Affiliation: University of Pisa
Migliore L, Coppede F. Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat Res. 2009;674:73-84 pubmed publisher
..The emerging interplay between environmental-induced oxidative stress and epigenetic modifications of critical genes for neurodegeneration is also discussed. ..
Migliore L, Cocchi L, Nesti C, Sabbioni E. Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts. Environ Mol Mutagen. 1999;34:279-84 pubmed
..A different efficiency was observed for the different metal compounds, in particular, KSbO(3) and CH(3)HgCl, which were highly genotoxic, whereas the others showed minimal effects. ..
Migliore L, Coppede F. Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases. Mutat Res. 2009;667:82-97 pubmed publisher
Migliore L, Saracino D, Bonelli A, Colognato R, D Errico M, Magrini A, et al
. Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells. Environ Mol Mutagen. 2010;51:294-303 pubmed publisher
..7 cells. Moreover, the modified version of the comet assay allows the specific detection of the induction of oxidative damage to DNA, which may be the underlying mechanism involved in the CNT-associated genotoxicity. ..
Migliore L, Coppede F, Fenech M, Thomas P. Association of micronucleus frequency with neurodegenerative diseases. Mutagenesis. 2011;26:85-92 pubmed publisher
..These changes in buccal cytome ratios may prove useful as potential future diagnostics to identify individuals of increased risk for these disorders. ..
Migliore L, Migheli F, Spisni R, Coppede F. Genetics, cytogenetics, and epigenetics of colorectal cancer. J Biomed Biotechnol. 2011;2011:792362 pubmed publisher
Migliore L, Migheli F, CoppedÃ¨ F. Susceptibility to aneuploidy in young mothers of Down syndrome children. ScientificWorldJournal. 2009;9:1052-60 pubmed publisher
..Studies performed in the last years that have shown that the brain is, in fact, a complex genetic mosaic of aneuploid and euploid cells support the unified hypothesis trying to relate DS, trisomy 21, and AD. ..
Migliore L, Frenzilli G, Nesti C, Fortaner S, Sabbioni E. Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds. Mutagenesis. 2002;17:411-7 pubmed
..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts...