45. ncbi request reprint Vulvar Paget disease. Two cases with cytokeratin 7 and 20 expression
    R Bilenchi
    Department of Dermatology, University of Siena, Italy
    Minerva Ginecol 53:363-6. 2001
    ..This finding suggested the diagnosis of primitive vulvar Paget's disease, a relatively benign form, unlike the aggressive and rapidly progressive secondary vulvar Paget's disease...
  46. ncbi request reprint Conjunctival edema and alopecia of the external third of the eyebrows in a patient with Meige syndrome
    P Rubegni
    Department of Dermatology, University of Siena, Policlinico Le Scotte, I 53100 Siena, Italy
    Graefes Arch Clin Exp Ophthalmol 238:98-100. 2000
    ..To describe a patient with Meige syndrome in whom we observed the coexistence of hereditary lymphedema of the lower legs, conjunctival edema and alopecia of the lateral third of the eyebrows...
  47. ncbi request reprint Intimal-type primary sarcoma of the aorta. Report of a case with evidence of rhabdomyosarcomatous differentiation
    C Miracco
    Institute of Pathological Anatomy and Histology, University of Siena, Italy
    Virchows Arch 435:62-6. 1999
    ..Electron microscopy and the use of a more comprehensive panel of immunohistochemical markers should be applied in the histological classification of"intimal" sarcoma...
  48. ncbi request reprint Hypertelorism, ptosis, and myopia associated with drug-resistant epilepsy, mental delay, growth deficiency, ectodermal defects, and osteopenia
    R Zannolli
    Department of Pediatrics, Obstetrics and Reproductive Medicine, Section of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Am J Med Genet A 127:212-6. 2004
    ..The ectodermal defects were present in a very intriguing form, were difficult to diagnose, and did not conform to any classification or previous description...
  49. ncbi request reprint Malignant hypercalcemia in vulvar cancer
    R Bilenchi
    Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy
    Minerva Ginecol 57:569-74. 2005
    ..To our knowledge, this is the first documented case with high serum concentrations of PTHrP and immunohistochemical confirmation of PTHrP production by neoplastic cells...
  50. ncbi request reprint Cutaneous leishmaniasis: usefulness of PCR on paraffin-embedded skin biopsies as part of routine investigation
    G Tordini
    Clinic and Laboratory of Infectious Diseases, Department of Molecular Biology, Universita di Siena, Policlinico Santa Maria alle Scotte, 53100 Siena, Italy
    Ann Trop Med Parasitol 101:745-9. 2007
  51. doi request reprint Identification of cancer stem cells from human glioblastomas: growth and differentiation capabilities and CD133/prominin-1 expression
    Federica Gambelli
    Molecular Medicine Section, Department of Neuroscience and Center for Stem Cell Research, University of Siena, Siena, Italy
    Cell Biol Int 36:29-38. 2012
    ..In conclusion, CSCs from human primary GBMs show different phenotypes and variable levels of CD133 expression, but these parameters did not directly correlate with the tumorigenic potential...
  52. ncbi request reprint Evaluation of tumour-infiltrating CD4+CD25+FOXP3+ regulatory T cells in human cutaneous benign and atypical naevi, melanomas and melanoma metastases
    V Mourmouras
    Department of Human Pathology and Oncology, Section of Pathological Anatomy, University of Siena, Siena 53100, Italy
    Br J Dermatol 157:531-9. 2007
    ..CD4+CD25+FOXP3+ regulatory T cells (Tregs) are thought to induce immunotolerance in melanoma. They have not yet been investigated in the entire spectrum of melanocytic cutaneous lesions within a tumour site...
  53. ncbi request reprint Different effects of interferon-alpha on melanoma cell lines: a study on telomerase reverse transcriptase, telomerase activity and apoptosis
    E Maellaro
    Department of Pathophysiology and Experimental Medicine, University of Siena, Italy
    Br J Dermatol 148:1115-24. 2003
    ..Only a few studies have investigated the effects of IFN-alpha on hTERT and TA, with controversial results. Objectives To study the hTERT mRNA expression, TA and apoptosis in human melanoma cells treated with IFN-alpha...
  54. doi request reprint Novel variants of muscle calpain 3 identified in human melanoma cells: cisplatin-induced changes in vitro and differential expression in melanocytic lesions
    D Moretti
    Department of Physiopathology, Experimental Medicine and Public Health, University of Siena, Italy
    Carcinogenesis 30:960-7. 2009
    ..On the whole, our observations suggest that calpain 3 variants can play a proapoptotic role in melanoma cells and its downregulation, as observed in highly aggressive lesions, could contribute to melanoma progression...
  55. doi request reprint Orbital glomangioma
    Simone Ulivieri
    Department of Neurosurgery, Santa Maria alle Scotte Hospital, Sien, Italy
    Orbit 31:216-8. 2012
    ..Our case adds to the very few cases of orbital glomangioma reported in the literature and demonstrates that this tumor can be safely removed...
  56. doi request reprint Ozonated sesame oil enhances cutaneous wound healing in SKH1 mice
    Giuseppe Valacchi
    Dipartimento di Scienze Biomediche, Universita degli Studi di Siena, Siena, Italy
    Wound Repair Regen 19:107-15. 2011
    ..The present study shows the validity of ozonated sesame oil in cutaneous wound healing and emphasizes the importance of the ozonation grade...
  57. ncbi request reprint Dysplastic naevus vs. in situ melanoma: digital dermoscopy analysis
    M Burroni
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Policlinico Le Scotte, 53100 Siena, Italy
    Br J Dermatol 152:679-84. 2005
    ..To date, much confusion exists about the biological significance of dysplastic naevi and about the relationship between melanocytic dysplasia and clinical atypia...
  58. doi request reprint CD105/endoglin expression in Gorham disease of bone
    A Franchi
    Department of Human Pathology and Oncology, University of Florence, Italy
    J Clin Pathol 62:163-7. 2009
    ....
  59. ncbi request reprint Acroangiodermatitis (pseudo-Kaposi sarcoma) associated with verrucous hyperplasia induced by suction-socket lower limb prosthesis
    Paolo Sbano
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, Universit of Siena, Siena, Italy
    J Cutan Pathol 32:429-32. 2005
    ..We report a case of amputation stump dermatitis, clinically resembling verrucous hyperplasia, but with predominant histological aspects of acroangiodermatitis in a patient with a suction-socket lower limb prosthesis...
  60. ncbi request reprint Global developmental delay, osteopenia and ectodermal defect: a new syndrome
    Raffaella Zannolli
    Department of Paediatrics, Obstetrics and Reproductive Medicine, Section of Paediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Brain Dev 28:155-61. 2006
    ....
  61. doi request reprint Tinea corporis purpurica and onychomycosis caused by Trichophyton violaceum
    Clara Romano
    Mycoses 54:175-8. 2011
    ..Cases of purpuric variants of tinea corporis are rare and this is the first report of probable self-inoculation of T. violaceum from onychomycosis...
  62. ncbi request reprint Association of nevus of jadassohn, sebaceoma and trichoblastoma in a scalp lesion
    Anna Brafa
    Matteo Campana, MD, Plastic Surgery Unit, University of Siena, S Maria Alle Scotte Universitary Hospital, Viale Bracci 1, I 53100 Siena, Italy
    Acta Dermatovenerol Croat 19:271-7. 2011
    ..While there is pilar differentiation, there is an area of alopecia...
  63. ncbi request reprint Intradural extramedullary spinal anaplastic ependymoma. Case illustration
    Alfonso Cerase
    Unit of Diagnostic and Therapeutic Neuroradiology, Department of Neurosciences, Azienda Ospedaliera Universitaria Senese, Policlinico Santa Maria alle Scotte, Siena, Italy
    J Neurosurg Spine 5:476. 2006
  64. ncbi request reprint Intracranial epidermoid cyst: case report
    Simone Ulivieri
    Department of Neurosurgery, Santa Maria alle Scotte Hospital, 53100 Siena, Italy
    Ann Ital Chir 79:445-6. 2008
    ..We describe an unusual case of pre-pontine epidermoid cyst arising in the temporal lobe and in inter-peduncles cistern: development and surgical treatment are discussed...
  65. ncbi request reprint Presacral ganglioneuroma: a case report and review of literature
    Guido Cerullo
    Department of Pathology and Oncology, University of Siena, Siena, Italy
    World J Gastroenterol 13:2129-31. 2007
    ..We report a case of a 64-year-old man with a presacral ganglioneuroma...
  66. ncbi request reprint Report of two cases of Rosai-Dorfman disease with only skin involvement
    V Mourmouras
    Department of Human Pathology and Oncology, Section of Anatomic Pathology, University of Siena, Italy
    Pathologica 100:414-5. 2008
    ..We herein report two cases of cutaneous lesions in the absence of lymph node localization and systemic symptoms or signs. Characteristic features of the disease, such as emperipolesis, were evident in both cases...
  67. ncbi request reprint Neurocutaneous syndrome with mental delay, autism, blockage in intracellular vescicular trafficking and melanosome defects
    S Buoni
    Section of Pediatric Neurology, Department of Pediatrics, Policlinico Le Scotte, University of Siena, Siena, Italy
    Eur J Neurol 13:842-51. 2006
    ..The ultrastructural abnormalities suggested a defect in cell trafficking involving several cell lines and compartments...
  68. ncbi request reprint Primary hepatic epithelioid hemangioendothelioma progressively responsive to interferon-alpha: is there room for novel anti-angiogenetic treatments?
    L Calabro
    Division of Medical Oncology and Immunotherapy, Department of Oncology University Hospital of Siena, Siena, Italy
    J Exp Clin Cancer Res 26:145-50. 2007
    ..Furthermore, based on the newly-identified expression of endoglin (CD105) on HEH, we discuss the clinical potential of novel anti-angiogenetic approaches to the disease...
  69. ncbi request reprint Composite cutaneous haemangioendothelioma: case report and review of the literature
    M Biagioli
    Department of Clinical Medicine and Immunological Sciences, Section of Dermatology, University of Siena, Italy
    Clin Exp Dermatol 30:385-7. 2005
    ..We report a new case of composite cutaneous haemangioendothelioma and discuss prognostic and therapeutic aspects of this neoplasm...
  70. ncbi request reprint Papillary glioneuronal tumor of the fourth ventricle: case report and review of the literature
    S Ulivieri
    Department of Neurosurgery, Santa Maria alle Scotte Hospital, Siena, Italy
    G Chir 31:368-70. 2010
    ..We present a case of papillary glioneuronal tumor occurring in a 44-year-old man with an unusual hemorrhagic onset. The clinical, morphological and immunohistochemical features are discussed and the published literature is reviewed...
  71. ncbi request reprint Report of a case of intraosseous frontal meningioma
    S Ulivieri
    Department of Neurosurgery, Santa Maria alle Scotte Hospital, Siena, Italy
    Pathologica 101:12-4. 2009
    ..Primary ectopic intraosseous meningiomas are uncommon, accounting for less than 2% of all meningiomas. Herein the authors describe a case of meningioma involving the frontal bone in a 43-year-old man and review the relevant literature...
  72. pmc Expression of macrophage migration inhibitory factor in diffuse systemic sclerosis
    E Selvi
    Institute of Rheumatology, University of Siena, Italy
    Ann Rheum Dis 62:460-4. 2003
    ..To evaluate whether, in patients with the diffuse form of systemic sclerosis (dSSc), macrophage migration inhibitory factor (MIF) production is dysregulated...
  73. ncbi request reprint Arginine metabolism in tumor-associated macrophages in cutaneous malignant melanoma: evidence from human and experimental tumors
    Daniela Massi
    Dipartimento di Patologia Umana ed Oncologia, Universita di Firenze, Florence 50134, Italy
    Hum Pathol 38:1516-25. 2007
    ..However, macrophages stimulated by murine melanoma cells secreted a level of NO compatible with an antitumor activity only in the presence of interferon gamma...
  74. ncbi request reprint Compound melanocytic nevus associated with dermatofibroma: an additional case
    Vasileios Mourmouras
    J Cutan Pathol 34:736-7. 2007
  75. ncbi request reprint Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes
    Kimberly R Byrnes
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA
    Photomed Laser Surg 22:281-90. 2004
    ..We investigated the effects of photobiomodulation (PBM) on cutaneous wound healing in an animal model of type II diabetes, Psammomys obesus (Sand Rats)...
  76. doi request reprint Neuroblastoma-like neurilemoma: an additional case
    Vasileios Mourmouras
    J Dermatol 35:548-9. 2008