Lucia Migliore

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. doi request reprint Environmental-induced oxidative stress in neurodegenerative disorders and aging
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Faculty of Medicine, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 674:73-84. 2009
  2. ncbi request reprint Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, Pisa University, 56126 Pisa, Italy
    Mutagenesis 19:43-9. 2004
  3. pmc Genetics, cytogenetics, and epigenetics of colorectal cancer
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Street S Giuseppe 22, 56126 Pisa, Italy
    J Biomed Biotechnol 2011:792362. 2011
  4. ncbi request reprint Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 27:710-6. 2006
  5. doi request reprint Association of micronucleus frequency with neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 26:85-92. 2011
  6. ncbi request reprint Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Pharmacogenet Genomics 16:87-99. 2006
  7. ncbi request reprint Relationship between genotoxicity biomarkers in somatic and germ cells: findings from a biomonitoring study
    L Migliore
    Department of Human and Environmental Sciences, Section of Genetics, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 21:149-52. 2006
  8. doi request reprint Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells
    Lucia Migliore
    Department of Human and Environmental Sciences, Faculty of Medicine, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Environ Mol Mutagen 51:294-303. 2010
  9. doi request reprint Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 667:82-97. 2009
  10. doi request reprint Susceptibility to aneuploidy in young mothers of Down syndrome children
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    ScientificWorldJournal 9:1052-60. 2009

Detail Information

Publications81

  1. doi request reprint Environmental-induced oxidative stress in neurodegenerative disorders and aging
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Faculty of Medicine, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 674:73-84. 2009
    ..The emerging interplay between environmental-induced oxidative stress and epigenetic modifications of critical genes for neurodegeneration is also discussed...
  2. ncbi request reprint Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, Pisa University, 56126 Pisa, Italy
    Mutagenesis 19:43-9. 2004
    ..Patients receiving ubidecarenone showed a statistically significant reduction in the frequency of micronucleated cells after therapy, while only a slight decrease was observed in the levels of both primary DNA damage and oxidized bases...
  3. pmc Genetics, cytogenetics, and epigenetics of colorectal cancer
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Street S Giuseppe 22, 56126 Pisa, Italy
    J Biomed Biotechnol 2011:792362. 2011
    ....
  4. ncbi request reprint Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 27:710-6. 2006
    ..1+/-9.1 per thousand versus 8.7+/-5.4 per thousand). Moreover, our data reveal that peripheral lymphocytes of MDS are more prone to chromosome non-disjunction with both chromosomes, 13 and 21, equally involved...
  5. doi request reprint Association of micronucleus frequency with neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 26:85-92. 2011
    ..These changes in buccal cytome ratios may prove useful as potential future diagnostics to identify individuals of increased risk for these disorders...
  6. ncbi request reprint Cytogenetic biomarkers, urinary metabolites and metabolic gene polymorphisms in workers exposed to styrene
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Pharmacogenet Genomics 16:87-99. 2006
    ..These observations may have relevance considering the risk of lymphatic and haematopoietic malignancies tentatively associated with styrene exposure...
  7. ncbi request reprint Relationship between genotoxicity biomarkers in somatic and germ cells: findings from a biomonitoring study
    L Migliore
    Department of Human and Environmental Sciences, Section of Genetics, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 21:149-52. 2006
    ..This is the first time that a field study shows a correlation between two biomarkers of genotoxicity evaluated at the same time in somatic and germ cells...
  8. doi request reprint Carbon nanotubes induce oxidative DNA damage in RAW 264.7 cells
    Lucia Migliore
    Department of Human and Environmental Sciences, Faculty of Medicine, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Environ Mol Mutagen 51:294-303. 2010
    ..7 cells. Moreover, the modified version of the comet assay allows the specific detection of the induction of oxidative damage to DNA, which may be the underlying mechanism involved in the CNT-associated genotoxicity...
  9. doi request reprint Genetics, environmental factors and the emerging role of epigenetics in neurodegenerative diseases
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 667:82-97. 2009
    ....
  10. doi request reprint Susceptibility to aneuploidy in young mothers of Down syndrome children
    Lucia Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    ScientificWorldJournal 9:1052-60. 2009
    ..Studies performed in the last years that have shown that the brain is, in fact, a complex genetic mosaic of aneuploid and euploid cells support the unified hypothesis trying to relate DS, trisomy 21, and AD...
  11. ncbi request reprint Genetic and environmental factors in cancer and neurodegenerative diseases
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126, Pisa, Italy
    Mutat Res 512:135-53. 2002
    ....
  12. ncbi request reprint Assessment of sperm DNA integrity in workers exposed to styrene
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Italy
    Hum Reprod 17:2912-8. 2002
    ..We investigated sperm DNA integrity in individuals occupationally exposed to styrene...
  13. ncbi request reprint Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Pisa, Italy
    Environ Mol Mutagen 34:279-84. 1999
    ..A different efficiency was observed for the different metal compounds, in particular, KSbO(3) and CH(3)HgCl, which were highly genotoxic, whereas the others showed minimal effects...
  14. ncbi request reprint Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Pisa, Italy
    Cytogenet Cell Genet 87:41-6. 1999
    ....
  15. ncbi request reprint Cytogenetic and oxidative damage induced in human lymphocytes by platinum, rhodium and palladium compounds
    Lucia Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 17:411-7. 2002
    ..This work highlights the stronger genotoxicity, likely mediated by oxidative damage induction, of Pt and Rh compounds compared with Pd salts...
  16. ncbi request reprint Detection of chromosome loss and gain induced by griseofulvin, estramustine, and vanadate in binucleated lymphocytes using FISH analysis
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Italy
    Environ Mol Mutagen 34:64-8. 1999
    ....
  17. ncbi request reprint Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, 56026 Pisa, Italy
    Int J Hyg Environ Health 204:61-6. 2001
    ..Glutathione S-transferase activity in plasma from PD patients and controls was also measured and the enzymatic activity in PD patients was lower than in healthy controls...
  18. ncbi request reprint Cytogenetic study and FISH analysis in lymphocytes of systemic lupus erythematosus (SLE) and systemic sclerosis (SS) patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Italy
    Mutagenesis 14:227-31. 1999
    ..The three patients whose plasma caused MN induction were subtyped as ACA-/Scl70+, whereas the other subjects had ACAs. The same tests on six SLE patients gave negative results...
  19. ncbi request reprint Induction of aneuploidy by the antineoplastic drug estramustine in human lymphocytes
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Italy
    Mutat Res 412:33-40. 1998
    ..On the basis of these observations, EM may be defined as a typical aneuploidy inducer, whereas it was not found to increase the frequency of structural chromosome aberrations and SCE frequency...
  20. doi request reprint Association of maternal polymorphisms in folate metabolizing genes with chromosome damage and risk of Down syndrome offspring
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Neurosci Lett 449:15-9. 2009
    ..0001) and, in the total population, a significant correlation between micronucleated cells and both MTHFR 677C>T (P=0.031) and 1298A>C (P=0.047) polymorphisms...
  21. ncbi request reprint Association of the hOGG1 Ser326Cys polymorphism with sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neurosciences, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 420:163-8. 2007
    ..Present results suggest a possible involvement of the hOGG1 Ser326Cys polymorphism in sALS pathogenesis...
  22. doi request reprint The hOGG1 Ser326Cys polymorphism and Huntington's disease
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Toxicology 278:199-203. 2010
    ..041) earlier disease onset than Ser326Ser wild-type individuals, suggesting a possible role of the hOGG1 Ser326Cys polymorphism in HD phenotype...
  23. doi request reprint Lack of association between the APEX1 Asp148Glu polymorphism and sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, 56126 Pisa, Italy
    Neurobiol Aging 31:353-5. 2010
    ..Present results do not support a role for the APEX1 Asp148Glu polymorphism in sALS pathogenesis in the Italian population...
  24. doi request reprint The MTR 2756A>G polymorphism and maternal risk of birth of a child with Down syndrome: a case-control study and a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via S Giuseppe 22, 56126, Pisa, IT, Italy
    Mol Biol Rep 40:6913-25. 2013
    ..No association of the studied polymorphism with circulating levels of hcy, folates, and vitamin B12 was observed. Present data do not support a role for MTR 2756A>G as independent maternal risk factor for a DS birth. ..
  25. ncbi request reprint A Ser326Cys polymorphism in the DNA repair gene hOGG1 is not associated with sporadic Alzheimer's disease
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 414:282-5. 2007
    ..03, p=0.86) or genotype (chi2=0.25, p=0.882) frequencies of hOGG1 Ser326Cys and the risk of sAD. Present results suggest that the Ser326Cys polymorphism of the hOGG1 gene is not an independent risk factor for sAD...
  26. ncbi request reprint Polymorphisms in folate and homocysteine metabolizing genes and chromosome damage in mothers of Down syndrome children
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 143:2006-15. 2007
    ....
  27. ncbi request reprint DNMT3B promoter polymorphisms and risk of late onset Alzheimer's disease
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Italy
    Curr Alzheimer Res 9:550-4. 2012
    ..Overall, present results do not support a major role for rs2424913 or rs1569686 in LOAD pathogenesis...
  28. ncbi request reprint Genes and the environment in neurodegeneration
    Fabio Coppede
    Department of Neurosciences, University of Pisa, Via Roma 67, Pisa 56126, Italy
    Biosci Rep 26:341-67. 2006
    ..and discuss possible links of gene-environment interplay including, where implicated, mitochondrial genes...
  29. doi request reprint The MTRR 66A>G polymorphism and maternal risk of birth of a child with Down syndrome in Caucasian women: a case-control study and a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126, Pisa, Italy
    Mol Biol Rep 41:5571-83. 2014
    ..However, the combined presence of other genetic factors and interactions with geographic and environmental ones, can modify the effect of the single polymorphism alone, leading to population specific effect sizes...
  30. doi request reprint The hOGG1 Ser326Cys polymorphism is not associated with sporadic Parkinson's disease
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Neurosci Lett 473:248-51. 2010
    ..Moreover, the hOGG1 Ser326Cys polymorphism was not associated with disease age at onset (p=0.791). Overall, present results suggest that the hOGG1 Ser326Cys polymorphism is not associated with sporadic PD...
  31. ncbi request reprint Sperm-FISH analysis and human monitoring: a study on workers occupationally exposed to styrene
    Alessio Naccarati
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 537:131-40. 2003
    ..Overall, confounding factors appeared to exert a more important effect than exposure to styrene on numerical chromosome alterations in sperm nuclei of subjects selected for normal semen parameters...
  32. doi request reprint DNMT3B promoter polymorphisms and maternal risk of birth of a child with Down syndrome
    Fabio Coppede
    Department of Laboratory Medicine, Pisa University Hospital AOUP, Via S Giuseppe 22, Pisa 56126, Italy
    Hum Reprod 28:545-50. 2013
    ..Are DNMT3B promoter polymorphisms among maternal risk factors for the birth of a child with Down syndrome (DS)?..
  33. doi request reprint Folate, homocysteine, vitamin B12, and polymorphisms of genes participating in one-carbon metabolism in late-onset Alzheimer's disease patients and healthy controls
    Fabio Coppede
    Faculty of Medicine, University of Pisa, Pisa, Italy
    Antioxid Redox Signal 17:195-204. 2012
    ..Moreover, we searched for correlation between each of the studied polymorphisms and available data on plasma homocysteine (Hcy), serum folate, and vitamin B12 values...
  34. ncbi request reprint DNA damage and repair in Alzheimer's disease
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    Curr Alzheimer Res 6:36-47. 2009
    ..The few studies performed so far suggest that some variants might play a role in AD pathogenesis and deserve further investigations. Here, we summarize the current knowledge of DNA damage and repair in AD pathogenesis...
  35. doi request reprint Association study between XRCC1 gene polymorphisms and sporadic amyotrophic lateral sclerosis
    Fabio Coppede
    Department of Neuroscience, Neurological Clinic, University of Pisa, Italy
    Amyotroph Lateral Scler 11:122-4. 2010
    ..We observed a statistically significant difference in XRCC1 Gln399 allele frequencies between SALS cases and controls (0.39/0.28; p=0.001). The present study suggests that the XRCC1 Arg399Gln polymorphism might contribute to SALS risk...
  36. doi request reprint Evidence linking genetics, environment, and epigenetics to impaired DNA repair in Alzheimer's disease
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Pisa, Italy
    J Alzheimers Dis 20:953-66. 2010
    ....
  37. pmc Efficacy and feasibility of the epithelial cell adhesion molecule (EpCAM) immunomagnetic cell sorter for studies of DNA methylation in colorectal cancer
    Alessandra Failli
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa 56126, Italy
    Int J Mol Sci 15:44-57. 2013
    ..The efficacy and feasibility of the immunomagnetic cell sorting for methylation studies are discussed. ..
  38. doi request reprint Multiple cytotoxic and genotoxic effects induced in vitro by differently shaped copper oxide nanomaterials
    Sebastiano Di Bucchianico
    Department of Translational Research and New Technologies in Medicine and Surgery, Medical Genetics, University of Pisa, Pisa, Italy
    Mutagenesis 28:287-99. 2013
    ..Independently of size and shape, all CuO NPs revealed a clear-cut cytotoxic and genotoxic potential; this suggests that CuO NPs are good candidates for positive controls in nanotoxicology...
  39. pmc Polymorphisms in folate-metabolizing genes, chromosome damage, and risk of Down syndrome in Italian women: identification of key factors using artificial neural networks
    Fabio Coppede
    Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy
    BMC Med Genomics 3:42. 2010
    ..Data were analysed using TWIST system in combination with supervised artificial neural networks, and a semantic connectivity map...
  40. ncbi request reprint Mitochondrial dysfunction, oxidative stress and neurodegeneration
    Michelangelo Mancuso
    Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    J Alzheimers Dis 10:59-73. 2006
    ..Here we examine the current evidences in this field, which indicate a key role of mitochondria and oxidative stress in contributing to the neurodegenerative processes...
  41. ncbi request reprint Folate gene polymorphisms and the risk of Down syndrome pregnancies in young Italian women
    Fabio Coppede
    Department of Human and Environmental Sciences, University of Pisa, Pisa, Italy
    Am J Med Genet A 140:1083-91. 2006
    ....
  42. ncbi request reprint Cytogenetic analysis oxidative damage in lymphocytes of Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, University of Pisa, Italy
    Neurol Sci 22:83-4. 2001
    ..05). The chromosome damage and the increased levels of oxidized purine bases observed in our patients support the hypothesis of oxidative stress as a relevant factor in the pathogenesis of PD...
  43. ncbi request reprint Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Neurology 58:1809-15. 2002
    ..Increased lipid peroxidation and oxidative DNA damage have been reported in the CNS. Markers of oxidative stress have been identified in the blood of patients with PD...
  44. ncbi request reprint Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, Clinical Neurology, Movement Disorders Unit, University of Pisa, Via Roma 67, I 56126 Pisa, Italy
    Neurol Sci 23:S97-8. 2002
    ..Different molecular mechanisms underlie cytogenetic alterations observed in peripheral lymphocytes of AD and PD patients...
  45. pmc Gene-Specific Methylation Analysis in Thymomas of Patients with Myasthenia Gravis
    Angela Lopomo
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy
    Int J Mol Sci 17:. 2016
    ..The present study suggests that MTHFR methylation is increased in thymomas obtained from MG patients; furthermore, some degrees of methylation of the DNMT3A gene were observed in thymic tissue with respect to blood...
  46. doi request reprint Methylation analysis of multiple genes in blood DNA of Alzheimer's disease and healthy individuals
    Pierpaola Tannorella
    Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Via Roma 55, Pisa 56126, Italy Department of Biology, University of Pisa, via Luca Ghini 13, Pisa 56126, Italy
    Neurosci Lett 600:143-7. 2015
    ..1% in AD and 30.7% in controls, P=0.58). Overall, present data suggest that none of the studied regions is differently methylated in blood DNA between AD and control subjects. ..
  47. pmc A pilot study evaluating the contribution of SLC19A1 (RFC-1) 80G>a polymorphism to Alzheimer's disease in Italian Caucasians
    Fabio Coppede
    Division of Medical Genetics, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Medical School, Via Roma 56, 56126 Pisa, Italy
    Biomed Res Int 2014:608104. 2014
    ..Present results do not support a role for the RFC-1 c.80G>A polymorphism as independent risk factor for sporadic AD in Italian Caucasians...
  48. pmc The reduced folate carrier (RFC-1) 80A>G polymorphism and maternal risk of having a child with Down syndrome: a meta-analysis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Via S Giuseppe 22, Pisa 56126, Italy
    Nutrients 5:2551-63. 2013
    ..14, 95% CI 1.01-1.30; p = 0.03). Present results suggest that the maternal RFC-1 80A>G polymorphism might be associated with an increased risk of having a birth with DS, particularly among carriers of the GG genotype. ..
  49. ncbi request reprint Molecular implications of the human glutathione transferase A-4 gene (hGSTA4) polymorphisms in neurodegenerative diseases
    Fabio Coppede
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutat Res 579:107-14. 2005
    ....
  50. doi request reprint Methylation analysis of DNA repair genes in Alzheimer's disease
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Via Roma 55, 56126 Pisa, Italy Electronic address
    Mech Ageing Dev . 2016
    ..Collectively, present data do not support an increased promoter methylation of some of the major DNA repair genes in blood DNA of AD patients...
  51. pmc Association study between the DNMT3A -448A>G polymorphism and risk of Alzheimer's disease in Caucasians of Italian origin
    Pierpaola Tannorella
    Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa Via Roma 55, 56126 Pisa, Italy
    Am J Neurodegener Dis 5:85-93. 2016
    ..Collectively, present results confirmed previous associations of increased hcy and decreased folate with LOAD risk, but do not support an association between the DNMT3A -448A>G polymorphism and AD in our population. ..
  52. doi request reprint Application of artificial neural networks to link genetic and environmental factors to DNA methylation in colorectal cancer
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Medical School, Via Roma 55, 56126 Pisa, Italy
    Epigenomics 7:175-86. 2015
    ....
  53. doi request reprint Epigenetic effects of nano-sized materials
    Andrea Stoccoro
    Department of Translational Research and New Technologies in Medicine and Surgery, Medical Genetics Laboratory, University of Pisa, Pisa, Italy
    Toxicology 313:3-14. 2013
    ....
  54. ncbi request reprint Modulation of palmitic acid-induced cell death by ergothioneine: evidence of an anti-inflammatory action
    Incoronata Laurenza
    Dipartimento di Endocrinologia, Ospedale di Cisanello, Pisa, Italy
    Biofactors 33:237-47. 2008
    ..001). In conclusion, these results indicate that 1. EGT has a protective role on PA-induced cell death, possibly via 2. reduced activity of MAPKs cascade having also 3. an anti-inflammatory action exerted on the IL-6 modulation...
  55. ncbi request reprint Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients
    F Trippi
    Dipartimento di Scienze dell'Uomo e dell'Ambiente, University of Pisa, Pisa, Italy
    Mutagenesis 16:323-7. 2001
    ....
  56. doi request reprint A panel of in vitro tests to evaluate genotoxic and morphological neoplastic transformation potential on Balb/3T3 cells by pristine and remediated titania and zirconia nanoparticles
    Andrea Stoccoro
    Laboratory of Medical Genetics, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa 56126, Italy, Doctoral School in GeneticsOncology and Clinical MedicineDepartment of Medical BiotechnologiesUniversity of Siena, 53100 Siena, Italy
    Mutagenesis 31:511-29. 2016
    ....
  57. doi request reprint Increased MTHFR promoter methylation in mothers of Down syndrome individuals
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Section of Medical Genetics, University of Pisa, Via Roma 55, 56126 Pisa, Italy Interdepartmental Research Center Nutrafood Nutraceuticals and Food for Health, University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy Electronic address
    Mutat Res 787:1-6. 2016
    ....
  58. pmc Comparison study of MS-HRM and pyrosequencing techniques for quantification of APC and CDKN2A gene methylation
    Francesca Migheli
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy
    PLoS ONE 8:e52501. 2013
    ..Overall, our new approach allows MS-HRM to be used as a quantitative assay which provides results which are comparable with those obtained by pyrosequencing...
  59. pmc Application of artificial neural networks to investigate one-carbon metabolism in Alzheimer's disease and healthy matched individuals
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, Pisa, Italy
    PLoS ONE 8:e74012. 2013
    ..The semantic connectivity map provided important information on the complex biological connections among one-carbon metabolic variables highlighting those most closely linked to the AD condition. ..
  60. ncbi request reprint Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine
    Renato Colognato
    Dip Scienze dell Uomo e dell Ambiente, Universita di Pisa, Sezione di Genetica Via S Giuseppe 22, 56126 Pisa, Italy
    Clin Nutr 25:135-45. 2006
    ..The aim of this study was to assess the effect of EGT in the prevention of H2O2-dependent cell death and oxidative damage on a model of neural cell derived from rat pheocromocytoma, the PC12...
  61. ncbi request reprint Formation of micronuclei and of clastogenic factor(s) in patients receiving therapeutic doses of iodine-131
    Michela Ballardin
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Pisa, Italy
    Mutat Res 514:77-85. 2002
    ..The possibility of reducing the genotoxic activity of radionuclide therapy by chemoprevention of CFs with antioxidant drugs remains to be explored...
  62. ncbi request reprint DNA repair in premature aging disorders and neurodegeneration
    Fabio Coppede
    Department of Neuroscience, University of Pisa, Via Roma 67, 56126 Pisa, Italy
    Curr Aging Sci 3:3-19. 2010
    ..Here, we review the current knowledge on the role of DNA repair in premature aging and neurodegenerative diseases...
  63. ncbi request reprint An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox
    F Franzoni
    Dipartimento di Medicina Interna, Universita di Pisa, 67, Pisa, Italia
    Biomed Pharmacother 60:453-7. 2006
    ..The aim of this in vitro study was to assess the antioxidant activity of the natural product ergothioneine (EGT), a compound of plant origin, which is assimilated and conserved by mammals in erythrocytes, kidney, seminal fluid and liver...
  64. ncbi request reprint Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:567-73. 2005
    ..Our results give a further indication that oxidative stress, at least at the DNA level, is an earlier event in the pathogenesis of AD...
  65. ncbi request reprint Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:587-95. 2005
    ....
  66. ncbi request reprint Genotoxicity induced by arsenic compounds in peripheral human lymphocytes analysed by cytokinesis-block micronucleus assay
    R Colognato
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 22:255-61. 2007
    ....
  67. doi request reprint Nanomaterials and neurodegeneration
    Lucia Migliore
    Medical Genetics Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma, 55 56126, Pisa, Italy
    Environ Mol Mutagen 56:149-70. 2015
    ..Therefore, a careful assessment of the risk-benefit ratio must be taken into consideration in using nanosized materials...
  68. pmc Aneuploidogenic effects and DNA oxidation induced in vitro by differently sized gold nanoparticles
    Sebastiano Di Bucchianico
    Department of Translational Research and New Technologies in Medicine and Surgery, Medical Genetics Unit, University of Pisa, Pisa, Italy
    Int J Nanomedicine 9:2191-204. 2014
    ..Results indicate that apoptosis, aneuploidy, and DNA oxidation play a pivotal role in the cytotoxicity and genotoxicity exerted by Au NPs in our cell models. ..
  69. pmc Association of the DNMT3B -579G>T polymorphism with risk of thymomas in patients with myasthenia gravis
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy
    PLoS ONE 8:e80846. 2013
    ..Present results suggest that the DNMT3B-579T allele might contribute to the risk of developing thymoma in MG patients, particularly in homozygous TT subjects. ..
  70. pmc Genetic and epigenetic biomarkers for diagnosis, prognosis and treatment of colorectal cancer
    Fabio Coppede
    Fabio Coppedè, Angela Lopomo, Lucia Migliore, Department of Translational Research and New Technologies in Medicine and Surgery, Division of Medical Genetics, University of Pisa, 56126 Pisa, Italy
    World J Gastroenterol 20:943-56. 2014
    ..Overall, combining genetic and epigenetic data might represent the most promising tool for a proper diagnostic, prognostic and therapeutic approach. ..
  71. doi request reprint DNA damage in neurodegenerative diseases
    Fabio Coppede
    Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy Electronic address
    Mutat Res 776:84-97. 2015
    ..We will address those issues in the context of Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis, which represent three of the most common neurodegenerative pathologies in humans. ..
  72. doi request reprint Genotoxic and epigenetic mechanisms in arsenic carcinogenicity
    Elisa Bustaffa
    Unit of Environmental Epidemiology and Diseases Registries, Institute of Clinical Physiology, National Council of Research, Via Moruzzi 1, 56123, Pisa, Italy
    Arch Toxicol 88:1043-67. 2014
    ..Studies on arsenic-exposed population should be designed in order to examine more comprehensively the presence and consequences of these genetic/epigenetic alterations. ..
  73. doi request reprint Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro
    R Colognato
    Department of Human and Environmental Sciences, Faculty of Medicine, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 23:377-82. 2008
    ..These findings suggest that nanosized Co can be internalized by human leukocytes and can interact with DNA leading to the observed genotoxic effects, which are, however, modulated both by donor's characteristics and/or by Co(2+) release...
  74. ncbi request reprint Molecular effects of fermented papaya preparation on oxidative damage, MAP Kinase activation and modulation of the benzo[a]pyrene mediated genotoxicity
    Okezie I Aruoma
    Faculty of Health and Social Care, London South Bank University, 103 Borough Road, London, UK
    Biofactors 26:147-59. 2006
    ..A significant reduction (P < or = 0.05) of DNA damage was observed at concentrations > or = 10 microg/ml FPP, with 50 microg/ml FPP reducing the genotoxic effect of H2O2 by about 1.5-fold compared to only H2O2 exposed cells...
  75. ncbi request reprint Chromosome aberrations in Raynaud's phenomenon
    Giovanni Porciello
    Servizio di Reumatologia Ospedale Misericordia e Dolce di Prato, Italy
    Eur J Dermatol 14:327-31. 2004
    ..No prevalence of aneuploidogenic or clastogenic events in micronucleus formation is revealed by fluorescence in situ hybridisation analysis...
  76. pmc Cytogenetic markers, DNA single-strand breaks, urinary metabolites, and DNA repair rates in styrene-exposed lamination workers
    Pavel Vodicka
    Institute of Experimental Medicine, Academy of Science of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic
    Environ Health Perspect 112:867-71. 2004
    ..The positive correlation between exposure parameters and DNA repair rates suggests that particular DNA repair pathways may be induced by styrene exposure...
  77. ncbi request reprint Spontaneous chromosome damage (micronuclei) in systemic sclerosis and Raynaud's phenomenon
    Giovanni Porciello
    Istituto di Reumatologia, University of Siena, Italy
    J Rheumatol 30:1244-7. 2003
    ....
  78. ncbi request reprint The effects of GSTM1 and GSTT1 polymorphisms on micronucleus frequencies in human lymphocytes in vivo
    Micheline Kirsch-Volders
    Laboratory of Cell Genetics, Vrije Universiteit Brussel, Pleinlaan 2, B 1050 Brussels, Belgium
    Cancer Epidemiol Biomarkers Prev 15:1038-42. 2006
    ..79). This study confirms that pooled analyses, by increasing the statistical power, are adequate for assessing the involvement of genetic variants on genome stability and for resolving discrepancies among individual studies...
  79. ncbi request reprint An increased micronucleus frequency in peripheral blood lymphocytes predicts the risk of cancer in humans
    Stefano Bonassi
    Unit of Molecular Epidemiology, National Cancer Research Institute, Genoa, Italy
    Carcinogenesis 28:625-31. 2007
    ..The current wide-spread use of the MN assay provides a valuable opportunity to apply this assay in the planning and validation of cancer surveillance and prevention programs...
  80. ncbi request reprint MTHFR and RFC-1 gene polymorphisms and the risk of Down syndrome in Italy
    Fabio Coppede
    Am J Med Genet A 143:1018-9. 2007
  81. ncbi request reprint Intra- and inter-laboratory variation in the scoring of micronuclei and nucleoplasmic bridges in binucleated human lymphocytes. Results of an international slide-scoring exercise by the HUMN project
    Michael Fenech
    CSIRO Health Sciences and Nutrition, Adelaide, SA, Australia
    Mutat Res 534:45-64. 2003
    ....