R Migheli

Summary

Affiliation: University of Sassari
Country: Italy

Publications

  1. doi request reprint Novel integrated microdialysis-amperometric system for in vitro detection of dopamine secreted from PC12 cells: design, construction, and validation
    Rossana Migheli
    Department of Neuroscience, Medical School, University of Sassari, 07100 Sassari, Italy
    Anal Biochem 380:323-30. 2008
  2. ncbi request reprint Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats
    M S Desole
    Department of Pharmacology, Gynecology and Obstetrics, Faculty of Medicine, University of Sassari, UK
    Aging (Milano) 12:470-7. 2000
  3. ncbi request reprint The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy
    J Biol Chem 277:34451-61. 2002
  4. pmc A study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats
    P A Serra
    Department of Pharmacology, University of Sassari, viale S. Pietro 43B, 07100 Sassari, Italy
    Br J Pharmacol 134:275-82. 2001
  5. ncbi request reprint Manganese and 1-methyl-4-(2'-ethylpheny1)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells
    M S Desole
    Institute of Pharmacology, University of Sassari, Italy
    Neurosci Lett 209:193-6. 1996
  6. ncbi request reprint Protective effect of deferoxamine on sodium nitroprusside-induced apoptosis in PC12 cells
    M S Desole
    Institute of Pharmacology, University of Sassari, Italy
    Neurosci Lett 247:1-4. 1998
  7. ncbi request reprint Effects of sufentanil on the release and metabolism of dopamine and ascorbic acid and glutamate release in the striatum of freely moving rats
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Neurosci Lett 344:9-12. 2003
  8. ncbi request reprint Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 39:409-18. 2005
  9. ncbi request reprint Signaling pathways in the nitric oxide and iron-induced dopamine release in the striatum of freely moving rats: role of extracellular Ca2+ and L-type Ca2+ channels
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Brain Res 1047:18-29. 2005
  10. ncbi request reprint Signalling pathways in the nitric oxide donor-induced dopamine release in the striatum of freely moving rats: evidence that exogenous nitric oxide promotes Ca2+ entry through store-operated channels
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Brain Res 1023:243-52. 2004

Collaborators

  • Luigi Sciola
  • Pier Andrea Serra
  • B Marchetti
  • Gaia Rocchitta
  • Egidio Miele
  • Maria S Desole
  • Gianfranco Bazzu
  • Giovanni Esposito
  • M S Desole
  • Maria P Mura
  • Maddalena Miele
  • Giammario Calia
  • Maria Speranza Desole
  • Maria Concetta Morale
  • M R Delogu
  • Patrizia Debetto
  • Morena Zusso
  • Jessica Grigoletto
  • Giulia Puggioni
  • Ylenia Spissu
  • Sonia Dedola
  • Giulia G M Puggioni
  • John P Lowry
  • Robert D O'Neill
  • Giuseppe Grella
  • Maria Rosaria Delogu
  • Nuccio Testa
  • Nicholas Barden
  • Rosaria M Delogu
  • Giuseppe Susini
  • Giovanna M Scoto
  • S Sircana
  • Francesca L'Episcopo
  • Florinda Gennuso
  • Cataldo Tirolo
  • Luigi Solinas
  • Salvo Caniglia
  • M Miele
  • G Esposito
  • L Fresu
  • G Rocchitta
  • G De Natale
  • G Piras
  • E Miele
  • C Godani

Detail Information

Publications17

  1. doi request reprint Novel integrated microdialysis-amperometric system for in vitro detection of dopamine secreted from PC12 cells: design, construction, and validation
    Rossana Migheli
    Department of Neuroscience, Medical School, University of Sassari, 07100 Sassari, Italy
    Anal Biochem 380:323-30. 2008
    ....
  2. ncbi request reprint Glutathione deficiency potentiates manganese-induced increases in compounds associated with high-energy phosphate degradation in discrete brain areas of young and aged rats
    M S Desole
    Department of Pharmacology, Gynecology and Obstetrics, Faculty of Medicine, University of Sassari, UK
    Aging (Milano) 12:470-7. 2000
    ....
  3. ncbi request reprint The neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine induces apoptosis in mouse nigrostriatal glia. Relevance to nigral neuronal death and striatal neurochemical changes
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, Viale San Pietro 43b, 07100 Sassari, Italy
    J Biol Chem 277:34451-61. 2002
    ..These data suggest that MPTP-induced activation/apoptotic death of glial cells plays a key role in the sequential linkage of neurochemical and cellular events leading to dopaminergic nigral neuron apoptotic death...
  4. pmc A study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats
    P A Serra
    Department of Pharmacology, University of Sassari, viale S. Pietro 43B, 07100 Sassari, Italy
    Br J Pharmacol 134:275-82. 2001
    ..5. These results suggest that iron plays a key role in SIN-1-induced release of striatal DA and do not support any role for either peroxynitrite or superoxide anion in SIN-1-induced release of striatal DA...
  5. ncbi request reprint Manganese and 1-methyl-4-(2'-ethylpheny1)-1,2,3,6-tetrahydropyridine induce apoptosis in PC12 cells
    M S Desole
    Institute of Pharmacology, University of Sassari, Italy
    Neurosci Lett 209:193-6. 1996
    ..We conclude that apoptosis may be an important mechanism of cell death in MPTP- and Mn-induced parkinsonism. However, an oxidative stress mechanism may be recognized only in the Mn-induced apoptosis...
  6. ncbi request reprint Protective effect of deferoxamine on sodium nitroprusside-induced apoptosis in PC12 cells
    M S Desole
    Institute of Pharmacology, University of Sassari, Italy
    Neurosci Lett 247:1-4. 1998
    ..Since deferoxamine (0.05-0.1 mM), a powerful iron chelator, inhibited both SNP-induced apoptosis and the decrease in cell viability, we suggest that these NO effects may be dependent upon iron mobilization within the cell...
  7. ncbi request reprint Effects of sufentanil on the release and metabolism of dopamine and ascorbic acid and glutamate release in the striatum of freely moving rats
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Neurosci Lett 344:9-12. 2003
    ..These results demonstrate that sufentanil, at clinical doses, increases striatal DA release and oxidative metabolism of both DA and xanthine acting at extrastriatal sites with a mu-receptor-mediated mechanism...
  8. ncbi request reprint Role of endogenous melatonin in the oxidative homeostasis of the extracellular striatal compartment: a microdialysis study in PC12 cells in vitro and in the striatum of freely moving rats
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 39:409-18. 2005
    ....
  9. ncbi request reprint Signaling pathways in the nitric oxide and iron-induced dopamine release in the striatum of freely moving rats: role of extracellular Ca2+ and L-type Ca2+ channels
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Brain Res 1047:18-29. 2005
    ....
  10. ncbi request reprint Signalling pathways in the nitric oxide donor-induced dopamine release in the striatum of freely moving rats: evidence that exogenous nitric oxide promotes Ca2+ entry through store-operated channels
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Brain Res 1023:243-52. 2004
    ....
  11. ncbi request reprint On the mechanism of levosimendan-induced dopamine release in the striatum of freely moving rats
    Gaia Rocchitta
    Department of Pharmacology, Faculty of Medicine, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    J Pharmacol Sci 95:299-304. 2004
    ..2) voltage-sensitive Ca(2+)-channel inhibitor omega-conotoxin GVIA. We conclude that LEV promotes striatal extracellular Ca(2+) entry through N-type Ca(2+) channels with a consequent increase in DA release...
  12. ncbi request reprint Endogenous melatonin protects L-DOPA from autoxidation in the striatal extracellular compartment of the freely moving rat: potential implication for long-term L-DOPA therapy in Parkinson's disease
    Gaia Rocchitta
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Pineal Res 40:204-13. 2006
    ..These results may be of relevance to the long-term L-DOPA therapy of Parkinson's disease...
  13. ncbi request reprint Role of the nitric oxide/cyclic GMP pathway and extracellular environment in the nitric oxide donor-induced increase in dopamine secretion from PC12 cells: a microdialysis in vitro study
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Neurochem 86:1403-13. 2003
    ..Extracellular Ca2+ entry may occur through nifedipine-insensitive channels. NO effects and DA concentrations in dialysates largely depend on both the timing of NO generation and the extracellular environment in which NO is generated...
  14. doi request reprint Real-time monitoring of brain tissue oxygen using a miniaturized biotelemetric device implanted in freely moving rats
    Gianfranco Bazzu
    Department of Neuroscience, Medical School, University of Sassari, Viale S Pietro 43 B, 07100 Sassari, Italy
    Anal Chem 81:2235-41. 2009
    ..The system serves as a rapid and reliable model for studying the effects of different drugs on brain oxygen and brain blood flow and it is suited to work with direct-reduction sensors or O(2)-consuming biosensors...
  15. ncbi request reprint Role of the nitric oxide/cyclic GMP pathway and ascorbic acid in 3-morpholinosydnonimine (SIN-1)-induced increases in dopamine secretion from PC12 cells. A microdialysis in vitro study
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, viale S Pietro 43B, 07100 Sassari, Italy
    Neurosci Lett 353:5-8. 2003
    ..Extracellular Ca(2+) entry occurs through nifedipine-insensitive channels. Ascorbic acid is a key determinant in modulating the distinct profiles of SIN-1 effects...
  16. ncbi request reprint alpha-Synuclein- and MPTP-generated rodent models of Parkinson's disease and the study of extracellular striatal dopamine dynamics: a microdialysis approach
    Gianfranco Bazzu
    Department of Neuroscience, University of Sassari, Italy
    CNS Neurol Disord Drug Targets 9:482-90. 2010
    ..This article will describe the above experimental PD models and demonstrate the utility of microdialysis for their characterization...
  17. ncbi request reprint Glucocorticoid receptor deficiency increases vulnerability of the nigrostriatal dopaminergic system: critical role of glial nitric oxide
    Maria Concetta Morale
    OASI Institute for Research and Care on Mental Retardation and Brain Aging IRCCS, Neuropharmacology Section, 94018 Troina, Italy
    FASEB J 18:164-6. 2004
    ..The iNOS inhibitor N6-(1-iminoethyl)-L-lysine normalized vulnerability of Tg mice, thus establishing a novel link between genetic impairment of GR function and vulnerability to MPTP...