L Migliore

Summary

Affiliation: University of Pisa
Country: Italy

Publications

  1. ncbi request reprint Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:587-95. 2005
  2. ncbi request reprint Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:567-73. 2005
  3. ncbi request reprint Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, 56026 Pisa, Italy
    Int J Hyg Environ Health 204:61-6. 2001
  4. ncbi request reprint Cytogenetic analysis oxidative damage in lymphocytes of Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, University of Pisa, Italy
    Neurol Sci 22:83-4. 2001
  5. ncbi request reprint Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, Clinical Neurology, Movement Disorders Unit, University of Pisa, Via Roma 67, I 56126 Pisa, Italy
    Neurol Sci 23:S97-8. 2002
  6. ncbi request reprint Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients
    F Trippi
    Dipartimento di Scienze dell'Uomo e dell'Ambiente, University of Pisa, Pisa, Italy
    Mutagenesis 16:323-7. 2001
  7. ncbi request reprint Relationship between genotoxicity biomarkers in somatic and germ cells: findings from a biomonitoring study
    L Migliore
    Department of Human and Environmental Sciences, Section of Genetics, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 21:149-52. 2006
  8. ncbi request reprint Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, Pisa University, 56126 Pisa, Italy
    Mutagenesis 19:43-9. 2004
  9. ncbi request reprint Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 27:710-6. 2006
  10. ncbi request reprint Induction of aneuploidy by the antineoplastic drug estramustine in human lymphocytes
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Italy
    Mutat Res 412:33-40. 1998

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Searching for the role and the most suitable biomarkers of oxidative stress in Alzheimer's disease and in other neurodegenerative diseases
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:587-95. 2005
    ....
  2. ncbi request reprint Oxidative DNA damage in peripheral leukocytes of mild cognitive impairment and AD patients
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 26:567-73. 2005
    ..Our results give a further indication that oxidative stress, at least at the DNA level, is an earlier event in the pathogenesis of AD...
  3. ncbi request reprint Chromosome and oxidative damage biomarkers in lymphocytes of Parkinson's disease patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, 56026 Pisa, Italy
    Int J Hyg Environ Health 204:61-6. 2001
    ..Glutathione S-transferase activity in plasma from PD patients and controls was also measured and the enzymatic activity in PD patients was lower than in healthy controls...
  4. ncbi request reprint Cytogenetic analysis oxidative damage in lymphocytes of Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, University of Pisa, Italy
    Neurol Sci 22:83-4. 2001
    ..05). The chromosome damage and the increased levels of oxidized purine bases observed in our patients support the hypothesis of oxidative stress as a relevant factor in the pathogenesis of PD...
  5. ncbi request reprint Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patients
    L Petrozzi
    Department of Neuroscience, Clinical Neurology, Movement Disorders Unit, University of Pisa, Via Roma 67, I 56126 Pisa, Italy
    Neurol Sci 23:S97-8. 2002
    ..Different molecular mechanisms underlie cytogenetic alterations observed in peripheral lymphocytes of AD and PD patients...
  6. ncbi request reprint Spontaneous and induced chromosome damage in somatic cells of sporadic and familial Alzheimer's disease patients
    F Trippi
    Dipartimento di Scienze dell'Uomo e dell'Ambiente, University of Pisa, Pisa, Italy
    Mutagenesis 16:323-7. 2001
    ....
  7. ncbi request reprint Relationship between genotoxicity biomarkers in somatic and germ cells: findings from a biomonitoring study
    L Migliore
    Department of Human and Environmental Sciences, Section of Genetics, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 21:149-52. 2006
    ..This is the first time that a field study shows a correlation between two biomarkers of genotoxicity evaluated at the same time in somatic and germ cells...
  8. ncbi request reprint Evaluation of cytogenetic and DNA damage in mitochondrial disease patients: effects of coenzyme Q10 therapy
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Via S Giuseppe 22, Pisa University, 56126 Pisa, Italy
    Mutagenesis 19:43-9. 2004
    ..Patients receiving ubidecarenone showed a statistically significant reduction in the frequency of micronucleated cells after therapy, while only a slight decrease was observed in the levels of both primary DNA damage and oxidized bases...
  9. ncbi request reprint Susceptibility to chromosome malsegregation in lymphocytes of women who had a Down syndrome child in young age
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Neurobiol Aging 27:710-6. 2006
    ..1+/-9.1 per thousand versus 8.7+/-5.4 per thousand). Moreover, our data reveal that peripheral lymphocytes of MDS are more prone to chromosome non-disjunction with both chromosomes, 13 and 21, equally involved...
  10. ncbi request reprint Induction of aneuploidy by the antineoplastic drug estramustine in human lymphocytes
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, University of Pisa, Italy
    Mutat Res 412:33-40. 1998
    ..On the basis of these observations, EM may be defined as a typical aneuploidy inducer, whereas it was not found to increase the frequency of structural chromosome aberrations and SCE frequency...
  11. doi request reprint Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro
    R Colognato
    Department of Human and Environmental Sciences, Faculty of Medicine, University of Pisa, Via S Giuseppe 22, 56100 Pisa, Italy
    Mutagenesis 23:377-82. 2008
    ..These findings suggest that nanosized Co can be internalized by human leukocytes and can interact with DNA leading to the observed genotoxic effects, which are, however, modulated both by donor's characteristics and/or by Co(2+) release...
  12. ncbi request reprint Genotoxicity induced by arsenic compounds in peripheral human lymphocytes analysed by cytokinesis-block micronucleus assay
    R Colognato
    Department of Human and Environmental Sciences, University of Pisa, Via S Giuseppe 22, 56126 Pisa, Italy
    Mutagenesis 22:255-61. 2007
    ....
  13. ncbi request reprint An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox
    F Franzoni
    Dipartimento di Medicina Interna, Universita di Pisa, 67, Pisa, Italia
    Biomed Pharmacother 60:453-7. 2006
    ..The aim of this in vitro study was to assess the antioxidant activity of the natural product ergothioneine (EGT), a compound of plant origin, which is assimilated and conserved by mammals in erythrocytes, kidney, seminal fluid and liver...
  14. ncbi request reprint Cytogenetic study and FISH analysis in lymphocytes of systemic lupus erythematosus (SLE) and systemic sclerosis (SS) patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Italy
    Mutagenesis 14:227-31. 1999
    ..The three patients whose plasma caused MN induction were subtyped as ACA-/Scl70+, whereas the other subjects had ACAs. The same tests on six SLE patients gave negative results...
  15. ncbi request reprint Detection of chromosome loss and gain induced by griseofulvin, estramustine, and vanadate in binucleated lymphocytes using FISH analysis
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Italy
    Environ Mol Mutagen 34:64-8. 1999
    ....
  16. ncbi request reprint Micronuclei assay and FISH analysis in human lymphocytes treated with six metal salts
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Universita di Pisa, Pisa, Italy
    Environ Mol Mutagen 34:279-84. 1999
    ..A different efficiency was observed for the different metal compounds, in particular, KSbO(3) and CH(3)HgCl, which were highly genotoxic, whereas the others showed minimal effects...
  17. ncbi request reprint Preferential occurrence of chromosome 21 malsegregation in peripheral blood lymphocytes of Alzheimer disease patients
    L Migliore
    Dipartimento di Scienze dell Uomo e dell Ambiente, Pisa, Italy
    Cytogenet Cell Genet 87:41-6. 1999
    ....
  18. ncbi request reprint Oxidative damage and cytogenetic analysis in leukocytes of Parkinson's disease patients
    L Migliore
    Department of Human and Environmental Sciences, University of Pisa, Italy
    Neurology 58:1809-15. 2002
    ..Increased lipid peroxidation and oxidative DNA damage have been reported in the CNS. Markers of oxidative stress have been identified in the blood of patients with PD...
  19. ncbi request reprint [Chromosome aberrations, valued as frequency of spontaneous micronuclei, in subjects with suspected presclerodermic Raynaud's phenomenon]
    G Porciello
    Istituto di Reumatologia, Universita di Siena, Italia
    Reumatismo 55:28-33. 2003
    ..To evaluate the prevalence of spontaneous chromosome damage in cultured peripheral lymphocytes of subjects with suspected presclerodermic Raynaud's phenomenon (RP), by means of molecular cytogenetic analysis...
  20. ncbi request reprint Nanomaterials and lung toxicity: interactions with airways cells and relevance for occupational health risk assessment
    E Bergamaschi
    Department of Clinical Medicine and Nephrology, University of Parma, Italy
    Int J Immunopathol Pharmacol 19:3-10. 2006
    ....
  21. ncbi request reprint [The high frequency of spontaneous micronuclei observed in lymphocytes of systemic sclerosis patients: preliminary results]
    G Porciello
    Istituto di Reumatologia, Universita degli Studi di Siena, Italia
    Reumatismo 54:36-9. 2002
    ..Aim of the study is to assess the presence of spontaneous chromosome damage in patients affected by limited (lSSc) or diffuse (dSSc) Systemic Slerosis, using the micronucleus (MN) assay...