Research Topics
Genomes and GenesSpecies | Luigi MessoriSummaryAffiliation: University of Florence Country: Italy Publications
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Publications
Mechanisms of cytotoxicity of selected organogold(III) compoundsMarcella Coronnello
Department of Pharmacology and Chemistry, University of Florence, Florence, Italy, Department of Chemistry, University of Sassari, Sassari, Italy
J Med Chem 48:6761-5. 2005..The mechanistic implications of these findings are discussed: mitochondrial pathways are proposed to be directly involved in the apoptotic process in relation to selective inhibition of thioredoxin reductase...- Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological propertiesChiara Gabbiani
Dipartimento di Chimica and CRIST, Centro Interdipartimentale di Cristallografia Strutturale, Universita di Firenze, Polo Scientifico, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
Inorg Chem 47:2368-79. 2008..In turn, theoretical predictions offer interesting hints for the design of new, more active binuclear gold(III) compounds... - Solution chemistry and cytotoxic properties of novel organogold(III) compoundsLuigi Messori
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
Bioorg Med Chem 12:6039-43. 2004..The solution chemistry of these compounds, under physiological-like conditions, was investigated through UV-vis absorption and (1)H NMR spectroscopies. Significant cytotoxic effects in vitro were observed in selected cases... - X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteinsL Messori
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Florence, Italy
J Biol Inorg Chem 16:491-9. 2011.... - Structural features of a new dinuclear platinum(II) complex with significant antiproliferative activityLuigi Messori
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino Florence, Italy
Inorg Chem 42:6166-8. 2003..Preliminary in vitro studies point out that this dinuclear platinum complex exhibits significant growth-inhibiting properties on a panel of cultured human tumor cell lines, although less pronounced than those of cisplatin... - The reaction of artemisinins with hemoglobin: a unified pictureLuigi Messori
Department of Chemistry, University of Florence, Florence, Italy
Bioorg Med Chem 14:2972-7. 2006..A unified description for the reactions of artemisinins with hemoglobin is given... - Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compoundsAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
J Med Chem 51:6773-81. 2008..Good agreement was generally found between the inhibiting potency of the RAPTA compounds and the computed stability of the corresponding cat B/RAPTA adducts... - Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligandLaura Maiore
Department of Chemistry, University of Sassari, Sassari SS, Italy
J Inorg Biochem 105:348-55. 2011..The implications of these results are thoroughly discussed in the light of current knowledge on gold based drugs... - Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studiesAngela Casini
Laboratory of Metals in Medicine, Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Firenze, Italy
J Inorg Biochem 102:995-1006. 2008..Remarkably, the structural and functional information achieved on the respective metallodrug-protein adducts allowed us to identify some general trends in the reactivity of anticancer metallodrugs with protein targets... - Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligandsAngela Casini
Department of Chemistry, University of Florence, Florence, Italy
J Med Chem 49:5524-31. 2006..Both tested compounds manifested a high and peculiar reactivity toward the mentioned model proteins; specific differences were detected in their reactivity with DNA. The mechanistic implications of these results are discussed... - Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic studyFrancesca Magherini
Department of Biochemical Sciences, University of Florence, Viale G Morgagni, 50, 50134, Florence, Italy
J Biol Inorg Chem 15:573-82. 2010.... - Reactions of gold(III) complexes with serum albuminGiordana Marcon
Department of Chemistry, University of Florence, Italy Department of Chemistry, University of Sassari, Italy
Eur J Biochem 270:4655-61. 2003..The implications of the present results for the pharmacological activity of these novel cytotoxic agents are discussed... - Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studiesStefania Nobili
Department of Preclinical and Clinical Pharmacology, University of Florence, Viale Pieraccini 6, 50139 Florence, Italy
Med Res Rev 30:550-80. 2010..The overall perspectives on the development of gold compounds as effective anticancer drugs with an innovative mechanism of action are critically discussed on the basis of the available experimental evidence... - Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome cAngela Casini
Laboratory of Metals in Medicine, Department of Chemistry, University of Florence, Via della Lastruccia 3 50019 Sesto Fiorentino, Italy
Biochemistry 46:12220-30. 2007..The biological and pharmacological implications of the described protein platination processes are discussed... - ESI-MS characterisation of protein adducts of anticancer ruthenium(II)-arene PTA (RAPTA) complexesAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
ChemMedChem 2:631-5. 2007 - Gold(III) complexes as a new family of cytotoxic and antitumor agentsGiordana Marcon
Department of Chemistry, University of Florence, Via Gino Capponi 7, 50121, Italy
Expert Rev Anticancer Ther 2:337-46. 2002..The implications of these results for the development of gold(III) complexes as a new family of cytotoxic and antitumor agents are discussed... - fac-{Ru(CO)(3)}(2+) selectively targets the histidine residues of the beta-amyloid peptide 1-28. Implications for new Alzheimer's disease treatments based on ruthenium complexesDaniela Valensin
Department of Chemistry, University of Siena, Via A Moro, 53100 Siena, Italy
Inorg Chem 49:4720-2. 2010..Notably, very similar ESI-MS results were obtained when I was reacted with Abeta(42). The implications of the above findings for a possible use of ruthenium compounds in Alzheimer's disease are discussed... - The C2 variant of human serum transferrin retains the iron binding properties of the native proteinPaolo Zatta
CNR Institute for Biomedical Technologies, Metalloproteins Unit, Department of Biology, University of Padova, Vle G Colombo, 3, 3512 Padova, Italy
Biochim Biophys Acta 1741:264-70. 2005..The implications of these results for the etiopathogenesis of Alzheimer's disease are discussed... - The crystal structure of the complex between a disaccharide anthracycline and the DNA hexamer d(CGATCG) reveals two different binding sites involving two DNA duplexesClaudia Temperini
Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto F.no (FI, Italy
Nucleic Acids Res 31:1464-9. 2003..We discuss the present findings with respect to the relevance of the amino group for DNA binding and to the potential role played by the second sugar in the interactions with topoisomerases or other cellular targets... - Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of actionAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
J Inorg Biochem 102:564-75. 2008..The mechanistic relevance of gold(III)-induced oxidative protein damage and of direct gold coordination to protein sidechains is specifically assessed. Perspectives for the future of this topics are briefly outlined... - Molecular structure, solution chemistry and biological properties of the novel [ImH][trans-IrCl(4)(Im)(DMSO)], (I) and of the orange form of [(DMSO)(2)H][trans-IrCl(4)(DMSO)(2)], (II), complexesLuigi Messori
Department of Chemistry, University of Florence, Sesto Fiorentino, Firenze, Italy
J Inorg Biochem 95:37-46. 2003.... - Gold(III) complexes with bipyridyl ligands: solution chemistry, cytotoxicity, and DNA binding propertiesGiordana Marcon
CIRCMSB, local Unit of Florence, University of Florence, Florence, Italy
J Med Chem 45:1672-7. 2002..The mechanistic implications of these findings are discussed... - Spectrophotometric and ESI-MS/HPLC studies reveal a common mechanism for the reaction of various artemisinin analogues with heminLuigi Messori
Department of Chemistry, University of Florence, Via della Lastruccia 3, I 50019 Sesto Fiorentino, Florence, Italy
Bioorg Med Chem Lett 13:4055-7. 2003..In the course of the reaction characteristic isomeric 1:1 drug-hemin adducts are formed as in the case of artemisinin; eventual disruption of the porphyrin ring takes place in all cases, most likely through oxidative degradation... - Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysisChiara Gabbiani
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019, Sesto Fiorentino, Italy
J Biol Inorg Chem 13:755-64. 2008..Additional ESI-MS measurements on enzymatically cleaved cytochrome c adducts suggest that protein platination probably occurs at Met65. The mechanistic implications of these findings are discussed... - Exploring the reactions of ?-amyloid (A?) peptide 1-28 with Al(III) and Fe(III) ionsDaniela Valensin
Department of Chemistry, University of Siena, Via A Moro, 53100 Siena, Italy
Inorg Chem 50:6865-7. 2011..The biological implications of these findings are discussed in the frame of current literature... - 2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compoundsFrancesca Guidi
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
Mol Biosyst 8:985-93. 2012..In conclusion, we performed a comprehensive analysis of proteins regulated by AuL12 and Au(2)Phen, providing a useful insight into their mechanisms of action... - Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compoundsFrancesca Guidi
Department of Biochemical Sciences, University of Florence, Viale G Morgagni, 50, 50134 Firenze, Italy
Metallomics 4:307-14. 2012..The implications of the obtained results are thoroughly discussed in the frame of current knowledge on cytotoxic gold agents... - New copper(II)/cyclic tetrapeptide system that easily oxidizes to copper(III) under atmospheric oxygenAlessandro Pratesi
PeptLab, Department of Organic Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Florence, Italy
Inorg Chem 46:10038-40. 2007..This donor set would greatly lower the redox potential for the CuIII/CuII couple, thus allowing easy oxidation of the coordinated copper(II) by atmospheric oxygen... - DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniquesLaura Ciani
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Florence, Italy
Biophys Chem 127:213-20. 2007..The resulting adducts showed peculiar and non-canonical CD spectra, while exhibiting appreciable stability at physiological pH... - Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome cAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Italy
J Biol Inorg Chem 12:1107-17. 2007..Notably, greatly different patterns of interaction were found to be operative for NAMI-A toward these two proteins. The biological implications of the present findings are discussed... - Proteomic and metallomic strategies for understanding the mode of action of anticancer metallodrugsChiara Gabbiani
Department of Chemistry, University of Florence, Via della Lastruccia, 3, 50019 Sesto Fiorentino, Florence, Italy
Anticancer Agents Med Chem 10:324-37. 2010..A further extension of those studies and a closer integration of proteomic and metallomic strategies and technologies might realistically lead to rapid and significant advancements in the mechanistic knowledge of anticancer metallodrugs... - Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's diseaseCristina Grossi
Department of Pharmacology, University of Florence, Florence, Italy
J Alzheimers Dis 17:423-40. 2009..e., copper, zinc, and iron) were highlighted following CQ treatment. The pharmacological and mechanistic implications of the above findings are thoroughly discussed... - Modeling of copper(II) sites in proteins based on histidyl and glycyl residuesMarco Orfei
Department of Chemistry, University of Florence, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Italy
J Inorg Biochem 97:299-307. 2003..Results are discussed in relation to the modeling of copper(II) binding sites in proteins, particular emphasis being devoted to the copper complexes of the prion protein... - Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexesMassimo Di Vaira
Department of Chemistry, University of Florence, Via della Lastruccia 3, Sesto Fiorentino, Florence, Italy
Inorg Chem 43:3795-7. 2004..A ligand to metal stoichiometry of 2:1 is found in both cases, though in the presence of quite different coordination polyhedra. The present findings are discussed in the frame of modern approaches to AD treatment... - New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitroGabriella Tamasi
Department of Chemistry, Universita di Siena, Via Aldo Moro 2, I 53100 Siena, Italy
J Inorg Biochem 104:799-814. 2010..Density functional methods help in finding rationale for the easiest dissociation of Pt-H(2)ISO/HISO bonds when compared to the Pt-N(1)(')-H(2)MEL/N(1)(')-HMEL linkages... - Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stabilityChiara Gabbiani
Laboratory of Metals in Medicine, Department of Chemistry, University of Florence, Florence, Italy
Metallomics 3:1318-23. 2011..Different molecular mechanisms are thus hypothesised for these two classes of dinuclear gold(III) agents... - Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: solution behavior, reactions with model proteins, antiproliferative propertiesLaura Maiore
Department of Chemistry, University of Sassari, Sassari SS, Italy
J Inorg Biochem 108:123-7. 2012..59 to 10.86 ?M in the resistant one. The common ability of these compounds to overcome cisplatin resistance is highlighted. The obtained results are thoroughly discussed in the frame of current knowledge on cytotoxic gold compounds... - Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarialsChiara Gabbiani
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
J Inorg Biochem 103:310-2. 2009..Notably, the antiplasmodial effects appear not to be correlated to in vitro anticancer properties. The mechanistic and pharmacological implications of the obtained results are discussed... - Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM studyMassimo Innocenti
Department of Chemistry, University of Florence, Sesto Fiorentino, Italy
J Alzheimers Dis 19:1323-9. 2010..The implications of these AFM results are discussed in the context of current concepts for AD metallobiology... - Gold complexes as antitumor agentsLuigi Messori
Department of Chemistry, University of Florence, I-50019 Sesto Fiorentino, Florence, Italy
Met Ions Biol Syst 42:385-424. 2004 - Gold complexes in the treatment of rheumatoid arthritisLuigi Messori
Department of Chemistry, University of Florence, I-50019 Sesto Fiorentino, Florence, Italy
Met Ions Biol Syst 41:279-304. 2004 - Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysisAlessandro Pratesi
Laboratory of Peptide and Protein Chemistry and Biology, Department of Chemistry Ugo Schiff, University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Firenze, Italy
Chem Commun (Camb) 46:7001-3. 2010..Remarkably, the main reaction products could be unambiguously identified providing valuable insight into the likely mechanisms of enzyme inhibition by gold compounds... - Structural investigation of cisplatin-protein interactions: selective platination of His19 in a cuprozinc superoxide dismutaseVito Calderone
Department of Chemistry, , Via Aldo Moro 1, 53100 Siena, Italy
Angew Chem Int Ed Engl 45:1267-9. 2006 - The disaccharide anthracycline MEN 10755 binds human serum albumin to a non-classical drug binding siteLuigi Messori
Department of Chemistry, University of Florence, Via Gino Capponi 7, Florence, Italy
Bioorg Med Chem 10:3425-30. 2002..On the basis of these results, it is proposed that MEN 10755 binds serum albumin tightly to a non-canonical surface binding site for which it competes specifically with ethacrinic acid... - Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configuredLuigi Messori
Dipartimento di Chimica, Universita di Firenze, Via della Lastruccia 3, 50019 Sesto Fiorentino, Italy
Inorg Chem 51:1717-26. 2012..Such differences in reactivity may have important mechanistic implications and a relevant impact on the respective pharmacological profiles... - Exploring metallodrug-protein interactions by ESI mass spectrometry: the reaction of anticancer platinum drugs with horse heart cytochrome cAngela Casini
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto, Fiorentino, Italy
ChemMedChem 1:413-7. 2006 - Simple and rapid physico-chemical methods to examine action of antimalarial drugs with hemin: its application to Artemisia annua constituentsAnna Rita Bilia
Department of Pharmaceutical Sciences, University of Florence, Firenze, Italy
Life Sci 70:769-78. 2002.... - Decomposition of ascorbic acid in the presence of cadmium ions leads to formation of a polymeric cadmium oxalate species with peculiar structural featuresPierluigi Orioli
Department of Chemistry, University of Florence, Via della Lastruccia 3, 50019 Sesto Fiorentino FI, Italy
Inorg Chem 41:4312-4. 2002..94; triclinic; space group P1 (No. 1); a = 6.010(1) A, b = 6.668(1) A, c = 8.498(1) A; alpha = 74.64(1) degrees, beta = 74.25(1) degrees, gamma = 80.91(1) degrees; V = 314.7(5) A(3); Z = 1... - Protein targets for anticancer gold compounds: mechanistic inferencesChiara Gabbiani
MetMed Lab, Department of Chemistry, University of Florence, Florence, Italy
Anticancer Agents Med Chem 11:929-39. 2011..The state of the art of this research area and the perspectives for future studies are herein critically analysed and discussed... - Study of ruthenium(II) complexes with anticancer drugs as ligands. Design of metal-based phototherapeutic agentsRenzo Cini
Department of Chemical and Biosystem Sciences and Technologies, University of Siena, Via A Moro 2, I 53100 Siena, Italy
Inorg Chem 42:8038-52. 2003..Furthermore, the spectral analysis of HTPYM, TPs, and their Ru(II) complexes in solution shows that intense absorptions occur in the UVA/vis region of light, whereas standard nucleobases absorb in the UVB region... - The copper(II) coordination abilities of three novel cyclic tetrapeptides with -His-Xaa-His- motifJustyna Brasun
Department of Inorganic Chemistry, Wrocław Medical University, Szewska 38, 50 139 Wrocław, Poland
J Inorg Biochem 101:452-60. 2007..This latter type of copper(II) chromophore has been carefully modelled by computational methods. The potentialities of the applied experimental strategy are stressed... - Spectroscopic and potentiometric study of the SOD mimic system copper(II)/acetyl-L-histidylglycyl-L-histidylglycineMario Casolaro
Dipartimento di Chimica and Istituto di Chimica dei Composti Organo Metallici del C.N.R, , Pian dei Mantellini 44, Italy
J Inorg Biochem 89:181-90. 2002..The logbeta values of the copper complexes of AcHGHG are by far lower than those of the corresponding species in the parent CuII-HGHG system... - Synthesis, structural characterization, solution chemistry, and preliminary biological studies of the ruthenium(III) complexes [TzH][trans-RuCl4(Tz)2] and [TzH][trans-RuCl4(DMSO)(Tz)].(DMSO), the thiazole analogues of antitumor ICR and NAMI-APasquale Mura
Institute of Crystallography, Sezione di Monterotondo, Area della Ricerca di Roma, CNR CP10, I 00016 Monterotondo Stazione, Rome, Italy
Inorg Chem 43:3863-70. 2004..A more extensive characterization of the pharmacological properties in vivo is presently in progress... - fac-{Ru(CO)3}2+-core complexes and design of metal-based drugs. synthesis, structure, and reactivity of Ru-thiazole derivative with serum proteins and absorption-release studies with acryloyl and silica hydrogels as carriers in physiological mediaRenzo Cini
Department of Chemical and Biosystem Sciences and Technologies, University of Siena, Via Aldo Moro 2, I 53100 Siena, Italy
Inorg Chem 46:79-92. 2007..Ruthenium species are slowly released from the loaded gels into physiological solutions at pH 7.4. The reactivity of 2 with biomolecules and synthetic hydrogels makes it a compound of interest for anticancer and antimetastases tests... - Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)]Pasquale Mura
Institute of Crystallography sezione di Monterotondo, Area della Ricerca di Roma, CNR, CP10, I 00016 Monterotondo Stazione, Rome, Italy
Inorg Chem 44:4897-9. 2005.... - The copper(II) binding properties of the cyclic peptide c(HGHK)Justyna Brasun
Department of Basic Medical Sciences, Wrocław Medical University, Kochanowskiego 14, 51 601 Wrocław, Poland
J Inorg Biochem 98:2016-21. 2004..A detailed comparison with the copper(II) binding properties of HGHG and Ac-HGHG ligands is also reported... - Gold complexes inhibit mitochondrial thioredoxin reductase: consequences on mitochondrial functionsMaria Pia Rigobello
Dipartimento di Chimica Biologica, , Viale G. Colombo 3, 35121 Padova, Italy
J Inorg Biochem 98:1634-41. 2004..They also inhibit mitochondrial respiration, decrease membrane potential and, finally, induce swelling... - Effects of chronic treatment with sodium tetrachloroaurate(III) in mice and membrane modelsMario Suwalsky
Faculty of Chemical Sciences, University of Concepcion, Chile
J Inorg Biochem 98:2080-6. 2004..These results show that toxic effects on animal brain upon treatment with sodium tetrachloroaurate develop with difficulty and may be observed only at high doses... - A novel class of peptides with facilitating action on neuronal nicotinic receptors of rat chromaffin cells in vitro: functional and molecular dynamics studiesSilvia Di Angelantonio
Biophysics Sector, International School for Advanced Studies, Trieste, Italy
Mol Pharmacol 61:43-54. 2002..CD measurements on CGRP(1-6) were compatible with these MD structural findings. Short terminal fragments of CGRP represent a novel class of substances with selective, rapid, and reversible potentiation of nAChRs... - Antimalarial properties of green teaAnna Rosa Sannella
Department of Infectious, Parasitic and Immunomediated Diseases, Vector Borne Diseases and International Health Section, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
Biochem Biophys Res Commun 353:177-81. 2007..The importance of these findings and their mechanistic implications are discussed in view of future therapeutic strategies... - New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implicationsAnna Rosa Sannella
Department of Infectious, Parasitic and Immunomediated Diseases, Vector Borne Diseases and International Health Section, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
FEBS Lett 582:844-7. 2008..falciparum thioredoxin reductase. The above findings and the safe toxicity profile of auranofin warrant rapid evaluation of AF for malaria treatment in animal models... - Activity of rat cytosolic thioredoxin reductase is strongly decreased by trans-[bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: first report of relevant thioredoxin reductase inhibition for a ruthenium compoundPasquale Mura
Institute of Crystallography, Area della Ricerca di Roma 1 CNR, Via Salaria Km 29, 300, Montelibretti, Rome, Italy
J Med Chem 50:5871-4. 2007..The selective inhibition of the cytosolic form of this selenoenzyme was documented, this being the first report of significant thioredoxin reductase inhibition by a ruthenium compound... - Potential pathogenic role of beta-amyloid(1-42)-aluminum complex in Alzheimer's diseaseDenise Drago
Department of Biology, University of Padova, Viale G Colombo, 3 35121 Padova, Italy
Int J Biochem Cell Biol 40:731-46. 2008....