Luigi Messori

Summary

Affiliation: University of Florence
Country: Italy

Publications

  1. Casini A, Gabbiani C, Sorrentino F, Rigobello M, Bindoli A, Geldbach T, et al. Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds. J Med Chem. 2008;51:6773-81 pubmed publisher
    ..Good agreement was generally found between the inhibiting potency of the RAPTA compounds and the computed stability of the corresponding cat B/RAPTA adducts. ..
  2. Cirri D, Pillozzi S, Gabbiani C, Tricomi J, Bartoli G, Stefanini M, et al. PtI2(DACH), the iodido analogue of oxaliplatin as a candidate for colorectal cancer treatment: chemical and biological features. Dalton Trans. 2017;46:3311-3317 pubmed publisher
    ..Overall, a rather promising picture emerges for this novel Pt drug that merits, in our opinion, a deeper and more extensive preclinical evaluation. ..
  3. Ciambellotti S, Pratesi A, Severi M, Ferraro G, Alessio E, Merlino A, et al. The NAMI A - human ferritin system: a biophysical characterization. Dalton Trans. 2018;47:11429-11437 pubmed publisher
    ..We also noted that NAMI A produces a partial inhibition of HuHf ferroxidase activity. The implications of the above results are discussed. ..
  4. Serratrice M, Maiore L, Zucca A, Stoccoro S, Landini I, Mini E, et al. Cytotoxic properties of a new organometallic platinum(II) complex and its gold(I) heterobimetallic derivatives. Dalton Trans. 2016;45:579-90 pubmed publisher
    ..The obtained results are comprehensively discussed. ..
  5. Bondžić A, Janjić G, Dramicanin M, Messori L, Massai L, Parac Vogt T, et al. Na/K-ATPase as a target for anticancer metal based drugs: insights into molecular interactions with selected gold(iii) complexes. Metallomics. 2017;9:292-300 pubmed publisher
    ..The present results offer further support to the view that Na/K-ATPase may be a relevant biomolecular target for cytotoxic gold(iii) compounds of medicinal interest and may thus be involved in their overall mode of action. ..
  6. Ferraro G, Marzo T, Cucciolito M, Ruffo F, Messori L, Merlino A. Reaction with Proteins of a Five-Coordinate Platinum(II) Compound. Int J Mol Sci. 2019;20: pubmed publisher
    ..Our findings also suggest that five-coordinate Pt(II) complexes can act either retaining their uncommon structure or functioning as prodrugs, i.e., releasing square-planar platinum complexes as bioactive species. ..
  7. Micale N, Schirmeister T, Ettari R, Cinellu M, Maiore L, Serratrice M, et al. Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities. J Inorg Biochem. 2014;141:79-82 pubmed publisher
    ..The present results further support the view that proteasome inhibition may play a major--yet not exclusive--role in the cytotoxic actions of gold based anticancer agents. ..
  8. Marzo T, Scaletti F, Michelucci E, Gabbiani C, Pescitelli G, Messori L, et al. Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation. Biometals. 2015;28:1079-85 pubmed publisher
    ..Binding competitions with mercury and bismuth ions were also explored. The relevance and the biological implications of the present results are discussed. ..
  9. Darabi F, Marzo T, Massai L, Scaletti F, Michelucci E, Messori L. Reactions of model proteins with aurothiomalate, a clinically established gold(I) drug: The comparison with auranofin. J Inorg Biochem. 2015;149:102-7 pubmed publisher
    ..The affinity constants of AuTm toward the three mentioned proteins were also initially assessed. The implications of the present findings are discussed. ..

More Information

Publications23

  1. Massai L, Fernández Gallardo J, Guerri A, Arcangeli A, Pillozzi S, Contel M, et al. Design, synthesis and characterisation of new chimeric ruthenium(II)-gold(I) complexes as improved cytotoxic agents. Dalton Trans. 2015;44:11067-76 pubmed publisher
    ..The mechanistic and pharmacological implications of the present findings are discussed. ..
  2. Marzo T, Pillozzi S, Hrabina O, Kasparkova J, Brabec V, Arcangeli A, et al. cis-Pt I2(NH3)2: a reappraisal. Dalton Trans. 2015;44:14896-905 pubmed publisher
    ..An ab initio DFT study is also included to support the interpretation of the solution behaviour of cisPtI2 under physiological and slightly acidic pH conditions. ..
  3. Messori L, Marzo T, Merlino A. Interactions of carboplatin and oxaliplatin with proteins: Insights from X-ray structures and mass spectrometry studies of their ribonuclease A adducts. J Inorg Biochem. 2015;153:136-142 pubmed publisher
    ..These results are potentially useful for a better understanding of the biological chemistry, toxicity and side effects of this important class of antitumor agents. ..
  4. Marzo T, Cirri D, Ciofi L, Gabbiani C, Feis A, Di Pasquale N, et al. Synthesis, characterization and DNA interactions of [Pt3(TPymT)Cl3], the trinuclear platinum(II) complex of the TPymT ligand. J Inorg Biochem. 2018;183:101-106 pubmed publisher
    ..In contrast to expectations, the obtained data reveal that no intercalative binding takes place; we propose that binding of Pt3TPymT to DNA mainly occurs through external/groove binding. ..
  5. Pratesi A, Cirri D, Đurović M, Pillozzi S, Petroni G, Bugarcić Z, et al. New gold carbene complexes as candidate anticancer agents. Biometals. 2016;29:905-11 pubmed publisher
    ..Moreover, a certain reactivity of the complex 2 was also detected toward GSH. The general implications of the obtained results are discussed. ..
  6. Battistin F, Scaletti F, Balducci G, Pillozzi S, Arcangeli A, Messori L, et al. Water-soluble Ru(II)- and Ru(III)-halide-PTA complexes (PTA=1,3,5-triaza-7-phosphaadamantane): Chemical and biological properties. J Inorg Biochem. 2016;160:180-8 pubmed publisher
    ..The chemical and biological profiles of compounds 1-5 are compared to those of established ruthenium drug candidates in clinical development. ..
  7. Massai L, Pratesi A, Bogojeski J, Banchini M, Pillozzi S, Messori L, et al. Antiproliferative properties and biomolecular interactions of three Pd(II) and Pt(II) complexes. J Inorg Biochem. 2016;165:1-6 pubmed publisher
    ..Interestingly our results revealed that DNA binding, as well as anticancer activity of 1-3 follows the order 2>3>1. The implications of these findings are discussed. ..
  8. Massai L, Cirri D, Michelucci E, Bartoli G, Guerri A, Cinellu M, et al. Organogold(III) compounds as experimental anticancer agents: chemical and biological profiles. Biometals. 2016;29:863-72 pubmed publisher
    ..The implications of these results are discussed in the frame of current knowledge on anticancer gold compounds. ..
  9. Gabbiani C, Pratesi A, Marchetti L, Casini A, Leoni P, Pillozzi S, et al. Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells. J Inorg Biochem. 2016;163:318-322 pubmed publisher
    ..Owing to the reported encouraging results, a more extensive biological and pharmacological evaluation of this Pt cluster is now warranted to better elucidate its mode of action. ..
  10. Marzo T, Navas F, Cirri D, Merlino A, Ferraro G, Messori L, et al. Reactions of a tetranuclear Pt-thiosemicarbazone complex with model proteins. J Inorg Biochem. 2018;181:11-17 pubmed publisher
  11. Marzo T, Bartoli G, Gabbiani C, Pescitelli G, Severi M, Pillozzi S, et al. Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles. Biometals. 2016;29:535-42 pubmed publisher
  12. Mügge C, Musumeci D, Michelucci E, Porru F, Marzo T, Massai L, et al. Elucidating the reactivity of Pt(II) complexes with (O,S) bidentate ligands towards DNA model systems. J Inorg Biochem. 2016;160:198-209 pubmed publisher
    ..Guanine was established as the preferential target within the DNA sequence, but in the absence or unavailability of guanines, alternative binding sites can be addressed. The implications of these results are thoroughly discussed. ..
  13. Marzo T, De Pascali S, Gabbiani C, Fanizzi F, Messori L, Pratesi A. ESI-MS studies of the reactions of novel platinum(II) complexes containing O,O'-chelated acetylacetonate and sulfur ligands with selected model proteins. Biometals. 2017;30:609-614 pubmed publisher
    ..Preferential binding to protein targets compared to DNA is supported by independent ICP-OES measurements. The implications of these findings are discussed. ..
  14. Messori L, Merlino A. Protein metalation by metal-based drugs: X-ray crystallography and mass spectrometry studies. Chem Commun (Camb). 2017;53:11622-11633 pubmed publisher
    ..Possible directions for future work in the field are delineated. ..